{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T06:18:13Z","timestamp":1783491493236,"version":"3.55.0"},"reference-count":194,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2026NSFSC1707"],"award-info":[{"award-number":["2026NSFSC1707"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Nucleophosmin1 (NPM1) proteins, initially recognized as central guardians of nucleolar architecture and function, have recently been redefined as pivotal hubs that integrate diverse forms of chronic cellular stress signaling. Although the roles of NPM1 have been extensively elucidated in tumor biology, its broad involvement in non-communicable chronic inflammatory diseases (NCDs) remains insufficiently and unsystematically summarized. Here, we highlight NPM1 as a key sensor of stress-induced nucleolar disassembly, nucleocytoplasmic translocation, and p53 stabilization. In pathological conditions such as myocardial ischemia, endothelial dysfunction, atherosclerosis, and chemotherapy-associated cardiotoxicity, NPM1 exhibits pronounced context dependence functioning either to initiate cytoprotective responses or to promote inflammation and apoptosis. In parallel, NPM1 plays a central role in maintaining genomic stability by sequestering, mobilizing, and regulating essential enzymes across multiple DNA damage repair pathways, including base excision repair (BER) and translesion synthesis (TLS). Dysregulation of these functions is closely linked to chronic pathological processes driven by metabolic stress, oxidative stress, and proteotoxicity. Collectively, available evidence suggests that NPM1, as a core node of the nucleolus\u2013nucleoplasm signaling axis, may constitute a common molecular pathological basis underlying multiple chronic inflammatory diseases, including cancer, cardiovascular diseases, diabetes, and neurodegenerative disorders. A deeper dissection of its post-translational modifications, stress-dependent subcellular re-localization, and interactions with partner proteins is expected to provide a novel conceptual framework and therapeutic avenues for the development of NPM1-based targeted interventions. Accordingly, this review synthesizes the core molecular mechanisms of the NPM1 in the maintenance of cellular homeostasis, including regulating nucleolar stress, DNA damage repair, and inflammation, We place a particular emphasis on how these baseline pathways translate into distinct functional phenotypes within the pathological processes of chronic diseases, including cardiovascular, metabolic, and neurodegenerative disorders.<\/jats:p>","DOI":"10.3389\/fcell.2026.1840902","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:54:19Z","timestamp":1783490059000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Nucleophosmin 1 proteins as potential therapeutic targets in non-communicable chronic inflammatory diseases: a review of pathophysiological mechanisms"],"prefix":"10.3389","volume":"14","author":[{"given":"Kaijie","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, North Sichuan Medical College","place":["Nanchong, Sichuan, China"]},{"name":"Department of Cardiovascular Medicine, The General Hospital of Western Theater Command","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The General Hospital of Western Theater Command","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, North Sichuan Medical College","place":["Nanchong, Sichuan, China"]},{"name":"Department of Cardiovascular Medicine, The General Hospital of Western Theater Command","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongshan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The General Hospital of Western Theater Command","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1016\/j.bbamcr.2015.04.012","article-title":"The HBx oncoprotein of hepatitis B virus engages nucleophosmin to promote rDNA transcription and cellular proliferation","volume":"1853","author":"Ahuja","year":"2015","journal-title":"Biochim. Biophys. Acta Mol. Cell. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"3839","DOI":"10.1016\/j.febslet.2008.10.023","article-title":"Nucleophosmin is required for chromosome congression, proper mitotic spindle formation, and kinetochore-microtubule attachment in HeLa cells","volume":"582","author":"Amin","year":"2008","journal-title":"FEBS Lett."},{"key":"B3","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s13024-020-00365-9","article-title":"Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS\/FTD","volume":"15","author":"Andrade","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"B4","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/j.chembiol.2010.06.014","article-title":"Nitric oxide-mediated histone hyperacetylation in oral cancer: target for a water-soluble HAT inhibitor, CTK7A","volume":"17","author":"Arif","year":"2010","journal-title":"Chem. Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"6145","DOI":"10.1073\/pnas.1017935108","article-title":"Nucleolar stress is an early response to myocardial damage involving nucleolar proteins nucleostemin and nucleophosmin","volume":"108","author":"Avitabile","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B6","doi-asserted-by":"publisher","first-page":"3096","DOI":"10.1182\/blood-2010-09-309674","article-title":"Targeting levels or oligomerization of nucleophosmin 1 induces differentiation and loss of survival of human AML cells with mutant NPM1","volume":"118","author":"Balusu","year":"2011","journal-title":"Blood"},{"key":"B7","doi-asserted-by":"publisher","first-page":"3431","DOI":"10.3390\/cancers16193431","article-title":"Honey targets ribosome biogenesis components to suppress the growth of human pancreatic cancer cells","volume":"16","author":"Bangash","year":"2024","journal-title":"Cancers"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.17305\/bb.2024.10249","article-title":"Regulation of TGF-beta2-induced epithelial-mesenchymal transition and autophagy in lens epithelial cells by the miR-492\/NPM1 axis","volume":"24","author":"Bao","year":"2024","journal-title":"Biomol. Biomed."},{"key":"B9","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/s12915-021-01058-5","article-title":"Doxorubicin induces an alarmin-like TLR4-dependent autocrine\/paracrine action of nucleophosmin in human cardiac mesenchymal progenitor cells","volume":"19","author":"Beji","year":"2021","journal-title":"BMC Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/s41419-025-07556-6","article-title":"Overexpression of betaTrCP1 elicits cell death in cisplatin-induced senescent cells","volume":"16","author":"Belmonte-Fern\u00e1ndez","year":"2025","journal-title":"Cell. Death Dis."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/ol.2025.15265","article-title":"Targeting menin in lysine methyltransferase 2A\/nucleophosmin-mutated leukemia: a novel strategy from epigenetic dysregulation to clinical therapy (review)","volume":"30","author":"Bi","year":"2025","journal-title":"Oncol. Lett."