{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:12:09Z","timestamp":1788426729073,"version":"build-2803163510"},"reference-count":140,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:p>sFRP2, a member of the secreted frizzled-related protein family, is an extracellular protein characterized by a cysteine-rich domain and a netrin-like (NTR) domain. By modulating ligand availability, receptor selection, and microenvironmental signal integration, sFRP2 exerts highly context-dependent biological effects. Accumulating evidence suggests that sFRP2 should no longer be viewed merely as a WNT antagonist, but rather as an extracellular regulatory molecule that links development, tissue repair, and pathological remodeling. This review summarizes the molecular structure, expression patterns, and functional duality of sFRP2, with particular emphasis on its roles in regulating canonical and non-canonical WNT signaling, coordinating receptor bias and receptor switching, and participating in TGF-\u03b2-driven fibrosis, CXADR\/NO-mediated WNT-independent growth control, endoplasmic reticulum stress-associated repair, and metabolic inflammation. We further discuss its functions within the tumor microenvironment, including the modulation of angiogenesis, cancer-associated fibroblasts, immunosuppression, and tumor cell survival. By integrating receptor bias and receptor switching with WNT-independent signaling, this review extends beyond a predominantly WNT-centered view of sFRP2 and proposes a context-stratified framework for biomarker interpretation and therapeutic targeting based on cellular origin, dominant signaling axis, disease stage, and tissue compartment.<\/jats:p>","DOI":"10.3389\/fcell.2026.1951467","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T08:12:11Z","timestamp":1788423131000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Secreted frizzled-related protein 2 as a context-dependent extracellular signaling hub in development, tissue remodeling, and disease"],"prefix":"10.3389","volume":"14","author":[{"given":"Xiaoping","family":"Luo","sequence":"first","affiliation":[{"name":"Clinical Medical College of Chengdu Medical College","place":["Chengdu, China"]},{"name":"Department of Nephrology, School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Medical College of Chengdu Medical College","place":["Chengdu, China"]},{"name":"Department of Nephrology, School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Huang","sequence":"additional","affiliation":[{"name":"Clinical Medical College of Chengdu Medical College","place":["Chengdu, China"]},{"name":"Department of Nephrology, School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Medical College of Chengdu Medical College","place":["Chengdu, China"]},{"name":"Department of Nephrology, School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"You","sequence":"additional","affiliation":[{"name":"Clinical Medical College of Chengdu Medical College","place":["Chengdu, China"]},{"name":"Department of Nephrology, School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sichong","family":"Ren","sequence":"additional","affiliation":[{"name":"Clinical Medical College of Chengdu Medical College","place":["Chengdu, China"]},{"name":"Department of Nephrology, School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/s41580-024-00794-0","article-title":"Homeostasis control in health and disease by the unfolded protein response","volume":"26","author":"Acosta-Alvear","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1042\/bst20200243","article-title":"The structural biology of canonical wnt signalling","volume":"48","author":"Agostino","year":"2020","journal-title":"Biochem. Soc. Trans."},{"key":"B3","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.cstres.2023.12.003","article-title":"Endoplasmic reticulum stress-mediated cell death in cardiovascular disease","volume":"29","author":"An","year":"2024","journal-title":"Cell Stress Chaperones"},{"key":"B4","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/s41568-024-00740-4","article-title":"CAF-induced physical constraints controlling T cell state and localization in solid tumours","volume":"24","author":"Arpinati","year":"2024","journal-title":"Nat. Rev. Cancer"},{"key":"B5","doi-asserted-by":"publisher","first-page":"10005","DOI":"10.3390\/ijms251810005","article-title":"Wnt\/\u03b2-Catenin signaling regulates yap\/taz activity during embryonic development in zebrafish","volume":"25","author":"Astone","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"107565","DOI":"10.1016\/j.phrs.2024.107565","article-title":"Wnt\/\u03b2-catenin and notch signaling pathways in cardiovascular disease: mechanisms and therapeutics approaches","volume":"211","author":"Azhdari","year":"2025","journal-title":"Pharmacol. Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1110\/ps.8.8.1636","article-title":"The NTR module: domains of netrins, secreted frizzled related proteins, and type I procollagen C-proteinase enhancer protein are homologous with tissue inhibitors of metalloproteases","volume":"8","author":"B\u00e1nyai","year":"1999","journal-title":"Protein Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2282","DOI":"10.1161\/01.Cir.0000093186.22847.4c","article-title":"Reduction of infarct size and prevention of cardiac rupture in transgenic mice overexpressing FrzA","volume":"108","author":"Barandon","year":"2003","journal-title":"Circulation"},{"key":"B9","doi-asserted-by":"publisher","first-page":"602","DOI":"10.3390\/cells9030602","article-title":"Designing novel therapies to mend broken hearts: ATF6 and cardiac proteostasis","volume":"9","author":"Blackwood","year":"2020","journal-title":"Cells"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1210\/me.2003-0498","article-title":"The wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice","volume":"18","author":"Bodine","year":"2004","journal-title":"Mol. Endocrinol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1186\/s12967-024-05329-x","article-title":"Identification of epigenetic silencing of the SFRP2 gene in colorectal cancer as a clinical biomarker and molecular significance","volume":"22","author":"Boughanem","year":"2024","journal-title":"J. Transl. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"7422","DOI":"10.1038\/s41467-024-51664-4","article-title":"Structural basis of frizzled 7 activation and allosteric regulation","volume":"15","author":"Bous","year":"2024","journal-title":"Nat. Commun."},{"key":"B13","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1242\/jcs.026096","article-title":"Beyond wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease","volume":"121","author":"Bovolenta","year":"2008","journal-title":"J. Cell Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"13730","DOI":"10.1074\/jbc.M116.733766","article-title":"Secreted frizzled-related protein 2 (sFRP2) redirects non-canonical wnt signaling from Fz7 to Ror2 during vertebrate gastrulation","volume":"291","author":"Brinkmann","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B15","doi-asserted-by":"publisher","first-page":"723205","DOI":"10.3389\/fcvm.2021.723205","article-title":"Inverse associations between circulating secreted frizzled related protein 2 (sFRP2) and cardiometabolic risk factors","volume":"8","author":"Cao","year":"2021","journal-title":"Front. Cardiovasc Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.canlet.2021.08.002","article-title":"The transformation of cancer-associated fibroblasts: current perspectives on the role of TGF-\u03b2 in CAF mediated tumor progression and therapeutic resistance","volume":"520","author":"Chandra Jena","year":"2021","journal-title":"Cancer Lett."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e50229","DOI":"10.1371\/journal.pone.0050229","article-title":"SFRP2 and slug contribute to cellular resistance to apoptosis in hypertrophic scars","volume":"7","author":"Chen","year":"2012","journal-title":"PLoS One"},{"key":"B18","doi-asserted-by":"publisher","first-page":"6850","DOI":"10.1038\/s41467-025-62248-1","article-title":"Identifying fibroblast-derived sFRP2 as a therapeutic target and engineering siRNA therapy for uterine scarring","volume":"16","author":"Cheng","year":"2025","journal-title":"Nat. Commun."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1161\/atvbaha.117.310649","article-title":"Effect of SFRP5 (secreted frizzled-related protein 5) on the WNT5A (Wingless-Type family member 5A)-Induced endothelial dysfunction and its relevance with arterial stiffness in human subjects","volume":"38","author":"Cho","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"e174598","DOI":"10.1172\/jci174598","article-title":"A fibroblast-dependent TGF-\u03b21\/sFRP2 noncanonical wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis","volume":"134","author":"Cohen","year":"2024","journal-title":"J. Clin. Invest."},{"key":"B21","doi-asserted-by":"publisher","first-page":"4621","DOI":"10.1158\/0008-5472.Can-08-3402","article-title":"Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin\/NFAT signaling pathway","volume":"69","author":"Courtwright","year":"2009","journal-title":"Cancer Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.devcel.2023.11.027","article-title":"Extracellular carriers control lipid-dependent secretion, delivery, and activity of WNT morphogens","volume":"59","author":"de Almeida Magalhaes","year":"2024","journal-title":"Dev. Cell"},{"key":"B23","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1634\/stemcells.2007-0475","article-title":"SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional autofeedback loop of Wnt3a","volume":"26","author":"Deb","year":"2008","journal-title":"Stem Cells"},{"key":"B24","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/s41392-024-01764-w","article-title":"TGF-\u03b2 signaling in health, disease, and therapeutics","volume":"9","author":"Deng","year":"2024","journal-title":"Signal Transduct. Target Ther."},{"key":"B25","doi-asserted-by":"publisher","first-page":"3815","DOI":"10.1242\/jcs.112.21.3815","article-title":"A secreted frizzled related protein, FrzA, selectively associates with Wnt-1 protein and regulates wnt-1 signaling","volume":"112","author":"Dennis","year":"1999","journal-title":"J. Cell Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1111\/wrr.13211","article-title":"Skin fibrosis is accompanied by increased expression of secreted frizzled-related protein-2","volume":"32","author":"Dolivo","year":"2024","journal-title":"Wound Repair Regen."