{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:15:43Z","timestamp":1788498943128,"version":"build-2803163510"},"reference-count":228,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Degenerative skeletal diseases, including osteoarthritis (OA), intervertebral disc degeneration (IVDD) and osteoporosis (OP), are major causes of chronic pain, disability and loss of skeletal function, yet effective disease-modifying therapies remain limited. Although these disorders affect distinct tissues and cell populations, they share persistent inflammation, oxidative stress, mitochondrial dysfunction, metabolic imbalance and defective tissue remodelling. Programmed cell death (PCD) is a critical link between these disturbances and progressive structural failure. Apoptosis, pyroptosis, necroptosis, ferroptosis and autophagy-associated cell-fate regulation rarely operate independently. Their activation and biological consequences are determined by cell type, anatomical niche, disease stage and stress intensity. However, the concurrent detection of multiple death-associated markers is often misinterpreted as mechanistic crosstalk, hindering accurate identification of causal pathways and therapeutic targets. This Review proposes an evidence-graded, disease-stage-, cell-type- and microenvironment-dependent framework for interpreting PCD interactions in OA, IVDD and OP. It distinguishes shared upstream triggers, convergent regulatory nodes, sequential transitions, direct molecular conversion and functional coexistence according to their evidential strength. We further evaluate therapeutic strategies targeting the cell death\u2013inflammation\u2013metabolism axis, including multi-target agents, nanomaterials, extracellular vesicles, biomaterials and tissue engineering. Most evidence remains preclinical, underscoring the urgent need for human validation, causal target confirmation and rigorous assessment of delivery, durability, safety and manufacturability. This framework may improve mechanistic precision and accelerate the development of context-specific therapies for degenerative skeletal diseases.<\/jats:p>","DOI":"10.3389\/fcell.2026.1876124","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:25:36Z","timestamp":1788495936000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Programmed cell death in degenerative skeletal diseases: molecular crosstalk and combinatorial therapeutic strategies"],"prefix":"10.3389","volume":"14","author":[{"given":"Rui","family":"Zhao","sequence":"first","affiliation":[{"name":"Clinical College of Chinese Medicine, Gansu University of Chinese Medicine","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jirong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Clinical College of Chinese Medicine, Gansu University of Chinese Medicine","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongnian","family":"Yin","sequence":"additional","affiliation":[{"name":"Clinical College of Chinese Medicine, Gansu University of Chinese Medicine","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhan","sequence":"additional","affiliation":[{"name":"Clinical College of Chinese Medicine, Gansu University of Chinese Medicine","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Ma","sequence":"additional","affiliation":[{"name":"Clinical College of Chinese Medicine, Gansu University of Chinese Medicine","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Xue","sequence":"additional","affiliation":[{"name":"Clinical College of Chinese Medicine, Gansu University of Chinese Medicine","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentong","family":"Yang","sequence":"additional","affiliation":[{"name":"Clinical College of Chinese Medicine, Gansu University of Chinese Medicine","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4719","DOI":"10.1038\/s41598-024-54944-7","article-title":"Pharmacological inhibition of endoplasmic reticulum stress mitigates osteoporosis in a mouse model of hindlimb suspension","volume":"14","author":"AL-Daghestani","year":"2024","journal-title":"Sci. Rep."},{"key":"B2","doi-asserted-by":"publisher","first-page":"7534","DOI":"10.18632\/aging.103109","article-title":"Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells","volume":"12","author":"Bai","year":"2020","journal-title":"Aging (Albany N Y)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"582","DOI":"10.3390\/life12040582","article-title":"Epigenetic regulation of chondrocytes and subchondral bone in osteoarthritis","volume":"12","author":"Ball","year":"2022","journal-title":"Life"},{"key":"B4","doi-asserted-by":"publisher","first-page":"18276","DOI":"10.1074\/jbc.RA120.015924","article-title":"ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis)","volume":"295","author":"Banoth","year":"2020","journal-title":"J. Biol. Chem."},{"key":"B5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/s41413-024-00341-9","article-title":"Induction of osteoblast apoptosis stimulates macrophage efferocytosis and paradoxical bone formation","volume":"12","author":"Batoon","year":"2024","journal-title":"Bone Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.2337\/db21-0573","article-title":"Exercise-linked skeletal irisin ameliorates diabetes-associated osteoporosis by inhibiting the oxidative damage\u2013dependent miR-150-FNDC5\/pyroptosis axis","volume":"71","author":"Behera","year":"2022","journal-title":"Diabetes"},{"key":"B7","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/s41422-025-01107-6","article-title":"Pyroptosis: molecular mechanisms and roles in disease","volume":"35","author":"Broz","year":"2025","journal-title":"Cell. Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"942982","DOI":"10.3389\/fgene.2022.942982","article-title":"Epigenetic regulation in knee osteoarthritis","volume":"13","author":"Cai","year":"2022","journal-title":"Front. Genetics"},{"key":"B9","doi-asserted-by":"publisher","first-page":"111","DOI":"10.31083\/j.fbl2704111","article-title":"Inflammatory stimulation mediates nucleus pulposus cell necroptosis through mitochondrial function disfunction and oxidative stress pathway","volume":"27","author":"Cao","year":"2022","journal-title":"Front. Biosci. Landmark Ed."},{"key":"B10","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1186\/s12951-024-02538-w","article-title":"Bio-nanoparticles loaded with synovial-derived exosomes ameliorate osteoarthritis progression by modifying the oxidative microenvironment","volume":"22","author":"Cao","year":"2024","journal-title":"J. Nanobiotechnology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jot.2024.10.005","article-title":"Paeonol inhibits ACSL4 to protect chondrocytes from ferroptosis and ameliorates osteoarthritis progression","volume":"50","author":"Cao","year":"2025","journal-title":"J. Orthop. Transl."},{"key":"B12","doi-asserted-by":"publisher","first-page":"155516","DOI":"10.1016\/j.phymed.2024.155516","article-title":"Luteolin rescues postmenopausal osteoporosis elicited by OVX through alleviating osteoblast pyroptosis via activating PI3K-AKT signaling","volume":"128","author":"Chai","year":"2024","journal-title":"Phytomedicine"},{"key":"B13","doi-asserted-by":"publisher","first-page":"3597","DOI":"10.7150\/ijbs.108832","article-title":"TrkC protects against osteoarthritis progression by maintaining articular cartilage homeostasis","volume":"21","author":"Chang","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/s12276-022-00753-9","article-title":"Grem1 accelerates nucleus pulposus cell apoptosis and intervertebral disc degeneration by inhibiting TGF-\u03b2-mediated Smad2\/3 phosphorylation","volume":"54","author":"Chen","year":"2022","journal-title":"Exp. and Mol. Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"14457","DOI":"10.18632\/aging.205373","article-title":"MiR-203a-3p attenuates apoptosis and pyroptosis of chondrocytes by regulating the MYD88\/NF-\u03baB pathway to alleviate osteoarthritis progression","volume":"15","author":"Chen","year":"","journal-title":"Aging (Albany NY)"},{"key":"B16","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3892\/mmr.2023.13089","article-title":"Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death","volume":"28","author":"Chen","year":"","journal-title":"Mol. Med. Rep."},{"key":"B17","doi-asserted-by":"publisher","first-page":"111661","DOI":"10.1016\/j.intimp.2024.111661","article-title":"Kongensin a attenuates intervertebral disc degeneration by inhibiting TAK1-mediated PANoptosis of nucleus pulposus cells","volume":"129","author":"Chen","year":"","journal-title":"Int. Immunopharmacol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.freeradbiomed.2024.05.007","article-title":"Inhibiting DNA methyltransferase DNMT3B confers protection against ferroptosis in nucleus pulposus and ameliorates intervertebral disc degeneration via upregulating SLC40A1","volume":"220","author":"Chen","year":"","journal-title":"Free Radic. Biol. Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1097\/cm9.0000000000003186","article-title":"EZH2\/miR-142-3p\/HMGB1 axis mediates chondrocyte pyroptosis by regulating endoplasmic reticulum stress in knee osteoarthritis","volume":"138","author":"Chen","year":"","journal-title":"Chin. Med. J. Engl."