{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T06:05:30Z","timestamp":1784786730625,"version":"3.55.0"},"reference-count":109,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Integrins are hetero-dimeric transmembrane receptors that facilitate bidirectional signaling between the extracellular matrix and the intracellular environment. Among these, the \u03b14 and \u03b19 subunits form a distinct subfamily when paired with the \u03b21 integrin subunit. \u03b14\u03b21 and \u03b19\u03b21 integrins play specialized roles in cell migration, adhesion, and mechanotransduction. In the ocular anterior segment, these integrins are recognized for their contributions to the physiological function of the trabecular meshwork (TM) and Schlemm\u2019s canal (SC). This review examines the structural and functional characteristics of \u03b14\u03b21 and \u03b19\u03b21, their involvement in aqueous humor (AH) outflow and intraocular pressure (IOP) regulation, and their specific interactions with the fibronectin extra domain A (FN+EDA). Furthermore, we explore the crosstalk between these integrins and the toll-like receptor 4 (TLR4) and transforming growth factor-beta (TGF\u03b2) signaling pathways, highlighting their potential role in driving a fibrotic-like response observed in the glaucomatous TM.<\/jats:p>","DOI":"10.3389\/fcell.2026.1862957","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:37:46Z","timestamp":1784785066000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrin \u03b14 and \u03b19 in trabecular meshwork and Schlemm\u2019s canal function: emerging regulators of intraocular pressure homeostasis"],"prefix":"10.3389","volume":"14","author":[{"given":"Tania","family":"Sharmin","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison","place":["Madison, WI, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen M.","family":"McDowell","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison","place":["Madison, WI, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e4449","DOI":"10.1371\/journal.pone.0004449","article-title":"The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells","volume":"4","author":"Alghisi","year":"2009","journal-title":"PLoS One"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1083\/jcb.105.3.1183","article-title":"Amino acid sequence of the human fibronectin receptor","volume":"105","author":"Argraves","year":"1987","journal-title":"J. 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