},{"key":"B27","doi-asserted-by":"publisher","first-page":"29735","DOI":"10.1074\/jbc.M109.018036","article-title":"Ischemia activates the ATF6 branch of the endoplasmic reticulum stress response","volume":"284","author":"Doroudgar","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"3097","DOI":"10.1161\/01.cir.0000039342.85015.5c","article-title":"FrzA, a secreted frizzled related protein, induced angiogenic response","volume":"106","author":"Dufourcq","year":"2002","journal-title":"Circulation"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1161\/atvbaha.123.320612","article-title":"Macrophage-derived GSDMD plays an essential role in atherosclerosis and cross talk between macrophages via the Mitochondria-STING-IRF3\/NF-\u03baB axis","volume":"44","author":"Fan","year":"2024","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"5709","DOI":"10.1158\/1078-0432.Ccr-20-0446","article-title":"sFRP2 supersedes VEGF as an age-related driver of angiogenesis in melanoma, affecting response to Anti-VEGF therapy in older patients","volume":"26","author":"Fane","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/cac2.12392","article-title":"Signaling pathways in cancer-associated fibroblasts: recent advances and future perspectives","volume":"43","author":"Fang","year":"2023","journal-title":"Cancer Commun. (Lond)"},{"key":"B32","doi-asserted-by":"publisher","first-page":"6770","DOI":"10.1073\/pnas.94.13.6770","article-title":"Purification and molecular cloning of a secreted, Frizzled-related antagonist of wnt action","volume":"94","author":"Finch","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B33","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1158\/1535-7163.Mct-12-1066","article-title":"A novel monoclonal antibody to secreted frizzled-related protein 2 inhibits tumor growth","volume":"12","author":"Fontenot","year":"2013","journal-title":"Mol. Cancer Ther."},{"key":"B34","doi-asserted-by":"publisher","first-page":"4782","DOI":"10.1245\/s10434-019-07800-2","article-title":"Development of a novel humanized monoclonal antibody to secreted frizzled-related Protein-2 that inhibits triple-negative breast cancer and angiosarcoma growth in vivo","volume":"26","author":"Garcia","year":"2019","journal-title":"Ann. Surg. Oncol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"108848","DOI":"10.1016\/j.jdiacomp.2024.108848","article-title":"The mechanism and promising therapeutic strategy of diabetic cardiomyopathy dysfunctions: focus on pyroptosis","volume":"38","author":"Geng","year":"2024","journal-title":"J. Diabetes Complicat."},{"key":"B36","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1186\/s12967-024-05411-4","article-title":"TGF-\u03b2 signaling: critical nexus of fibrogenesis and cancer","volume":"22","author":"Giarratana","year":"2024","journal-title":"J. Transl. Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"3906","DOI":"10.3390\/cancers14163906","article-title":"Cancer-associated fibroblasts: tumorigenicity and targeting for cancer therapy","volume":"14","author":"Glabman","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B38","doi-asserted-by":"publisher","first-page":"4573","DOI":"10.1038\/s41467-023-40213-0","article-title":"Pathway selectivity in frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations","volume":"14","author":"Gr\u00e4tz","year":"2023","journal-title":"Nat. Commun."},{"key":"B39","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1158\/1541-7786.Mcr-23-0616","article-title":"ROR2\/Wnt5a signaling regulates directional cell migration and early tumor cell invasion in ovarian cancer","volume":"22","author":"Grither","year":"2024","journal-title":"Mol. Cancer Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/164_2021_531","article-title":"Extracellular WNTs: trafficking, exosomes, and ligand-receptor interaction","volume":"269","author":"Gross","year":"2021","journal-title":"Handb. Exp. Pharmacol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"712217","DOI":"10.3389\/fendo.2021.712217","article-title":"Secreted frizzled related proteins in cardiovascular and metabolic diseases","volume":"12","author":"Guan","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1007\/s10555-024-10186-7","article-title":"Cancer-associated fibroblasts: a versatile mediator in tumor progression, metastasis, and targeted therapy","volume":"43","author":"Guo","year":"2024","journal-title":"Cancer Metastasis Rev."},{"key":"B43","doi-asserted-by":"publisher","first-page":"21110","DOI":"10.1073\/pnas.1004708107","article-title":"Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction","volume":"107","author":"He","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B44","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/s41586-020-2938-9","article-title":"Fibrosis: from mechanisms to medicines","volume":"587","author":"Henderson","year":"2020","journal-title":"Nature"},{"key":"B45","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.yjmcc.2024.02.001","article-title":"ATF6 protects against protein misfolding during cardiac hypertrophy","volume":"189","author":"Hofmann","year":"2024","journal-title":"J. Mol. Cell Cardiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1007\/s11626-024-00917-z","article-title":"Wnt signaling in cardiac development and heart diseases","volume":"60","author":"Horitani","year":"2024","journal-title":"Vitro Cell Dev. Biol. Anim."