{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T06:19:26Z","timestamp":1787552366823,"version":"build-2736575974"},"reference-count":155,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>\n                    Although the mitochondria are known as the cellular powerhouse, their function is beyond energy generation. These organelles regulate cellular metabolism, yet maintains a tightly regulated reactive oxygen species (ROS) generation and optimal redox state. In addition, mitochondria serve as mediators of physiological and pathological processes, such as maintenance of calcium balance, and control of apoptosis and mitophagy. All these make the mitochondria a major factor in both cellular and organismal regulation. However, mitochondria dysfunction may occur through many processes, including genetic mutations, increased production of ROS, metabolic failure from impaired electron transport chain activity, and dysregulated dynamics or mitophagy. Several self-perpetuating damages accumulate from these processes and influence clinical pathologies, such as aging, metabolic syndrome, cancer, neurodegeneration, and reproductive disorders. Recent studies demonstrate promising therapeutic targets for mitochondrial dysfunction. Examples include targeted antioxidants, such as MitoQ and SkQ1, to selectively neutralize mitochondrial ROS, pharmacological modulators to enhance mitochondrial biogenesis and to restore NAD\n                    <jats:sup>+<\/jats:sup>\n                    homeostasis via PGC-1\u03b1 activation, gene-editing technologies, such as mitoTALENs and mtZFNs to selectively eliminate pathogenic mitochondrial DNA mutations, and mitochondrial transplantation as a new technique to replace damaged organelles. Together, these novel approaches highlight the need for research in mitochondrial function to change the therapeutic landscape in the management of mitochondrial dysfunction-associated diseases.\n                  <\/jats:p>","DOI":"10.3389\/fcell.2026.1929130","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T05:30:39Z","timestamp":1787549439000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondria in health and disease: cellular powerhouses, signaling centers, and drivers of dysfunction"],"prefix":"10.3389","volume":"14","author":[{"given":"Olufemi Akintayo","family":"Akinkunmi","sequence":"first","affiliation":[{"name":"Department of Physiology, Ladoke Akintola University of Technology","place":["Ogbomoso, Oyo, Nigeria"]},{"name":"Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital","place":["Osogbo, Osun, Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feyikemi Funmilayo","family":"Araba","sequence":"additional","affiliation":[{"name":"Department of Physiology, Ladoke Akintola University of Technology","place":["Ogbomoso, Oyo, Nigeria"]},{"name":"Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital","place":["Osogbo, Osun, Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica Adaeze","family":"Chukwudebelu","sequence":"additional","affiliation":[{"name":"Department of Physiology, Ladoke Akintola University of Technology","place":["Ogbomoso, Oyo, Nigeria"]},{"name":"Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital","place":["Osogbo, Osun, Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Ademola","family":"Adenle","sequence":"additional","affiliation":[{"name":"Department of Physiology, Ladoke Akintola University of Technology","place":["Ogbomoso, Oyo, Nigeria"]},{"name":"Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital","place":["Osogbo, Osun, Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajibola Ayomide","family":"Odeyemi","sequence":"additional","affiliation":[{"name":"Department of Physiology, Ladoke Akintola University of Technology","place":["Ogbomoso, Oyo, Nigeria"]},{"name":"Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital","place":["Osogbo, Osun, Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tunmise Maryanne","family":"Akhigbe","sequence":"additional","affiliation":[{"name":"Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital","place":["Osogbo, Osun, Nigeria"]},{"name":"Department of Agronomy, Osun State University","place":["Ejigbo, Osun, Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland Eghoghosoa","family":"Akhigbe","sequence":"additional","affiliation":[{"name":"Department of Physiology, Ladoke Akintola University of Technology","place":["Ogbomoso, Oyo, Nigeria"]},{"name":"Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital","place":["Osogbo, Osun, Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"F79","DOI":"10.1530\/REP-22-0126","article-title":"Oxidative stress and reproductive function: the impact of oxidative stress on reproduction: a focus on gametogenesis and fertilization","volume":"164","author":"Aitken","year":"2022","journal-title":"Reproduction"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1657872","DOI":"10.3389\/frph.2025.1657872","article-title":"Oxidative stress and male fertility","volume":"7","author":"Akhigbe","year":"2025","journal-title":"Front. Reproductive Health"},{"key":"B3","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s12944-021-01493-x","article-title":"Co-administration of HAART and antikoch triggers cardiometabolic dysfunction through an oxidative stress-mediated pathway","volume":"20","author":"Akhigbe","year":"2021","journal-title":"Lipids Health Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10522-025-10343-7","article-title":"The aging male: impact of aging on male reproduction","volume":"26","author":"Akhigbe","year":"2025","journal-title":"Biogerontology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e014501","DOI":"10.1161\/JAHA.119.014501","article-title":"Bioenergetics consequences of mitochondrial transplantation in cardiomyocytes","volume":"9","author":"Ali Pour","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"B6","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1002\/path.4809","article-title":"The genetics and pathology