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1038\/leu.2011.367","article-title":"Consequences of heat shock protein 72 (Hsp72) expression and activity on stress-induced apoptosis in CD30+ NPM-ALK+ anaplastic large-cell lymphomas","volume":"26","author":"Bonvini","year":"2012","journal-title":"Leukemia"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1080\/15384101.2016.1166319","article-title":"mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with pten inactivation","volume":"15","author":"Boudra","year":"2016","journal-title":"Cell. Cycle"},{"key":"B14","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12867-016-0073-9","article-title":"Nucleophosmin: from structure and function to disease development","volume":"17","author":"Box","year":"2016","journal-title":"BMC Mol. Biol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1002\/pmic.200300409","article-title":"Proteomic study of human umbilical vein endothelial cells in culture","volume":"3","author":"Bruneel","year":"2003","journal-title":"Proteomics"},{"key":"B16","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.ccell.2018.08.005","article-title":"Mutant NPM1 maintains the leukemic state through HOX expression","volume":"34","author":"Brunetti","year":"2018","journal-title":"Cancer Cell."},{"key":"B17","doi-asserted-by":"publisher","first-page":"244","DOI":"10.3390\/hematolrep16020024","article-title":"A 2024 update on menin inhibitors. A new class of target agents against KMT2A-rearranged and NPM1-mutated acute myeloid leukemia","volume":"16","author":"Candoni","year":"2024","journal-title":"Hematol. Rep."},{"key":"B18","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1093\/ajcp\/aqaa150","article-title":"Clinicopathologic characterization of hypocellular acute myeloid leukemia (AML) showed fewer genetic abnormalities involving cell proliferation and NPM1 when compared with nonhypocellular AML","volume":"155","author":"Carlsen","year":"2021","journal-title":"Am. J. Clin. Pathol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3854","DOI":"10.1038\/onc.2015.456","article-title":"Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency","volume":"35","author":"Ceccon","year":"2016","journal-title":"Oncogene"},{"key":"B20","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s00109-012-0950-8","article-title":"Estrogen stimulates the proliferation of human endometrial cancer cells by stabilizing nucleophosmin\/B23 (NPM\/B23)","volume":"91","author":"Chao","year":"2013","journal-title":"J. Mol. Med. Berl."},{"key":"B21","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.bbrc.2015.08.118","article-title":"Upregulation of B23 promotes tumor cell proliferation and predicts poor prognosis in glioma","volume":"466","author":"Chen","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B22","doi-asserted-by":"publisher","first-page":"e202103160","DOI":"10.1083\/jcb.202103160","article-title":"Phase separation and toxicity of C9orf72 Poly(PR) depends on alternate distribution of arginine","volume":"220","author":"Chen","year":"2021","journal-title":"J. Cell. Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1080\/15548627.2022.2026097","article-title":"Vascular smooth muscle cell-derived hydrogen sulfide promotes atherosclerotic plaque stability via TFEB (transcription factor EB)-Mediated autophagy","volume":"18","author":"Chen","year":"2022","journal-title":"Autophagy"},{"key":"B24","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/s41419-024-06485-0","article-title":"AURKA inhibition induces Ewing's sarcoma apoptosis and ferroptosis through NPM1\/YAP1 axis","volume":"15","author":"Chen","year":"2024","journal-title":"Cell. Death Dis."},{"key":"B25","doi-asserted-by":"publisher","first-page":"e182429","DOI":"10.1172\/jci.insight.182429","article-title":"AURKB inhibition induces rhabdomyosarcoma apoptosis and ferroptosis through NPM1\/SP1\/ACSL5 axis","volume":"10","author":"Chen","year":"2025","journal-title":"JCI Insight"},{"key":"B26","doi-asserted-by":"publisher","first-page":"2238827","DOI":"10.1080\/01443615.2023.2238827","article-title":"KLF2 transcription suppresses endometrial cancer cell proliferation, invasion, and migration through the inhibition of NPM1","volume":"43","author":"Cheng","year":"2023","journal-title":"J. Obstet. Gynaecol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1016\/j.lfs.2007.03.004","article-title":"Involvement of nPKC-MAPK pathway in the decrease of nucleophosmin\/B23 during megakaryocytic differentiation of human myelogenous leukemia K562 cells","volume":"80","author":"Chou","year":"2007","journal-title":"Life Sci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"8874","DOI":"10.1128\/MCB.25.20.8874-8886.2005","article-title":"Nucleophosmin is required for DNA integrity and p19Arf protein stability","volume":"25","author":"Colombo","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2787","DOI":"10.1182\/blood-2003-09-3144","article-title":"Bcl-XL down-regulation suppresses the tumorigenic potential of NPM\/ALK in vitro and in vivo","volume":"103","author":"Coluccia","year":"2004","journal-title":"Blood"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.humpath.2009.12.010","article-title":"p53, and Ki-67 expression patterns on an oral squamous cell carcinoma tissue microarray","volume":"41","author":"Coutinho-Camillo","year":"2010","journal-title":"Hum. Pathol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1038\/s41417-025-00954-0","article-title":"MALNC: a new mutant NPM1\/IDH2R140 and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response","volume":"32","author":"Cozzi","year":"2025","journal-title":"Cancer Gene Ther."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1152\/japplphysiol.90470.2008","article-title":"Inflammation and endothelial dysfunction during aging: role of NF-kappaB","volume":"105","author":"Csiszar","year":"2008","journal-title":"J. Appl. Physiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"e1008463","DOI":"10.1371\/journal.pgen.1008463","article-title":"NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes","volume":"15","author":"Darracq","year":"2019","journal-title":"PLoS Genet."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3296","DOI":"10.1158\/0008-5472.CAN-10-3459","article-title":"A simple approach to cancer therapy afforded by multivalent pseudopeptides that target cell-surface nucleoproteins","volume":"71","author":"Destouches","year":"2011","journal-title":"Cancer Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"69397","DOI":"10.18632\/oncotarget.8043","article-title":"Implication of NPM1 phosphorylation and preclinical evaluation of the nucleoprotein antagonist N6L in prostate cancer","volume":"7","author":"Destouches","year":"2016","journal-title":"Oncotarget"},{"key":"B36","doi-asserted-by":"publisher","first-page":"16409","DOI":"10.1074\/jbc.M109.005736","article-title":"Nucleophosmin blocks mitochondrial localization of p53 and apoptosis","volume":"284","author":"Dhar","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"3672","DOI":"10.3390\/ijms22073672","article-title":"The nucleolar protein nucleophosmin is physiologically secreted by endothelial cells in response to stress exerting proangiogenic activity both in vitro and in vivo","volume":"22","author":"Di Carlo","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1007\/s00018-007-7305-6","article-title":"Histone chaperones: 30 years from isolation to elucidation of the mechanisms of nucleosome assembly and disassembly","volume":"65","author":"Eitoku","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"892","DOI":"10.18632\/oncoscience.254","article-title":"TPL2-NPM-P53 pathway monitors nucleolar stress","volume":"2","author":"Eliopoulos","year":"2015","journal-title":"Oncoscience"},{"key":"B40","doi-asserted-by":"publisher","first-page":"2882","DOI":"10.1093\/hmg\/ddx170","article-title":"The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis","volume":"26","author":"Farg","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.4161\/cc.8.9.8302","article-title":"Upregulation of the CDC25A phosphatase downstream of the NPM\/ALK oncogene participates in Anaplastic large cell lymphoma enhanced proliferation","volume":"8","author":"Fernandez-Vidal","year":"2009","journal-title":"Cell. Cycle"},{"key":"B42","doi-asserted-by":"publisher","first-page":"167551","DOI":"10.1016\/j.bbadis.2024.167551","article-title":"Increased NPM1 inhibit ferroptosis and aggravate renal fibrosis via Nrf2 pathway in chronic kidney disease","volume":"1871","author":"Fu","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B43","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s40478-015-0257-4","article-title":"Altered machinery of protein synthesis is Region- and stage-dependent and is associated with \u03b1-Synuclein oligomers in parkinson\u2019s disease","volume":"3","author":"Garcia-Esparcia","year":"2015","journal-title":"Acta Neuropathol. Commun."