{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:04:57Z","timestamp":1785305097980,"version":"3.55.0"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Postmenopausal osteoporosis, driven by oxidative stress and impaired osteoblast function, remains a major health crisis with limited anabolic therapies. Exosomes from curcumin-preconditioned mesenchymal stem cells (MSCs) are promising cell-free therapeutics, yet their cellular targets and molecular mechanisms remain elusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      BMSCs were isolated, pretreated with curcumin, and exosomes were purified by ultracentrifugation. Exploratory scRNA-seq,\n                      <jats:italic>in vitro<\/jats:italic>\n                      H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      stress assays, and ovariectomized (OVX) mouse models were employed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Curcumin pretreatment enhanced exosomal osteogenic potential without altering physicochemical properties. scRNA-seq identified osteoblast-lineage cells as major transcriptional responders. Cur-BMSC-Exo activated PINK1\/Parkin-mediated mitophagy, eliminated damaged mitochondria, and restored mitochondrial function. This effect was abrogated by Mdivi1. Systemic Cur-BMSC-Exo administration significantly increased bone volume and trabecular thickness in OVX mice, whereas Mdivi1 abolished these benefits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cur-BMSC-Exo ameliorates osteoporosis by activating mitophagy in osteoblast-lineage cells, offering a novel cell-free therapeutic strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcell.2026.1891247","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:57:57Z","timestamp":1785304677000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Curcumin-preconditioned bone marrow mesenchymal stem cell exosomes ameliorate postmenopausal osteoporosis by activating mitophagy in osteoblast-lineage cells"],"prefix":"10.3389","volume":"14","author":[{"given":"Chao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science","place":["Xiangyang, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xufeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science","place":["Xiangyang, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kechong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Urology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science","place":["Xiangyang, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science","place":["Xiangyang, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaqing","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science","place":["Xiangyang, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1001\/jama.285.11.1415","article-title":"Treatment of postmenopausal osteoporosis","volume":"285","author":"Altkorn","year":"2001","journal-title":"Jama."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1007\/s40265-015-0417-7","article-title":"Modulating bone resorption and bone formation in opposite directions in the treatment of postmenopausal osteoporosis","volume":"75","author":"Appelman-Dijkstra","year":"2015","journal-title":"Drugs"},{"key":"B3","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1056\/NEJMcp1513724","article-title":"Clinical practice. 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