},{"key":"B20","doi-asserted-by":"publisher","first-page":"20417314251351011","DOI":"10.1177\/20417314251351011","article-title":"Amelioration of intervertebral disc degeneration using engineered extracellular vesicle-delivered ZDHHC5 via inhibiting PANoptosis","volume":"16","author":"Chen","year":"","journal-title":"J. Tissue Eng."},{"key":"B21","doi-asserted-by":"publisher","first-page":"103919","DOI":"10.4252\/wjsc.v17.i4.103919","article-title":"Human umbilical cord mesenchymal stem cell-derived exosomal miR-199a-3p inhibits the MAPK4\/NF-\u03baB signaling pathway to relieve osteoarthritis","volume":"17","author":"Chen","year":"","journal-title":"World J. Stem Cells"},{"key":"B22","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.freeradbiomed.2025.02.027","article-title":"Exosomes inhibit ferroptosis to alleviate intervertebral disc degeneration via the p62-KEAP1-NRF2 pathway","volume":"232","author":"Chen","year":"","journal-title":"Free Radic. Biol. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s10863-023-09991-6","article-title":"Chondroprotective effects of bone marrow mesenchymal stem cell-derived exosomes in osteoarthritis","volume":"56","author":"Cheng","year":"2024","journal-title":"J. Bioenergetics Biomembr."},{"key":"B24","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/s41413-025-00441-0","article-title":"Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration","volume":"13","author":"Cheng","year":"2025","journal-title":"Bone Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.18632\/aging.204612","article-title":"PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway","volume":"15","author":"Cui","year":"2023","journal-title":"Aging (Albany NY)"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e17212","DOI":"10.7717\/peerj.17212","article-title":"Regulation of endoplasmic reticulum stress on autophagy and apoptosis of nucleus pulposus cells in intervertebral disc degeneration and its related mechanisms","volume":"12","author":"Dai","year":"2024","journal-title":"PeerJ"},{"key":"B27","doi-asserted-by":"publisher","first-page":"155282","DOI":"10.1016\/j.phymed.2023.155282","article-title":"Mangiferin attenuates osteoporosis by inhibiting osteoblastic ferroptosis through Keap1\/Nrf2\/SLC7A11\/GPX4 pathway","volume":"124","author":"Deng","year":"2024","journal-title":"Phytomedicine"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1633618","DOI":"10.3389\/fphys.2025.1633618","article-title":"Passive hydrotherapy preserves cartilage and muscle integrity in a murine osteoarthritis model: potential role of integrin \u03b1V\/TGF-\u03b2 mechanotransduction","volume":"16","author":"DI","year":"2025","journal-title":"Front. Physiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1126\/science.1215691","article-title":"miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay","volume":"336","author":"Djuranovic","year":"2012","journal-title":"Science"},{"key":"B30","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1089\/dna.2023.0341","article-title":"Exosomes derived from quercetin-treated bone marrow derived mesenchymal stem cells inhibit the progression of osteoarthritis through delivering miR-124-3p to chondrocytes","volume":"43","author":"Dong","year":"2024","journal-title":"DNA Cell. Biol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1186\/s13287-021-02507-2","article-title":"Extracellular vesicles derived from LPS-Preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model","volume":"12","author":"Duan","year":"2021","journal-title":"Stem Cell Research and Therapy"},{"key":"B32","doi-asserted-by":"publisher","first-page":"994307","DOI":"10.3389\/fendo.2022.994307","article-title":"Necroptosis of nucleus pulposus cells involved in intervertebral disc degeneration through MyD88 signaling","volume":"13","author":"Fan","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B33","doi-asserted-by":"publisher","first-page":"3594","DOI":"10.1016\/j.ymthe.2023.10.016","article-title":"FUNDC1\/PFKP-mediated mitophagy induced by KD025 ameliorates cartilage degeneration in osteoarthritis","volume":"31","author":"Fang","year":"2023","journal-title":"Mol. Ther."},{"key":"B34","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1369\/00221554231225514","article-title":"General control non-derepressible 2 alleviates cartilage degeneration and inhibits NLRP3 inflammasome activation in osteoarthritis","volume":"72","author":"Fang","year":"2024","journal-title":"J. Histochem. and Cytochem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1016\/j.spinee.2014.04.022","article-title":"Lumbar disc nomenclature: version 2.0: recommendations of the combined task forces of the north American spine society, the American society of spine radiology and the American society of neuroradiology","volume":"14","author":"Fardon","year":"2014","journal-title":"Spine Journal"},{"key":"B36","doi-asserted-by":"publisher","first-page":"103255","DOI":"10.1016\/j.redox.2024.103255","article-title":"Inhibition of ferroptosis rescues M2 macrophages and alleviates arthritis by suppressing the HMGB1\/TLR4\/STAT3 axis in M1 macrophages","volume":"75","author":"Feng","year":"","journal-title":"Redox Biology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"135863","DOI":"10.1016\/j.ijbiomac.2024.135863","article-title":"Intra-articular injection of platinum nanozyme-loaded silk fibroin\/pullulan hydrogels relieves osteoarthritis through ROS scavenging and ferroptosis suppression","volume":"280","author":"Feng","year":"","journal-title":"Int. J. Biol. Macromol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s10020-024-00819-6","article-title":"CHMP5 attenuates osteoarthritis via inhibiting chondrocyte apoptosis and extracellular matrix degradation: involvement of NF-\u03baB pathway","volume":"30","author":"Gao","year":"","journal-title":"Mol. Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1007\/s13577-024-01067-w","article-title":"PMAIP1 regulates autophagy in osteoblasts via the AMPK\/mTOR pathway in osteoporosis","volume":"37","author":"Gao","year":"","journal-title":"Hum. Cell."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2401103","DOI":"10.1002\/adhm.202401103","article-title":"ROS\u2010Responsive injectable hydrogel loaded with SLC7A11\u2010modRNA inhibits ferroptosis and mitigates intervertebral disc degeneration in rats","volume":"13","author":"Gao","year":"","journal-title":"Adv. Healthc. Mater."},{"key":"B41","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1042\/CS20243438","article-title":"Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis","volume":"139","author":"Gao","year":"2025","journal-title":"Clin. Sci. (Lond)"},{"key":"B42","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s10787-022-01098-5","article-title":"Maltol ameliorates intervertebral disc degeneration through inhibiting PI3K\/AKT\/NF-\u03baB pathway and regulating NLRP3 inflammasome-mediated pyroptosis","volume":"31","author":"Gong","year":"2023","journal-title":"Inflammopharmacology"},{"key":"B43","doi-asserted-by":"publisher","first-page":"3027954","DOI":"10.1155\/2021\/3027954","article-title":"Chronic ethanol consumption induces osteopenia via activation of osteoblast necroptosis","volume":"2021","author":"Guo","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2403892","DOI":"10.1002\/adhm.202403892","article-title":"Injectable nanocomposite hydrogels for intervertebral disc degeneration: combating oxidative stress, mitochondrial dysfunction, and ferroptosis","volume":"14","author":"Guo","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"B45","doi-asserted-by":"publisher","first-page":"e13677","DOI":"10.1111\/acel.13677","article-title":"p300 arrests intervertebral disc degeneration by regulating the FOXO3\/Sirt1\/Wnt\/\u03b2\u2010catenin axis","volume":"21","author":"Hao","year":"2022","journal-title":"Aging Cell."},{"key":"B46","doi-asserted-by":"publisher","first-page":"790613","DOI":"10.3389\/fmolb.2021.790613","article-title":"Comparison of necroptosis with apoptosis for OVX-induced osteoporosis","volume":"8","author":"He","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s11658-024-00605-6","article-title":"\u03b1-Ketoglutarate alleviates osteoarthritis by inhibiting ferroptosis via the ETV4\/SLC7A11\/GPX4 signaling pathway","volume":"29","author":"He","year":"","journal-title":"Cell. Mol. Biol. Lett."},{"key":"B48","doi-asserted-by":"publisher","first-page":"116697","DOI":"10.1016\/j.biopha.2024.116697","article-title":"Vitamin K2 ameliorates osteoarthritis by suppressing ferroptosis and extracellular matrix degradation through activation GPX4\u2019s dual functions","volume":"175","author":"He","year":"","journal-title":"Biomed. and Pharmacother."},{"key":"B49","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3892\/mmr.2026.13823","article-title":"Epigenetic crossroads in intervertebral disc degeneration: unlocking novel therapeutic avenues","volume":"33","author":"Hou","year":"2026","journal-title":"Mol. Med. Rep."},{"key":"B50","doi-asserted-by":"publisher","first-page":"6647","DOI":"10.1097\/JS9.0000000000002783","article-title":"Targeting SIRT3 to regulate mitophagy-dependent ferroptosis for preventing glucocorticoid-induced osteoporosis","volume":"111","author":"Hu","year":"2025","journal-title":"Int. J. Surg."