},{"key":"B44","doi-asserted-by":"publisher","first-page":"3945","DOI":"10.1073\/pnas.0800135105","article-title":"Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin","volume":"105","author":"Garzon","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B45","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1161\/CIRCRESAHA.114.303788","article-title":"Molecular mechanisms of autophagy in the cardiovascular system","volume":"116","author":"Gatica","year":"2015","journal-title":"Circ. Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1369\/jhc.2009.954024","article-title":"Cytoplasmic p53 and activated bax regulate p53-dependent, transcription-independent neural precursor cell apoptosis","volume":"58","author":"Geng","year":"2010","journal-title":"J. Histochem Cytochem"},{"key":"B47","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s10735-006-9040-y","article-title":"DNA damage, p14ARF, nucleophosmin (NPM\/B23), and cancer","volume":"37","author":"Gjerset","year":"2006","journal-title":"J. Mol. Histol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"7386","DOI":"10.1038\/sj.onc.1204870","article-title":"Expression of the oncogenic NPM-ALK chimeric protein in human lymphoid T-cells inhibits drug-induced, but not Fas-induced apoptosis","volume":"20","author":"Greenland","year":"2001","journal-title":"Oncogene"},{"key":"B49","doi-asserted-by":"publisher","first-page":"4622","DOI":"10.1182\/blood-2003-03-0820","article-title":"NPM-ALK fusion kinase of Anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a","volume":"103","author":"Gu","year":"2004","journal-title":"Blood"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1038\/leu.2008.204","article-title":"Rapamycin reverses NPM-ALK-induced glucocorticoid resistance in lymphoid tumor cells by inhibiting mTOR signaling pathway, enhancing G1 cell cycle arrest and apoptosis","volume":"22","author":"Gu","year":"2008","journal-title":"Leukemia"},{"key":"B51","doi-asserted-by":"publisher","first-page":"4260","DOI":"10.1172\/JCI97117","article-title":"Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates","volume":"128","author":"Gu","year":"2018","journal-title":"J. Clin. Invest."},{"key":"B52","doi-asserted-by":"publisher","first-page":"4694","DOI":"10.1182\/blood-2011-03-341255","article-title":"Fine-tuning nucleophosmin in macrophage differentiation and activation","volume":"118","author":"Guery","year":"2011","journal-title":"Blood"},{"key":"B53","doi-asserted-by":"publisher","first-page":"2899","DOI":"10.1096\/fj.201500194R","article-title":"Oxidative stress disassembles the p38\/NPM\/PP2A complex, which leads to modulation of nucleophosmin-mediated signaling to DNA damage response","volume":"30","author":"Guillonneau","year":"2016","journal-title":"FASEB J."},{"key":"B54","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/j.bbadis.2013.09.016","article-title":"Stressing on the nucleolus in cardiovascular disease","volume":"1842","author":"Hariharan","year":"2014","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B55","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/bpa.12335","article-title":"Altered machinery of protein synthesis in alzheimer\u2019s disease: from the nucleolus to the ribosome","volume":"6","author":"Hernandez-Ortega","year":"2017","journal-title":"Am. J. Neurodegener. Dis."},{"key":"B56","doi-asserted-by":"publisher","first-page":"10040","DOI":"10.3390\/ijms221810040","article-title":"Significance of NPM1 gene mutations in AML","volume":"22","author":"Hindley","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13072-025-00581-x","article-title":"Function of HP1BP3 as a linker histone is regulated by linker histone chaperones, NPM1 and TAF-I","volume":"18","author":"Hisaoka","year":"2025","journal-title":"Epigenetics Chromatin"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.3324\/haematol.2024.285616","article-title":"Bleximenib, the novel menin-KMT2A inhibitor JNJ-75276617, impairs long-term proliferation and immune evasion in acute myeloid leukemia","volume":"110","author":"Hogeling","year":"2024","journal-title":"Haematologica"},{"key":"B59","doi-asserted-by":"publisher","first-page":"34601","DOI":"10.1074\/jbc.M114.569244","article-title":"Loss of nucleolar histone chaperone NPM1 triggers rearrangement of heterochromatin and synergizes with a deficiency in DNA methyltransferase DNMT3A to drive ribosomal DNA transcription","volume":"289","author":"Holmberg Olausson","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B60","volume-title":"Down-Regulation of nucleophosmin\/B23 During Retinoic acid-induced Differentiation of Human Promyelocytic Leukemia HL-60 Cells","author":"Hsu","year":"2026"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1038\/sj.bjc.6601100","article-title":"Involvement of nucleophosmin\/B23 in TPA-Induced megakaryocytic differentiation of K562 cells","volume":"89","author":"Hsu","year":"2003","journal-title":"Br. J. Cancer"},{"key":"B62","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1080\/07357900701206372","article-title":"Downregulation of NPM-ALK by siRNA causes anaplastic large cell lymphoma cell growth inhibition and augments the anti cancer effects of chemotherapy in vitro","volume":"25","author":"Hsu","year":"2007","journal-title":"Cancer Invest."},{"key":"B63","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1080\/10245332.2017.1396045","article-title":"Involvement of oncogenic tyrosine kinase NPM-ALK in trifluoperazine-induced cell cycle arrest and apoptosis in ALK+ anaplastic large cell lymphoma","volume":"23","author":"Hu","year":"2018","journal-title":"Hematology"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.3390\/ijms24021624","article-title":"Cytoplasmic expression of TP53INP2 modulated by demethylase FTO and mutant NPM1 promotes autophagy in leukemia cells","volume":"24","author":"Huang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"e2015339118","DOI":"10.1073\/pnas.2015339118","article-title":"SIRT7-dependent deacetylation of NPM promotes p53 stabilization following UV-induced genotoxic stress","volume":"118","author":"Ianni","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/s1097-2765(03)00431-3","article-title":"Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation","volume":"12","author":"Itahana","year":"2003","journal-title":"Mol. Cell."