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1602452","DOI":"10.3389\/fonc.2025.1602452","article-title":"Role of TGF\u03b2-activated cancer-associated fibroblasts in the resistance to checkpoint blockade immunotherapy","volume":"15","author":"Hou","year":"2025","journal-title":"Front. Oncol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/s13058-025-02176-6","article-title":"Secreted frizzled-related protein 2 monoclonal antibody-mediated IFN-\u03d2 reprograms tumor-associated macrophages to suppress triple negative breast cancer","volume":"27","author":"Hsu","year":"2025","journal-title":"Breast Cancer Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"3920","DOI":"10.1038\/s41598-023-31144-3","article-title":"Novel method of differentiating human induced pluripotent stem cells to mature cardiomyocytes via Sfrp2","volume":"13","author":"Hsueh","year":"2023","journal-title":"Sci. Rep."},{"key":"B50","doi-asserted-by":"publisher","first-page":"100337","DOI":"10.1016\/j.labinv.2024.100337","article-title":"Gasdermin D-Mediated pyroptosis promotes the development of atherosclerosis","volume":"104","author":"Huang","year":"2024","journal-title":"Lab. Invest."},{"key":"B51","doi-asserted-by":"publisher","first-page":"112103","DOI":"10.1016\/j.celrep.2023.112103","article-title":"Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma","volume":"42","author":"Jayabal","year":"2023","journal-title":"Cell Rep."},{"key":"B52","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/s41392-023-01559-5","article-title":"Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies","volume":"8","author":"Jing","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"B53","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1126\/science.271.5247.360","article-title":"Bone morphogenetic protein-1: the type I procollagen C-proteinase","volume":"271","author":"Kessler","year":"1996","journal-title":"Science"},{"key":"B54","doi-asserted-by":"publisher","first-page":"E11128","DOI":"10.1073\/pnas.1814044115","article-title":"Oncogenic role of SFRP2 in p53-mutant osteosarcoma development via autocrine and paracrine mechanism","volume":"115","author":"Kim","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B55","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/ncb1811","article-title":"Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction","volume":"11","author":"Kobayashi","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"66","DOI":"10.3892\/mmr.2024.13190","article-title":"SFRP2 suppresses trophoblast cell migration by inhibiting the Wnt\/\u03b2-catenin pathway","volume":"29","author":"Lan","year":"2024","journal-title":"Mol. Med. Rep."},{"key":"B57","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.drudis.2021.12.008","article-title":"Unlocking the wnt pathway: therapeutic potential of selective targeting FZD(7) in cancer","volume":"27","author":"Larasati","year":"2022","journal-title":"Drug Discov. Today"},{"key":"B58","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.cell.2005.12.018","article-title":"Embryonic dorsal-ventral signaling: secreted frizzled-related proteins as inhibitors of tolloid proteinases","volume":"124","author":"Lee","year":"2006","journal-title":"Cell"},{"key":"B59","doi-asserted-by":"publisher","first-page":"e25937","DOI":"10.1016\/j.heliyon.2024.e25937","article-title":"Molecular mechanism of ATF6 in unfolded protein response and its role in disease","volume":"10","author":"Lei","year":"2024","journal-title":"Heliyon"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1748759","DOI":"10.3389\/fonc.2026.1748759","article-title":"Stool-based SDC2\/SFRP2\/TFPI2 methylation assay for colorectal neoplasia screening: a multicenter, case-control study","volume":"16","author":"Li","year":"2026","journal-title":"Front. Oncol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1016\/j.celrep.2019.07.023","article-title":"SFRPs are biphasic modulators of wnt-signaling-elicited cancer stem cell properties beyond extracellular control","volume":"28","author":"Liang","year":"2019","journal-title":"Cell Rep."},{"key":"B62","doi-asserted-by":"publisher","first-page":"C710","DOI":"10.1152\/ajpcell.00137.2016","article-title":"sFRP2 activates Wnt\/\u03b2-catenin signaling in cardiac fibroblasts: differential roles in cell growth, energy metabolism, and extracellular matrix remodeling","volume":"311","author":"Lin","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.trsl.2025.05.006","article-title":"Intermittent caloric restriction protects against diabetic heart inflammation via GSDMD-Dependent sFRP2-ATF6-NF-\u03baB pathway","author":"Lin","year":"2025","journal-title":"Transl. Res."},{"key":"B64","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41392-021-00762-6","article-title":"Wnt\/\u03b2-catenin signalling: function, biological mechanisms, and therapeutic opportunities","volume":"7","author":"Liu","year":"2022","journal-title":"Signal Transduct. Target Ther."},{"key":"B65","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1186\/s13046-024-03255-w","article-title":"SPP1+ macrophages promote head and neck squamous cell carcinoma progression by secreting TNF-\u03b1 and IL-1\u03b2","volume":"43","author":"Liu","year":"","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1038\/s41401-024-01270-3","article-title":"Frizzled receptors (FZDs) in wnt signaling: potential therapeutic targets for human cancers","volume":"45","author":"Liu","year":"","journal-title":"Acta Pharmacol. Sin."