{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:05:10Z","timestamp":1784099110565,"version":"3.55.0"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014717","name":"Youth Science Fund Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>\n                    Primary ovarian insufficiency (POI) is a major cause of female infertility and endocrine dysfunction, for which effective therapies remain limited. We investigated whether rutin, a bioactive compound from traditional Chinese medicine, protects ovarian function in POI by regulating mitochondrial homeostasis and pyroptosis.\n                    <jats:italic>In vitro<\/jats:italic>\n                    assays using chemically injured oocytes showed that rutin alleviated mitochondrial defects, rescued developmental arrest, enhanced antioxidant signaling, promoted mitophagy, and reduced inflammatory cell death. In a cyclophosphamide-induced murine POI model, rutin restored estrous cyclicity, improved follicle development, normalized hormone levels, and enhanced ovulation, litter outcome, and\n                    <jats:italic>in vitro<\/jats:italic>\n                    -fertilization (IVF)-related developmental competence. Ovarian histological and molecular analyses further showed reduced inflammasome-related pyroptotic signaling, lower oxidative stress levels, and improved mitochondrial integrity. These findings identify rutin as a promising ovarian-protective candidate in POI-associated infertility and support further investigation of its therapeutic potential in female reproductive disorders.\n                  <\/jats:p>","DOI":"10.3389\/fcell.2026.1872070","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:10:15Z","timestamp":1784095815000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Rutin rescues oocyte developmental competence in primary ovarian insufficiency by restoring mitophagy and suppressing pyroptosis"],"prefix":"10.3389","volume":"14","author":[{"given":"Ying","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Chinese Medicine, The First Affiliated Hospital of Wenzhou Medical University","place":["Wenzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Yang","sequence":"additional","affiliation":[{"name":"Hangzhou Hospital of TCM Affiliated to Zhejiang Chinese Medical University","place":["Hangzhou, China"]},{"name":"The Third Clinical Medical College, Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyun","family":"Miao","sequence":"additional","affiliation":[{"name":"Hangzhou Hospital of TCM Affiliated to Zhejiang Chinese Medical University","place":["Hangzhou, China"]},{"name":"College of Life Science, Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Third Clinical Medical College, Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Xiao","sequence":"additional","affiliation":[{"name":"The Third Clinical Medical College, Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruye","family":"Wang","sequence":"additional","affiliation":[{"name":"Hangzhou Hospital of TCM Affiliated to Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Chen","sequence":"additional","affiliation":[{"name":"Hangzhou Hospital of TCM Affiliated to Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Ren","sequence":"additional","affiliation":[{"name":"Hangzhou Hospital of TCM Affiliated to Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Hangzhou Hospital of TCM Affiliated to Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haimo","family":"Qian","sequence":"additional","affiliation":[{"name":"Hangzhou Hospital of TCM Affiliated to Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Dai","sequence":"additional","affiliation":[{"name":"Hangzhou Hospital of TCM Affiliated to Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Third Clinical Medical College, Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hangzhou Hospital of TCM Affiliated to Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ma","sequence":"additional","affiliation":[{"name":"Hangzhou Hospital of TCM Affiliated to Zhejiang Chinese Medical University","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"104649","DOI":"10.1016\/j.jri.2025.104649","article-title":"The impact of platelet-rich plasma (PRP) on ovarian function and oocyte quality: a comprehensive review","volume":"172","author":"Ahmadi","year":"2025","journal-title":"J. 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