{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T07:00:56Z","timestamp":1785481256117,"version":"3.56.0"},"reference-count":169,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>\n                    Normal physiological activity of the heart depends on the coordinated regulation of various ion channels in cardiomyocytes (CM), and dysfunction of these channels serves as a key pathological basis for cardiac diseases, including arrhythmias and heart failure Mitochondria play a central role in maintaining the cardiac redox balance and calcium (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ) homeostasis, and cardiac mitochondrial dysfunction constitutes a core mechanism underlying ion channel dysregulation and heart disease pathogenesis. A disintegrin and metalloproteinases (ADAMs) are a family of transmembrane proteases that play critical roles in cell adhesion, migration, and intercellular communication\n                    <jats:italic>via<\/jats:italic>\n                    the cleavage of diverse substrates on the plasma membrane. The abnormal expression of various bioactive ADAM family substrates and their hydrolysis are closely related to the occurrence of many cardiac diseases. Previous studies have shown that ADAMs and their substrates participate in the maintenance of cardiac Ca\n                    <jats:sup>2+<\/jats:sup>\n                    homeostasis, action potential formation, and electrical signal transduction by affecting the expression, localization, and function of cardiac ion channels. This review systematically summarizes the regulatory effects of ADAMs and their substrates on cardiac ion channels and discusses their potential relationship with mitochondrial dysfunction and cardiac remodeling. We also summarize the current therapeutic drugs targeting cardiac ion channels, to provide potential strategies for mechanistic research and clinical interventions for heart disease.\n                  <\/jats:p>","DOI":"10.3389\/fcell.2026.1856816","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T06:52:11Z","timestamp":1785480731000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ion channels and cardiac disease: mechanisms and functions of a disintegrin and metalloproteases and their substrates"],"prefix":"10.3389","volume":"14","author":[{"given":"Yaru","family":"Liu","sequence":"first","affiliation":[{"name":"College of Life Sciences, Shandong Normal University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhui","family":"Xia","sequence":"additional","affiliation":[{"name":"College of Clinical Medical, Jining Medical University","place":["Jining, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Clinical Medical, Jining Medical University","place":["Jining, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxuan","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Stomatology, Jining Medical University","place":["Jining, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizhu","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Clinical Medical, Jining Medical University","place":["Jining, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjie","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Clinical Medical, Jining Medical University","place":["Jining, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Ding","sequence":"additional","affiliation":[{"name":"College of Clinical Medical, Jining Medical University","place":["Jining, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Li","sequence":"additional","affiliation":[{"name":"College of Medical Imaging and Laboratory, Jining Medical University","place":["Jining, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Luo","sequence":"additional","affiliation":[{"name":"Shandong Lifei Biological Group","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Adu-Amankwaah","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Southern University of Science and Technology","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxiang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Lin He\u2019s Academician Workstation of New Medicine and Clinical Translation, Jining Medical University","place":["Jining, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Basic Medical Sciences, Southwest Medical University","place":["Luzhou, China"]},{"name":"Department of Cardiology, Institute of Cardiovascular Research, The Affiliated Hospital, Southwest Medical University","place":["Luzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Meng","sequence":"additional","affiliation":[{"name":"Lin He\u2019s Academician Workstation of New Medicine and Clinical Translation, Jining Medical University","place":["Jining, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Shandong Normal University","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s00395-020-0775-5","article-title":"TRPV4 deletion protects heart from myocardial infarction-induced adverse remodeling via modulation of cardiac fibroblast differentiation","volume":"115","author":"Adapala","year":"2020","journal-title":"Basic Res. 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