},{"key":"B139","doi-asserted-by":"publisher","first-page":"4095","DOI":"10.1002\/art.23137","article-title":"Articular cartilage and biomechanical properties of the long bones in Frzb\u2010knockout mice","volume":"56","author":"Lories","year":"2007","journal-title":"Arthritis Rheum."},{"key":"B67","doi-asserted-by":"publisher","first-page":"166933","DOI":"10.1016\/j.bbadis.2023.166933","article-title":"Sfrp2 promotes renal dysfunction of diabetic kidney disease via modulating Fzd5-induced cytosolic calcium ion concentration and caMKII\/mek\/erk pathway in mesangial cells","volume":"1870","author":"Lv","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B68","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1007\/s00239-025-10249-5","article-title":"Evolutionary and structural assessment of the human secreted frizzled-related protein (SFRP) family","volume":"93","author":"Mafakher","year":"2025","journal-title":"J. Mol. Evol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"4007","DOI":"10.1016\/j.cell.2023.07.036","article-title":"TGF-\u03b2 signaling in health and disease","volume":"186","author":"Massagu\u00e9","year":"2023","journal-title":"Cell"},{"key":"B70","doi-asserted-by":"publisher","first-page":"C531","DOI":"10.1152\/ajpcell.00238.2013","article-title":"Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention","volume":"306","author":"Mastri","year":"2014","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1694102","DOI":"10.3389\/fimmu.2025.1694102","article-title":"Endoplasmic reticulum stress and unfolded protein response in immune cell function","volume":"16","author":"Matsushima","year":"2025","journal-title":"Front. Immunol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/s41580-024-00823-y","article-title":"Mechanistic insights into Wnt-\u03b2-catenin pathway activation and signal transduction","volume":"26","author":"Maurice","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"631","DOI":"10.3389\/fcell.2020.00631","article-title":"Heparan sulfate proteoglycan clustering in wnt signaling and dispersal","volume":"8","author":"Mii","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1073\/pnas.0610024104","article-title":"Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair","volume":"104","author":"Mirotsou","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B75","doi-asserted-by":"publisher","first-page":"2696","DOI":"10.3390\/cancers13112696","article-title":"Overcoming PD-1 inhibitor resistance with a monoclonal antibody to secreted frizzled-related protein 2 in metastatic osteosarcoma","volume":"13","author":"Nasarre","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B76","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1158\/0008-5472.Can-18-1742","article-title":"CXADR-mediated formation of an AKT inhibitory signalosome at tight junctions controls epithelial-mesenchymal plasticity in breast cancer","volume":"79","author":"Nilchian","year":"2019","journal-title":"Cancer Res."},{"key":"B77","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.cell.2020.11.038","article-title":"Structural basis of WLS\/Evi-Mediated wnt transport and secretion","volume":"184","author":"Nygaard","year":"2021","journal-title":"Cell"},{"key":"B78","doi-asserted-by":"publisher","first-page":"C527","DOI":"10.1152\/ajpcell.00020.2014","article-title":"A new molecular target for blunting organ fibrosis. Focus on secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention","volume":"306","author":"Ostrom","year":"2014","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1042\/bst20221203","article-title":"Contributions of coxsackievirus adenovirus receptor to tumorigenesis","volume":"51","author":"Owczarek","year":"2023","journal-title":"Biochem. Soc. Trans."},{"key":"B80","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s10456-017-9574-5","article-title":"Frizzled-5: a high affinity receptor for secreted frizzled-related protein-2 activation of nuclear factor of activated T-cells c3 signaling to promote angiogenesis","volume":"20","author":"Peterson","year":"2017","journal-title":"Angiogenesis"},{"key":"B81","doi-asserted-by":"publisher","first-page":"5028","DOI":"10.1016\/j.cell.2023.09.021","article-title":"Molecular basis of wnt biogenesis, secretion, and Wnt7-specific signaling","volume":"186","author":"Qi","year":"2023","journal-title":"Cell"},{"key":"B82","doi-asserted-by":"publisher","first-page":"7644","DOI":"10.1038\/s41467-024-52174-z","article-title":"Structural basis of frizzled 4 in recognition of dishevelled 2 unveils mechanism of WNT signaling activation","volume":"15","author":"Qian","year":"2024","journal-title":"Nat. Commun."},{"key":"B83","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s13148-020-00904-7","article-title":"Fecal DNA methylation markers for detecting stages of colorectal cancer and its precursors: a systematic review","volume":"12","author":"Raut","year":"2020","journal-title":"Clin. Epigenetics"},{"key":"B84","doi-asserted-by":"publisher","first-page":"105350","DOI":"10.1016\/j.jbc.2023.105350","article-title":"ROR2 homodimerization is sufficient to activate a neuronal wnt\/Calcium signaling pathway","volume":"299","author":"Riquelme","year":"2023","journal-title":"J. Biol. Chem."