{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:05:13Z","timestamp":1790661913688,"version":"4.1.0"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hepatocellular carcinoma (HCC) remains one of the most prevalent malignancies worldwide, with high recurrence rates and chemotherapy resistance posing major clinical challenges. Cancer stem cells (CSCs) are recognized as an important contributors of HCC initiation, metastasis, and recurrence. Within the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) can maintain CSC properties through intercellular communication. Exosomes serve as essential mediators of this process by delivering long noncoding RNAs (lncRNAs) from various TME cells (including CAFs, MSCs, macrophages, and HCC cells themselves) to recipient HCC cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature search of PubMed and Web of Science Core Collection (inception to March 2026) was conducted using key terms including \u201cHCC\u201d, \u201cCAFs\u201d, \u201cMSCs\u201d, \u201cMacrophages\u201d, \u201cExosome\u201d, \u201cLncRNA\u201d, and \u201cNeoplastic Stem Cells\u201d. Studies were selected based on topic relevance and methodological rigor; those with incomplete or inaccessible data were excluded. The retrieved literature was synthesized to elucidate the mechanisms by which lncRNAs modulate downstream signaling pathways and to evaluate their translational potential as diagnostic biomarkers and therapeutic targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This review identifies multiple mechanisms through which stromal or exosome derived lncRNAs regulate HCC cell stemness, including YAP liquid\u2013liquid phase separation, chromatin remodeling via recruitment of SWI\/SNF, INO80, NuRD, and BRM\/BRG1 complexes, Wnt\/\u03b2-catenin pathway modulation through protein stabilization and competing endogenous RNA (ceRNA) networks, STAT3 pathway regulation via direct transcriptional repression and transcription factor recruitment, and BMP signaling pathway engagement. Functional classification reveals that these lncRNAs converge on core stemness pathways through complementary transcriptional, posttranscriptional, and protein-level regulatory mechanisms, while integrating signals from the TME.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Stromal or exosome derived lncRNAs constitute a critical regulatory layer in HCC stemness maintenance and hold significant promise as noninvasive diagnostic biomarkers via liquid biopsy. Antisense oligonucleotide (ASO)-based therapeutic strategies targeting the stromal cell\u2013lncRNA\u2013CSC axis represent a promising direction. Nevertheless, systematic characterization of stromal or exosome derived lncRNA species, elucidation of lncRNA sorting and uptake mechanisms, and clinical validation of biomarker and therapeutic applications remain important challenges for future investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcell.2026.1957154","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:46:53Z","timestamp":1790660813000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Stromal or exosome derived lncRNAs regulate stemness in hepatocellular carcinoma"],"prefix":"10.3389","volume":"14","author":[{"given":"Tianyu","family":"Gao","sequence":"first","affiliation":[{"name":"Baotou Medical College, Inner Mongolia University of Science and Technology","place":["Baotou, Inner Mongolia, China"]},{"name":"Department of Oncology, Inner Mongolia People\u2019s Hospital","place":["Hohhot, Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology, Inner Mongolia People\u2019s Hospital","place":["Hohhot, Inner Mongolia, China"]},{"name":"Inner Mongolia Medical University","place":["Hohhot, Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Baotou Medical College, Inner Mongolia University of Science and Technology","place":["Baotou, Inner Mongolia, China"]},{"name":"Department of Oncology, Inner Mongolia People\u2019s Hospital","place":["Hohhot, Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Oncology, Inner Mongolia People\u2019s Hospital","place":["Hohhot, Inner Mongolia, China"]},{"name":"Inner Mongolia Medical University","place":["Hohhot, Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Oncology, Inner Mongolia People\u2019s Hospital","place":["Hohhot, Inner Mongolia, China"]},{"name":"Inner Mongolia Medical University","place":["Hohhot, Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology, Inner