of mitochondrial disease","volume":"241","author":"Alston","year":"2017","journal-title":"J. Pathology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"101195","DOI":"10.1016\/j.molmet.2021.101195","article-title":"Role of NAD+ in regulating cellular and metabolic signaling pathways","volume":"49","author":"Amjad","year":"2021","journal-title":"Mol. Metabolism"},{"key":"B8","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/s41574-021-00626-7","article-title":"Mitochondrial and metabolic dysfunction in ageing and age-related diseases","volume":"18","author":"Amorim","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.bbabio.2017.09.005","article-title":"Metabolic control by sirtuins and other enzymes that sense NAD+, NADH, or their ratio","volume":"1858","author":"Anderson","year":"2017","journal-title":"Biochimica Biophysica Acta (BBA)-Bioenergetics"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1089\/ars.2011.4085","article-title":"Mitochondrial regulation of cell cycle and proliferation","volume":"16","author":"Antico Arciuch","year":"2012","journal-title":"Antioxidants and Redox Signaling"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2519","DOI":"10.3390\/cells9112519","article-title":"\u201cthe loss of golden touch\u201d: Mitochondria-organelle interactions, metabolism, and cancer","volume":"9","author":"Audano","year":"2020","journal-title":"Cells"},{"key":"B12","doi-asserted-by":"publisher","first-page":"119573","DOI":"10.1016\/j.bbamcr.2023.119573","article-title":"Reactive oxygen species and cell signaling. Review","volume":"1871","author":"Averill-Bates","year":"2024","journal-title":"Biochimica Biophysica Acta (BBA)-Molecular Cell Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/bs.mcb.2019.12.004","article-title":"Manipulation of mitochondrial genes and mtDNA heteroplasmy","volume":"155","author":"Bacman","year":"2020","journal-title":"Methods Cell Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"102132","DOI":"10.1016\/j.omtn.2024.102132","article-title":"mitoTALEN reduces the mutant mtDNA load in neurons","volume":"35","author":"Bacman","year":"2024","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.3390\/ijms21051772","article-title":"PINK1\/parkin mediated mitophagy, Ca2+ signalling, and ER\u2013mitochondria contacts in Parkinson\u2019s disease","volume":"21","author":"Barazzuol","year":"2020","journal-title":"Int. Journal Molecular Sciences"},{"key":"B16","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/s41571-020-0341-y","article-title":"Targeting apoptosis in cancer therapy","volume":"17","author":"Carneiro","year":"2020","journal-title":"Nat. Reviews Clin. Oncology"},{"key":"B17","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.stem.2021.02.011","article-title":"Mitochondria as signaling organelles control Mammalian stem cell fate","volume":"28","author":"Chakrabarty","year":"2021","journal-title":"Cell Stem Cell"},{"key":"B18","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial dynamics and its involvement in disease","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Review Pathology Mechanisms Disease"},{"key":"B19","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","article-title":"Mitochondrial dynamics in health and disease: mechanisms and potential targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduction Targeted Therapy"},{"key":"B20","doi-asserted-by":"publisher","first-page":"e70657","DOI":"10.1111\/cns.70657","article-title":"AMPK\/SIRT1\/PGC\u20101\u03b1 signaling pathway: molecular mechanisms and targeted strategies from energy homeostasis regulation to disease therapy","volume":"31","author":"Chen","year":"2025","journal-title":"CNS Neurosci. and Ther."},{"key":"B21","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1093\/ije\/dyr232","article-title":"Epigenetics, epidemiology and mitochondrial DNA diseases","volume":"41","author":"Chinnery","year":"2012","journal-title":"Int. Journal Epidemiology"},{"key":"B22","doi-asserted-by":"publisher","first-page":"856316","DOI":"10.3389\/fgwh.2022.856316","article-title":"Endometriosis-associated angiogenesis and anti-angiogenic therapy for endometriosis","volume":"3","author":"Chung","year":"2022","journal-title":"Front. Glob. Women's Health"},{"key":"B23","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.tibs.2016.01.001","article-title":"Mitochondrial cristae: where beauty meets functionality","volume":"41","author":"Cogliati","year":"2016","journal-title":"Trends Biochemical Sciences"},{"key":"B24","doi-asserted-by":"publisher","first-page":"20220210","DOI":"10.1098\/rstb.2022.0210","article-title":"Reactive oxygen species: role in obesity and mitochondrial energy efficiency","volume":"378","author":"Corkey","year":"2023","journal-title":"Philosophical Trans. R. Soc. B Biol. Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/s41580-023-00629-4","article-title":"Mechanisms of BCL-2 family proteins in mitochondrial apoptosis","volume":"24","author":"Czabotar","year":"2023","journal-title":"Nat. Reviews Mol. Cell Biology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"7254","DOI":"10.1158\/1078-0432.CCR-07-1598","article-title":"BCL-2 family proteins: critical checkpoints of apoptotic cell death","volume":"13","author":"Danial","year":"2007","journal-title":"Clin. Cancer Research"},{"key":"B27","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1002\/em.20575","article-title":"Mitochondrial dysfunction in neurodegenerative diseases and cancer","volume":"51","author":"De Moura","year":"2010","journal-title":"Environ. Molecular Mutagenesis"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2463","DOI":"10.3390\/cells10092463","article-title":"Mitochondrial biogenesis, mitochondrial dynamics, and mitophagy in the maturation of cardiomyocytes","volume":"10","author":"Ding","year":"2021","journal-title":"Cells"},{"key":"B29","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.bbrc.2017.04.124","article-title":"Mitochondrial adventures at the organelle society","volume":"500","author":"Diogo","year":"2018","journal-title":"Biochem. Biophysical Res. Commun."