},{"key":"B85","doi-asserted-by":"publisher","first-page":"4210","DOI":"10.1038\/sj.onc.1203783","article-title":"Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells","volume":"19","author":"Roth","year":"2000","journal-title":"Oncogene"},{"key":"B86","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s00418-025-02415-z","article-title":"Secreted Frizzled-related proteins in animal development","volume":"163","author":"Sadriev","year":"2025","journal-title":"Histochem Cell Biol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.niox.2017.02.012","article-title":"sFRP4 signalling of apoptosis and angiostasis uses nitric oxide-cGMP-permeability axis of endothelium","volume":"66","author":"Saran","year":"2017","journal-title":"Nitric Oxide"},{"key":"B88","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1242\/dev.02274","article-title":"Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis","volume":"133","author":"Satoh","year":"2006","journal-title":"Development"},{"key":"B89","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1002\/dvg.20369","article-title":"Sfrp1, Sfrp2, and Sfrp5 regulate the wnt\/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse","volume":"46","author":"Satoh","year":"2008","journal-title":"Genesis"},{"key":"B90","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.yjmcc.2015.06.003","article-title":"Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of wnt pathways","volume":"85","author":"Schmeckpeper","year":"2015","journal-title":"J. Mol. Cell Cardiol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1111\/j.1524-475X.2007.00343.x","article-title":"Identification of unique gene expression patterns within different lesional sites of keloids","volume":"16","author":"Seifert","year":"2008","journal-title":"Wound Repair Regen."},{"key":"B92","doi-asserted-by":"publisher","first-page":"2567","DOI":"10.1242\/dev.032888","article-title":"Pax6 is essential for lens fiber cell differentiation","volume":"136","author":"Shaham","year":"2009","journal-title":"Development"},{"key":"B93","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.3390\/biom10121666","article-title":"Transforming growth Factor-\u03b2 signaling in fibrotic diseases and cancer-associated fibroblasts","volume":"10","author":"Shi","year":"2020","journal-title":"Biomolecules"},{"key":"B94","doi-asserted-by":"publisher","first-page":"e20412","DOI":"10.1371\/journal.pone.0020412","article-title":"The role of calcineurin\/NFAT in SFRP2 induced angiogenesis--a rationale for breast cancer treatment with the calcineurin inhibitor tacrolimus","volume":"6","author":"Siamakpour-Reihani","year":"2011","journal-title":"PLoS One"},{"key":"B95","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s13045-024-01563-4","article-title":"Wnt\/\u03b2-catenin signaling pathway in carcinogenesis and cancer therapy","volume":"17","author":"Song","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1097\/cej.0000000000000185","article-title":"The variation trends of SFRP2 methylation of tissue, feces, and blood detection in colorectal cancer development","volume":"25","author":"Sui","year":"2016","journal-title":"Eur. J. Cancer Prev."},{"key":"B97","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s11010-011-0736-2","article-title":"shRNA targeting SFRP2 promotes the apoptosis of hypertrophic scar fibroblast","volume":"352","author":"Sun","year":"2011","journal-title":"Mol. Cell Biochem."},{"key":"B98","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1007\/s00432-019-02992-2","article-title":"A novel panel of stool-based DNA biomarkers for early screening of colorectal neoplasms in a Chinese population","volume":"145","author":"Sun","year":"2019","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.bbcan.2013.11.004","article-title":"Secreted frizzled related proteins: implications in cancers","volume":"1845","author":"Surana","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"B100","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/ng1330","article-title":"Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer","volume":"36","author":"Suzuki","year":"2004","journal-title":"Nat. Genet."},{"key":"B101","doi-asserted-by":"publisher","first-page":"4384","DOI":"10.1038\/s41467-021-24607-6","article-title":"Myofibroblast transcriptome indicates SFRP2(hi) fibroblast progenitors in systemic sclerosis skin","volume":"12","author":"Tabib","year":"2021","journal-title":"Nat. Commun."},{"key":"B102","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.ccell.2025.04.008","article-title":"Stromal barriers to the abscopal effect","volume":"43","author":"Tian","year":"2025","journal-title":"Cancer Cell"},{"key":"B103","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/s42003-024-05881-8","article-title":"Soluble Frizzled-related proteins promote exosome-mediated wnt re-secretion","volume":"7","author":"Tran","year":"2024","journal-title":"Commun. Biol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"e159884","DOI":"10.1172\/jci159884","article-title":"Noncanonical WNT5A controls the activation of latent TGF-\u03b2 to drive fibroblast activation and tissue fibrosis","volume":"134","author":"Trinh-Minh","year":"2024","journal-title":"J. Clin. Invest."