},{"key":"B51","doi-asserted-by":"publisher","first-page":"e23672","DOI":"10.1016\/j.heliyon.2023.e23672","article-title":"Identifying potential ferroptosis key genes for diagnosis and treatment of postmenopausal osteoporosis through competitive endogenous RNA network analysis","volume":"10","author":"Huang","year":"2024","journal-title":"Heliyon"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1002\/iub.2656","article-title":"Iron overload\u2010induced ferroptosis of osteoblasts inhibits osteogenesis and promotes osteoporosis: an in vitro and in vivo study","volume":"74","author":"Jiang","year":"2022","journal-title":"IUBMB Life"},{"key":"B53","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1042\/ebc20200060","article-title":"Circular RNAs as microRNA sponges: evidence and controversies","volume":"65","author":"Jarlstad Olesen","year":"2021","journal-title":"Essays Biochem."},{"key":"B54","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1186\/s12951-024-02740-w","article-title":"Injectable hydrogel encapsulating siMMP13 with anti-ROS and anti-apoptotic functions for osteoarthritis treatment","volume":"22","author":"Ji","year":"2024","journal-title":"J. Nanobiotechnology"},{"key":"B55","doi-asserted-by":"publisher","first-page":"9725","DOI":"10.2147\/JIR.S484529","article-title":"Inhibition of EGFR pathway suppresses M1 macrophage polarization and osteoclastogenesis, mitigating titanium particle-induced bone resorption","volume":"17","author":"Jia","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"B56","doi-asserted-by":"publisher","first-page":"110587","DOI":"10.1016\/j.intimp.2023.110587","article-title":"Pharmacological activation of the Nrf2 pathway by taxifolin remodels articular cartilage microenvironment for the therapy of osteoarthritis","volume":"122","author":"Jiang","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"2307388","DOI":"10.1002\/advs.202307388","article-title":"Ferroptosis in osteocytes as a target for protection against postmenopausal osteoporosis","volume":"11","author":"Jiang","year":"","journal-title":"Adv. Sci."},{"key":"B58","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13020-024-00909-x","article-title":"Trachelogenin alleviates osteoarthritis by inhibiting osteoclastogenesis and enhancing chondrocyte survival","volume":"19","author":"Jiang","year":"","journal-title":"Chin. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"10099","DOI":"10.1002\/fsn3.4554","article-title":"Morin improves the bone histomorphology and biochemical markers in an animal model of ovariectomy\u2010induced osteoporosis by suppressing autophagy and apoptosis","volume":"12","author":"Jiang","year":"","journal-title":"Food Sci. and Nutr."},{"key":"B60","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.immuni.2013.02.003","article-title":"Necroptosis: the release of damage-associated molecular patterns and its physiological relevance","volume":"38","author":"Kaczmarek","year":"2013","journal-title":"Immunity"},{"key":"B61","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1084\/jem.186.4.489","article-title":"Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclasts","volume":"186","author":"Kameda","year":"1997","journal-title":"J. Experimental Medicine"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1181156","DOI":"10.3389\/fimmu.2023.1181156","article-title":"Exosomes from osteoarthritic fibroblast-like synoviocytes promote cartilage ferroptosis and damage via delivering microRNA-19b-3p to target SLC7A11 in osteoarthritis","volume":"14","author":"Kong","year":"2023","journal-title":"Front. Immunol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"116273","DOI":"10.1016\/j.biopha.2024.116273","article-title":"Koumine inhibits IL-1\u03b2-induced chondrocyte inflammation and ameliorates extracellular matrix degradation in osteoarthritic cartilage through activation of PINK1\/Parkin-mediated mitochondrial autophagy","volume":"173","author":"Kong","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"B64","doi-asserted-by":"publisher","first-page":"e22145","DOI":"10.1096\/fj.202100896r","article-title":"C10orf10\/DEPP activates mitochondrial autophagy and maintains chondrocyte viability in the pathogenesis of osteoarthritis","volume":"36","author":"Kuwahara","year":"2022","journal-title":"FASEB J."},{"key":"B65","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s10753-023-01896-1","article-title":"Suppression of IRF9 promotes osteoclast differentiation by decreased ferroptosis via STAT3 activation","volume":"47","author":"Lan","year":"2024","journal-title":"Inflammation"},{"key":"B66","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.joca.2010.09.013","article-title":"OARSI-FDA initiative: defining the disease state of osteoarthritis","volume":"19","author":"Lane","year":"2011","journal-title":"Osteoarthr. Cartilage"},{"key":"B67","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/s41586-021-03875-8","article-title":"AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence","volume":"597","author":"Lee","year":"2021","journal-title":"Nature"},{"key":"B68","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s11658-023-00517-x","article-title":"Molecular mechanism and therapeutic potential of HDAC9 in intervertebral disc degeneration","volume":"28","author":"Lei","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"key":"B69","doi-asserted-by":"publisher","first-page":"9549","DOI":"10.1038\/s41598-022-13791-0","article-title":"The integrative analysis of competitive endogenous RNA regulatory networks in osteoporosis","volume":"12","author":"Li","year":"","journal-title":"Sci. Rep."},{"key":"B70","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s13018-021-02886-5","article-title":"miR-155 inhibits chondrocyte pyroptosis in knee osteoarthritis by targeting SMAD2 and inhibiting the NLRP3\/Caspase-1 pathway","volume":"17","author":"Li","year":"","journal-title":"J. Orthopaedic Surgery Research"},{"key":"B71","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41419-023-05595-5","article-title":"PINK1\/Parkin-mediated mitophagy inhibits osteoblast apoptosis induced by advanced oxidation protein products","volume":"14","author":"Li","year":"","journal-title":"Cell. Death and Disease"},{"key":"B72","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13020-023-00748-2","article-title":"Monotropein attenuates apoptosis and pyroptosis in chondrocytes and alleviates osteoarthritis progression in mice","volume":"18","author":"Li","year":"","journal-title":"Chin. Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"109489","DOI":"10.1016\/j.intimp.2022.109489","article-title":"Methyl gallate prevents oxidative stress induced apoptosis and ECM degradation in chondrocytes via restoring Sirt3 mediated autophagy and ameliorates osteoarthritis progression","volume":"114","author":"Li","year":"","journal-title":"Int. Immunopharmacol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"736","DOI":"10.3724\/abbs.2023078","article-title":"The Nrf2\/HMGB1\/NF-\u03baB axis modulates chondrocyte apoptosis and extracellular matrix degradation in osteoarthritis: nrf2\/HMGB1 affects osteoarthritis","volume":"42","author":"Li","year":"","journal-title":"Clin. Exp. Rheumatol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"e13689","DOI":"10.1111\/cpr.13689","article-title":"Tetrahedral framework nucleic acids-based delivery of microRNA-155 alleviates intervertebral disc degeneration through targeting Bcl-2\/Bax apoptosis pathway","volume":"57","author":"Li","year":"","journal-title":"Cell. Prolif."},{"key":"B76","doi-asserted-by":"publisher","first-page":"101202","DOI":"10.1016\/j.mtbio.2024.101202","article-title":"Therapeutic framework nucleic acid complexes targeting oxidative stress and pyroptosis for the treatment of osteoarthritis","volume":"28","author":"Li","year":"","journal-title":"Mater Today Bio"},{"key":"B77","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1007\/s11033-024-09810-0","article-title":"Analysis of PANoptosis-related ceRNA network reveals lncRNA MIR17HG involved in osteogenic differentiation inhibition impaired by tumor necrosis factor-\u03b1","volume":"51","author":"Li","year":"","journal-title":"Mol. Biol. Rep."},{"key":"B78","doi-asserted-by":"publisher","first-page":"2305363","DOI":"10.1002\/advs.202305363","article-title":"Reprogramming macrophage polarization, depleting ROS by astaxanthin and thioketal\u2010containing polymers delivering rapamycin for osteoarthritis treatment","volume":"11","author":"Li","year":"","journal-title":"Adv. Sci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"2307683","DOI":"10.1002\/advs.202307683","article-title":"Near infrared responsive gold nanorods attenuate osteoarthritis progression by targeting TRPV1","volume":"11","author":"Li","year":"","journal-title":"Adv. Science"},{"key":"B80","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/s41413-024-00319-7","article-title":"A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior delivery of curcumin and alleviation of diabetic osteoporosis","volume":"12","author":"Li","year":"","journal-title":"Bone Res."