},{"key":"B30","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s41392-025-02311-x","article-title":"Mitochondrial metabolism and cancer therapeutic innovation","volume":"10","author":"Du","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.3390\/ijms24031969","article-title":"Mitochondrial transplantation in mitochondrial medicine: current challenges and future perspectives","volume":"24","author":"D\u2019Amato","year":"2023","journal-title":"Int. Journal Molecular Sciences"},{"key":"B155","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.molmet.2019.12.008","article-title":"Cyb5r3 links FoxO1-dependent mitochondrial dysfunction with \u03b2-cell failure","volume":"34","author":"Fan","year":"2020","journal-title":"Molecular Metabolism"},{"key":"B32","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1093\/abbs\/gmaa074","article-title":"JNK inhibition alleviates oxidative DNA damage, germ cell apoptosis, and mitochondrial dysfunction in testicular ischemia reperfusion injury","volume":"52","author":"Fadel","year":"2020","journal-title":"Acta Biochimica Biophysica Sinica"},{"key":"B33","doi-asserted-by":"publisher","first-page":"3739","DOI":"10.3390\/ijms24043739","article-title":"Mitochondria-targeted antioxidants, an innovative class of antioxidant compounds for neurodegenerative diseases: perspectives and limitations","volume":"24","author":"Fields","year":"2023","journal-title":"Int. J. Molecular Sciences"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1111\/j.1478-3231.2010.02250.x","article-title":"The mitochondria\u2010targeted anti\u2010oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients","volume":"30","author":"Gane","year":"2010","journal-title":"Liver International"},{"key":"B35","doi-asserted-by":"publisher","first-page":"347","DOI":"10.3109\/1061186X.2014.997736","article-title":"Mitochondria-targeted antioxidant SkQT1 decreases trauma-induced neurological deficit in rat and prevents amyloid-\u03b2-induced impairment of long-term potentiation in rat hippocampal slices","volume":"23","author":"Genrikhs","year":"2015","journal-title":"J. Drug Targeting"},{"key":"B36","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1089\/ars.2014.6223","article-title":"Mitochondria-associated membranes: composition, molecular mechanisms, and physiopathological implications","volume":"22","author":"Giorgi","year":"2015","journal-title":"Antioxidants and Redox Signaling"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1091\/mbc.E16-07-0509","article-title":"Lynn margulis and the endosymbiont hypothesis: 50 years later","volume":"28","author":"Gray","year":"2017","journal-title":"Mol. Biology Cell"},{"key":"B38","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1186\/s12967-025-06605-0","article-title":"Targeting mitochondria with natural polyphenols for treating neurodegenerative diseases: a comprehensive scoping review from oxidative stress perspective","volume":"23","author":"Guan","year":"2025","journal-title":"J. Transl. Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1139\/apnm-2020-0005","article-title":"PGC-1\u03b1-mediated regulation of mitochondrial function and physiological implications","volume":"45","author":"Halling","year":"2020","journal-title":"Appl. Physiology, Nutr. Metabolism"},{"key":"B40","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/978-3-031-57446-7_3","article-title":"The evolutionary origin of mitochondria and mitochondrion-related organelles","volume-title":"Endosymbiotic Organelle Acquisition: Solutions to the Problem of Protein Localization and Membrane Passage","author":"Hampl","year":"2024"},{"key":"B41","doi-asserted-by":"publisher","first-page":"100416","DOI":"10.1016\/j.coisb.2022.100416","article-title":"Organelle dysfunction and its contribution to metabolic impairments in aging and age-related diseases","volume":"30","author":"Heiby","year":"2022","journal-title":"Curr. Opin. Syst. Biol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3892\/ijmm.2025.5513","article-title":"Oxidative stress in endometriosis: sources, mechanisms and therapeutic potential of antioxidants","volume":"55","author":"Huang","year":"2025","journal-title":"Int. J. Mol. Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1146\/annurev-nutr-120420-025558","article-title":"Ins and outs of the TCA cycle: the central role of anaplerosis","volume":"41","author":"Inigo","year":"2021","journal-title":"Annu. Review Nutrition"},{"key":"B44","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00018-024-05164-9","article-title":"Molecular hallmarks of ageing in amyotrophic lateral sclerosis","volume":"81","author":"Jagaraj","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"14708","DOI":"10.1074\/jbc.M611463200","article-title":"Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases","volume":"282","author":"James","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B46","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1089\/ars.2022.0173","article-title":"Mitochondrial cristae morphology reflecting metabolism, superoxide formation, redox homeostasis, and pathology","volume":"39","author":"Je\u017eek","year":"2023","journal-title":"Antioxidants and Redox Signal."