},{"key":"B67","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s13072-023-00511-9","article-title":"Nucleophosmin 1 cooperates with the methyltransferase DOT1L to preserve peri-nucleolar heterochromatin organization by regulating H3K27me3 levels and DNA repeats expression","volume":"16","author":"Izzo","year":"2023","journal-title":"Epigenetics Chromatin"},{"key":"B68","doi-asserted-by":"publisher","first-page":"3633","DOI":"10.1182\/blood-2009-03-208843","article-title":"Colony-stimulating factor-1-induced oscillations in phosphatidylinositol-3 kinase\/AKT are required for caspase activation in monocytes undergoing differentiation into macrophages","volume":"114","author":"Jacquel","year":"2009","journal-title":"Blood"},{"key":"B69","doi-asserted-by":"publisher","first-page":"4909","DOI":"10.1038\/s41467-024-49199-9","article-title":"Tobacco-induced hyperglycemia promotes lung cancer progression via cancer cell-macrophage interaction through paracrine IGF2\/IR\/NPM1-Driven PD-L1 expression","volume":"15","author":"Jang","year":"2024","journal-title":"Nat. Commun."},{"key":"B70","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1186\/s13046-021-02122-2","article-title":"Mutant NPM1-regulated lncRNA HOTAIRM1 promotes leukemia cell autophagy and proliferation by targeting EGR1 and ULK3","volume":"40","author":"Jing","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B71","doi-asserted-by":"publisher","first-page":"815","DOI":"10.18632\/aging.100222","article-title":"Core transcription factors, Oct4, Sox2 and nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination","volume":"2","author":"Johansson","year":"2010","journal-title":"Aging"},{"key":"B72","doi-asserted-by":"publisher","first-page":"2160","DOI":"10.4161\/cc.9.11.11841","article-title":"Translationally controlled tumor protein interacts with nucleophosmin during mitosis in ES cells","volume":"9","author":"Johansson","year":"2010","journal-title":"Cell. Cycle"},{"key":"B73","doi-asserted-by":"publisher","first-page":"8903","DOI":"10.1038\/srep08903","article-title":"The nucleolar protein nucleophosmin is essential for autophagy induced by inhibiting pol I transcription","volume":"5","author":"Katagiri","year":"2015","journal-title":"Sci. Rep."},{"key":"B74","doi-asserted-by":"publisher","first-page":"2554","DOI":"10.1038\/sj.onc.1210044","article-title":"Nucleophosmin is a novel bax chaperone that regulates apoptotic cell death","volume":"26","author":"Kerr","year":"2007","journal-title":"Oncogene"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1111\/jcmm.12474","article-title":"GLTSCR 2 is an upstream negative regulator of nucleophosmin in cervical cancer","volume":"19","author":"Kim","year":"2015","journal-title":"J. Cell. Mol. Med."},{"key":"B76","doi-asserted-by":"publisher","first-page":"2882","DOI":"10.1021\/acs.jproteome.3c00509","article-title":"ARID3C acts as a regulator of monocyte-to-macrophage differentiation interacting with NPM1","volume":"23","author":"Kim","year":"2024","journal-title":"J. Proteome Res."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1080\/10715760500306695","article-title":"Proteomic characterization of oxidative dysfunction in human umbilical vein endothelial cells (HUVEC) induced by exposure to oxidized LDL","volume":"39","author":"Kinumi","year":"2005","journal-title":"Free Radic. Res."},{"key":"B78","doi-asserted-by":"publisher","first-page":"e88087","DOI":"10.1371\/journal.pone.0088087","article-title":"Pharmacological AMP kinase activators target the nucleolar organization and control cell proliferation","volume":"9","author":"Kodiha","year":"2014","journal-title":"PLoS One"},{"key":"B79","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/s0741-5214(96)80014-0","article-title":"Differential-display polymerase chain reaction identifies nucleophosmin as an estrogen-regulated gene in human vascular smooth muscle cells","volume":"23","author":"Koike","year":"1996","journal-title":"J. Vasc. Surg."},{"key":"B80","doi-asserted-by":"publisher","first-page":"6746","DOI":"10.1158\/0008-5472.CAN-10-0382","article-title":"Recruitment of phosphorylated NPM1 to sites of DNA damage through RNF8-dependent ubiquitin conjugates","volume":"70","author":"Koike","year":"2010","journal-title":"Cancer Res."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1038\/cdd.2013.66","article-title":"A neuroprotective phase precedes striatal degeneration upon nucleolar stress","volume":"20","author":"Kreiner","year":"2013","journal-title":"Cell. Death Differ."},{"key":"B82","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/s1535-6108(04)00110-2","article-title":"Nucleophosmin, HDM2 and p53: players in UV damage incited nucleolar stress response","volume":"3","author":"Kurki","year":"2004","journal-title":"Cell. Cycle"},{"key":"B83","doi-asserted-by":"publisher","first-page":"100935","DOI":"10.1016\/j.jbc.2021.100935","article-title":"Molecular basis for RASSF10\/NPM\/RNF2 feedback cascade-mediated regulation of gastric cancer cell proliferation","volume":"297","author":"Lakshmi","year":"2021","journal-title":"J. Biol. Chem."},{"key":"B84","doi-asserted-by":"publisher","first-page":"9834","DOI":"10.1158\/0008-5472.CAN-05-1759","article-title":"DNA damage disrupts the p14ARF-B23(nucleophosmin) interaction and triggers a transient subnuclear redistribution of p14ARF","volume":"65","author":"Lee","year":"2005","journal-title":"Cancer Res."},{"key":"B85","doi-asserted-by":"publisher","first-page":"3286","DOI":"10.1182\/blood-2009-12-256149","article-title":"Mutant nucleophosmin deregulates cell death and myeloid differentiation through excessive caspase-6 and -8 inhibition","volume":"116","author":"Leong","year":"2010","journal-title":"Blood"},{"key":"B86","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1182\/blood-2006-11-059451","article-title":"NPM-ALK oncogenic kinase promotes cell-cycle progression through activation of JNK\/CJun signaling in Anaplastic large-cell lymphoma","volume":"110","author":"Leventaki","year":"2007","journal-title":"Blood"},{"key":"B87","doi-asserted-by":"publisher","first-page":"16536","DOI":"10.1074\/jbc.M601386200","article-title":"Nucleophosmin regulates cell cycle progression and stress response in hematopoietic stem\/progenitor cells","volume":"281","author":"Li","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B88","doi-asserted-by":"publisher","first-page":"18794","DOI":"10.1073\/pnas.0806879105","article-title":"Nucleophosmin interacts directly with c-Myc and controls c-Myc-induced hyperproliferation and transformation","volume":"105","author":"Li","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.3109\/07357900902918452","article-title":"Localization and altered expression of nucleophosmin in the nuclear matrix during the differentiation of human hepatocarcinoma SMMC-7721 cells induced by HMBA","volume":"28","author":"Li","year":"2010","journal-title":"Cancer Invest."},{"key":"B90","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1111\/jop.12482","article-title":"Downregulation of nucleophosmin expression inhibited proliferation and induced apoptosis in salivary gland adenoid cystic carcinoma","volume":"46","author":"Li","year":"2017","journal-title":"J. Oral Pathol. Med."},{"key":"B91","doi-asserted-by":"publisher","first-page":"126","DOI":"10.3892\/or.2023.8563","article-title":"Nucleophosmin promotes lung adenocarcinoma cell proliferation, migration and invasion by activating the EGFR\/MAPK signaling pathway","volume":"49","author":"Li","year":"2023","journal-title":"Oncol. Rep."},{"key":"B92","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1530\/REP-20-0051","article-title":"Nucleolar stress regulates stromal-epithelial transition via NPM1 during decidualization","volume":"160","author":"Liang","year":"2020","journal-title":"Reproduction"},{"key":"B93","doi-asserted-by":"publisher","first-page":"367","DOI":"10.3724\/abbs.2023021","article-title":"Long noncoding RNA LINC01088 inhibits esophageal squamous cell carcinoma progression by targeting the NPM1-HDM2-p53 axis","volume":"55","author":"Liang","year":"2023","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"B94","doi-asserted-by":"publisher","first-page":"4409","DOI":"10.1091\/mbc.E10-03-0239","article-title":"Dephosphorylation of nucleophosmin by PP1\u03b2 facilitates pRB binding and consequent E2F1-dependent DNA repair","volume":"21","author":"Lin","year":"2010","journal-title":"Mol. Biol. Cell."