{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:52:44Z","timestamp":1790715164053,"version":"4.1.0"},"reference-count":83,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T00:00:00Z","timestamp":1542326400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"DOI":"10.3389\/fchem.2018.00559","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T04:46:21Z","timestamp":1542343581000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":70,"title":["SO2 Donors and Prodrugs, and Their Possible Applications: A Review"],"prefix":"10.3389","volume":"6","author":[{"given":"Wenyi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binghe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,11,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1034\/j.1600-0773.2003.930306.x","article-title":"Carbon monoxide specifically inhibits cytochrome c oxidase of human mitochondrial respiratory chain","volume":"93","author":"Alonso","year":"2003","journal-title":"Pharmacol. Toxicol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"27359","DOI":"10.1039\/c8ra03658f","article-title":"Small molecule generators of biologically reactive sulfur species","volume":"8","author":"Bora","year":"2018","journal-title":"RSC Adv."},{"key":"B3","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1021\/ar00006a001","article-title":"Hydrophobic effects on simple organic reactions in water","volume":"24","author":"Breslow","year":"2002","journal-title":"Acc. Chem. Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1152\/jappl.1990.68.2.604","article-title":"In vivo binding of carbon monoxide to cytochrome c oxidase in rat brain","volume":"68","author":"Brown","year":"1990","journal-title":"J. Appl. Physiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1289\/ehp.1002681","article-title":"Ambient air pollution and lipoprotein-associated phospholipase A(2) in survivors of myocardial infarction","volume":"119","author":"Bruske","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"B6","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/labinvest.2014.147","article-title":"Endogeous sulfur dioxide protects against oleic acid-induced acute lung injury in association with inhibition of oxidative stress in rats","volume":"95","author":"Chen","year":"2015","journal-title":"Lab. Invest."},{"key":"B7","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/S0021-9258(18)62501-3","article-title":"Hepatic Sulfite Oxidase: a functional role for molybdenum","volume":"246","author":"Cohen","year":"1971","journal-title":"J. Biol. Chem."},{"key":"B8","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1007\/s00018-013-1470-6","article-title":"Carbon dioxide-sensing in organisms and its implications for human disease","volume":"71","author":"Cummins","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1021\/acschembio.6b00106","article-title":"Benzothiazole Sulfinate: a water-soluble and slow-releasing Sulfur dioxide donor","volume":"11","author":"Day","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1111\/j.1745-7254.2008.00845.x","article-title":"Endogenously generated sulfur dioxide and its vasorelaxant effect in rats","volume":"29","author":"Du","year":"2008","journal-title":"Acta Pharmacol. Sin."},{"key":"B11","doi-asserted-by":"publisher","first-page":"341","DOI":"10.6028\/jres.090.024","article-title":"Thermodynamics of solution of SO2(g) in water and of aqueous sulfur dioxide solutions","volume":"90","author":"Goldberg","year":"1985","journal-title":"J. Res. Natl. Bur. Stand."},{"key":"B12","doi-asserted-by":"publisher","first-page":"81","DOI":"10.2486\/indhealth.23.81","article-title":"Effects of exhaust pollutant sulfur dioxide on lipid metabolism of guinea pig organs","volume":"23","author":"Haider","year":"1985","journal-title":"Ind. Health"},{"key":"B13","doi-asserted-by":"publisher","first-page":"8961951","DOI":"10.1155\/2016\/8961951","article-title":"Endogenous Sulfur dioxide: a new member of gasotransmitter family in the cardiovascular system","volume":"2016","author":"Huang","year":"2016","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"B14","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1539\/joh.L8075","article-title":"Effects of SO2 on respiratory system of adult Miyakejima resident 2 years after returning to the Island","volume":"51","author":"Iwasawa","year":"2009","journal-title":"J. Occup. Health"},{"key":"B15","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1021\/acs.orglett.6b03805","article-title":"Click and release: SO2 prodrugs with tunable release rates","volume":"19","author":"Ji","year":"2017","journal-title":"Org. Lett."