},{"key":"B81","doi-asserted-by":"publisher","first-page":"157292","DOI":"10.1016\/j.phymed.2025.157292","article-title":"Gut microbiota metabolite urolithin B inhibits chondrocyte ferroptosis by rewriting iron homeostasis via FGFR3\/NCOA4\/FTH1 axis, alleviating osteoarthritis","volume":"148","author":"Li","year":"","journal-title":"Phytomedicine"},{"key":"B82","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.freeradbiomed.2025.09.056","article-title":"MOTS-c attenuates mitochondrial dysfunction induces pyroptosis and cartilage degradation in osteoarthritis via an Nrf2-Dependent mechanism","volume":"241","author":"Li","year":"","journal-title":"Free Radic. Biol. Med"},{"key":"B83","doi-asserted-by":"publisher","first-page":"2504768","DOI":"10.1002\/advs.202504768","article-title":"Functionalized biomimetic nanoparticles targeting the IL\u201010\/IL\u201010R\u03b1\/glycolytic axis in synovial macrophages alleviate cartilage degeneration in osteoarthritis","volume":"12","author":"Li","year":"","journal-title":"Adv. Sci."},{"key":"B84","doi-asserted-by":"publisher","first-page":"3087","DOI":"10.1007\/s10495-025-02179-w","article-title":"Mechanism of the enterobacterial metabolite sodium butyrate mediating ferroptosis to affect osteogenic ability of BMSCs in mice with estrogen deficiency-caused osteoporosis via the PTEN\/PI3K\/AKT pathway","volume":"30","author":"Li","year":"","journal-title":"Apoptosis"},{"key":"B85","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1186\/s12951-025-03990-y","article-title":"An injectable dihydroartemisinin nanocomposite hydrogel for dual-targeting PANoptosis and inflammation to treat osteoarthritis","volume":"24","author":"Li","year":"2026","journal-title":"J. Nanobiotechnology"},{"key":"B86","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1126\/science.1146361","article-title":"IRE1 signaling affects cell fate during the unfolded protein response","volume":"318","author":"Lin","year":"2007","journal-title":"Science"},{"key":"B87","doi-asserted-by":"publisher","first-page":"745621","DOI":"10.3389\/fcell.2021.745621","article-title":"Eicosapentaenoic acid-induced autophagy attenuates intervertebral disc degeneration by suppressing endoplasmic reticulum stress, extracellular matrix degradation, and apoptosis","volume":"9","author":"Lin","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/s12276-024-01196-0","article-title":"Involvement of DJ-1 in the pathogenesis of intervertebral disc degeneration via hexokinase 2-mediated mitophagy","volume":"56","author":"Lin","year":"","journal-title":"Exp. and Mol. Med."},{"key":"B89","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41420-024-01986-5","article-title":"Macrophage-derived ectosomal miR-350-3p promotes osteoarthritis progression through downregulating chondrocyte H3K36 methyltransferase NSD1","volume":"10","author":"Lin","year":"","journal-title":"Cell. Death Discov."},{"key":"B90","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1186\/s12951-024-02517-1","article-title":"Chondrocyte-targeted exosome-mediated delivery of Nrf2 alleviates cartilaginous endplate degeneration by modulating mitochondrial fission","volume":"22","author":"Lin","year":"","journal-title":"J. Nanobiotechnology"},{"key":"B91","doi-asserted-by":"publisher","first-page":"20364","DOI":"10.1073\/pnas.1319661110","article-title":"Autosis is a na+, K+-ATPase\u2013regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia\u2013ischemia","volume":"110","author":"Liu","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B92","doi-asserted-by":"publisher","first-page":"3450","DOI":"10.1080\/21655979.2021.2024685","article-title":"Timosaponin B-II alleviates osteoarthritis-related inflammation and extracellular matrix degradation through inhibition of mitogen-activated protein kinases and nuclear factor-\u03baB pathways in vitro","volume":"13","author":"Liu","year":"2022","journal-title":"Bioengineered"},{"key":"B93","doi-asserted-by":"publisher","first-page":"114118","DOI":"10.1016\/j.biopha.2022.114118","article-title":"Exercise induced meteorin-like protects chondrocytes against inflammation and pyroptosis in osteoarthritis by inhibiting PI3K\/Akt\/NF-\u03baB and NLRP3\/caspase-1\/GSDMD signaling","volume":"158","author":"Liu","year":"","journal-title":"Biomed. and Pharmacother."},{"key":"B94","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1186\/s13075-023-03214-4","article-title":"Resatorvid alleviates experimental inflammatory TMJOA by restraining chondrocyte pyroptosis and synovial inflammation","volume":"25","author":"Liu","year":"","journal-title":"Arthritis Research and Therapy"},{"key":"B95","doi-asserted-by":"publisher","first-page":"1140653","DOI":"10.3389\/fimmu.2023.1140653","article-title":"Sirtuins in osteoarthritis: current understanding","volume":"14","author":"Liu","year":"","journal-title":"Front. Immunol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"736","DOI":"10.55563\/clinexprheumatol\/chmuts","article-title":"Vitamin D plays a protective role in osteoarthritis by regulating AMPK\/mTOR signalling pathway to activate chondrocyte autophagy","volume":"42","author":"Liu","year":"2024","journal-title":"Clin. Experimental Rheumatology"},{"key":"B97","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s00223-025-01411-8","article-title":"Impacts of nonenzymatic glycation crosslinks in bone matrix on the mechanosensitivity of osteocyte","volume":"116","author":"Liu","year":"2025","journal-title":"Calcif. Tissue Int."},{"key":"B98","doi-asserted-by":"publisher","first-page":"6670497","DOI":"10.1155\/2021\/6670497","article-title":"Ferroportin\u2010dependent iron homeostasis protects against oxidative stress\u2010induced nucleus pulposus cell ferroptosis and ameliorates intervertebral disc degeneration in vivo","volume":"2021","author":"Lu","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"B99","doi-asserted-by":"publisher","first-page":"e20701","DOI":"10.7717\/peerj.20701","article-title":"Identification and validation of a glutamine metabolism-related gene signature as a diagnostic and therapeutic target in osteoarthritis through integrated multi-omics analysis","volume":"14","author":"Lu","year":"2026","journal-title":"PeerJ"},{"key":"B100","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/s42003-025-07989-x","article-title":"Glucocorticoids regulate the expression of Srsf1 through Hdac4\/Foxc1 axis to induce apoptosis of osteoblasts","volume":"8","author":"Luo","year":"2025","journal-title":"Commun. Biol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41420-022-01002-8","article-title":"MFG-E8 alleviates intervertebral disc degeneration by suppressing pyroptosis and extracellular matrix degradation in nucleus pulposus cells via Nrf2\/TXNIP\/NLRP3 axis","volume":"8","author":"Ma","year":"2022","journal-title":"Cell. Death Discov."},{"key":"B102","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.jare.2024.05.033","article-title":"GYY4137-induced p65 sulfhydration protects synovial macrophages against pyroptosis by improving mitochondrial function in osteoarthritis development","volume":"71","author":"Ma","year":"2025","journal-title":"J. Advanced Research"},{"key":"B103","doi-asserted-by":"publisher","first-page":"12375","DOI":"10.1074\/jbc.R116.760884","article-title":"Long non-coding RNAs (lncRNAs) and their transcriptional control of inflammatory responses","volume":"292","author":"Mathy","year":"2017","journal-title":"J. Biol. Chem."},{"key":"B104","doi-asserted-by":"publisher","first-page":"10048","DOI":"10.3389\/ebm.2024.10048","article-title":"Collagen II enrichment through scAAV6-RNAi-mediated inhibition of matrix-metalloproteinases 3 and 13 in degenerative nucleus-pulposus cells degenerative disc disease and biological treatment strategies","volume":"249","author":"Mern","year":"2024","journal-title":"Exp. Biol. Med."},{"key":"B105","doi-asserted-by":"publisher","first-page":"103847","DOI":"10.1016\/j.ebiom.2022.103847","article-title":"Contribution of ferroptosis and GPX4\u2019s dual functions to osteoarthritis progression","volume":"76","author":"Miao","year":"2022","journal-title":"EBioMedicine"},{"key":"B106","doi-asserted-by":"publisher","first-page":"17319","DOI":"10.3390\/ijms242417319","article-title":"Bcl2l1 deficiency in osteoblasts reduces the trabecular bone due to enhanced osteoclastogenesis likely through osteoblast apoptosis","volume":"24","author":"Moriishi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B107","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/978-981-99-9781-7_9","article-title":"Necroptosis and its involvement in various diseases","volume":"1444","author":"Nakano","year":"2024","journal-title":"Adv. Exp. Med. Biol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.freeradbiomed.2021.04.027","article-title":"Hypoxia inhibits RANKL-Induced ferritinophagy and protects osteoclasts from ferroptosis","volume":"169","author":"Ni","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"B109","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1001\/jama.285.6.785","article-title":"Osteoporosis prevention, diagnosis, and therapy","volume":"285","year":"2001","journal-title":"Jama"},{"key":"B110","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1080\/03008207.2025.2521404","article-title":"Temsirolimus, a water-soluble mTOR inhibitor, alleviates osteoarthritic changes in human chondrocytes and mouse osteoarthritis models","volume":"66","author":"Otsuki","year":"2025","journal-title":"Connect. Tissue Res."