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.3390\/cancers11071025","article-title":"Palbociclib promotes dephosphorylation of NPM\/B23 at threonine 199 and inhibits endometrial cancer cell growth","volume":"11","author":"Lin","year":"2019","journal-title":"Cancers"},{"key":"B96","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/cdd.2009.145","article-title":"Regulation of stress-induced nuclear protein redistribution: a new function of bax and bak uncoupled from Bcl-xL","volume":"17","author":"Lindenboim","year":"2010","journal-title":"Cell. Death Differ."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2011\/195209","article-title":"NPM1\/B23: a multifunctional chaperone in ribosome biogenesis and chromatin remodeling","volume":"2011","author":"Lindstr\u00f6m","year":"2011","journal-title":"Biochem. Res. Int."},{"key":"B98","doi-asserted-by":"publisher","first-page":"9679","DOI":"10.1073\/pnas.0701806104","article-title":"Sumoylation of nucleophosmin\/B23 regulates its subcellular localization, mediating cell proliferation and survival","volume":"104","author":"Liu","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1002\/hep.26209","article-title":"A novel interaction of nucleophosmin with BCL2-associated X protein regulating death evasion and drug sensitivity in human hepatoma cells","volume":"57","author":"Lo","year":"2013","journal-title":"Hepatology"},{"key":"B100","doi-asserted-by":"publisher","first-page":"140532","DOI":"10.1016\/j.bbapap.2020.140532","article-title":"Nucleophosmin, a multifunctional nucleolar organizer with a role in DNA repair","volume":"1868","author":"L\u00f3pez","year":"","journal-title":"Biochim. Biophys. Acta Proteins Proteom"},{"key":"B101","doi-asserted-by":"publisher","first-page":"102809","DOI":"10.1016\/j.dnarep.2020.102809","article-title":"Nucleophosmin interaction with APE1: insights into DNA repair regulation","volume":"88","author":"L\u00f3pez","year":"","journal-title":"DNA Repair"},{"key":"B102","doi-asserted-by":"publisher","first-page":"e96293","DOI":"10.1371\/journal.pone.0096293","article-title":"NPM1 silencing reduces tumour growth and MAPK signalling in prostate cancer cells","volume":"9","author":"Loubeau","year":"2014","journal-title":"PLoS One"},{"key":"B103","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/s41419-021-04035-6","article-title":"HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity","volume":"12","author":"Luo","year":"2021","journal-title":"Cell. Death Dis."},{"key":"B104","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1007\/s10565-022-09695-4","article-title":"Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1\/FHL1-mediated cell-cycle-checkpoint protein activity","volume":"39","author":"Luo","year":"2023","journal-title":"Cell. Biol. Toxicol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1046\/j.1440-1789.2002.t01-5-00001.x","article-title":"Alterations of chaperone protein expression in presenilin mutant neurons in response to glutamate excitotoxicity","volume":"52","author":"Maezawa","year":"2002","journal-title":"Pathol. Int. Rapid Commun"},{"key":"B106","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.bbrc.2011.11.152","article-title":"Nucleolar stress characterized by downregulation of nucleophosmin: a novel cause of neuronal degeneration","volume":"417","author":"Marquez-Lona","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B107","doi-asserted-by":"publisher","first-page":"113484","DOI":"10.1016\/j.celrep.2023.113484","article-title":"An atypical GABARAP binding module drives the pro-autophagic potential of the AML-Associated NPM1c variant","volume":"42","author":"Mende","year":"2023","journal-title":"Cell. Rep."},{"key":"B108","doi-asserted-by":"publisher","first-page":"3676","DOI":"10.1242\/jcs.03090","article-title":"Effects of interphase and mitotic phosphorylation on the mobility and location of nucleolar protein B23","volume":"119","author":"Negi","year":"2006","journal-title":"J. Cell. Sci."},{"key":"B109","doi-asserted-by":"publisher","first-page":"2938","DOI":"10.1016\/j.celrep.2016.02.074","article-title":"NPM and BRG1 mediate transcriptional resistance to retinoic acid in acute promyelocytic leukemia","volume":"14","author":"Nichol","year":"2016","journal-title":"Cell. Rep."},{"key":"B110","doi-asserted-by":"publisher","first-page":"4861","DOI":"10.1093\/nar\/gks162","article-title":"Function of homo- and hetero-oligomers of human nucleoplasmin\/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling","volume":"40","author":"Okuwaki","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"B111","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s00280-004-0974-z","article-title":"Genistein-induced apoptosis via akt signaling pathway in Anaplastic large-cell lymphoma","volume":"56","author":"Park","year":"2005","journal-title":"Cancer Chemother. Pharmacol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"3241","DOI":"10.1158\/0008-5472.can-20-2297","article-title":"NPM-ALK-induced reprogramming of mature TCR-Stimulated T cells results in dedifferentiation and malignant transformation","volume":"81","author":"Pawlicki","year":"2021","journal-title":"Cancer Res."},{"key":"B113","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1691\/ph.2017.7473","article-title":"Effect of NPM1 type B mutation on the proliferation, invasion and chemosensitivity of THP-1 leukemia cells","volume":"10","author":"Peng","year":"2017","journal-title":"Pharmazie"},{"key":"B114","doi-asserted-by":"publisher","first-page":"35330","DOI":"10.1002\/ijc.35332","article-title":"Targeting the menin-KMT2A interaction in leukemia: lessons learned and future directions","author":"Perner","year":"2025","journal-title":"Int. J. Cancer"},{"key":"B115","doi-asserted-by":"publisher","first-page":"156","DOI":"10.3389\/fncel.2019.00156","article-title":"Emerging role of the nucleolar stress response in autophagy","volume":"13","author":"Pfister","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"B116","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/leu.2016.311","article-title":"Arsenic trioxide degrades NPM-ALK fusion protein and inhibits growth of ALK-Positive Anaplastic large cell lymphoma","volume":"31","author":"Piao","year":"2017","journal-title":"Leukemia"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1091\/mbc.E13-12-0717","article-title":"Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins","volume":"25","author":"Poletto","year":"2014","journal-title":"Mol. Biol. Cell."},{"key":"B118","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.3109\/10428194.2013.830303","article-title":"NPM-RAR, not the RAR-NPM reciprocal t(5;17)(q35;q21) acute promyelocytic leukemia fusion protein, inhibits myeloid differentiation","volume":"55","author":"Pollock","year":"2014","journal-title":"Leuk. Lymphoma"},{"key":"B119","doi-asserted-by":"publisher","first-page":"4210","DOI":"10.1038\/onc.2008.54","article-title":"NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells","volume":"27","author":"Qi","year":"2008","journal-title":"Oncogene"},{"key":"B120","doi-asserted-by":"publisher","first-page":"287","DOI":"10.7150\/ijms.8.287","article-title":"Knockdown of NPM1 by RNA interference inhibits cells proliferation and induces apoptosis in leukemic cell line","volume":"8","author":"Qin","year":"2011","journal-title":"Int. J. Med. Sci."