{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:02:22Z","timestamp":1789459342498,"version":"build-2803163510"},"reference-count":238,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>\n                    Smoke inhalation injury (SII) is a prevalent yet underrecognized cause of acute respiratory failure and longer-term airway-alveolar remodeling after fires, wildfires, and industrial accidents. Beyond inflammation and generic oxidative stress, accumulating evidence supports ferroptosis as a mechanistically distinct, self-amplifying axis that can sustain epithelial\/endothelial damage, barrier breakdown, and maladaptive repair. Ferroptosis is driven by iron-dependent phospholipid peroxidation and collapse of membrane redox homeostasis, and in SII is promoted by iron dyshomeostasis including heme\/hemoglobin-derived iron and ferritinophagy, PUFA-phospholipid remodeling, and failure of antioxidant checkpoints centered on the System Xc\n                    <jats:sup>\u2212<\/jats:sup>\n                    -GSH-GPX4 pathway, with complementary protection via FSP1-CoQ10 and related radical-trapping systems. Despite rapid progress, how ferroptotic signaling integrates with other regulated cell-death programs and inflammatory circuits across the temporal phases of SII remains incompletely defined. In this review, we synthesize molecular mechanisms, crosstalk networks, candidate biomarkers, and preclinical evidence for therapeutically actionable nodes, highlighting ferroptosis inhibitors, iron-targeting approaches, and redox-restorative strategies as candidates for mechanism-guided, disease-modifying intervention in SII.\n                  <\/jats:p>","DOI":"10.3389\/fcell.2026.1832061","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:03:23Z","timestamp":1789455803000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ferroptosis in smoke inhalation injury: from mechanisms to potential therapeutic targets"],"prefix":"10.3389","volume":"14","author":[{"given":"Nayab","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Key Laboratory of Medical Rescue Key Technology and Equipment, Ministry of Emergency Management, School of Disaster and Emergency Medicine, Tianjin University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Rescue Key Technology and Equipment, Ministry of Emergency Management, School of Disaster and Emergency Medicine, Tianjin University","place":["Tianjin, China"]},{"name":"Wenzhou Safety (Emergency) Institute of Tianjin University","place":["Wenzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Rescue Key Technology and Equipment, Ministry of Emergency Management, School of Disaster and Emergency Medicine, Tianjin University","place":["Tianjin, China"]},{"name":"Wenzhou Safety (Emergency) Institute of Tianjin University","place":["Wenzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanlong","family":"Li","sequence":"additional","affiliation":[{"name":"Wenzhou Safety (Emergency) Institute of Tianjin University","place":["Wenzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Shao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Medical Materials and Devices, School of Medicine, Tianjin University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenping","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Medical Materials and Devices, School of Medicine, Tianjin University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Shi","sequence":"additional","affiliation":[{"name":"Wenzhou Safety (Emergency) Institute of Tianjin University","place":["Wenzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Rescue Key Technology and Equipment, Ministry of Emergency Management, School of Disaster and Emergency Medicine, Tianjin University","place":["Tianjin, China"]},{"name":"Research Center, Wenzhou People\u2019s Hospital","place":["Wenzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrui","family":"Dong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Rescue Key Technology and Equipment, Ministry of Emergency Management, School of Disaster and Emergency Medicine, Tianjin University","place":["Tianjin, China"]},{"name":"State Key Laboratory of Advanced Medical Materials and Devices, School of Medicine, Tianjin University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojun","family":"Fan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Rescue Key Technology and Equipment, Ministry of Emergency Management, School of Disaster and Emergency Medicine, Tianjin University","place":["Tianjin, China"]},{"name":"Wenzhou Safety (Emergency) Institute of Tianjin University","place":["Wenzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"527","DOI":"10.3390\/antiox14050527","article-title":"Ferroptosis and iron homeostasis: molecular mechanisms and neurodegenerative disease implications","volume":"14","author":"Abdukarimov","year":"2025","journal-title":"Antioxidants (Basel)"},{"key":"B2","doi-asserted-by":"publisher","first-page":"581","DOI":"10.3390\/diagnostics15050581","article-title":"Carbon monoxide poisoning: diagnosis, prognostic factors, treatment strategies, and future perspectives","volume":"15","author":"Afzal","year":"2025","journal-title":"Diagn. 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