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1021\/acs.accounts.8b00019","article-title":"Strategies toward organic Carbon monoxide prodrugs","volume":"51","author":"Ji","year":"2018","journal-title":"Acc. Chem. Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.niox.2013.04.008","article-title":"Sulfur dioxide preconditioning increases antioxidative capacity in rat with myocardial ischemia reperfusion (I\/R) injury","volume":"32","author":"Jin","year":"2013","journal-title":"Nitric Oxide"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1111\/j.1745-7254.2008.00864.x","article-title":"Effects of endogenous sulfur dioxide on monocrotaline-induced pulmonary hypertension in rats","volume":"29","author":"Jin","year":"2008","journal-title":"Acta Pharmacol. Sin."},{"key":"B19","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.molcel.2008.04.009","article-title":"Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway","volume":"30","author":"Kaelin","year":"2008","journal-title":"Mol. Cell"},{"key":"B20","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1681\/ASN.V115923","article-title":"Elevated levels of serum sulfite in patients with chronic renal failure","volume":"11","author":"Kajiyama","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s00726-004-0072-x","article-title":"Endogenous production of hydrogen sulfide in mammals","volume":"26","author":"Kamoun","year":"2004","journal-title":"Amino Acids"},{"key":"B22","doi-asserted-by":"publisher","first-page":"3459","DOI":"10.1039\/b505789m","article-title":"Structural analysis of missense mutations causing isolated sulfite oxidase deficiency","author":"Karakas","year":"2005","journal-title":"Dalton Trans."},{"key":"B23","doi-asserted-by":"publisher","first-page":"360815","DOI":"10.1155\/2013\/360815","article-title":"Therapeutic applications of Carbon monoxide","volume":"2013","author":"Knauert","year":"2013","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1039\/c4cc07790c","article-title":"A diarylethene as the SO2 gas generator upon UV irradiation","volume":"51","author":"Kodama","year":"2015","journal-title":"Chem. Commun."},{"key":"B25","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.snb.2016.11.132","article-title":"An aza-coumarin-hemicyanine based near-infrared fluorescent probe for rapid, colorimetric and ratiometric detection of bisulfite in food and living cells","volume":"243","author":"Li","year":"2017","journal-title":"Sens. Actuat. B"},{"key":"B26","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.atherosclerosis.2010.12.037","article-title":"Regulatory effects of sulfur dioxide on the development of atherosclerotic lesions and vascular hydrogen sulfide in atherosclerotic rats","volume":"215","author":"Li","year":"2011","journal-title":"Atherosclerosis"},{"key":"B27","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/labinvest.2010.156","article-title":"Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats","volume":"91","author":"Liang","year":"2011","journal-title":"Lab. Invest."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e1251","DOI":"10.1038\/cddis.2014.229","article-title":"Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk\/MAP kinase pathway mediated by cAMP\/PKA signaling","volume":"5","author":"Liu","year":"2014","journal-title":"Cell Death Dis."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.2174\/138955710793177421","article-title":"Sulfur dioxide: a novel gaseous signal in the regulation of cardiovascular functions","volume":"10","author":"Liu","year":"2010","journal-title":"Mini-Rev. Med. Chem."},{"key":"B30","doi-asserted-by":"publisher","first-page":"10236","DOI":"10.1039\/c5cc03055b","article-title":"A mitochondria-targeted colorimetric and ratiometric fluorescent probe for biological SO2 derivatives in living cells","volume":"51","author":"Liu","year":"2015","journal-title":"Chem. Commun."},{"key":"B31","doi-asserted-by":"publisher","first-page":"3430","DOI":"10.1039\/c5cc10505f","article-title":"A water-soluble and fast-response mitochondria-targeted fluorescent probe for colorimetric and ratiometric sensing of endogenously generated SO2 derivatives in living cells","volume":"52","author":"Liu","year":"2016","journal-title":"Chem. Commun."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1183\/09031936.00056408","article-title":"Carotid body oxygen sensing","volume":"32","author":"Lopez-Barneo","year":"2008","journal-title":"Eur. Respir. J."},{"key":"B33","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1007\/s002040050256","article-title":"Effects of sub-chronic exposure to SO2 on lipid and carbohydrate metabolism in rats","volume":"70","author":"Lovati","year":"1996","journal-title":"Arch. Toxicol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1039\/c4ob02466d","article-title":"Benzosulfones as photochemically activated sulfur dioxide (SO2) donors","volume":"13","author":"Malwal","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1021\/ol400190f","article-title":"Benzosultines as sulfur dioxide (SO2) donors","volume":"15","author":"Malwal","year":"2013","journal-title":"Org. Lett."