{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:51:29Z","timestamp":1781679089819,"version":"3.54.5"},"reference-count":100,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008235","name":"Peking Union Medical College Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008235","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>\n                    H\n                    <jats:sub>2<\/jats:sub>\n                    S-mediated protein S-sulfhydration is an emerging post-translational modification that regulates key biological processes via regulating enzyme activities, controlling protein\u2013protein interactions, and modulating signal transduction. Lipid metabolism represents an important target of S-sulfhydration\u2013mediated regulation, which fine-tunes lipid metabolic networks including fatty acid turnover, triglyceride metabolism, and cholesterol homeostasis. This review aims to systematically summarize current knowledge on the regulation of lipid metabolism with a focus on S-sulfhydration, and highlight novel molecular targets identified in recent research. By integrating emerging evidence, we demonstrate how S-sulfhydration acts as a regulatory module linking redox signaling and lipid homeostasis, which may be leveraged therapeutically to treat lipid-associated disorders, either using H\n                    <jats:sub>2<\/jats:sub>\n                    S donors or sulfhydrated protein\u2013targeted medications.\n                  <\/jats:p>","DOI":"10.3389\/fcell.2026.1866744","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T05:51:54Z","timestamp":1781675514000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["H2S-mediated protein S-sulfhydration: a novel regulatory module in lipid metabolism"],"prefix":"10.3389","volume":"14","author":[{"given":"Mingchang","family":"Pang","sequence":"first","affiliation":[{"name":"Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyang","family":"Chen","sequence":"additional","affiliation":[{"name":"Eight-year MD Program, Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuofeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huayu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilei","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfa","family":"Huang","sequence":"additional","affiliation":[{"name":"Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University","place":["Beijing, China"]},{"name":"Clinical Center for Pediatric Liver Transplantation, Capital Medical University","place":["Beijing, China"]},{"name":"Beijing Key Laboratory of Organ Cultivation and Organ Protection in Transplantation, Beijing Friendship Hospital, Capital Medical University","place":["Beijing, China"]},{"name":"State Key Laboratory of Digestive Health","place":["Beijing, China"]},{"name":"Laboratory for Clinical Medicine, Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"105269","DOI":"10.1016\/j.chemphyslip.2022.105269","article-title":"Fatty acid transport proteins (FATPs) in cancer","volume":"250","author":"Acharya","year":"2023","journal-title":"Chem. 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