{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T07:02:15Z","timestamp":1779778935818,"version":"3.53.1"},"reference-count":255,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Ageing is a complicated phenomenon that is defined by the progressive decline in the body\u2019s functions that leads to weakened regenerative potential and greater vulnerability to various age-related diseases. There is evidence that highlights that stem cell dysfunction and exhaustion are the primary reasons for tissue degeneration that progresses with age and hence provide aid to regenerative therapeutic approaches. Stem cells have shown the ability to influence age-related cellular dysfunction in preclinical models mainly via paracrine signaling, immune modulation and tissue repair processes. Nonetheless, clinical evidence primarily confines to early-phase trials, showing inconsistent results based on cell type, delivery method and disease context. Several types of stem cells are being studied rigorously for their regenerative, immunomodulatory, and anti-ageing properties. Pre-clinical and early-phase clinical studies suggest potential benefits of stem cell-based interventions in musculoskeletal, cardiovascular and neurodegenerative disorders although effect sizes vary and long-term efficacy remains under investigation. Furthermore, emerging technologies such as tissue reprogramming, senolytics and niche modulation also contribute to improving therapeutic strategies. This review aims to provide a comprehensive overview of the existing knowledge of stem cell biology and therapies from various preclinical and clinical studies, along with rejuvenation approaches.<\/jats:p>","DOI":"10.3389\/fcell.2026.1830358","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T06:03:22Z","timestamp":1779775402000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Stem cell dysfunction and rejuvenation strategies in ageing: emerging advances in regenerative medicine"],"prefix":"10.3389","volume":"14","author":[{"given":"Khuzin","family":"Dinislam","sequence":"first","affiliation":[{"name":"Department of General Chemistry, Bashkir State Medical University","place":["Ufa, Republic Of Bashkortostan, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas","family":"Shamsi","sequence":"additional","affiliation":[{"name":"Centre of Medical and Bio-Allied Health Sciences Research, Ajman University","place":["Ajman, United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed","family":"Tasqeruddin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University","place":["Abha, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleha","family":"Anwar","sequence":"additional","affiliation":[{"name":"Centre of Medical and Bio-Allied Health Sciences Research, Ajman University","place":["Ajman, United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moyad","family":"Shahwan","sequence":"additional","affiliation":[{"name":"Centre of Medical and Bio-Allied Health Sciences Research, Ajman University","place":["Ajman, United Arab Emirates"]},{"name":"Center of Excellence in Precision Medicine and Digital Health, Department of Physiology, Faculty of Dentistry, Chulalongkorn University","place":["Bangkok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.placenta.2017.04.003","article-title":"Immunomodulatory properties of human placental mesenchymal stem\/stromal cells","volume":"59","author":"Abumaree","year":"2017","journal-title":"Placenta"},{"key":"B2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/B978-0-443-27302-5.00013-9","article-title":"Biology of cancer","volume-title":"Genetics and Epigenetics of Genitourinary Diseases","author":"Aghamir","year":"2025"},{"key":"B3","doi-asserted-by":"crossref","DOI":"10.5772\/intechopen.90236","article-title":"Introductory chapter: update on mesenchymal and induced pluripotent stem cells","volume-title":"Update on Mesenchymal and Induced Pluripotent Stem Cells","author":"Ahmed Al-Anazi","year":"2020"},{"key":"B4","doi-asserted-by":"publisher","first-page":"13742","DOI":"10.1073\/PNAS.93.24.13742","article-title":"Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts","volume":"93","author":"Alcorta","year":"1996","journal-title":"Proc. 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