},{"key":"B121","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jns.2007.09.029","article-title":"Role of Npm1 in proliferation, apoptosis and differentiation of neural stem cells","volume":"266","author":"Qing","year":"2008","journal-title":"J. Neurol. Sci."},{"key":"B122","doi-asserted-by":"publisher","first-page":"e377","DOI":"10.1016\/j.jtcvs.2019.10.152","article-title":"Nucleophosmin contributes to vascular inflammation and endothelial dysfunction in atherosclerosis progression","volume":"161","author":"Rao","year":"2021","journal-title":"J. Thorac. Cardiovasc Surg."},{"key":"B123","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.tibs.2019.10.001","article-title":"Nucleolus: a protein quality control compartment","volume":"45","author":"Rekulpally","year":"2020","journal-title":"Trends Biochem. Sci."},{"key":"B124","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.bbrc.2011.12.151","article-title":"Influence of heart failure on nucleolar organization and protein expression in human hearts","volume":"418","author":"Rosell\u00f3-Llet\u00ed","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B125","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/s0301-472x(03)00007-9","article-title":"Constitutive activation of Jak2 contributes to proliferation and resistance to apoptosis in NPM\/ALK-transformed cells","volume":"31","author":"Ruchatz","year":"2003","journal-title":"Exp. Hematol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1016\/j.leukres.2013.09.024","article-title":"Interaction with RXR is necessary for NPM-RAR-induced myeloid differentiation blockade","volume":"37","author":"Rush","year":"2013","journal-title":"Leuk. Res."},{"key":"B127","doi-asserted-by":"publisher","first-page":"624933","DOI":"10.3389\/fcell.2021.624933","article-title":"Nucleophosmin protein dephosphorylation by DUSP3 is a fine-tuning regulator of p53 signaling to maintain genomic stability","volume":"9","author":"Russo","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"eadj3145","DOI":"10.1126\/sciadv.adj3145","article-title":"Caspase-2 is essential for proliferation and self-renewal of nucleophosmin-mutated acute myeloid leukemia","volume":"10","author":"Sakthivel","year":"2024","journal-title":"Sci. Adv"},{"key":"B129","doi-asserted-by":"publisher","first-page":"3488","DOI":"10.3324\/haematol.2022.282621","article-title":"Revumenib for patients with acute leukemia: a new tool for differentiation therapy","volume":"109","author":"Salman","year":"2024","journal-title":"Haematologica"},{"key":"B130","doi-asserted-by":"publisher","first-page":"4790","DOI":"10.1158\/0008-5472.CAN-06-4470","article-title":"Nucleophosmin mediates Mammalian target of rapamycin-dependent actin cytoskeleton dynamics and proliferation in neurofibromin-deficient astrocytes","volume":"67","author":"Sandsmark","year":"2007","journal-title":"Cancer Res."},{"key":"B131","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1139\/bcb-2016-0068","article-title":"Nucleolin and nucleophosmin: nucleolar proteins with multiple functions in DNA repair","volume":"94","author":"Scott","year":"2016","journal-title":"Biochem. Cell. Biol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1158\/0008-5472.can-22-3631","article-title":"Nucleophosmin plays a role in repairing DNA damage and is a target for cancer treatment","volume":"83","author":"Sekhar","year":"2023","journal-title":"Cancer Res."},{"key":"B133","doi-asserted-by":"publisher","first-page":"6490","DOI":"10.1158\/1078-0432.CCR-11-1054","article-title":"The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double-strand breaks and enhancing radiosensitization","volume":"17","author":"Sekhar","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"B134","doi-asserted-by":"publisher","first-page":"5080","DOI":"10.3390\/ijms25105080","article-title":"Monocytic differentiation of human acute myeloid leukemia cells: a proteomic and phosphoproteomic comparison of FAB-M4\/M5 patients with and without nucleophosmin 1 mutations","volume":"25","author":"Selheim","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B135","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1186\/s12967-024-04985-3","article-title":"RGS6 drives cardiomyocyte death following nucleolar stress by suppressing nucleolin\/miRNA-21","volume":"22","author":"Sengar","year":"2024","journal-title":"J. Transl. Med."},{"key":"B136","doi-asserted-by":"publisher","first-page":"2198","DOI":"10.1016\/j.febslet.2014.05.014","article-title":"Phosphorylation of multifunctional nucleolar protein nucleophosmin (NPM1) by Aurora kinase B is critical for mitotic progression","volume":"588","author":"Shandilya","year":"2014","journal-title":"FEBS Lett."},{"key":"B137","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.3390\/cancers15041177","article-title":"NPM 1 mutations in AML\u2014The landscape in 2023","volume":"15","author":"Sharma","year":"2023","journal-title":"Cancers"},{"key":"B138","doi-asserted-by":"publisher","first-page":"112","DOI":"10.7150\/jca.62630","article-title":"Long non-coding RNA NNT-AS1 positively regulates NPM1 expression to affect the proliferation of estrogen-mediated endometrial carcinoma by interacting","volume":"13","author":"Shen","year":"2022","journal-title":"J. Cancer"},{"key":"B139","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/jcb.22663","article-title":"Localization of nucleophosmin in nuclear matrix and changes in its expression during the differentiation of human neuroblastoma induced by retinoic acid","volume":"111","author":"Shi","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"B140","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1038\/s41375-021-01318-x","article-title":"Integrated genomic-metabolic classification of acute myeloid leukemia defines a subgroup with NPM1 and cohesin\/DNA damage mutations","volume":"35","author":"Simonetti","year":"2021","journal-title":"Leukemia"},{"key":"B141","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1038\/cdd.2017.19","article-title":"Non-apoptotic functions of caspases in myeloid cell differentiation","volume":"24","author":"Solier","year":"2017","journal-title":"Cell. Death Differ."},{"key":"B142","doi-asserted-by":"publisher","first-page":"4817","DOI":"10.2147\/CMAR.S252847","article-title":"Aurora-B promotes osteosarcoma cell growth and metastasis through activation of the NPM1\/ERK\/NF-kappaB\/MMPs axis","volume":"12","author":"Song","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"B143","doi-asserted-by":"publisher","first-page":"3447","DOI":"10.1182\/blood-2012-08-449553","article-title":"The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model","volume":"121","author":"Sportoletti","year":"2013","journal-title":"Blood"},{"key":"B144","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.3390\/cells13151266","article-title":"Nucleophosmin: a nucleolar phosphoprotein orchestrating cellular stress responses","volume":"13","author":"Taha","year":"2024","journal-title":"Cells"},{"key":"B145","doi-asserted-by":"publisher","first-page":"e21192","DOI":"10.1096\/fj.201903183RRR","article-title":"NPM1 mutant maintains ULK1 protein stability via TRAF6-dependent ubiquitination to promote autophagic cell survival in leukemia","volume":"35","author":"Tang","year":"2021","journal-title":"FASEB J."