{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:05:03Z","timestamp":1785305103359,"version":"3.55.0"},"reference-count":84,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>Recent advances in spatial transcriptomics, spatial proteomics, spatial metabolomics, and multimodal integration strategies have substantially transformed current understanding of the maternal\u2013fetal interface. Rather than functioning as a uniform tissue, the placenta is increasingly recognized as a highly organized multicellular ecosystem in which trophoblast, immune, vascular, and metabolic compartments establish spatially coordinated microenvironments that regulate trophoblast differentiation, immune adaptation, vascular remodeling, and placental homeostasis. Emerging evidence further suggests that placental disorders are driven not simply by trophoblast-intrinsic abnormalities but by dysregulation of localized microenvironmental niches within placental tissues. In particular, preeclampsia (PE) and placenta accreta spectrum (PAS) appear to represent opposite spatial ecosystem states characterized by invasion-restrictive versus invasion-permissive microenvironments, respectively. In this review, we summarize recent spatial multiomic studies focused on the maternal\u2013fetal interface and discuss how spatially resolved approaches are reshaping current understanding of placental disease through a spatial microenvironmental framework.<\/jats:p>","DOI":"10.3389\/fcell.2026.1911385","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:57:39Z","timestamp":1785304659000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Insights into the maternal-fetal interface from spatial multi-omics"],"prefix":"10.3389","volume":"14","author":[{"given":"Xiaowei","family":"Wei","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]},{"name":"Department of Pathology, Montefiore Medical Center\/Albert Einstein College of Medicine","place":["Bronx, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyi","family":"Jia","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanmei","family":"Qin","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sifan","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwell Health","place":["New Hyde Park, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxuan","family":"Hou","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Montefiore Medical Center\/Albert Einstein College of Medicine","place":["Bronx, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Montefiore Medical Center\/Albert Einstein College of Medicine","place":["Bronx, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"General Hospital of Ningxia Medical University","place":["Yinchuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfang","family":"Wang","sequence":"additional","affiliation":[{"name":"General Hospital of Ningxia Medical University","place":["Yinchuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.ajog.2023.10.001","article-title":"Placenta accreta spectrum disorder at single-cell resolution: a loss of boundary limits in the decidua and endothelium","volume":"230","author":"Afshar","year":"2024","journal-title":"Am. 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