},{"key":"B47","doi-asserted-by":"publisher","first-page":"8837893","DOI":"10.1155\/2020\/8837893","article-title":"Mitochondria\u2010targeted antioxidants: a step towards disease treatment","volume":"2020","author":"Jiang","year":"2020","journal-title":"Oxidative Medicine Cellular Longevity"},{"key":"B48","doi-asserted-by":"publisher","first-page":"e70295","DOI":"10.1002\/mco2.70295","article-title":"PI3K\/AKT\/mTOR axis in cancer: from pathogenesis to treatment","volume":"6","author":"Jiang","year":"2025","journal-title":"MedComm"},{"key":"B49","doi-asserted-by":"publisher","first-page":"4642","DOI":"10.3390\/ijms22094642","article-title":"The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies","volume":"22","author":"Juan","year":"2021","journal-title":"Int. Journal Molecular Sciences"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.3390\/antiox11112167","article-title":"The link between oxidative stress, mitochondrial dysfunction and neuroinflammation in the pathophysiology of Alzheimer\u2019s disease: therapeutic implications and future perspectives","volume":"11","author":"Jurc\u0103u","year":"2022","journal-title":"Antioxidants"},{"key":"B51","doi-asserted-by":"publisher","first-page":"44799","DOI":"10.1038\/s41598-025-28494-5","article-title":"Uptake mechanisms and functions of isolated mitochondria in mesenchymal stromal cells","volume":"15","author":"Kanai","year":"2025","journal-title":"Sci. Reports"},{"key":"B52","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1002\/ana.21743","article-title":"Phase II trial of CoQ10 for ALS finds insufficient evidence to justify phase III","volume":"66","author":"Kaufmann","year":"2009","journal-title":"Ann. Neurology Official J. Am. Neurological Assoc. Child Neurology Soc."},{"key":"B53","doi-asserted-by":"publisher","first-page":"2446","DOI":"10.1007\/s12015-025-10956-y","article-title":"Metabolic plasticity and cancer stem cell metabolism: exploring the glycolysis-OXPHOS switch as a mechanism for resistance and tumorigenesis","volume":"21","author":"Keoh","year":"2025","journal-title":"Stem Cell Rev. Rep."},{"key":"B54","doi-asserted-by":"publisher","first-page":"3903","DOI":"10.1007\/s12035-021-02387-w","article-title":"Sirtuin acetylation and deacetylation: a complex paradigm in neurodegenerative disease","volume":"58","author":"Khan","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.3390\/pharmaceutics14122657","article-title":"Mitochondrial dysfunction: pathophysiology and mitochondria-targeted drug delivery approaches","volume":"14","author":"Khan","year":"2022","journal-title":"Pharmaceutics"},{"key":"B56","doi-asserted-by":"publisher","first-page":"488","DOI":"10.5483\/BMBRep.2023-0098","article-title":"Mitochondrial transplantation: an overview of a promising therapeutic approach","volume":"56","author":"Kim","year":"2023","journal-title":"BMB Reports"},{"key":"B57","doi-asserted-by":"publisher","first-page":"813","DOI":"10.3390\/ph18060813","article-title":"Warburg-like metabolic reprogramming in endometriosis: from molecular mechanisms to therapeutic approaches","volume":"18","author":"Kim","year":"2025","journal-title":"Pharmaceuticals"},{"key":"B58","doi-asserted-by":"publisher","first-page":"e11487","DOI":"10.1016\/j.heliyon.2022.e11487","article-title":"Recent advances in understanding the metabolic plasticity of ovarian cancer: a systematic review","volume":"8","author":"Kobayashi","year":"2022","journal-title":"Heliyon"},{"key":"B59","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1111\/jog.15791","article-title":"The role of mitochondrial dynamics in the pathophysiology of endometriosis","volume":"49","author":"Kobayashi","year":"2023","journal-title":"J. Obstetrics Gynaecol. Res."},{"key":"B60","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/s41420-025-02543-4","article-title":"Unveiling the nexus between environmental exposures and testicular damages: revelations from autophagy and oxidative stress imbalance","volume":"11","author":"Kong","year":"2025","journal-title":"Cell Death Discov."},{"key":"B61","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1021\/acs.jmedchem.0c01671","article-title":"A novel triphenylphosphonium carrier to target mitochondria without uncoupling oxidative phosphorylation","volume":"64","author":"Kulkarni","year":"2021","journal-title":"J. Medicinal Chemistry"},{"key":"B62","doi-asserted-by":"publisher","first-page":"100200","DOI":"10.1016\/j.crtox.2024.100200","article-title":"Estrogen replacement therapy reverses spatial memory loss and pyramidal cell neurodegeneration in the prefrontal cortex of lead-exposed ovariectomized wistar rats","volume":"7","author":"Lasisi-Sholola","year":"2024","journal-title":"Curr. Res. Toxicol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"S454","DOI":"10.1097\/01.CCM.0000278044.19217.73","article-title":"Mitochondrial function and substrate availability","volume":"35","author":"Leverve","year":"2007","journal-title":"Crit. Care Medicine"},{"key":"B64","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41583-021-00535-8","article-title":"Energy matters: presynaptic metabolism and the maintenance of synaptic transmission","volume":"23","author":"Li","year":"2022","journal-title":"Nat. Rev. Neurosci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1451989","DOI":"10.3389\/fimmu.2024.1451989","article-title":"Advancements in mitochondrial-targeted nanotherapeutics: overcoming biological obstacles and optimizing drug delivery","volume":"15","author":"Li","year":"2024","journal-title":"Front. Immunol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"2232","DOI":"10.1002\/anie.201915826","article-title":"Smart design of nanomaterials for mitochondria\u2010targeted nanotherapeutics","volume":"60","author":"Liew","year":"2021","journal-title":"Angew. Chem. Int. Ed."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12989-024-00562-0","article-title":"ROS\/mtROS promotes TNTs formation via the PI3K\/AKT\/mTOR pathway to protect against mitochondrial damages in glial cells induced by engineered nanomaterials","volume":"21","author":"Lin","year":"2024","journal-title":"Part. Fibre Toxicol."