},{"key":"B146","doi-asserted-by":"publisher","first-page":"1478139","DOI":"10.3389\/fendo.2025.1478139","article-title":"Identification and validation of endoplasmic reticulum stress-related diagnostic biomarkers for type 1 diabetic cardiomyopathy based on bioinformatics and machine learning","volume":"16","author":"Tang","year":"2025","journal-title":"Front. Endocrinol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"3625","DOI":"10.1038\/s41388-025-03518-6","article-title":"LIMK2 promotes centrosome clustering and cancer progression by activating MST4-mediated phosphorylation of NPM1","volume":"44","author":"Tian","year":"2025","journal-title":"Oncogene"},{"key":"B148","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/s41514-024-00183-z","article-title":"Multimorbidity is associated with myocardial DNA damage, nucleolar stress, dysregulated energy metabolism, and senescence in cardiovascular disease","volume":"10","author":"Tomkova","year":"2024","journal-title":"NPJ Aging"},{"key":"B149","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1002\/1878-0261.12822","article-title":"EBP2, a novel NPM-ALK-interacting protein in the nucleolus, contributes to the proliferation of ALCL cells by regulating tumor suppressor p53","volume":"15","author":"Uchihara","year":"2021","journal-title":"Mol. Oncol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/art.10914","article-title":"Autoantibodies against B23, a nucleolar phosphoprotein, occur in scleroderma and are associated with pulmonary hypertension","volume":"49","author":"Ulanet","year":"2003","journal-title":"Arthritis Care Res."},{"key":"B151","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/art.11485","article-title":"Selective cleavage of nucleolar autoantigen B23 by granzyme B in differentiated vascular smooth muscle cells: insights into the association of specific autoantibodies with distinct disease phenotypes","volume":"50","author":"Ulanet","year":"2004","journal-title":"Arthritis Rheum."},{"key":"B152","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.phymed.2015.06.003","article-title":"The germacranolide sesquiterpene lactone neurolenin B of the medicinal plant Neurolaena Lobata (L.) r.Br. Ex cass inhibits NPM\/ALK-driven cell expansion and NF-kappaB-driven tumour intravasation","volume":"22","author":"Unger","year":"2015","journal-title":"Phytomedicine"},{"key":"B153","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1111\/j.1432-1033.1995.843_a.x","article-title":"Identification of mRNAs that show modulated expression during Colon carcinoma cell differentiation","volume":"234","author":"Van Belzen","year":"1995","journal-title":"Eur. J. Biochem."},{"key":"B154","doi-asserted-by":"publisher","first-page":"e2402847121","DOI":"10.1073\/pnas.2402847121","article-title":"C9orf72-Linked arginine-rich dipeptide repeats aggravate pathological phase separation of G3BP1","volume":"121","author":"Van Nerom","year":"2024","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B155","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.1128\/MCB.00015-13","article-title":"Nucleophosmin, a critical bax cofactor in ischemia-induced cell death","volume":"33","author":"Wang","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1681\/ASN.2018040401","article-title":"Nucleophosmin phosphorylation as a diagnostic and therapeutic target for ischemic AKI","volume":"30","author":"Wang","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"key":"B157","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.bbrc.2019.01.127","article-title":"Nucleophosmin\/B23 contributes to hepatic insulin resistance through the modulation of NF-\u03baB pathway","volume":"511","author":"Wang","year":"2019","journal-title":"Biochem. Biophysical Res. Commun."},{"key":"B158","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1038\/s41422-020-00458-6","article-title":"Mutual dependency between lncRNA LETN and protein NPM1 in controlling the nucleolar structure and functions sustaining cell proliferation","volume":"31","author":"Wang","year":"2021","journal-title":"Cell. Res."},{"key":"B159","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/s41420-022-00984-9","article-title":"Elevated FAM84B promotes cell proliferation via interacting with NPM1 in esophageal squamous cell carcinoma","volume":"8","author":"Wang","year":"2022","journal-title":"Cell. Death Discov."},{"key":"B160","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1093\/jleuko\/qiad023","article-title":"Mutant NPM1 maintains RASGRP3 protein stability via interaction with MID1 to promote acute myeloid leukemia cell proliferation and autophagy","volume":"113","author":"Wang","year":"2023","journal-title":"J. Leukoc. Biol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1186\/s13287-024-03898-8","article-title":"Targeting NPM1 inhibits proliferation and promotes apoptosis of hepatic progenitor cells via suppression of mTOR signalling pathway","volume":"15","author":"Wang","year":"2024","journal-title":"Stem Cell. Res. Ther."},{"key":"B162","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1038\/ncb1764","article-title":"A ribosomal protein L23-nucleophosmin circuit coordinates Miz1 function with cell growth","volume":"10","author":"Wanzel","year":"2008","journal-title":"Nat. Cell. Biol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.molcel.2019.03.019","article-title":"C9orf72 Poly(PR) dipeptide repeats disturb biomolecular phase separation and disrupt nucleolar function","volume":"74","author":"White","year":"2019","journal-title":"Mol. Cell."},{"key":"B164","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1093\/carcin\/23.1.93","article-title":"Resistance to UV-induced cell-killing in nucleophosmin\/B23 over-expressed NIH 3T3 fibroblasts: enhancement of DNA repair and up-regulation of PCNA in association with nucleophosmin\/B23 over-expression","volume":"23","author":"Wu","year":"2002","journal-title":"Carcinogenesis"},{"key":"B165","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1007\/s11427-016-0413-3","article-title":"Acidic domains differentially read histone H3 lysine 4 methylation status and are widely present in chromatin-associated proteins","volume":"60","author":"Wu","year":"2017","journal-title":"Sci. China Life Sci."},{"key":"B166","doi-asserted-by":"publisher","first-page":"817584","DOI":"10.3389\/fonc.2022.817584","article-title":"Mutant NPM1-regulated FTO-Mediated m6A demethylation promotes leukemic cell survival via PDGFRB\/ERK signaling axis","volume":"12","author":"Xiao","year":"2022","journal-title":"Front. Oncol."},{"key":"B167","doi-asserted-by":"publisher","first-page":"108801","DOI":"10.1016\/j.jdiacomp.2024.108801","article-title":"N6-methyladenosine demethylase fat mass and obesity-associated protein suppresses hyperglycemia-induced endothelial cell injury by inhibiting reactive oxygen species formation via autophagy promotion","volume":"38","author":"Xie","year":"2024","journal-title":"J. Diabetes Complicat."},{"key":"B168","doi-asserted-by":"publisher","first-page":"264","DOI":"10.3892\/ijo.2014.2407","article-title":"Regulatory role of nucleophosmin during the differentiation of human liver cancer cells","volume":"45","author":"Xu","year":"2014","journal-title":"Int. J. Oncol."},{"key":"B169","doi-asserted-by":"publisher","first-page":"1045455","DOI":"10.3389\/fcvm.2022.1045455","article-title":"Nucleolar stress: friend or foe in cardiac function?","volume":"9","author":"Yan","year":"2022","journal-title":"Front. Cardiovasc Med."},{"key":"B170","doi-asserted-by":"publisher","first-page":"109443","DOI":"10.1016\/j.envint.2025.109443","article-title":"A methionine\/aspartate-rich synthetic peptide delineated from N-terminal region of nucleophosmin protein effectively protects against cadmium-induced toxicity","volume":"199","author":"Yan","year":"2025","journal-title":"Environ. Int."