},{"key":"B105","doi-asserted-by":"publisher","first-page":"e86642","DOI":"10.1371\/journal.pone.0086642","article-title":"Ultrasound molecular imaging of secreted frizzled related protein-2 expression in murine angiosarcoma","volume":"9","author":"Tsuruta","year":"2014","journal-title":"PLoS One"},{"key":"B106","doi-asserted-by":"publisher","first-page":"e0174281","DOI":"10.1371\/journal.pone.0174281","article-title":"Optimizing ultrasound molecular imaging of secreted frizzled related protein 2 expression in angiosarcoma","volume":"12","author":"Tsuruta","year":"2017","journal-title":"PLoS One"},{"key":"B107","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s10555-020-09941-3","article-title":"Secreted frizzled-related protein 2: a key player in noncanonical wnt signaling and tumor angiogenesis","volume":"40","author":"van Loon","year":"2021","journal-title":"Cancer Metastasis Rev."},{"key":"B108","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/s00395-020-0808-0","article-title":"Secreted frizzled-related protein 2, a novel mechanism to induce myocardial ischemic protection through angiogenesis","volume":"115","author":"Vatner","year":"2020","journal-title":"Basic Res. Cardiol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"42719","DOI":"10.1038\/srep42719","article-title":"A pan-cancer analysis of secreted Frizzled-related proteins: re-examining their proposed tumour suppressive function","volume":"7","author":"Vincent","year":"2017","journal-title":"Sci. Rep."},{"key":"B110","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.bbrc.2010.08.043","article-title":"Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling","volume":"400","author":"von Marschall","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B111","doi-asserted-by":"publisher","first-page":"45","DOI":"10.14348\/molcells.2017.2245","article-title":"Concurrent hypermethylation of SFRP2 and DKK2 activates the Wnt\/\u03b2-Catenin pathway and is associated with poor prognosis in patients with gastric cancer","volume":"40","author":"Wang","year":"2017","journal-title":"Mol. Cells"},{"key":"B140","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s13105-025-01099-2","article-title":"Crosstalk between MST1\u2010Hippo and Wnt\/\u03b2\u2010Catenin, Notch, and PI3K\/Akt pathways in cardiac physiology and pathology","volume":"81","author":"Wang","year":"2025","journal-title":"J. Physiol. Biochem."},{"key":"B112","doi-asserted-by":"publisher","first-page":"603","DOI":"10.3389\/fendo.2019.00603","article-title":"TLR4\/NF-\u03baB signaling induces GSDMD-related pyroptosis in tubular cells in diabetic kidney disease","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B113","doi-asserted-by":"publisher","first-page":"1322907","DOI":"10.3389\/fendo.2023.1322907","article-title":"Role of pyroptosis in diabetic cardiomyopathy: an updated review","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B114","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/s41698-024-00716-5","article-title":"Single cell analysis revealed SFRP2 cancer associated fibroblasts drive tumorigenesis in head and neck squamous cell carcinoma","volume":"8","author":"Wang","year":"2024","journal-title":"NPJ Precis. Oncol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s11010-020-03802-x","article-title":"Secreted frizzled-related protein 2 prevents pressure-overload-induced cardiac hypertrophy by targeting the Wnt\/\u03b2-catenin pathway","volume":"472","author":"Wei","year":"2020","journal-title":"Mol. Cell Biochem."},{"key":"B116","doi-asserted-by":"publisher","first-page":"730","DOI":"10.7150\/ijbs.40923","article-title":"Multiple roles of sFRP2 in cardiac development and cardiovascular disease","volume":"16","author":"Wu","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"B117","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s10456-025-10024-6","article-title":"Secreted frizzled-related proteins in angiogenesis: molecular mechanisms and clinical implications","volume":"29","author":"Wu","year":"2025","journal-title":"Angiogenesis"},{"key":"B118","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.3892\/or.2015.4221","article-title":"Promoting roles of the secreted frizzled-related protein 2 as a wnt agonist in lung cancer cells","volume":"34","author":"Xiao","year":"2015","journal-title":"Oncol. Rep."},{"key":"B119","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/s41392-025-02142-w","article-title":"Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances","volume":"10","author":"Xue","year":"2025","journal-title":"Signal Transduct. Target Ther."},{"key":"B120","doi-asserted-by":"publisher","first-page":"33339","DOI":"10.1038\/srep33339","article-title":"Methylation of SFRP2 gene as a promising noninvasive biomarker using feces in colorectal cancer diagnosis: a systematic meta-analysis","volume":"6","author":"Yang","year":"2016","journal-title":"Sci. Rep."