Mongolia People\u2019s Hospital","place":["Hohhot, Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Oncology, Inner Mongolia People\u2019s Hospital","place":["Hohhot, Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Baotou Tumor Hospital","place":["Baotou, Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Inner Mongolia People\u2019s Hospital","place":["Hohhot, Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e0778","DOI":"10.1097\/HC9.0000000000000778","article-title":"Secreted lumican from the tumor microenvironment potentiates HCC stemness and progression","volume":"9","author":"Chan","year":"2025","journal-title":"Hepatol. Commun."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.3390\/cells9041020","article-title":"Targeting the epigenetic non-coding RNA MALAT1\/Wnt signaling axis as a therapeutic approach to suppress stemness and metastasis in hepatocellular carcinoma","volume":"9","author":"Chang","year":"2020","journal-title":"Cells"},{"key":"B3","doi-asserted-by":"publisher","first-page":"12598","DOI":"10.1038\/ncomms12598","article-title":"LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression","volume":"7","author":"Chen","year":"2016","journal-title":"Nat. Commun."},{"key":"B4","doi-asserted-by":"publisher","first-page":"14433","DOI":"10.18632\/aging.203059","article-title":"Chronic alcohol exposure promotes HCC stemness and metastasis through \u03b2-catenin\/miR-22-3p\/TET2 axis","volume":"13","author":"Chen","year":"2021","journal-title":"Aging (Albany NY)."},{"key":"B5","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1186\/s12964-025-02256-2","article-title":"The cancer-associated fibroblast facilitates YAP liquid-liquid phase separation to promote cancer cell stemness in HCC","volume":"23","author":"Chen","year":"2025","journal-title":"Cell Commun. Signal"},{"key":"B6","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1186\/s12943-015-0426-x","article-title":"CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA","volume":"14","author":"Conigliaro","year":"2015","journal-title":"Mol. Cancer"},{"key":"B7","doi-asserted-by":"publisher","first-page":"120974","DOI":"10.1016\/j.lfs.2022.120974","article-title":"Functional roles of lncRNA-TUG1 in hepatocellular carcinoma","volume":"308","author":"Farzaneh","year":"2022","journal-title":"Life Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e82090","DOI":"10.7759\/cureus.82090","article-title":"Tumor microenvironment: a complex landscape of cancer development and drug resistance","volume":"17","author":"Fatima","year":"2025","journal-title":"Cureus"},{"key":"B9","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.jhep.2015.05.016","article-title":"Hotair mediates hepatocarcinogenesis through suppressing miRNA-218 expression and activating P14 and P16 signaling","volume":"63","author":"Fu","year":"2015","journal-title":"J. Hepatol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.bbrc.2020.04.142","article-title":"Matrine reduces the secretion of exosomal circSLC7A6 from cancer-associated fibroblast to inhibit tumorigenesis of colorectal cancer by regulating CXCR5","volume":"527","author":"Gu","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1007\/s13577-021-00599-9","article-title":"Mesenchymal stem cell-derived exosomes block malignant behaviors of hepatocellular carcinoma stem cells through a lncRNA C5orf66-AS1\/microRNA-127-3p\/DUSP1\/ERK axis","volume":"34","author":"Gu","year":"2021","journal-title":"Hum. Cell"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1158\/1078-0432.CCR-14-3106","article-title":"ICAM-1-Related noncoding RNA in cancer stem cells maintains ICAM-1 expression in hepatocellular carcinoma","volume":"22","author":"Guo","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-019-0328-x","article-title":"Silencing of long noncoding RNA HOXA11-AS inhibits the Wnt signaling pathway via the upregulation of HOXA11 and thereby inhibits the proliferation, invasion, and self-renewal of hepatocellular carcinoma stem cells","volume":"51","author":"Guo","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2908","DOI":"10.1002\/jcb.26823","article-title":"Interaction of lncRNA-MALAT1 and miR-124 regulates HBx-induced cancer stem cell properties in HepG2 through PI3K\/Akt signaling","volume":"120","author":"He","year":"2019","journal-title":"J. Cell Biochem."