{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:01:19Z","timestamp":1790834479993,"version":"4.1.0"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004001","name":"Guizhou Provincial Science and Technology Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Deep skin injuries often heal with scarring and lack skin appendage regeneration, posing a significant clinical challenge. This study aimed to develop an hAAM-based combinatorial strategy for co-delivery of human hair follicle stem cells (HFSCs) and dermal papilla cells (DPCs) to full-thickness skin wounds, and to evaluate its effects on wound repair and appendage-like structure formation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>hAAM was prepared and characterized. HFSCs and DPCs were isolated from human hair follicles and identified. The composite construct (hAAM + HFSCs + DPCs) was applied to full-thickness skin wounds in nude mice. Wound healing rates were monitored. Histological and immunohistochemical analyses were performed to assess re-epithelialization, collagen deposition, the presence of CD31-positive vascular structures, cell proliferation, fibrosis-related markers, and morphological features suggestive of appendage-like structures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The hAAM scaffold co-loaded with HFSCs and DPCs was associated with accelerated wound closure, tissue repair, and altered expression of fibrosis-associated markers, including TGF-\u03b2 and \u03b1-SMA, together with altered collagen deposition. The treatment was also associated with the appearance of PPAR-\u03b3-positive structures with morphological features resembling sebaceous glands, as well as epithelial bud-like structures morphologically suggestive of early follicular development, in a subset of specimens. Although these morphological observations are preliminary and require further characterization with additional lineage-specific markers, they represent preliminary morphological observations of appendage-like structures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The hAAM scaffold co-loaded with HFSCs and DPCs was associated with accelerated wound closure, tissue repair, and altered extracellular matrix remodeling in a murine full-thickness wound model. Structures with morphological features resembling sebaceous glands and epithelial bud-like structures suggestive of early follicular development were observed in some samples; however, their cellular identity, maturity, and functionality remain to be determined. Further lineage-specific characterization and long-term functional studies are required to establish whether this strategy can promote appendage-like structure formation and functional skin restoration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcell.2026.1947836","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:41:35Z","timestamp":1790833295000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Human acellular amniotic membrane loaded with hair follicle-derived cells promotes wound repair and appendage-like structure formation"],"prefix":"10.3389","volume":"14","author":[{"given":"Yanxin","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwen","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xichao","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyao","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengliang","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shune","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1097\/DSS.0000000000001748","article-title":"Distinct patterns of hair graft survival after transplantation into 2 nonhealing ulcers: is location everything?","volume":"45","author":"Alam","year":"2019","journal-title":"Dermatol Surg."},{"key":"B2","doi-asserted-by":"publisher","first-page":"99","DOI":"10.29252\/ibj.24.2.99","article-title":"Effects of hair follicle stem cells on partial-thickness burn wound healing and tensile strength","volume":"24","author":"Babakhani","year":"2020","journal-title":"Iran. 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