},{"key":"B111","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/978-981-13-1426-1_6","article-title":"Circular RNAs act as miRNA sponges","volume":"1087","author":"Panda","year":"2018","journal-title":"Circular RNAs Biogenesis Functions"},{"key":"B112","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s13075-025-03589-6","article-title":"Decoding the impact of exercise and \u03b1CGRP signaling on murine post-traumatic osteoarthritis progression","volume":"27","author":"Pann","year":"2025","journal-title":"Arthritis Res. and Ther."},{"key":"B113","doi-asserted-by":"publisher","first-page":"114528","DOI":"10.1016\/j.biopha.2023.114528","article-title":"The bcr-abl inhibitor DCC-2036 inhibits necroptosis and ameliorates osteoarthritis by targeting RIPK1 and RIPK3 kinases","volume":"161","author":"Piao","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"B114","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.actbio.2024.05.014","article-title":"Modulating synovial macrophage pyroptosis and mitophagy interactions to mitigate osteoarthritis progression using functionalized nanoparticles","volume":"181","author":"Qi","year":"2024","journal-title":"Acta Biomater."},{"key":"B115","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1007\/s10565-025-10071-1","article-title":"Asperosaponin VI mitigates mitochondrial dysfunction and chondrocyte apoptosis in osteoarthritis by modulating the AMPK-SIRT3 pathway","volume":"41","author":"Qiao","year":"2025","journal-title":"Cell. Biol. Toxicol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"110678","DOI":"10.1016\/j.cellsig.2023.110678","article-title":"MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting ROR\u03b1 in nucleus pulposus cells","volume":"107","author":"Qin","year":"2023","journal-title":"Cell. Signal"},{"key":"B117","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1038\/s12276-024-01345-5","article-title":"The muscle\u2013intervertebral disc interaction mediated by L-BAIBA modulates extracellular matrix homeostasis and PANoptosis in nucleus pulposus cells","volume":"56","author":"Qin","year":"2024","journal-title":"Exp. and Mol. Med."},{"key":"B118","doi-asserted-by":"publisher","first-page":"827","DOI":"10.4055\/cios23365","article-title":"Protein kinase C and matrix metalloproteinases expression using phorbol myristate acetate in degenerative intervertebral disc cells","volume":"16","author":"Quan","year":"2024","journal-title":"Clin. Orthop. Surg."},{"key":"B119","doi-asserted-by":"publisher","first-page":"4022","DOI":"10.3390\/ijms24044022","article-title":"Gsmtx4 alleviated osteoarthritis through Piezo1\/Calcineurin\/NFAT1 signaling axis under excessive mechanical strain","volume":"24","author":"Ren","year":"2023","journal-title":"Int. Journal Molecular Sciences"},{"key":"B120","doi-asserted-by":"publisher","first-page":"14128","DOI":"10.1038\/ncomms14128","article-title":"Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic\/pyroptotic cell death","volume":"8","author":"Rogers","year":"2017","journal-title":"Nat. Communications"},{"key":"B121","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1186\/s13018-022-03334-8","article-title":"miR-124-3p sabotages lncRNA MALAT1 stability to repress chondrocyte pyroptosis and relieve cartilage injury in osteoarthritis","volume":"17","author":"Rozi","year":"2022","journal-title":"J. Orthopaedic Surgery Research"},{"key":"B122","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/s41413-024-00365-1","article-title":"DNMT aberration-incurred GPX4 suppression prompts osteoblast ferroptosis and osteoporosis","volume":"12","author":"Ruan","year":"2024","journal-title":"Bone Res."},{"key":"B123","doi-asserted-by":"publisher","first-page":"32744","DOI":"10.1021\/acsnano.5c10692","article-title":"Metal\u2013organic framework-integrated nanoplatform orchestrates osteochondral-synovial homeostasis for osteoarthritis therapy","volume":"19","author":"Shao","year":"2025","journal-title":"ACS Nano"},{"key":"B124","doi-asserted-by":"publisher","first-page":"e93612","DOI":"10.1172\/jci.insight.93612","article-title":"DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism","volume":"2","author":"Shen","year":"2017","journal-title":"JCI Insight"},{"key":"B125","doi-asserted-by":"publisher","first-page":"150683","DOI":"10.1016\/j.bbrc.2024.150683","article-title":"The role of ferroptosis in osteoarthritis: progress and prospects","volume":"733","author":"Sheng","year":"2024","journal-title":"Biochem. Biophysical Research Communications"},{"key":"B126","doi-asserted-by":"publisher","first-page":"3461","DOI":"10.1007\/s10787-024-01552-6","article-title":"Oxysophocarpine attenuates inflammatory osteolysis by modulating the NF-\u03bab pathway and the reactive oxygen species-related Nrf2 signaling pathway: X. Shi et al","volume":"32","author":"Shi","year":"2024","journal-title":"Inflammopharmacology"},{"key":"B127","doi-asserted-by":"publisher","first-page":"113895","DOI":"10.1016\/j.intimp.2024.113895","article-title":"Ferristatin II protects nucleus pulposus against degeneration through inhibiting ferroptosis and activating HIF-1\u03b1 pathway mediated mitophagy","volume":"147","author":"Su","year":"","journal-title":"Int. Immunopharmacol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.jot.2025.01.013","article-title":"Inhibition of ERK1\/2 mediated activation of Drp1 alleviates intervertebral disc degeneration via suppressing pyroptosis and apoptosis in nucleus pulposus cells","volume":"51","author":"Su","year":"","journal-title":"J. Orthop. Transl."},{"key":"B129","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1080\/15548627.2020.1822097","article-title":"Mitophagy in degenerative joint diseases","volume":"17","author":"Sun","year":"2021","journal-title":"Autophagy"},{"key":"B130","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.freeradbiomed.2023.03.008","article-title":"JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy","volume":"200","author":"Sun","year":"","journal-title":"Free Radic. Biol. Med."},{"key":"B131","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/s41420-023-01406-0","article-title":"Inhibition of TRADD ameliorates chondrocyte necroptosis and osteoarthritis by blocking RIPK1-TAK1 pathway and restoring autophagy","volume":"9","author":"Sun","year":"","journal-title":"Cell. Death Discov."},{"key":"B132","doi-asserted-by":"publisher","first-page":"2416149","DOI":"10.1002\/advs.202416149","article-title":"Glycolysis\u2010derived lactate induces ACSL4 expression and lactylation to activate ferroptosis during intervertebral disc degeneration","volume":"12","author":"Sun","year":"","journal-title":"Adv. Science"},{"key":"B133","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/s11658-025-00802-x","article-title":"PPAR\u03b3-Axl axis ameliorates intervertebral disc degeneration by activating PI3K\/AKT-mediated autophagy to suppress ferroptosis","volume":"30","author":"Sun","year":"","journal-title":"Cell. and Mol. Biol. Lett."},{"key":"B134","doi-asserted-by":"publisher","first-page":"5023","DOI":"10.1002\/jcp.27304","article-title":"Effect of autophagy gene DRAM on proliferation, cell cycle, apoptosis, and autophagy of osteoblast in osteoporosis rats","volume":"234","author":"Tang","year":"2019","journal-title":"J. Cellular Physiology"},{"key":"B135","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jot.2023.11.005","article-title":"The IRF1\/GBP5 axis promotes osteoarthritis progression by activating chondrocyte pyroptosis","volume":"44","author":"Tang","year":"2024","journal-title":"J. Orthopaedic Translation"},{"key":"B136","doi-asserted-by":"publisher","first-page":"105967","DOI":"10.1016\/j.phrs.2021.105967","article-title":"Urolithin A suppresses RANKL-Induced osteoclastogenesis and postmenopausal osteoporosis by, suppresses inflammation and downstream NF-\u03baB activated pyroptosis pathways","volume":"174","author":"Tao","year":"2021","journal-title":"Pharmacol. Research"},{"key":"B137","doi-asserted-by":"publisher","first-page":"19877","DOI":"10.1038\/s41598-024-70991-6","article-title":"NOX1-mediated oxidative stress induces chondrocyte ferroptosis by inhibiting the Nrf2\/HO-1 pathway","volume":"14","author":"Tao","year":"2024","journal-title":"Sci. Reports"},{"key":"B138","doi-asserted-by":"publisher","first-page":"970607","DOI":"10.1155\/2014\/970607","article-title":"Mechanisms of miRNA\u2010mediated gene regulation from common downregulation to mRNA\u2010specific upregulation","volume":"2014","author":"Valinezhad Orang","year":"2014","journal-title":"Int. Journal Genomics"},{"key":"B139","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.3390\/cells12141821","article-title":"Epigenetic modifications of MiRNAs in osteoarthritis: a systematic review on their methylation levels and effects on chondrocytes, extracellular matrix and joint inflammation","volume":"12","author":"Veronesi","year":"2023","journal-title":"Cells"},{"key":"B140","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1038\/s41418-023-01153-w","article-title":"Apoptotic cell death in disease\u2014Current understanding of the NCCD 2023","volume":"30","author":"Vitale","year":"2023","journal-title":"Cell. Death and Differ."