},{"key":"B15","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s12943-017-0734-4","article-title":"Dysregulated long noncoding RNAs (lncRNAs) in hepatocellular carcinoma: implications for tumorigenesis, disease progression, and liver cancer stem cells","volume":"16","author":"Huo","year":"2017","journal-title":"Mol. Cancer"},{"key":"B16","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.jhep.2017.04.009","article-title":"Non-coding RNA in hepatocellular carcinoma: mechanisms, biomarkers and therapeutic targets","volume":"67","author":"Klingenberg","year":"2017","journal-title":"J. Hepatol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.3390\/ijms21061927","article-title":"NEAT1 is required for the expression of the liver cancer stem cell marker CD44","volume":"21","author":"Koyama","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"548335","DOI":"10.3389\/fcell.2020.548335","article-title":"Recent advances in liver cancer stem cells: Non-coding RNAs, oncogenes and oncoproteins","volume":"8","author":"Li","year":"2020","journal-title":"Front. Cell Dev. Bio."},{"key":"B19","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.scib.2025.12.022","article-title":"Global, regional, and national burden of hepatocellular carcinoma and contribution of nine modifiable risk factors across 185 countries\/territories in 2022","volume":"71","author":"Li","year":"2026","journal-title":"Sci. Bull. (Beijing)"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2610","DOI":"10.3390\/cells11162610","article-title":"LPAL2 suppresses tumor growth and metastasis of hepatocellular carcinoma by modulating MMP9 expression","volume":"11","author":"Lin","year":"2022","journal-title":"Cells"},{"key":"B21","doi-asserted-by":"publisher","first-page":"3742","DOI":"10.3390\/ijms19123742","article-title":"Long non-coding RNAs as mediators of tumor microenvironment and liver cancer cell communication","volume":"19","author":"Lin","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1016\/j.apsb.2021.01.001","article-title":"The biology, function, and applications of exosomes in cancer","volume":"11","author":"Liu","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"B23","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.stem.2024.04.004","article-title":"Hallmarks of cancer stemness","volume":"31","author":"Loh","year":"2024","journal-title":"Cell Stem Cell"},{"key":"B24","doi-asserted-by":"publisher","first-page":"625","DOI":"10.3727\/096504017X14953948675395","article-title":"Long noncoding RNA lncCAMTA1 promotes proliferation and cancer stem cell-like properties of liver cancer by inhibiting CAMTA1","volume":"26","author":"Lu","year":"2018","journal-title":"Oncol. Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s11658-022-00309-9","article-title":"Exosomal lncRNA TUG1 from cancer-associated fibroblasts promotes liver cancer cell migration, invasion, and glycolysis by regulating the miR-524-5p\/SIX1 axis","volume":"27","author":"Lu","year":"2022","journal-title":"Cell Mol. Biol. Lett."},{"key":"B26","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.canlet.2018.01.001","article-title":"Noncoding RNAs in liver cancer stem cells: the big impact of little things","volume":"418","author":"Lv","year":"2018","journal-title":"Cancer Lett."},{"key":"B27","doi-asserted-by":"publisher","first-page":"117177","DOI":"10.1016\/j.taap.2024.117177","article-title":"CALML3-AS1 enhances malignancies and stemness of small cell lung cancer cells through interacting with DAXX protein and promoting GLUT4-mediated aerobic glycolysis","volume":"495","author":"Mao","year":"2025","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1111\/liv.15230","article-title":"Long non-coding RNA H19 as a biomarker for hepatocellular carcinoma","volume":"42","author":"Rojas","year":"2022","journal-title":"Liver Int."},{"key":"B29","doi-asserted-by":"publisher","first-page":"711","DOI":"10.3390\/ijms23020711","article-title":"NEAT1 confers radioresistance to hepatocellular carcinoma cells by inducing autophagy through GABARAP","volume":"23","author":"Sakaguchi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"684","DOI":"10.3390\/cancers12030684","article-title":"The cancer stem cell in hepatocellular carcinoma","volume":"12","author":"Schulte","year":"2020","journal-title":"Cancers (Basel)"},{"key":"B31","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1038\/s41419-022-05424-1","article-title":"The long noncoding RNA TINCR promotes self-renewal of human liver cancer stem cells through autophagy activation","volume":"13","author":"Shi","year":"2022","journal-title":"Cell Death Dis."