},{"key":"B68","first-page":"1707","article-title":"Metabolic reprogramming shapes the progression and therapeutic landscape of ovarian cancer","volume-title":"Cancer Manag. Res.","author":"Liu","year":"2025"},{"key":"B69","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/978-981-10-4567-7_4","article-title":"Endoplasmic reticulum-mitochondria communication through Ca2+ signaling: the importance of mitochondria-associated membranes (MAMs)","author":"Marchi","year":"2017","journal-title":"Organelle Contact Sites: From Molecular Mechanism to Disease"},{"key":"B70","doi-asserted-by":"publisher","first-page":"2685","DOI":"10.1089\/ars.2009.2695","article-title":"Mitochondrial glutathione, a key survival antioxidant","volume":"11","author":"Mar\u00ed","year":"2009","journal-title":"Antioxidants and Redox Signaling"},{"key":"B71","doi-asserted-by":"publisher","first-page":"20476","DOI":"10.1039\/d3ra03313a","article-title":"Recent advances in small molecules for improving mitochondrial disorders","volume":"13","author":"Meng","year":"2023","journal-title":"RSC Advances"},{"key":"B72","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.freeradbiomed.2025.03.029","article-title":"Reductive stress and mitochondrial dysfunction: the hidden link in chronic disease","volume":"233","author":"Mercola","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1585508","DOI":"10.3389\/fragi.2025.1585508","article-title":"Preclinical models of mitochondrial dysfunction: mtDNA and nuclear-encoded regulators in diverse pathologies","volume":"6","author":"Miller","year":"2025","journal-title":"Front. Aging"},{"key":"B74","doi-asserted-by":"publisher","first-page":"189453","DOI":"10.1016\/j.bbcan.2025.189453","article-title":"Intricate role of DRP1 and associated mitochondrial fission signaling in carcinogenesis and cancer progression","volume":"1880","author":"Mishra","year":"2025","journal-title":"Biochimica Biophysica Acta (BBA)-Reviews Cancer"},{"key":"B75","volume-title":"Investigation of senescence in inner annulus fibrosus cells master's thesis","author":"Montgomery-Song","year":"2022"},{"key":"B76","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1111\/brv.12764","article-title":"The mitochondrial permeability transition pore: an evolving concept critical for cell life and death","volume":"96","author":"Morciano","year":"","journal-title":"Biol. Rev."},{"key":"B77","doi-asserted-by":"publisher","first-page":"436","DOI":"10.3390\/life11050436","article-title":"Mitochondrial bioenergetics and dynamism in the failing heart","volume":"11","author":"Morciano","year":"","journal-title":"Life"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.3390\/biomedicines11061577","article-title":"Ca2+-Mediated signaling pathways: a promising target for the successful generation of mature and functional stem cell-derived pancreatic beta cells in vitro","volume":"11","author":"Mu-U-Min","year":"2023","journal-title":"Biomedicines"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/bj20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. Journal"},{"key":"B80","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3390\/life12020205","article-title":"Impaired mitochondrial bioenergetics under pathological conditions","volume":"12","author":"Nesci","year":"2022","journal-title":"Life"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1007\/s43032-020-00164-z","article-title":"Endometriosis: the role of iron overload and ferroptosis","volume":"27","author":"Ng","year":"2020","journal-title":"Reprod. Sci."},{"key":"B82","doi-asserted-by":"publisher","first-page":"EMBR201949612","DOI":"10.15252\/embr.201949612","article-title":"Mitochondrial DNA heteroplasmy in disease and targeted nuclease\u2010based therapeutic approaches","volume":"21","author":"Nissanka","year":"2020","journal-title":"EMBO Rep."},{"key":"B83","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1186\/s13048-025-01817-w","article-title":"Pathogenesis and treatment of obesity-related polycystic ovary syndrome","volume":"18","author":"Ouyang","year":"2025","journal-title":"J. Ovarian Res."},{"key":"B84","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1007\/s11033-025-10368-8","article-title":"Pharmacological approaches to enhance mitochondrial biogenesis: focus on PGC-1\u0391, AMPK, and SIRT1 in cellular health","volume":"52","author":"Palabiyik","year":"2025","journal-title":"Mol. Biol. Rep."},{"key":"B85","doi-asserted-by":"publisher","first-page":"12740","DOI":"10.3390\/ijms252312740","article-title":"Role of fatty acids \u03b2-oxidation in the metabolic interactions between organs","volume":"25","author":"Panov","year":"2024","journal-title":"Int. Journal Molecular Sciences"},{"key":"B86","doi-asserted-by":"publisher","first-page":"633","DOI":"10.3390\/life11070633","article-title":"mtDNA heteroplasmy: origin, detection, significance, and evolutionary consequences","volume":"11","author":"Parakatselaki","year":"2021","journal-title":"Life"},{"key":"B87","doi-asserted-by":"publisher","first-page":"4793","DOI":"10.3390\/ijms22094793","article-title":"Mitochondrial transplantation as a novel therapeutic strategy for mitochondrial diseases","volume":"22","author":"Park","year":"2021","journal-title":"Int. Journal Molecular Sciences"},{"key":"B88","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1080\/13543784.2025.2609734","article-title":"Targeting inflammation in endometriosis: emerging therapeutic options","volume":"34","author":"Perrone","year":"2025","journal-title":"Expert Opin. Investigational Drugs"},{"key":"B89","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1007\/s12325-015-0274-5","article-title":"SkQ1 ophthalmic solution for dry eye treatment: results of a phase 2 safety and efficacy clinical study in the environment and during challenge in the controlled adverse environment model","volume":"33","author":"Petrov","year":"2016","journal-title":"Adv. Therapy"},{"key":"B90","doi-asserted-by":"publisher","first-page":"R170","DOI":"10.1016\/j.cub.2018.01.004","article-title":"Mitophagy and quality control mechanisms in mitochondrial maintenance","volume":"28","author":"Pickles","year":"2018","journal-title":"Curr. Biol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"6791","DOI":"10.3390\/ijms26146791","article-title":"Metabolic disturbances involved in cardiovascular diseases: the role of mitochondrial dysfunction, altered bioenergetics and oxidative stress","volume":"26","author":"Pietrangelo","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"B92","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/jimd.12281","article-title":"Moving