},{"key":"B141","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1042\/cs1030441","article-title":"Role of macrophage CD44 in the disposal of inflammatory cell corpses","volume":"103","author":"Vivers","year":"2002","journal-title":"Clin. Sci."},{"key":"B142","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.freeradbiomed.2021.05.014","article-title":"Timosaponin BII improved osteoporosis caused by hyperglycemia through promoting autophagy of osteoblasts via suppressing the mTOR\/NF\u03baB signaling pathway","volume":"171","author":"Wang","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"B143","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin","volume":"547","author":"Wang","year":"2017","journal-title":"Nature"},{"key":"B144","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.bbrc.2018.06.031","article-title":"PINK1 protects against oxidative stress induced senescence of human nucleus pulposus cells via regulating mitophagy","volume":"504","author":"Wang","year":"2018","journal-title":"Biochem. Biophysical Research Communications"},{"key":"B145","doi-asserted-by":"publisher","first-page":"4875","DOI":"10.3892\/mmr.2019.10732","article-title":"miR-222 induces apoptosis in human intervertebral disc nucleus pulposus cells by targeting Bcl-2","volume":"20","author":"Wang","year":"2019","journal-title":"Mol. Medicine Reports"},{"key":"B146","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jare.2022.01.004","article-title":"Mechanical overloading induces GPX4-regulated chondrocyte ferroptosis in osteoarthritis via Piezo1 channel facilitated calcium influx","volume":"41","author":"Wang","year":"","journal-title":"J. Advanced Research"},{"key":"B147","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.freeradbiomed.2022.08.018","article-title":"Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes","volume":"190","author":"Wang","year":"","journal-title":"Free Radic. Biol. Med."},{"key":"B148","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1007\/s12011-021-02627-z","article-title":"Mitochondrial ferritin deficiency promotes osteoblastic ferroptosis via mitophagy in type 2 diabetic osteoporosis","volume":"200","author":"Wang","year":"","journal-title":"Biol. Trace Element Research"},{"key":"B149","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1186\/s12891-023-07003-7","article-title":"Upregulating miR-181b promotes ferroptosis in osteoarthritic chondrocytes by inhibiting SLC7A11","volume":"24","author":"Wang","year":"2023","journal-title":"BMC Musculoskelet. Disord."},{"key":"B150","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.jare.2025.09.060","article-title":"MK8722 alleviates osteoarthritis by activating Sesn2 and transcriptionally upregulating BNIP3 to promote mitophagy and inhibit chondrocyte ferroptosis","volume":"84","author":"Wang","year":"2026","journal-title":"J. Adv. Res"},{"key":"B151","doi-asserted-by":"publisher","first-page":"3131","DOI":"10.1038\/s41467-025-58447-5","article-title":"Injectable ECM-Mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through delivering nucleus pulposus progenitor cell-derived exosomes","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"key":"B152","doi-asserted-by":"publisher","first-page":"0814","DOI":"10.34133\/research.0814","article-title":"Human amniotic epithelial stem cell exosomes regulate chondrocyte ferroptosis through ACTA2-AS1-targeted binding to ACSL4 for osteoarthritis intervention","volume":"8","author":"Wang","year":"2025","journal-title":"Research"},{"key":"B153","doi-asserted-by":"publisher","first-page":"156176","DOI":"10.1016\/j.phymed.2024.156176","article-title":"GelMA@ APPA microspheres promote chondrocyte regeneration and alleviate osteoarthritis via Fgfr2 activation","volume":"137","author":"Wang","year":"2025","journal-title":"Phytomedicine"},{"key":"B154","doi-asserted-by":"publisher","first-page":"e0332769","DOI":"10.1371\/journal.pone.0332769","article-title":"Multimodal analysis investigating the shared pathogenic mechanisms of osteoporosis and osteoarthritis with an initial exploration of the role of ferroptosis","volume":"20","author":"Wang","year":"2025","journal-title":"Plos One"},{"key":"B155","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s10495-025-02231-9","article-title":"DDIT3 drives nucleus pulposus cell PANoptosis and intervertebral disc degeneration progression","volume":"31","author":"Wang","year":"2026","journal-title":"Apoptosis"},{"key":"B156","doi-asserted-by":"publisher","first-page":"4026128","DOI":"10.1155\/2022\/4026128","article-title":"Apoptosis activation and autophagy inhibition of chondrocytes by leptin by the upregulation of LOXL3 in osteoarthritis pathogenesis","volume":"2022","author":"Wei","year":"2022","journal-title":"J. Healthc. Eng."},{"key":"B157","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41420-023-01331-2","article-title":"Resveratrol protects osteocytes against oxidative stress in ovariectomized rats through AMPK\/JNK1-dependent pathway leading to promotion of autophagy and inhibition of apoptosis","volume":"9","author":"Wei","year":"2023","journal-title":"Cell. Death Discov."},{"key":"B158","doi-asserted-by":"publisher","first-page":"e12404","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J. Extracellular Vesicles"},{"key":"B159","doi-asserted-by":"publisher","first-page":"9914417","DOI":"10.1155\/2021\/9914417","article-title":"LDHA\u2010mediated glycolytic metabolism in nucleus pulposus cells is a potential therapeutic target for intervertebral disc degeneration","volume":"2021","author":"Wu","year":"2021","journal-title":"BioMed Res. Int."},{"key":"B160","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s13020-023-00824-7","article-title":"Ajugol's upregulation of TFEB-Mediated autophagy alleviates endoplasmic reticulum stress in chondrocytes and retards osteoarthritis progression in a mouse model","volume":"18","author":"Wu","year":"2023","journal-title":"Chin. Med."},{"key":"B161","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1089\/ars.2023.0384","article-title":"Glutamine mitigates oxidative stress-induced matrix degradation, ferroptosis, and pyroptosis in nucleus pulposus cells via deubiquitinating and stabilizing Nrf2","volume":"41","author":"Wu","year":"2024","journal-title":"Antioxidants and Redox Signaling"},{"key":"B162","doi-asserted-by":"publisher","first-page":"2842","DOI":"10.1080\/15548627.2025.2544287","article-title":"UCHL1 alleviates nucleus pulposus cell senescence by promoting chaperone-mediated autophagy antagonizing autophagy-dependent ferroptosis through deubiquitination of HSPA8","volume":"21","author":"Wu","year":"2025","journal-title":"Autophagy"},{"key":"B163","doi-asserted-by":"publisher","first-page":"4093","DOI":"10.1111\/jcmm.17994","article-title":"ELP2-NLRP3-GSDMD\/GSDME-mediated pyroptosis is induced by TNF-\u03b1 in MC3T3-E1 cells during osteogenic differentiation","volume":"27","author":"Xia","year":"","journal-title":"J. Cell. Mol. Med."},{"key":"B164","doi-asserted-by":"publisher","first-page":"2302475","DOI":"10.1002\/adhm.202302475","article-title":"Retuning mitochondrial apoptosis\/mitophagy balance via SIRT3\u2010Energized and microenvironment\u2010modulated hydrogel microspheres to impede osteoarthritis","volume":"12","author":"Xia","year":"","journal-title":"Adv. Healthc. Mater."},{"key":"B165","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/s41419-023-06160-w","article-title":"REPIN1 regulates iron metabolism and osteoblast apoptosis in osteoporosis","volume":"14","author":"Xia","year":"","journal-title":"Cell. Death and Dis."},{"key":"B166","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1186\/s40001-025-02702-4","article-title":"Identification of the pyroptosis, apoptosis, and necroptosis (PANoptosis) involved in osteogenic differentiation inhibition impaired by tumor necrosis factor-\u03b1","volume":"30","author":"Xia","year":"","journal-title":"Eur. J. Med. Res."},{"key":"B167","doi-asserted-by":"publisher","first-page":"1604652","DOI":"10.3389\/fimmu.2025.1604652","article-title":"Ferroptosis in osteoarthritis: metabolic reprogramming, immunometabolic crosstalk, and targeted intervention strategies","volume":"16","author":"Xia","year":"","journal-title":"Front. Immunol."},{"key":"B168","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.14336\/AD.2023.0325-1","article-title":"USP7 inhibits osteoclastogenesis via dual effects of attenuating TRAF6\/TAK1 axis and stimulating STING signaling","volume":"14","author":"Xie","year":"","journal-title":"Aging Dis."},{"key":"B169","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1186\/s13018-023-04342-y","article-title":"ITGB1 alleviates osteoarthritis by inhibiting cartilage inflammation and apoptosis via activating cAMP pathway","volume":"18","author":"Xie","year":"","journal-title":"J. Orthop. Surg. Res."},{"key":"B170","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1186\/s12951-021-00991-5","article-title":"Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration","volume":"19","author":"Xing","year":"2021","journal-title":"J. Nanobiotechnology"},{"key":"B171","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1186\/s13018-023-04010-1","article-title":"Circ-STC2 promotes the ferroptosis of nucleus pulposus cells via targeting miR-486-3p\/TFR2 axis","volume":"18","author":"Xiong","year":"2023","journal-title":"J. Orthop. Surg. Res."