},{"key":"B36","doi-asserted-by":"publisher","first-page":"3603","DOI":"10.1016\/j.bmcl.2012.04.048","article-title":"Synthesis and antimycobacterial activity of prodrugs of sulfur dioxide (SO2)","volume":"22","author":"Malwal","year":"","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"B37","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1021\/jm201023g","article-title":"Design, synthesis, and evaluation of thiol-activated sources of Sulfur dioxide (SO) as antimycobacterial agents","volume":"55","author":"Malwal","year":"","journal-title":"J. Med. Chem."},{"key":"B38","doi-asserted-by":"publisher","first-page":"394970","DOI":"10.1155\/2011\/394970","article-title":"Sulfurous gases as biological messengers and toxins: comparative genetics of their metabolism in model organisms","volume":"2011","author":"Mathew","year":"2011","journal-title":"J. Toxicol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1080\/08958370304476","article-title":"Oxidative damage of sulfur dioxide on various organs of mice: sulfur dioxide is a systemic oxidative damage agent","volume":"15","author":"Meng","year":"2003","journal-title":"Inhal. Toxicol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1080\/08958370390215785","article-title":"Blood pressure of rats lowered by sulfur dioxide and its derivatives","volume":"15","author":"Meng","year":"2003","journal-title":"Inhal. Toxicol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.3109\/08958370902798463","article-title":"Vasodilator effect of gaseous sulfur dioxide and regulation of its level by Ach in rat vascular tissues","volume":"21","author":"Meng","year":"2009","journal-title":"Inhal. Toxicol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1093\/mutage\/geh058","article-title":"DNA damaging effects of sulfur dioxide derivatives in cells from various organs of mice","volume":"19","author":"Meng","year":"2004","journal-title":"Mutagenesis"},{"key":"B43","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/01.shk.0000105501.75189.85","article-title":"Increased levels of serum sulfite in patients with acute pneumonia","volume":"21","author":"Mitsuhashi","year":"2004","journal-title":"Shock"},{"key":"B44","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1002\/jlb.64.5.595","article-title":"Sulfite is released by human neutrophils in response to stimulation with lipopolysaccharide","volume":"64","author":"Mitsuhashi","year":"1998","journal-title":"J. Leukoc. Biol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1097\/01.shk.0000183393.83272.de","article-title":"Oxidative stress-dependent conversion of Hydrogen Sulfide to Sulfite by activated neutrophils","volume":"24","author":"Mitsuhashi","year":"2005","journal-title":"Shock"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1021\/ja963701y","article-title":"DNA damage from sulfite autoxidation catalyzed by a nickel(II) peptide","volume":"119","author":"Muller","year":"1997","journal-title":"J. Am. Chem. Soc."},{"key":"B47","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/nature15818","article-title":"Gene therapy returns to centre stage","volume":"526","author":"Naldini","year":"2015","journal-title":"Nature"},{"key":"B48","doi-asserted-by":"publisher","first-page":"S32","DOI":"10.1086\/514920","article-title":"Antibiotic resistance caused by gram-negative multidrug efflux pumps","volume":"27","author":"Nikaido","year":"1998","journal-title":"Clin Infect Dis."},{"key":"B49","doi-asserted-by":"publisher","first-page":"2694","DOI":"10.1016\/j.bmcl.2015.04.046","article-title":"Thiol activated prodrugs of sulfur dioxide (SO2) as MRSA inhibitors","volume":"25","author":"Pardeshi","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"B50","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1021\/acs.orglett.7b02544","article-title":"Esterase sensitive self-immolative Sulfur dioxide donors","volume":"20","author":"Pardeshi","year":"2018","journal-title":"Org. Lett."},{"key":"B51","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.neuint.2007.05.016","article-title":"Hydrogen sulfide: neurochemistry and neurobiology","volume":"52","author":"Qu","year":"2008","journal-title":"Neurochem. Int."},{"key":"B52","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1093\/toxsci\/kfq010","article-title":"SO2 inhalation contributes to the development and progression of ischemic stroke in the brain","volume":"114","author":"Sang","year":"2010","journal-title":"Toxicol. Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/0167-4889(93)90006-b","article-title":"The nitric oxide and cGMP signal transduction system: regulation and mechanism of action","volume":"1178","author":"Schmidt","year":"1993","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1006\/bbrc.1994.2641","article-title":"8-Hydroxy-2\u2032-deoxyguanosine formation and DNA damage induced by Sulfur trioxide anion radicals","volume":"205","author":"Shi","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B55","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/0003-9861(56)90363-0","article-title":"Intermediary metabolism of l-cysteinesulfinic acid in animal tissues","volume":"61","author":"Singer","year":"1956","journal-title":"Arch. Biochem. Biophys."},{"key":"B56","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1146\/annurev.nu.06.070186.001143","article-title":"Metabolism of sulfur-containing amino acids","volume":"6","author":"Stipanuk","year":"1986","journal-title":"Annu. Rev. Nutr."},{"key":"B57","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.snb.2013.11.051","article-title":"A fluorescent turn-on probe based on benzo[e]indolium for bisulfite through 1,4-addition reaction","volume":"193","author":"Sun","year":"2014","journal-title":"Sens. Actuat. B"},{"key":"B58","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/labinvest.2009.102","article-title":"Effects of sulfur dioxide on hypoxic pulmonary vascular structural remodeling","volume":"90","author":"Sun","year":"2010","journal-title":"Lab. Invest."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1021\/jp983752c","article-title":"Electrochemical reduction of bisulfite in mildly acidic buffers: kinetics of sulfur dioxide bisulfite interconversion","volume":"103","author":"Tolmachev","year":"1999","journal-title":"J. Phys. Chem. A"},{"key":"B60","doi-asserted-by":"publisher","first-page":"4035","DOI":"10.1021\/jp212120h","article-title":"Characterization of sulfurous acid, sulfite, and bisulfite aerosol systems","volume":"116","author":"Townsend","year":"2012","journal-title":"J. Phys. Chem. A"},{"key":"B61","doi-asserted-by":"publisher","first-page":"3859","DOI":"10.1021\/jp0377578","article-title":"On the formation of the Sulfonate ion from Hydrated Sulfur dioxide","volume":"108","author":"Voegele","year":"2004","journal-title":"J. Phys. Chem. A"},{"key":"B62","doi-asserted-by":"publisher","first-page":"15890","DOI":"10.1039\/c4cc07748b","article-title":"A click-and-release approach to CO prodrugs","volume":"50","author":"Wang","year":"2014","journal-title":"Chem. Commun."},{"key":"B63","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.dyepig.2016.07.030","article-title":"A mitochondria-targeted colorimetric and two-photon fluorescent probe for biological SO2 derivatives in living cells","volume":"134","author":"Wang","year":"2016","journal-title":"Dyes Pigm."},{"key":"B64","doi-asserted-by":"publisher","first-page":"e0188289","DOI":"10.1371\/journal.pone.0188289","article-title":"Sulfur dioxide alleviates programmed cell death in barley aleurone by acting as an antioxidant","volume":"12","author":"Wang","year":"2017","journal-title":"PLoS ONE"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1039\/c6cc08844a","article-title":"Sulfur dioxide prodrugs: triggered release of SO2via a click reaction","volume":"53","author":"Wang","year":"2017","journal-title":"Chem. Commun."},{"key":"B66","doi-asserted-by":"publisher","first-page":"10124","DOI":"10.1039\/c7cc05392d","article-title":"Esterase-sensitive sulfur dioxide prodrugs inspired by modified Julia olefination","volume":"53","author":"Wang","year":"2017","journal-title":"Chem. Commun."},{"key":"B67","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1007\/s00395-011-0176-x","article-title":"Effect of sulfur dioxide preconditioning on rat myocardial ischemia\/reperfusion injury by inducing endoplasmic reticulum stress","volume":"106","author":"Wang","year":"","journal-title":"Basic Res. Cardiol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.lfs.2013.12.027","article-title":"Sulfur dioxide, a double-faced molecule in mammals","volume":"98","author":"Wang","year":"2014","journal-title":"Life Sci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.ejphar.2015.06.044","article-title":"Signal pathways involved in the biological effects of Sulfur dioxide","volume":"764","author":"Wang","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"B70","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s00395-011-0176-x","article-title":"Effect of sulfur dioxide preconditioning on rat myocardial ischemia\/reperfusion injury by inducing endoplasmic reticulum stress","volume":"106","author":"Wang","year":"","journal-title":"Basic Res. Cardiol."