towards clinical trials for mitochondrial diseases","volume":"44","author":"Pitceathly","year":"2021","journal-title":"J. Inherited Metabolic Disease"},{"key":"B93","doi-asserted-by":"publisher","first-page":"E3100","DOI":"10.1073\/pnas.1307096110","article-title":"Protective effect of mitochondria-targeted antioxidants in an acute bacterial infection","volume":"110","author":"Plotnikov","year":"2013","journal-title":"Proc. National Academy Sciences"},{"key":"B94","doi-asserted-by":"publisher","first-page":"6321","DOI":"10.3390\/ijms25126321","article-title":"Decreasing intracellular entropy by increasing mitochondrial efficiency and reducing ROS Formation\u2014The effect on the ageing process and age-related damage","volume":"25","author":"Polj\u0161ak","year":"2024","journal-title":"Int. Journal Molecular Sciences"},{"key":"B95","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.3390\/ijms24032959","article-title":"The central role of the NAD+ molecule in the development of aging and the prevention of chronic age-related diseases: strategies for NAD+ modulation","volume":"24","author":"Polj\u0161ak","year":"2023","journal-title":"Int. Journal Molecular Sciences"},{"key":"B96","doi-asserted-by":"publisher","first-page":"4892","DOI":"10.1111\/jcmm.15194","article-title":"Mitochondrial biogenesis: an update","volume":"24","author":"Popov","year":"2020","journal-title":"J. Cellular Molecular Medicine"},{"key":"B97","doi-asserted-by":"publisher","first-page":"985363","DOI":"10.3389\/fonc.2022.985363","article-title":"The role of BCL-2 family proteins in regulating apoptosis and cancer therapy","volume":"12","author":"Qian","year":"2022","journal-title":"Front. Oncology"},{"key":"B98","doi-asserted-by":"publisher","first-page":"1607641","DOI":"10.3389\/fendo.2025.1607641","article-title":"The role of mitochondrial function in the pathogenesis of diabetes","volume":"16","author":"Qin","year":"2025","journal-title":"Front. Endocrinol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"293893","DOI":"10.1155\/2013\/293893","article-title":"Mitochondrial fusion proteins and human diseases","volume":"2013","author":"Ranieri","year":"2013","journal-title":"Neurology Research International"},{"key":"B100","doi-asserted-by":"publisher","first-page":"2806","DOI":"10.1182\/blood-2013-08-519470","article-title":"Antiapoptotic potency of Bcl-2 proteins primarily relies on their stability, not binding selectivity","volume":"123","author":"Rooswinkel","year":"2014","journal-title":"Blood, J. Am. Soc. Hematol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/j.bbamcr.2018.10.016","article-title":"Calcium, mitochondria and cell metabolism: a functional triangle in bioenergetics","volume":"1866","author":"Rossi","year":"2019","journal-title":"Biochimica Biophysica Acta (BBA)-Molecular Cell Res."},{"key":"B102","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s11357-021-00341-1","article-title":"Targeting mitochondrial dysfunction with small molecules in intervertebral disc aging and degeneration","volume":"43","author":"Saberi","year":"2021","journal-title":"Geroscience"},{"key":"B103","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s40360-021-00518-6","article-title":"Mitochondrial targeted antioxidants, mitoquinone and SKQ1, not vitamin C, mitigate doxorubicin-induced damage in H9c2 myoblast: pretreatment vs. co-treatment","volume":"22","author":"Sacks","year":"2021","journal-title":"BMC Pharmacol. Toxicol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"127883","DOI":"10.1016\/j.jtemb.2026.127883","article-title":"L-arginine mitigates against cisplatin-induced defective cardiac metabolic flexibility by activating Nrf2\/HO-1 and upregulating glutathione in male wistar rat","volume":"95","author":"Saka","year":"","journal-title":"J. Trace Elem. Med. Biol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/01480545.2025.2592930","article-title":"Silymarin ameliorates post-weaning bisphenol A exposure-induced cardiotoxicity via suppression of TLR4\/VCAM signaling in male wistar rats","volume":"49","author":"Saka","year":"","journal-title":"Drug Chem. Toxicol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"10973","DOI":"10.3390\/ijms252010973","article-title":"Mitochondrial dysfunction as a potential mechanism mediating cardiac comorbidities in Parkinson\u2019s disease","volume":"25","author":"Salis Torres","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B107","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12929-025-01186-y","article-title":"TCA cycle-derived oncometabolites in cancer and the immune microenvironment","volume":"32","author":"Sarkar","year":"2025","journal-title":"J. Biomed. Sci."},{"key":"B108","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1089\/ars.2021.0145","article-title":"Mitochondrial fusion, fission, and mitophagy in cardiac diseases: challenges and therapeutic opportunities","volume":"36","author":"Scheffer","year":"2022","journal-title":"Antioxidants and Redox Signaling"},{"key":"B109","doi-asserted-by":"publisher","first-page":"526","DOI":"10.3390\/biomedicines8110526","article-title":"Mitochondria at work: new insights into regulation and dysregulation of cellular energy supply and metabolism","volume":"8","author":"Schirrmacher","year":"2020","journal-title":"Biomedicines"},{"key":"B110","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.molcel.2012.09.025","article-title":"Physiological roles of mitochondrial reactive oxygen species","volume":"48","author":"Sena","year":"2012","journal-title":"Mol. Cell"},{"key":"B111","doi-asserted-by":"publisher","first-page":"551","DOI":"10.3390\/ijms22020551","article-title":"Mitochondrial DNA replacement techniques to prevent human mitochondrial diseases","volume":"22","author":"Sendra","year":"2021","journal-title":"Int. Journal Molecular Sciences"},{"key":"B112","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.cell.2015.10.001","article-title":"Mitochondrial ROS signaling in