{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:05:17Z","timestamp":1784009117381,"version":"3.55.0"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Liver is a common site of metastatic involvement from non-small cell lung cancer (NSCLC). Spatially fractionated radiotherapy (SFRT) has emerged as a promising technique for controlling bulky lesions while minimizing toxicity. We report two patients with advanced NSCLC and hepatic oligoprogression who underwent SFRT to selected liver lesions. Both achieved excellent local control within the irradiated field, yet developed explosive progression in non-irradiated hepatic regions within 3\u00a0months, while extrahepatic disease remained stable. These cases highlight a striking intrahepatic response dissociation, potentially driven by intratumoral heterogeneity, clonal selection and local hepatic immune remodeling under targeted\/systemic therapy. The findings underscore the need for further investigation into SFRT\u2019s immunobiology and optimal integration with systemic agents.<\/jats:p>","DOI":"10.3389\/fcell.2026.1867630","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:40:17Z","timestamp":1784007617000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Spatially fractionated radiotherapy for liver metastases: two cases of intrahepatic response dissociation"],"prefix":"10.3389","volume":"14","author":[{"given":"Yucui","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"]},{"name":"Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education), Second Affiliated Hospital","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bicheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"]},{"name":"Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education), Second Affiliated Hospital","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"]},{"name":"Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education), Second Affiliated Hospital","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qichun","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"]},{"name":"Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education), Second Affiliated Hospital","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine","place":["Hangzhou, Zhejiang, China"]},{"name":"Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, National Ministry of Education), Second Affiliated Hospital","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s13014-024-02514-6","article-title":"Spatially fractionated GRID radiation potentiates immune-mediated tumor control","volume":"19","author":"Bekker","year":"2024","journal-title":"Radiat. 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