},{"key":"B32","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s13046-021-01854-5","article-title":"LINC00680 enhances hepatocellular carcinoma stemness behavior and chemoresistance by sponging miR-568 to upregulate AKT3","volume":"40","author":"Shu","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1186\/s13046-025-03546-w","article-title":"A novel lncRNA-mediated signaling axis governs cancer stemness and splicing reprogramming in hepatocellular carcinoma with therapeutic potential","volume":"44","author":"Si","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41419-020-2274-x","article-title":"LncRNA RUNX1-IT1 which is downregulated by hypoxia-driven histone deacetylase 3 represses proliferation and cancer stem-like properties in hepatocellular carcinoma cells","volume":"11","author":"Sun","year":"2020","journal-title":"Cell Death Dis."},{"key":"B35","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.fob.2014.04.007","article-title":"Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer","volume":"4","author":"Takahashi","year":"2014","journal-title":"FEBS Open Bio"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the international society for extracellular vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J. Extracell. Vesicles"},{"key":"B37","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s12964-020-00602-0","article-title":"lncRNA HOTAIR overexpression induced downregulation of c-Met signaling promotes hybrid epithelial\/mesenchymal phenotype in hepatocellular carcinoma cells","volume":"18","author":"Topel","year":"2020","journal-title":"Cell Commun. Signal"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1002\/2211-5463.70042","article-title":"Long non\u2010coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application","volume":"15","author":"Tran","year":"2025","journal-title":"FEBS Open Bio."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1038\/s41416-020-0823-9","article-title":"Cancer stemness in hepatocellular carcinoma: mechanisms and translational potential","volume":"122","author":"Tsui","year":"2020","journal-title":"Br. J. Cancer"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1002\/hep.27239","article-title":"Oncofetal long noncoding RNA PVT1 promotes proliferation and stem cell-like property of hepatocellular carcinoma cells by stabilizing NOP2","volume":"60","author":"Wang","year":"2014","journal-title":"Hepatology"},{"key":"B41","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.stem.2015.03.003","article-title":"The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling","volume":"16","author":"Wang","year":"2015","journal-title":"Cell Stem Cell"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1016\/j.jhep.2016.01.019","article-title":"Long non-coding RNA DILC regulates liver cancer stem cells via IL-6\/STAT3 axis","volume":"64","author":"Wang","year":"2016","journal-title":"J. Hepatol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"e101110","DOI":"10.15252\/embj.2018101110","article-title":"LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling","volume":"38","author":"Wang","year":"2019","journal-title":"EMBO J."},{"key":"B44","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.canlet.2021.01.011","article-title":"Tumor-associated mesenchymal stem cells promote hepatocellular carcinoma metastasis via a DNM3OS\/KDM6B\/TIAM1 axis","volume":"503","author":"Wang","year":"2021","journal-title":"Cancer Lett."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1593827","DOI":"10.3389\/fonc.2025.1593827","article-title":"Tumor-derived exosomal lncRNA SNHG4 promotes triple-negative breast cancer progression by targeting XPO5","volume":"15","author":"Wang","year":"2025","journal-title":"Front. Oncol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s13577-016-0147-5","article-title":"Long noncoding RNA TCF7 promotes invasiveness and self-renewal of human non-small cell lung cancer cells","volume":"30","author":"Wu","year":"2017","journal-title":"Hum. Cell"},{"key":"B47","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.jhep.2018.12.015","article-title":"The long non-coding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of hedgehog signaling","volume":"70","author":"Wu","year":"2019","journal-title":"J. Hepatol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s40364-022-00387-z","article-title":"The role of YAP1 in liver cancer stem cells: proven and potential mechanisms","volume":"10","author":"Wu","year":"2022","journal-title":"Biomark. Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"2320","DOI":"10.7150\/ijbs.33750","article-title":"Exosomal miRNA-139 in cancer-associated fibroblasts inhibits gastric cancer progression by repressing MMP11 expression","volume":"15","author":"Xu","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1186\/s13046-022-02458-3","article-title":"Tumor associated macrophages-derived exosomes facilitate hepatocellular carcinoma malignance by transferring lncMMPA to tumor cells and activating glycolysis pathway","volume":"41","author":"Xu","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"6704","DOI":"10.1158\/0008-5472.CAN-17-1915","article-title":"Mesenchymal stem cells promote hepatocarcinogenesis via lncRNA-MUF interaction with ANXA2 and miR-34a","volume":"77","author":"Yan","year":"2017","journal-title":"Cancer Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13062-023-00376-8","article-title":"TM4SF1 upregulates MYH9 to activate the NOTCH pathway to promote cancer stemness and lenvatinib resistance in HCC","volume":"18","author":"Yang","year":"2023","journal-title":"Biol. Direct"},{"key":"B53","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.canlet.2019.11.001","article-title":"Macrophages-induced long noncoding RNA H19 up-regulation triggers and activates the miR-193b\/MAPK1 axis and promotes cell aggressiveness in hepatocellular carcinoma","volume":"469","author":"Ye","year":"2020","journal-title":"Cancer Lett."},{"key":"B54","doi-asserted-by":"publisher","first-page":"e68263","DOI":"10.7554\/elife.68263","article-title":"PHAROH lncRNA regulates Myc translation in hepatocellular carcinoma via sequestering TIAR","volume":"10","author":"Yu","year":"2021","journal-title":"Elife"},{"key":"B55","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1002\/hep.27893","article-title":"Long noncoding RNA DANCR increases stemness features of hepatocellular carcinoma by derepression of CTNNB1","volume":"63","author":"Yuan","year":"2016","journal-title":"Hepatology"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1002\/hep.30153","article-title":"A transforming growth Factor-\u03b2 and H19 signaling axis in tumor-initiating hepatocytes that regulates hepatic carcinogenesis","volume":"69","author":"Zhang","year":"2019","journal-title":"Hepatology"},{"key":"B58","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s12943-019-1044-9","article-title":"The molecular mechanism of LncRNA34a-mediated regulation of bone metastasis in hepatocellular carcinoma","volume":"18","author":"Zhang","year":"2019","journal-title":"Mol. Cancer"},{"key":"B59","doi-asserted-by":"publisher","first-page":"3197","DOI":"10.1111\/cas.13740","article-title":"Long noncoding RNA n339260 promotes vasculogenic mimicry and cancer stem cell development in hepatocellular carcinoma","volume":"109","author":"Zhao","year":"2018","journal-title":"Cancer Sci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1002\/jcp.30599","article-title":"LINC00662: a new oncogenic lncRNA with great potential","volume":"237","author":"Zhong","year":"2022","journal-title":"J. Cell Physiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"13608","DOI":"10.1038\/ncomms13608","article-title":"LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells","volume":"7","author":"Zhu","year":"","journal-title":"Nat. Commun."},{"key":"B62","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/nsmb.3235","article-title":"lnc-\u03b2-Catm elicits EZH2-dependent \u03b2-catenin stabilization and sustains liver CSC self-renewal","volume":"23","author":"Zhu","year":"","journal-title":"Nat. Struct. Mol. Biol."}],"container-title":["Frontiers in Cell and Developmental Biology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2026.1957154\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:46:54Z","timestamp":1790660814000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcell.2026.1957154\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":61,"alternative-id":["10.3389\/fcell.2026.1957154"],"URL":"https:\/\/doi.org\/10.3389\/fcell.2026.1957154","relation":{},"ISSN":["2296-634X"],"issn-type":[{"value":"2296-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"article-number":"1957154"}}