{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:00:34Z","timestamp":1790586034621,"version":"4.1.0"},"reference-count":132,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004333"],"award-info":[{"award-number":["82004333"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ21H290002"],"award-info":[{"award-number":["LQ21H290002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY24H270009"],"award-info":[{"award-number":["LY24H270009"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cell Dev. Biol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Correa cascade foregrounds infection, inflammation, and epithelial change but does not fully explain how the physical tissue environment influences progression from atrophy to metaplasia and dysplasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We integrated human observations, gastric organoid and animal perturbation studies, advanced gastric-cancer experiments, and cross-tissue evidence using the Gastric Precancer Mechanobiology Evidence Stratification framework, which ranks evidence by proximity to causal human precancerous mechanics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Direct human mechanical measurements remain sparse and methodologically heterogeneous, precluding a universal stiffening trajectory. YAP has the strongest functional support across gastric regeneration and metaplastic remodeling, integrin\u2013adhesion signaling is convergent but mechanically under-specified, and Piezo1 evidence derives mainly from advanced cancer. Three non-exclusive models\u2014mechanical driver, epithelial-first remodeling, and inflammation-mediated feedback\u2014produce distinct temporal predictions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Gastric precancer is best understood through a mechanically extended Correa framework in which static matrix properties, dynamic loading, regional anatomy, inflammatory context, and lineage state jointly determine whether injury resolves or stabilizes abnormal epithelial states. Spatial human mechanics linked to dynamic patient-derived perturbation models are required before mechanical biomarkers or pathway-directed interventions can guide clinical care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcell.2026.1970363","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T08:47:54Z","timestamp":1790585274000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The mechanical niche in gastric precancer: extracellular matrix remodeling, mechanotransduction, and stem-cell fate"],"prefix":"10.3389","volume":"14","author":[{"given":"Lanshuo","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Tongde Hospital of Zhejiang Province","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanchun","family":"Huang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhejiang Chinese Medical University","place":["Hangzhou, China"]},{"name":"Zhejiang Provincial Hospital of Traditional Chinese Medicine","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University Traditional Chinese Medicine Clinical Medical School (Xiyuan), Peking University Health Science Center","place":["Beijing, China"]},{"name":"Peking University Health Science Center","place":["Beijing, China"]},{"name":"Institute of Digestive Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeqian","family":"Wu","sequence":"additional","affiliation":[{"name":"Tongde Hospital of Zhejiang Province Affiliated to Zhejiang Chinese Medical University (College of Integrated Traditional Chinese and Western Medicine Clinical Medicine)","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangjun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tongde Hospital of Zhejiang Province","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tongde Hospital of Zhejiang Province","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Tang","sequence":"additional","affiliation":[{"name":"Institute of Digestive Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoying","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tongde Hospital of Zhejiang Province","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1111\/j.1365-2559.2005.02223.x","article-title":"Expression of a candidate marker for progenitor cells, Musashi-1, in the proliferative regions of human antrum and its decreased expression in intestinal metaplasia","volume":"47","author":"Akasaka","year":"2005","journal-title":"Histopathology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.actbio.2019.11.038","article-title":"Biomechanical and microstructural characterisation of the porcine stomach wall: Location- and layer-dependent investigations","volume":"102","author":"Bauer","year":"2020","journal-title":"Acta Biomater."},{"key":"B3","doi-asserted-by":"publisher","first-page":"80688","DOI":"10.18632\/oncotarget.12486","article-title":"Deletion of IQGAP1 promotes helicobacter pylori-induced gastric dysplasia in mice and acquisition of cancer stem cell properties in vitro","volume":"7","author":"Bessede","year":"2016","journal-title":"Oncotarget"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.3390\/ijms19041096","article-title":"Molecular characterization of gastric epithelial cells using flow cytometry","volume":"19","author":"Bockerstett","year":"2018","journal-title":"Int. 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