},{"key":"B172","doi-asserted-by":"publisher","first-page":"871","DOI":"10.3389\/fcell.2020.00871","article-title":"miRNA-141 induced pyroptosis in intervertebral disk degeneration by targeting ROS generation and activating TXNIP\/NLRP3 signaling in nucleus pulpous cells","volume":"8","author":"Xu","year":"","journal-title":"Front. Cell. Dev. Biol."},{"key":"B173","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.bbrc.2020.04.097","article-title":"Epigenetic regulation of chondrocyte hypertrophy and apoptosis through Sirt1\/P53\/P21 pathway in surgery-induced osteoarthritis","volume":"528","author":"Xu","year":"","journal-title":"Biochem. Biophysical Research Communications"},{"key":"B174","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.ijbiomac.2021.02.029","article-title":"SIRT3 ameliorates osteoarthritis via regulating chondrocyte autophagy and apoptosis through the PI3K\/Akt\/mTOR pathway","volume":"175","author":"Xu","year":"2021","journal-title":"Int. Journal Biological Macromolecules"},{"key":"B175","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.freeradbiomed.2022.11.013","article-title":"VDR activation attenuates osteoblastic ferroptosis and senescence by stimulating the Nrf2\/GPX4 pathway in age-related osteoporosis","volume":"193","author":"Xu","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"B176","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1177\/19476035221142011","article-title":"Ferroptosis plays a role in human chondrocyte of osteoarthritis induced by IL-1\u03b2 in vitro","volume":"14","author":"Xu","year":"","journal-title":"Cartilage"},{"key":"B177","doi-asserted-by":"publisher","first-page":"2303946","DOI":"10.1002\/advs.202303946","article-title":"Impaired efferocytosis enables apoptotic osteoblasts to escape osteoimmune surveillance during aging","volume":"10","author":"Xu","year":"","journal-title":"Adv. Sci."},{"key":"B178","doi-asserted-by":"publisher","first-page":"1234563","DOI":"10.3389\/fendo.2023.1234563","article-title":"Aconine attenuates osteoclast-mediated bone resorption and ferroptosis to improve osteoporosis via inhibiting NF-\u03baB signaling","volume":"14","author":"Xue","year":"","journal-title":"Front. Endocrinology"},{"key":"B179","doi-asserted-by":"publisher","first-page":"eado7249","DOI":"10.1126\/sciadv.ado7249","article-title":"Magnetically attracting hydrogel reshapes iron metabolism for tissue repair","volume":"10","author":"Xu","year":"2024","journal-title":"Sci. Advances"},{"key":"B180","doi-asserted-by":"publisher","first-page":"201","DOI":"10.3892\/ijmm.2016.2618","article-title":"MicroRNA-34a affects chondrocyte apoptosis and proliferation by targeting the SIRT1\/p53 signaling pathway during the pathogenesis of osteoarthritis","volume":"38","author":"Yan","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"B181","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3892\/etm.2022.11146","article-title":"Metformin reduces chondrocyte pyroptosis in an osteoarthritis mouse model by inhibiting NLRP3 inflammasome activation","volume":"23","author":"Yan","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"B182","doi-asserted-by":"publisher","first-page":"6691","DOI":"10.1002\/jcp.30331","article-title":"Exosomes derived from vascular endothelial cells antagonize glucocorticoid-induced osteoporosis by inhibiting ferritinophagy with resultant limited ferroptosis of osteoblasts","volume":"236","author":"Yang","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"B183","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/s41413-022-00198-w","article-title":"Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis","volume":"10","author":"Yang","year":"","journal-title":"Bone Research"},{"key":"B184","doi-asserted-by":"publisher","first-page":"2817","DOI":"10.1080\/15548627.2022.2048432","article-title":"TET2 regulates osteoclastogenesis by modulating autophagy in OVX-Induced bone loss","volume":"18","author":"Yang","year":"","journal-title":"Autophagy"},{"key":"B185","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/s41419-023-06263-4","article-title":"Exosome-targeted delivery of METTL14 regulates NFATc1 m6A methylation levels to correct osteoclast-induced bone resorption","volume":"14","author":"Yang","year":"","journal-title":"Cell. Death and Dis."},{"key":"B186","doi-asserted-by":"publisher","first-page":"2207216","DOI":"10.1002\/advs.202207216","article-title":"Polydopamine nanoparticles targeting ferroptosis mitigate intervertebral disc degeneration via reactive oxygen species depletion, iron ions chelation, and GPX4 ubiquitination suppression","volume":"10","author":"Yang","year":"","journal-title":"Adv. Sci."},{"key":"B187","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.3724\/abbs.2025014","article-title":"Knockdown of lncRNA XR_877193. 1 suppresses ferroptosis and promotes osteogenic differentiation via the PI3K\/AKT signaling pathway in SONFH: LncRNA XR_877193. 1 knockdown inhibits ferroptosis of MC3T3-E1 cells","volume":"57","author":"Yang","year":"2025","journal-title":"Acta Biochimica Biophysica Sinica"},{"key":"B188","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jot.2020.09.006","article-title":"Chondrocyte ferroptosis contribute to the progression of osteoarthritis","volume":"27","author":"Yao","year":"2021","journal-title":"J. Orthopaedic Translation"},{"key":"B189","doi-asserted-by":"publisher","first-page":"e3488","DOI":"10.1002\/jgm.3488","article-title":"BACH1 promotes intervertebral disc degeneration by regulating HMOX1\/GPX4 to mediate oxidative stress, ferroptosis, and lipid metabolism in nucleus pulposus cells","volume":"25","author":"Yao","year":"2023","journal-title":"J. Gene Med."},{"key":"B190","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1007\/s10753-024-02096-1","article-title":"EZH2-H3K27me3-mediated epigenetic silencing of DKK1 induces nucleus pulposus cell pyroptosis in intervertebral disc degeneration by activating NLRP3 and NAIP\/NLRC4","volume":"48","author":"Yao","year":"2025","journal-title":"Inflammation"},{"key":"B191","doi-asserted-by":"publisher","first-page":"113648","DOI":"10.1016\/j.yexcr.2023.113648","article-title":"BASP1 knockdown suppresses chondrocyte apoptosis and extracellular matrix degradation in vivo and in vitro: a possible therapeutic approach for osteoarthritis","volume":"429","author":"Yin","year":"2023","journal-title":"Exp. Cell. Res."},{"key":"B192","doi-asserted-by":"publisher","first-page":"113447","DOI":"10.1016\/j.jep.2020.113447","article-title":"Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-\u03baB signaling","volume":"266","author":"Yu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"B193","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s10020-023-00623-8","article-title":"BMP7 ameliorates intervertebral disc degeneration in type 1 diabetic rats by inhibiting pyroptosis of nucleus pulposus cells and NLRP3 inflammasome activity","volume":"29","author":"Yu","year":"2023","journal-title":"Mol. Med."},{"key":"B194","doi-asserted-by":"publisher","first-page":"156431","DOI":"10.1016\/j.phymed.2025.156431","article-title":"Palmatine activation of TFEB enhances autophagy and alleviates endoplasmic reticulum stress in intervertebral disc degeneration","volume":"139","author":"Yu","year":"","journal-title":"Phytomedicine"},{"key":"B195","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1248\/bpb.b25-00139","article-title":"P-Synephrine loaded by injectable gelma hydrogel ameliorates cartilage degeneration in osteoarthritis by inhibiting the MAPK and NF-\u03baB signaling pathways","volume":"48","author":"Yu","year":"","journal-title":"Biol. Pharm. Bull."},{"key":"B196","doi-asserted-by":"publisher","first-page":"40288","DOI":"10.1021\/acsami.5c10090","article-title":"Multifunctional biomimetic nanomedicine for osteoarthritis alleviation by mitigating cartilage degeneration and promoting cartilage regeneration","volume":"17","author":"Yue","year":"2025","journal-title":"ACS Appl. Mater. and Interfaces"},{"key":"B197","doi-asserted-by":"publisher","first-page":"111453","DOI":"10.1016\/j.intimp.2023.111453","article-title":"MicroRNA-18a regulates the pyroptosis, apoptosis, and necroptosis (PANoptosis) of osteoblasts induced by tumor necrosis factor-\u03b1 via hypoxia-inducible factor-1\u03b1","volume":"128","author":"Zhang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"B198","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1186\/s12891-020-03497-7","article-title":"LncRNA SNHG9 is downregulated in osteoarthritis and inhibits chondrocyte apoptosis by downregulating miR-34a through methylation","volume":"21","author":"Zhang","year":"2020","journal-title":"BMC Musculoskeletal Disorders"},{"key":"B199","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1186\/s13018-021-02545-9","article-title":"Vitamin D inhibits TNF-\u03b1 induced apoptosis of human nucleus pulposus cells through regulation of NF-kB signaling pathway","volume":"16","author":"Zhang","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"key":"B200","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/s12276-022-00729-9","article-title":"Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis","volume":"54","author":"Zhang","year":"","journal-title":"Exp. and Molecular Medicine"},{"key":"B201","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s12951-022-01245-8","article-title":"Exosomes derived from platelet-rich plasma administration in site mediate cartilage protection in subtalar osteoarthritis","volume":"20","author":"Zhang","year":"","journal-title":"J. Nanobiotechnology"},{"key":"B202","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.freeradbiomed.2023.01.026","article-title":"Osteoporotic bone loss from excess iron accumulation is driven by NOX4-triggered ferroptosis in osteoblasts","volume":"198","author":"Zhang","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"B203","doi-asserted-by":"publisher","first-page":"101231","DOI":"10.1016\/j.preteyeres.2023.101231","article-title":"The endoplasmic reticulum: homeostasis and crosstalk in retinal health and disease","volume":"98","author":"Zhang","year":"","journal-title":"Prog. Retin Eye Res."