},{"key":"B121","doi-asserted-by":"publisher","first-page":"2563508","DOI":"10.1155\/2020\/2563508","article-title":"Secreted frizzled-related protein 2 and extracellular volume fraction in patients with heart failure","volume":"2020","author":"Yang","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"B122","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12860-023-00470-9","article-title":"The DNA demethylation-regulated SFRP2 dictates the progression of endometriosis via activation of the Wnt\/\u03b2-catenin signaling pathway","volume":"24","author":"Yang","year":"2023","journal-title":"BMC Mol. Cell Biol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"1432402","DOI":"10.3389\/fimmu.2024.1432402","article-title":"SFRP2 modulates functional phenotype transition and energy metabolism of macrophages during diabetic wound healing","volume":"15","author":"Yang","year":"2024","journal-title":"Front. Immunol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1070973","DOI":"10.3389\/fphar.2023.1070973","article-title":"Post-myocardial infarction fibrosis: pathophysiology, examination, and intervention","volume":"14","author":"Yin","year":"2023","journal-title":"Front. Pharmacol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"101026","DOI":"10.1016\/j.gendis.2023.04.042","article-title":"The evolving roles of wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities","volume":"11","author":"Yu","year":"2024","journal-title":"Genes Dis."},{"key":"B126","doi-asserted-by":"publisher","first-page":"28413","DOI":"10.1038\/s41598-025-11765-6","article-title":"The prognostic value of secreted frizzled-related protein 2 in elderly patients with heart failure: a single-center retrospective study","volume":"15","author":"Yu","year":"2025","journal-title":"Sci. Rep."},{"key":"B127","doi-asserted-by":"publisher","first-page":"115344","DOI":"10.1016\/j.biopha.2023.115344","article-title":"Secreted frizzled-related proteins: a promising therapeutic target for cancer therapy through wnt signaling inhibition","volume":"166","author":"Zhang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"B128","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s13045-024-01600-2","article-title":"Cancer associated fibroblasts and metabolic reprogramming: unraveling the intricate crosstalk in tumor evolution","volume":"17","author":"Zhang","year":"","journal-title":"J. Hematol. Oncol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1016\/j.stem.2024.07.006","article-title":"A primate-specific endogenous retroviral envelope protein sequesters SFRP2 to regulate human cardiomyocyte development","volume":"31","author":"Zhang","year":"","journal-title":"Cell Stem Cell"},{"key":"B130","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41421-023-00627-y","article-title":"A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways","volume":"10","author":"Zhang","year":"","journal-title":"Cell Discov."},{"key":"B131","doi-asserted-by":"publisher","first-page":"1595362","DOI":"10.3389\/fcell.2025.1595362","article-title":"Hippo\/YAP signaling's multifaceted crosstalk in cancer","volume":"13","author":"Zhang","year":"","journal-title":"Front. Cell Dev. Biol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/s41427-025-00610-x","article-title":"Polydopamine-modified hydrogel nanofibers for sustained SFRP2 release: synergistic promotion of angiogenesis and nerve regeneration","volume":"17","author":"Zhang","year":"","journal-title":"NPG Asia Mater."},{"key":"B133","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/j.ccell.2025.02.024","article-title":"PAI-1-driven SFRP2(high) cancer-associated fibroblasts hijack the abscopal effect of radioimmunotherapy","volume":"43","author":"Zhang","year":"","journal-title":"Cancer Cell"},{"key":"B134","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.cca.2020.01.010","article-title":"A novel plasma based early colorectal cancer screening assay base on methylated SDC2 and SFRP2","volume":"503","author":"Zhao","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"B135","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.7150\/jca.52478","article-title":"Methylated SFRP2 and SDC2 in stool specimens for colorectal cancer early detection: a cost-effective strategy for Chinese population","volume":"12","author":"Zhao","year":"2021","journal-title":"J. Cancer"},{"key":"B136","doi-asserted-by":"publisher","first-page":"166989","DOI":"10.1016\/j.bbadis.2023.166989","article-title":"Secreted frizzled-related protein 2 ameliorates diabetic cardiomyopathy by activating mitophagy","volume":"1870","author":"Zheng","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B137","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1002\/1873-3468.13291","article-title":"Synergistic effect of PCPE1 and sFRP2 on the processing of procollagens via BMP1","volume":"593","author":"Zhu","year":"2019","journal-title":"FEBS Lett."},{"key":"B138","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1002\/ijc.21045","article-title":"Aberrant methylation of secreted frizzled-related protein genes in esophageal adenocarcinoma and barrett's esophagus","volume":"116","author":"Zou","year":"2005","journal-title":"Int. J. Cancer"}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2026.1951467\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T08:12:13Z","timestamp":1788423133000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2026.1951467\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,3]]},"references-count":140,"alternative-id":["10.3389\/fcell.2026.1951467"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2026.1951467","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,3]]},"article-number":"1951467"}}