organismal homeostasis","volume":"163","author":"Shadel","year":"2015","journal-title":"Cell"},{"key":"B113","doi-asserted-by":"publisher","first-page":"e00325","DOI":"10.1016\/j.neurot.2024.e00325","article-title":"Biomarkers of mitochondrial disorders","volume":"21","author":"Shayota","year":"2024","journal-title":"Neurotherapeutics"},{"key":"B114","doi-asserted-by":"publisher","first-page":"103244","DOI":"10.1016\/j.ebiom.2021.103244","article-title":"Pharmacological advances in mitochondrial therapy","volume":"65","author":"Singh","year":"2021","journal-title":"EBioMedicine"},{"key":"B115","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1002\/mds.23148","article-title":"A double\u2010blind, placebo\u2010controlled study to assess the mitochondria\u2010targeted antioxidant MitoQ as a disease\u2010modifying therapy in parkinson's disease","volume":"25","author":"Snow","year":"2010","journal-title":"Mov. Disord."},{"key":"B116","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1186\/s12967-022-03685-0","article-title":"Current advances in gene therapy of mitochondrial diseases","volume":"20","author":"Soldatov","year":"2022","journal-title":"J. Translational Medicine"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1384966","DOI":"10.3389\/fphys.2024.1384966","article-title":"Mitochondrial dysfunction and its association with age-related disorders","volume":"15","author":"Somasundaram","year":"2024","journal-title":"Front. Physiology"},{"key":"B118","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.3390\/antiox14091076","article-title":"SIRT1-mediated redox and senescence regulation in cancer: mechanisms and therapeutic implications","volume":"14","author":"Son","year":"2025","journal-title":"Antioxidants"},{"key":"B119","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/s41556-018-0124-1","article-title":"The multifaceted contributions of mitochondria to cellular metabolism","volume":"20","author":"Spinelli","year":"2018","journal-title":"Nat. Cell Biology"},{"key":"B120","doi-asserted-by":"publisher","first-page":"102784","DOI":"10.1016\/j.ebiom.2020.102784","article-title":"Genetics of mitochondrial diseases: identifying mutations to help diagnosis","volume":"56","author":"Stenton","year":"2020","journal-title":"EBioMedicine"},{"key":"B121","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s00424-019-02258-3","article-title":"Mitochondrial dynamics in exercise physiology","volume":"472","author":"Tanaka","year":"2020","journal-title":"Pfl\u00fcgers Archiv-European J. Physiology"},{"key":"B122","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1007\/s13346-025-01840-w","article-title":"Peptide-functionalized nanoparticles for brain-targeted therapeutics","volume":"16","author":"Tang","year":"2026","journal-title":"Drug Deliv. Transl. Res."},{"key":"B123","doi-asserted-by":"publisher","first-page":"7221","DOI":"10.3390\/ijms24087221","article-title":"Mitochondrial bioenergy in neurodegenerative disease: Huntington and parkinson","volume":"24","author":"Tassone","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B124","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.yjmcc.2020.04.015","article-title":"The role of Drp1 in mitophagy and cell death in the heart","volume":"142","author":"Tong","year":"2020","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"3404","DOI":"10.1016\/j.molcel.2023.08.021","article-title":"Mitochondrial degradation: mitophagy and beyond","volume":"83","author":"Uoselis","year":"2023","journal-title":"Mol. Cell"},{"key":"B126","doi-asserted-by":"publisher","first-page":"140","DOI":"10.18632\/aging.100636","article-title":"Antioxidant SkQ1 delays sarcopenia-associated damage of mitochondrial ultrastructure","volume":"6","author":"Vays","year":"2014","journal-title":"Aging (Albany NY)"},{"key":"B127","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1080\/0031302021000009306","article-title":"Chromosomal translocations and their role in the pathogenesis of non-hodgkin's lymphomas","volume":"34","author":"Vega","year":"2002","journal-title":"Pathology"},{"key":"B128","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.3390\/ijms21062173","article-title":"The role of reactive oxygen species in the life cycle of the mitochondrion","volume":"21","author":"Venditti","year":"2020","journal-title":"Int. Journal Molecular Sciences"},{"key":"B129","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s40035-021-00278-7","article-title":"Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration","volume":"11","author":"Verma","year":"2022","journal-title":"Transl. Neurodegeneration"},{"key":"B130","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1530\/JME-20-0196","article-title":"Aging, senescence and mitochondria: the PGC-1\/ERR axis","volume":"66","author":"Vernier","year":"2021","journal-title":"J. Mol. Endocrinol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"950","DOI":"10.3390\/ijms27020950","article-title":"Oxidative stress and SIRT1-Nrf2 anti-ferroptotic pathways in granulosa cells: a molecular key to follicular atresia and ovarian aging","volume":"27","author":"Voros","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"B132","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.cell.2016.07.002","article-title":"Mitochondria and cancer","volume":"166","author":"Vyas","year":"2016","journal-title":"Cell"},{"key":"B133","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1146\/annurev.pathol.4.110807.092314","article-title":"Mitochondrial energetics and therapeutics","volume":"5","author":"Wallace","year":"2010","journal-title":"Annu. Rev. Pathology Mech. Dis."},{"key":"B134","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s12906-020-02904-9","article-title":"Mechanism of heshouwuyin inhibiting the cyt c\/Apaf-1\/Caspase-9\/Caspase-3 pathway in spermatogenic cell apoptosis","volume":"20","author":"Wang","year":"2020","journal-title":"BMC Complementary Medicine Therapies"},{"key":"B135","doi-asserted-by":"publisher","first-page":"105433","DOI":"10.1016\/j.phrs.2021.105433","article-title":"Role of mitophagy in mitochondrial quality control: mechanisms and potential implications for neurodegenerative diseases","volume":"165","author":"Wang","year":"2021","journal-title":"Pharmacol. Res."