},{"key":"B204","doi-asserted-by":"publisher","first-page":"113589","DOI":"10.1016\/j.intimp.2024.113589","article-title":"Isoliensinine suppresses chondrocytes pyroptosis against osteoarthritis via the MAPK\/NF-\u03baB signaling pathway","volume":"143","author":"Zhang","year":"","journal-title":"Int. Immunopharmacol."},{"key":"B205","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.ncrna.2024.06.002","article-title":"New mechanism of LncRNA: in addition to act as a ceRNA","volume":"9","author":"Zhang","year":"","journal-title":"Non-coding RNA Research"},{"key":"B206","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1186\/s40001-024-01903-7","article-title":"CircZfp644-205 inhibits osteoblast differentiation and induces apoptosis of pre-osteoblasts via sponging miR-455-3p and promoting SMAD2 expression","volume":"29","author":"Zhang","year":"","journal-title":"Eur. J. Med. Res."},{"key":"B207","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1186\/s13018-025-06033-2","article-title":"VMP1 attenuates ferroptosis and mitochondrial dysfunction in nucleus pulposus cells through the PINK1\/Parkin-mediated mitophagy pathway","volume":"20","author":"Zhang","year":"","journal-title":"J. Orthop. Surg. Res."},{"key":"B208","doi-asserted-by":"publisher","first-page":"115055","DOI":"10.1016\/j.intimp.2025.115055","article-title":"Acetyl zingerone inhibits chondrocyte pyroptosis and alleviates osteoarthritis progression by promoting mitophagy through the PINK1\/parkin signaling pathway","volume":"161","author":"Zhang","year":"","journal-title":"Int. Immunopharmacol."},{"key":"B209","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.gene.2017.07.043","article-title":"Epigenetic silencing of miRNA-143 regulates apoptosis by targeting BCL2 in human intervertebral disc degeneration","volume":"628","author":"Zhao","year":"2017","journal-title":"Gene"},{"key":"B210","doi-asserted-by":"publisher","first-page":"e12941","DOI":"10.1111\/cpr.12941","article-title":"Acid\u2010sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration","volume":"54","author":"Zhao","year":"2021","journal-title":"Cell. Proliferation"},{"key":"B211","doi-asserted-by":"publisher","first-page":"127824","DOI":"10.1016\/j.ijbiomac.2023.127824","article-title":"A novel lncRNA GM15416 regulates osteoblast apoptosis and differentiation through the c-Fos\/Fas axis and mitigates osteoporosis","volume":"254","author":"Zhao","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"B212","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1152\/physrev.00031.2024","article-title":"Ferroptosis: when metabolism meets cell death","volume":"105","author":"Zheng","year":"2025","journal-title":"Physiol. Rev."},{"key":"B213","doi-asserted-by":"publisher","first-page":"737552","DOI":"10.3389\/fphar.2021.737552","article-title":"Xanthohumol inhibited mechanical stimulation-induced articular ECM degradation by mediating lncRNA GAS5\/miR-27a axis","volume":"12","author":"Zheng","year":"","journal-title":"Front. Pharmacol."},{"key":"B214","doi-asserted-by":"publisher","first-page":"753931","DOI":"10.3389\/fcell.2021.753931","article-title":"Interactions among lncRNA\/circRNA, miRNA, and mRNA in musculoskeletal degenerative diseases","volume":"9","author":"Zheng","year":"","journal-title":"Front. Cell. Dev. Biol."},{"key":"B215","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.2147\/DDDT.S417598","article-title":"Paroxetine attenuates chondrocyte pyroptosis and inhibits osteoclast formation by inhibiting NF-\u03baB pathway activation to delay osteoarthritis progression","volume":"17","author":"Zheng","year":"2023","journal-title":"Drug Des. Dev. Ther."},{"key":"B216","doi-asserted-by":"publisher","first-page":"e70288","DOI":"10.1111\/jcmm.70288","article-title":"Aucubin promotes BMSCs proliferation and differentiation of postmenopausal osteoporosis patients by regulating ferroptosis and BMP2 signalling","volume":"29","author":"Zheng","year":"2025","journal-title":"J. Cellular Molecular Medicine"},{"key":"B217","doi-asserted-by":"publisher","first-page":"1168780","DOI":"10.3389\/fimmu.2023.1168780","article-title":"Identification of aging-related biomarkers and immune infiltration characteristics in osteoarthritis based on bioinformatics analysis and machine learning","volume":"14","author":"Zhou","year":"2023","journal-title":"Front. Immunology"},{"key":"B218","doi-asserted-by":"publisher","first-page":"e18132","DOI":"10.1111\/jcmm.18132","article-title":"\u03b1-Solanine attenuates chondrocyte pyroptosis to improve osteoarthritis via suppressing NF-\u03baB pathway","volume":"28","author":"Zhou","year":"2024","journal-title":"J. Cell. Mol. Med."},{"key":"B219","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13062-025-00629-8","article-title":"Exploring the mechanisms of PANoptosis in osteoarthritis and the therapeutic potential of andrographolide through bioinformatics and single-cell analysis","volume":"20","author":"Zhou","year":"","journal-title":"Biol. Direct"},{"key":"B220","doi-asserted-by":"publisher","first-page":"114820","DOI":"10.1016\/j.intimp.2025.114820","article-title":"Perillaldehyde protect chondrocytes from mitophagy-associated apoptosis and NLRP3-mediated inflammation by regulating ALOX5\/NF-kB signaling in osteoarthritis","volume":"158","author":"Zhou","year":"","journal-title":"Int. Immunopharmacol."},{"key":"B221","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1080\/15384101.2023.2200291","article-title":"Hesperidin mitigates oxidative stress-induced ferroptosis in nucleus pulposus cells via Nrf2\/NF-\u03baB axis to protect intervertebral disc from degeneration","volume":"22","author":"Zhu","year":"2023","journal-title":"Cell. Cycle"},{"key":"B222","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s11033-023-09095-9","article-title":"LncRNA MEG3 suppresses erastin-induced ferroptosis of chondrocytes via regulating miR-885-5p\/SLC7A11 axis","volume":"51","author":"Zhu","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"B223","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.jot.2024.12.002","article-title":"Humanin reduces nucleus pulposus cells ferroptosis to alleviate intervertebral disc degeneration: an in vitro and in vivo study","volume":"50","author":"Zhu","year":"","journal-title":"J. Orthop. Transl."},{"key":"B224","doi-asserted-by":"publisher","first-page":"2868","DOI":"10.1007\/s10495-025-02169-y","article-title":"RIPK1-targeted therapy alleviates intervertebral disc degeneration via inhibiting nucleus pulposus PANoptosis","volume":"30","author":"Zhu","year":"","journal-title":"Apoptosis"},{"key":"B225","doi-asserted-by":"publisher","first-page":"6153","DOI":"10.1038\/s41467-025-61486-7","article-title":"DDX1 methylation mediated MATR3 splicing regulates intervertebral disc degeneration by initiating chromatin reprogramming","volume":"16","author":"Zhu","year":"","journal-title":"Nat. Commun."},{"key":"B226","doi-asserted-by":"publisher","first-page":"114365","DOI":"10.1016\/j.isci.2025.114365","article-title":"PHB2 mitigates intervertebral disc degeneration by modulating mitophagy to inhibit necroptosis in nucleus pulposus cells","volume":"29","author":"Zhu","year":"2026","journal-title":"iScience"},{"key":"B227","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1002\/jor.25492","article-title":"Procyanidin B2 alleviates oxidative stress-induced nucleus pulposus cells apoptosis through upregulating Nrf2 via PI3K-Akt pathway","volume":"41","author":"Zou","year":"2023","journal-title":"J. Orthop. Res."},{"key":"B228","doi-asserted-by":"publisher","first-page":"2305023","DOI":"10.1002\/advs.202305023","article-title":"Regulating chondro\u2010bone metabolism for treatment of osteoarthritis via high\u2010permeability micro\/nano hydrogel microspheres","volume":"11","author":"Zuo","year":"2024","journal-title":"Adv. Sci."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2026.1876124\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:25:39Z","timestamp":1788495939000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2026.1876124\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,4]]},"references-count":228,"alternative-id":["10.3389\/fcell.2026.1876124"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2026.1876124","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,4]]},"article-number":"1876124"}}