},{"key":"B71","doi-asserted-by":"crossref","first-page":"4110","DOI":"10.3760\/cma.j.issn.0366-6999.20133059","article-title":"Changes of Sulfur dioxide, nuclear factor-kappaB, and interleukin-8 levels in pediatric acute lymphoblastic leukemia with bacterial inflammation","volume":"127","author":"Wu","year":"2014","journal-title":"Chin. Med. J."},{"key":"B72","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.bios.2015.10.049","article-title":"A mitochondria-targeted ratiometric fluorescent probe for rapid, sensitive and specific detection of biological SO2 derivatives in living cells","volume":"77","author":"Xu","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biomaterials.2015.03.038","article-title":"A mitochondria-targeted ratiometric fluorescent probe to monitor endogenously generated Sulfur dioxide derivatives in living cells","volume":"56","author":"Xu","year":"2015","journal-title":"Biomaterials"},{"key":"B74","doi-asserted-by":"publisher","first-page":"625","DOI":"10.3760\/cma.j.issn.0578-1310.2014.08.016","article-title":"[Correlation between endogenous Sulfur dioxide and homocysteine in children with pulmonary arterial hypertension associated with congenital heart disease]","volume":"52","author":"Yang","year":"2014","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"B75","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.2174\/138161210791920496","article-title":"Factors that control the circulation time of nanoparticles in blood: challenges, solutions and future prospects","volume":"16","author":"Yoo","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"B76","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1021\/jacs.7b09795","article-title":"Toward direct Protein S-Persulfidation: a prodrug approach that directly delivers Hydrogen persulfide","volume":"140","author":"Yu","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"B77","doi-asserted-by":"publisher","first-page":"e003910","DOI":"10.1161\/JAHA.116.003910","article-title":"Sulfur dioxide protects against collagen accumulation in pulmonary artery in association with downregulation of the transforming growth factor beta1\/smad pathway in pulmonary hypertensive rats","volume":"5","author":"Yu","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"B78","doi-asserted-by":"publisher","first-page":"3396","DOI":"10.1021\/ol301370s","article-title":"Methylsulfonyl benzothiazole (MSBT): a selective protein thiol blocking reagent","volume":"14","author":"Zhang","year":"2012","journal-title":"Org. Lett."},{"key":"B79","doi-asserted-by":"publisher","first-page":"882","DOI":"10.3389\/fimmu.2018.00882","article-title":"The increased endogenous Sulfur dioxide acts as a compensatory mechanism for the downregulated endogenous Hydrogen sulfide pathway in the endothelial cell inflammation","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Immunol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1172\/JCI115980","article-title":"Mitochondrial oxidative stress after carbon monoxide hypoxia in the rat brain","volume":"90","author":"Zhang","year":"1992","journal-title":"J. Clin. Invest."},{"key":"B81","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1002\/tox.20628","article-title":"The negative inotropic effects of gaseous sulfur dioxide and its derivatives in the isolated perfused rat heart","volume":"27","author":"Zhang","year":"2012","journal-title":"Environ. Toxicol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.3321\/j.issn:0376-2491.2008.18.011","article-title":"[Effects of sulfur dioxide, on the proliferation and apoptosis of aorta smooth muscle cells in hypertension: experiments with rats]","volume":"88","author":"Zhao","year":"2008","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"B83","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1002\/med.21433","article-title":"Toward Hydrogen sulfide based therapeutics: critical drug delivery and developability issues","volume":"38","author":"Zheng","year":"2018","journal-title":"Med. Res. Rev."}],"container-title":["Frontiers in Chemistry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fchem.2018.00559\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T12:37:47Z","timestamp":1720787867000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fchem.2018.00559\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,16]]},"references-count":83,"alternative-id":["10.3389\/fchem.2018.00559"],"URL":"https:\/\/doi.org\/10.3389\/fchem.2018.00559","relation":{},"ISSN":["2296-2646"],"issn-type":[{"value":"2296-2646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,16]]},"article-number":"559"}}