},{"key":"B136","doi-asserted-by":"publisher","first-page":"116958","DOI":"10.1016\/j.celrep.2026.116958","article-title":"A CRISPR-Based mitochondrial gene therapy tool derived by engineering guide RNAs","volume":"45","author":"Wang","year":"2026","journal-title":"Cell Rep."},{"key":"B137","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41392-024-02044-3","article-title":"Mitochondrial diseases: from molecular mechanisms to therapeutic advances","volume":"10","author":"Wen","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"B138","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.3390\/biomedicines13081994","article-title":"Engineering targeted gene delivery systems for primary hereditary skeletal myopathies: current strategies and future perspectives","volume":"13","author":"Wu","year":"2025","journal-title":"Biomedicines"},{"key":"B139","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.14336\/AD.2023.0203","article-title":"Targeting mitochondrial sirtuins in age-related neurodegenerative diseases and fibrosis","volume":"14","author":"Xiao","year":"2023","journal-title":"Aging Disease"},{"key":"B140","doi-asserted-by":"publisher","first-page":"bqad080","DOI":"10.1210\/endocr\/bqad080","article-title":"\u03b1-ketoglutarate-dependent enzymes in breast cancer and therapeutic implications","volume":"164","author":"Xiong","year":"2023","journal-title":"Endocrinology"},{"key":"B141","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/s41392-025-02253-4","article-title":"Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"B142","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s13287-021-02194-z","article-title":"The role and mechanism of mitochondrial functions and energy metabolism in the function regulation of the mesenchymal stem cells","volume":"12","author":"Yan","year":"2021","journal-title":"Stem Cell Res. and Ther."},{"key":"B143","doi-asserted-by":"publisher","first-page":"1173402","DOI":"10.3389\/fendo.2023.1173402","article-title":"Inflammation, oxidative stress and mitochondrial dysfunction in the progression of type II diabetes mellitus with coexisting hypertension","volume":"14","author":"Yousef","year":"2023","journal-title":"Front. Endocrinology"},{"key":"B144","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/s44324-025-00067-0","article-title":"The role of NAD+ metabolism and its modulation of mitochondria in aging and disease","volume":"3","author":"Yusri","year":"2025","journal-title":"Npj Metabolic Health Dis."},{"key":"B145","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13064-025-00223-8","article-title":"A review of mitochondrial dysfunction, pathophysiology and therapeutic prospects in neurodegenerative diseases","volume":"20","author":"Yusuf","year":"2025","journal-title":"Discov. Neurosci."},{"key":"B146","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1111\/joim.13055","article-title":"DNA\u2010editing enzymes as potential treatments for heteroplasmic mtDNA diseases","volume":"287","author":"Zekonyte","year":"2020","journal-title":"J. Internal Medicine"},{"key":"B147","doi-asserted-by":"publisher","first-page":"5785","DOI":"10.3390\/ijms24065785","article-title":"The Drp1-mediated mitochondrial fission protein interactome as an emerging core player in mitochondrial dynamics and cardiovascular disease therapy","volume":"24","author":"Zerihun","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B148","doi-asserted-by":"publisher","first-page":"1112363","DOI":"10.3389\/fendo.2023.1112363","article-title":"The impact of oxidative stress-induced mitochondrial dysfunction on diabetic microvascular complications","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Endocrinology"},{"key":"B150","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s11658-024-00682-7","article-title":"Systematic and comprehensive insights into HIF-1 stabilization under normoxic conditions: implications for cellular adaptation and therapeutic strategies in cancer","volume":"30","author":"Zhang","year":"","journal-title":"Cell. and Mol. Biol. Lett."},{"key":"B149","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1186\/s12964-025-02308-7","article-title":"Mitochondrial dysfunction in the regulation of aging and aging-related diseases","volume":"23","author":"Zhang","year":"","journal-title":"Cell Commun. Signal."},{"key":"B151","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.62347\/PMYV3832","article-title":"Verteporfin suppressed mitophagy via PINK1\/parkin pathway in endometrial cancer","volume":"14","author":"Zhao","year":"2024","journal-title":"Am. Journal Cancer Research"},{"key":"B152","doi-asserted-by":"publisher","first-page":"202","DOI":"10.2174\/1874467212666181127151059","article-title":"Mitochondria-targeted drugs","volume":"12","author":"Zinovkin","year":"2019","journal-title":"Curr. Mol. Pharmacol."},{"key":"B153","volume-title":"Mechanistic Studies on Retinitis Pigmentosa for Gene Therapy Approaches","author":"Zobel","year":"2022"},{"key":"B154","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/s41392-024-01839-8","article-title":"Mitochondrial dysfunction: mechanisms and advances in therapy","volume":"9","author":"Zong","year":"2024","journal-title":"Signal Transduction Targeted Therapy"}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2026.1929130\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T05:30:41Z","timestamp":1787549441000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2026.1929130\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,24]]},"references-count":155,"alternative-id":["10.3389\/fcell.2026.1929130"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2026.1929130","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,24]]},"article-number":"1929130"}}