},{"key":"B171","doi-asserted-by":"publisher","first-page":"2251","DOI":"10.1093\/nar\/30.10.2251","article-title":"Identification of nucleolin and nucleophosmin as genotoxic stress-responsive RNA-Binding proteins","volume":"30","author":"Yang","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"B172","doi-asserted-by":"publisher","first-page":"13599","DOI":"10.1038\/ncomms13599","article-title":"A redox mechanism underlying nucleolar stress sensing by nucleophosmin","volume":"7","author":"Yang","year":"2016","journal-title":"Nat. Commun."},{"key":"B173","doi-asserted-by":"publisher","first-page":"e159860","DOI":"10.1172\/jci159860","article-title":"Repression of rRNA gene transcription by endothelial SPEN deficiency normalizes tumor vasculature via nucleolar stress","volume":"133","author":"Yang","year":"2023","journal-title":"J. Clin. Invest."},{"key":"B174","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1038\/onc.2009.473","article-title":"B23 acts as a nucleolar stress sensor and promotes cell survival through its dynamic interaction with hnRNPU and hnRNPA1","volume":"29","author":"Yao","year":"2010","journal-title":"Oncogene"},{"key":"B175","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1158\/0008-5472.CAN-07-2865","article-title":"DNA damage-dependent translocation of B23 and p19ARF is regulated by the Jun N-terminal kinase pathway","volume":"68","author":"Yogev","year":"2008","journal-title":"Cancer Res."},{"key":"B176","first-page":"5531","article-title":"Proteomic analysis identifies nucleophosmin (NPM1) and several chaperone proteins as potential biomarkers of parkinson\u2019s disease in the MPP+-induced SH-SY5Y cell model","volume":"8","author":"Yu","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"B177","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1080\/15384047.2020.1839278","article-title":"Inhibition of nucleophosmin 1 suppresses colorectal cancer tumor growth of patient-derived xenografts via activation of p53 and inhibition of AKT","volume":"22","author":"Yu","year":"2021","journal-title":"Cancer Biol. Ther."},{"key":"B178","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/s41467-025-66991-3","article-title":"Nucleophosmin 1 lactylation in graft kidney induces ferroptotic trigger waves that exacerbate delayed graft function","volume":"17","author":"Yu","year":"2025","journal-title":"Nat. Commun."},{"key":"B179","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.febslet.2004.08.089","article-title":"c-Myc-mediated expression of nucleophosmin\/B23 decreases during retinoic acid-induced differentiation of human leukemia HL-60 cells","volume":"578","author":"Yung","year":"2004","journal-title":"FEBS Lett."},{"key":"B180","doi-asserted-by":"publisher","first-page":"22174","DOI":"10.18632\/aging.104094","article-title":"Nucleolar stress induces a senescence-like phenotype in smooth muscle cells and promotes development of vascular degeneration","volume":"12","author":"Zhang","year":"2020","journal-title":"Aging"},{"key":"B181","doi-asserted-by":"publisher","first-page":"143","DOI":"10.2147\/CMAR.S191176","article-title":"Knockdown of nucleophosmin 1 suppresses proliferation of triple-negative breast cancer cells through activating CDH1\/Skp2\/p27kip1 pathway","volume":"11","author":"Zeng","year":"2018","journal-title":"Cancer Manag. Res."},{"key":"B182","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/BF02703936","article-title":"Mechanisms of all-trans retinoic acid-induced differentiation of acute promyelocytic leukemia cells","volume":"25","author":"Zhang","year":"2000","journal-title":"J. Biosci."},{"key":"B183","doi-asserted-by":"publisher","first-page":"2848","DOI":"10.1111\/j.1742-4658.2012.08663.x","article-title":"Erythroid differentiation-associated gene interacts with NPM1 (nucleophosmin\/B23) and increases its protein stability, resisting cell apoptosis","volume":"279","author":"Zhang","year":"2012","journal-title":"FEBS J."},{"key":"B184","doi-asserted-by":"publisher","first-page":"4123","DOI":"10.7150\/ijbs.84097","article-title":"DDX24 mutation alters NPM1 phase behavior and disrupts nucleolar homeostasis in vascular malformations","volume":"19","author":"Zhang","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"B185","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1161\/circulationaha.123.065506","article-title":"Targeting NPM1 epigenetically promotes postinfarction cardiac repair by reprogramming reparative macrophage metabolism","volume":"149","author":"Zhang","year":"2024","journal-title":"Circulation"},{"key":"B186","first-page":"95","article-title":"Cell cycle-dependent phosphorylation of nucleophosmin and its potential regulation by peptidyl-prolyl cis\/trans isomerase","volume":"4","author":"Zhao","year":"2015","journal-title":"J. Mol. Biochem."},{"key":"B187","doi-asserted-by":"publisher","first-page":"9255","DOI":"10.1111\/jcmm.16846","article-title":"KPNA2 promotes renal cell carcinoma proliferation and metastasis via NPM","volume":"25","author":"Zheng","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"B188","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1111\/apm.12043","article-title":"Clinical significance of nucleophosmin\/B23 and human epidermal growth factor receptor 2\/neu expressions in gastric cancers","volume":"121","author":"Zhou","year":"2013","journal-title":"APMIS"},{"key":"B189","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41418-024-01284-8","article-title":"Diverse functions of cytochrome c in cell death and disease","volume":"31","author":"Zhou","year":"2024","journal-title":"Cell. Death Differ."},{"key":"B190","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.1038\/s41467-021-22095-2","article-title":"HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia","volume":"12","author":"Zhu","year":"2021","journal-title":"Nat. Commun."},{"key":"B191","doi-asserted-by":"publisher","first-page":"5437","DOI":"10.1038\/ncomms6437","article-title":"Identification of novel DNA-Damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin","volume":"5","author":"Ziv","year":"2014","journal-title":"Nat. Commun."},{"key":"B192","doi-asserted-by":"publisher","first-page":"5728","DOI":"10.1074\/jbc.M709932200","article-title":"Nucleophosmin\/B23 negatively regulates GCN5-dependent histone acetylation and transactivation","volume":"283","author":"Zou","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B193","doi-asserted-by":"publisher","first-page":"71477","DOI":"10.18632\/oncotarget.12216","article-title":"The human nucleophosmin 1 mutation A inhibits myeloid differentiation of leukemia cells by modulating miR-10b","volume":"7","author":"Zou","year":"2016","journal-title":"Oncotarget"},{"key":"B194","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.7150\/thno.19439","article-title":"NPM1 mutant mediated PML delocalization and stabilization enhances autophagy and cell survival in leukemic cells","volume":"7","author":"Zou","year":"2017","journal-title":"Theranostics"}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2026.1840902\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:54:22Z","timestamp":1783490062000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2026.1840902\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,8]]},"references-count":194,"alternative-id":["10.3389\/fcell.2026.1840902"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2026.1840902","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,8]]},"article-number":"1840902"}}