{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T06:12:27Z","timestamp":1788502347279,"version":"build-2803163510"},"reference-count":84,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["10.55776\/PAT2555923"],"award-info":[{"award-number":["10.55776\/PAT2555923"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>\n                    Sound detection occurs in the cochlea, where sensory inner hair cells (IHC) accurately convert auditory stimuli into neurochemical signals. Presynaptically, IHCs harbor synaptic ribbons, specialized scaffolds that facilitate ultrafast and indefatigable exocytosis. During synapse assembly and subsequent maturation, IHC ribbons increase in volume and synaptic vesicle tethering capacity. This development is thought to result from progressive precursor aggregation. However, the underlying mechanisms of ribbon synapse formation have remained elusive thus far. In this study, we established a novel triple-color live-cell imaging approach to monitor IHC presynaptogenesis\n                    <jats:italic>in situ<\/jats:italic>\n                    . We found that ribbon precursors are highly dynamic and undergo bidirectional plasticity. The presynaptic active zone (AZ) forms a focal point for dramatic structural remodeling of precursors, which the AZ recruits, confines and redistributes. Furthermore, silencing spontaneous synaptic activity decreased precursor mobility and plasticity at the AZ. This suggests a fundamental role for activity-dependent Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx in regulating the dynamic assembly of auditory ribbon synapses.\n                  <\/jats:p>","DOI":"10.3389\/fcell.2026.1866692","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:28:43Z","timestamp":1788499723000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic structural plasticity facilitates the developmental assembly of cochlear inner hair cell ribbon synapses"],"prefix":"10.3389","volume":"14","author":[{"given":"Roos A.","family":"Voorn","sequence":"first","affiliation":[{"name":"Auditory Neuroscience Group, Institute of Physiology, Medical University Innsbruck","place":["Innsbruck, Austria"]},{"name":"Presynaptogenesis and Intracellular Transport in Hair Cells Junior Research Group, Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Goettingen","place":["Goettingen, Germany"]},{"name":"Collaborative Research Center 889 \u201cCellular Mechanisms of Sensory Processing\u201d","place":["Goettingen, Germany"]},{"name":"G\u00f6ttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences","place":["Goettingen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sternbach","sequence":"additional","affiliation":[{"name":"G\u00f6ttingen Graduate Center for Neurosciences, Biophysics and Molecular Biosciences","place":["Goettingen, Germany"]},{"name":"Max Planck Institute for Dynamics and Self-Organization","place":["Goettingen, Germany"]},{"name":"G\u00f6ttingen Campus Institute for Dynamics of Biological Networks, University of G\u00f6ttingen","place":["Goettingen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Bourien","sequence":"additional","affiliation":[{"name":"INM, University Montpellier, INSERM","place":["Montpellier, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru H.","family":"Komiyama","sequence":"additional","affiliation":[{"name":"Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh","place":["Edinburgh, United Kingdom"]},{"name":"Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh","place":["Edinburgh, United Kingdom"]},{"name":"The Patrick Wild Centre for Research into Autism, Fragile X Syndrome and Intellectual Disabilities, Centre for Discovery Brain Sciences, University of Edinburgh","place":["Edinburgh, United Kingdom"]},{"name":"Muir Maxwell Epilepsy Centre, University of Edinburgh","place":["Edinburgh, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladan","family":"Rankovi\u010d","sequence":"additional","affiliation":[{"name":"Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Goettingen","place":["Goettingen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Wolf","sequence":"additional","affiliation":[{"name":"Collaborative Research Center 889 \u201cCellular Mechanisms of Sensory Processing\u201d","place":["Goettingen, Germany"]},{"name":"Max Planck Institute for Dynamics and Self-Organization","place":["Goettingen, Germany"]},{"name":"G\u00f6ttingen Campus Institute for Dynamics of Biological Networks, University of G\u00f6ttingen","place":["Goettingen, Germany"]},{"name":"Bernstein Center for Computational Neuroscience","place":["Goettingen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth G. 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