{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:42:08Z","timestamp":1789065728962,"version":"build-2803163510"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T00:00:00Z","timestamp":1550016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["355866"],"award-info":[{"award-number":["355866"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003151","name":"Fonds de Recherche du Qu\u00e9bec - Nature et Technologies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005242","name":"Universit\u00e9 de Montr\u00e9al","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"DOI":"10.3389\/fchem.2019.00023","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T04:25:07Z","timestamp":1550031907000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Probing Anti-inflammatory Properties Independent of NF-\u03baB Through Conformational Constraint of Peptide-Based Interleukin-1 Receptor Biased Ligands"],"prefix":"10.3389","volume":"7","author":[{"given":"Azade","family":"Geranurimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin W. H.","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Quiniou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"St-Cyr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Beauregard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vadim","family":"Bernard-Gauthier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Chemtob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Lubell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,2,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1002\/chin.199908314","article-title":"ChemInform abstract: synthetic routes to lactam peptidomimetics","author":"Aube","year":"1999","journal-title":"Cheminform"},{"key":"B2","doi-asserted-by":"publisher","first-page":"11875","DOI":"10.1038\/s41598-018-30087-4","article-title":"Antenatal IL-1-dependent inflammation persists postnatally and causes retinal and sub-retinal vasculopathy in progeny","volume":"8","author":"Beaudry-Richard","year":"2018","journal-title":"Sci. Rep."},{"key":"B3","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.jmb.2012.09.021","article-title":"One target-two different binding modes: structural insights into gevokizumab and canakinumab interactions to interleukin-1\u03b2","volume":"425","author":"Blech","year":"2013","journal-title":"J. Mol. Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1139\/cjc-2014-0289","article-title":"Synthesis of azabicycloalkanone amino acid and azapeptide mimics and their application as modulators of the prostaglandin F2\u03b1 receptor for delaying preterm birth","volume":"92","author":"Bourguet","year":"2014","journal-title":"Can. J. Chem."},{"key":"B5","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1002\/psc.1337","article-title":"Examination of the active secondary structure of the peptide 101.10, an allosteric modulator of the interleukin-1 receptor, by positional scanning using \u03b2-amino \u03b3-lactams","volume":"17","author":"Boutard","year":"2011","journal-title":"J. Pept. Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/nrd1342","article-title":"Targeting IL-1 in inflammatory disease: new opportunities for therapeutic intervention","volume":"3","author":"Braddock","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"B7","doi-asserted-by":"publisher","first-page":"4951","DOI":"10.1021\/bi00616a015","article-title":"Circular dichroism of \u03b2 turns in peptides and proteins","volume":"17","author":"Bush","year":"1978","journal-title":"Biochemistry"},{"key":"B8","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1007\/s10930-013-9505-2","article-title":"Improved protease stability of the antimicrobial peptide Pin2 substituted with D-amino acids","volume":"32","author":"Carmona","year":"2013","journal-title":"Protein J."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1021\/ja410385c","article-title":"Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity","volume":"136","author":"Carney","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"B10","doi-asserted-by":"publisher","first-page":"3947","DOI":"10.4049\/jimmunol.169.7.3947","article-title":"NF-kappa B regulation in human neutrophils by nuclear I kappa B alpha: correlation to apoptosis","volume":"169","author":"Castro-Alcaraz","year":"2002","journal-title":"J. Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.preteyeres.2016.12.001","article-title":"Pharmacokinetic aspects of retinal drug delivery","volume":"57","author":"del Amo","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"key":"B12","first-page":"S1","article-title":"The IL-1 family and inflammatory diseases","volume":"20","author":"Dinarello","year":"2002","journal-title":"Clin. Exp. Rheumatol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"R147","DOI":"10.1016\/S0960-9822(99)80085-2","article-title":"Fever: links with an ancient receptor","volume":"9","author":"Dinarello","year":"1999","journal-title":"Curr. Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/nrd3800","article-title":"Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases","volume":"11","author":"Dinarello","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"B15","doi-asserted-by":"publisher","first-page":"208","DOI":"10.3389\/fnagi.2017.00208","article-title":"Microglial Activation in Traumatic Brain Injury","volume":"9","author":"Donat","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"5553","DOI":"10.1021\/jm030484k","article-title":"Design and synthesis of novel bioactive peptides and peptidomimetics","volume":"46","author":"Freidinger","year":"2003","journal-title":"J. Med. Chem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1021\/jo00340a023","article-title":"Protected lactam-bridged dipeptides for use as conformational constraints in peptides","volume":"47","author":"Freidinger","year":"1982","journal-title":"J. Org. Chem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1126\/science.7001627","article-title":"Bioactive conformation of luteinizing hormone-releasing hormone: evidence from a conformationally constrained analog","volume":"210","author":"Freidinger","year":"1980","journal-title":"Science"},{"key":"B19","first-page":"774","article-title":"Vaso-obliteration and retrolental fibroplasia","volume":"64","author":"Garner","year":"1971","journal-title":"Proc. R. Soc. Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"6126","DOI":"10.1021\/acs.orglett.8b02575","article-title":"Diversity-oriented syntheses of \u03b2-substituted \u03b1-amino \u03b3-lactam peptide mimics with constrained backbone and side chain residues","volume":"20","author":"Geranurimi","year":"2018","journal-title":"Org. Lett."},{"key":"B21","doi-asserted-by":"publisher","first-page":"a000182","DOI":"10.1101\/cshperspect.a000182","article-title":"Roles of the NF-kappaB pathway in lymphocyte development and function","volume":"2","author":"Gerondakis","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1136\/ard.61.11.960","article-title":"Potential therapeutic uses of interleukin 1 receptor antagonists in human diseases","volume":"61","author":"Hallegua","year":"2002","journal-title":"Ann. Rheum. Dis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"16384","DOI":"10.1074\/jbc.271.27.16384","article-title":"A peptide derived from a \u03b22-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation","volume":"271","author":"Hebert","year":"1996","journal-title":"J. Biol. Chem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1016\/S0140-6736(13)60178-6","article-title":"Retinopathy of prematurity","volume":"382","author":"Hellstr\u00f6m","year":"2013","journal-title":"Lancet"},{"key":"B25","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1124\/jpet.113.205443","article-title":"Detailed mechanistic analysis of gevokizumab, an allosteric anti-IL-1\u03b2 antibody with differential receptor-modulating properties","volume":"348","author":"Issafras","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B26","doi-asserted-by":"publisher","first-page":"7917","DOI":"10.1021\/ja9010628","article-title":"Positional scanning for peptide secondary structure by systematic solid-phase synthesis of amino lactam peptides","volume":"131","author":"Jamieson","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"B27","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1111\/cbdd.12042","article-title":"Peptide scanning for studying structure-activity relationships in drug discovery","volume":"81","author":"Jamieson","year":"2013","journal-title":"Chem. Biol. Drug Design"},{"key":"B28","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0029-7844(97)00176-2","article-title":"Trophoblastic apoptosis in mice with preterm delivery and its suppression by urinary trypsin inhibitor","volume":"90","author":"Kakinuma","year":"1997","journal-title":"Obstet. Gynecol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.bbapap.2005.06.005","article-title":"How to study proteins by circular dichroism","volume":"1751","author":"Kelly","year":"2005","journal-title":"Biochim. Biophys. Acta Protein Proteom."},{"key":"B30","first-page":"v","article-title":"Preface","volume-title":"Peptidomimetics I","author":"Lubell","year":"2017"},{"key":"B31","first-page":"713","article-title":"Peptides","volume-title":"Science of Synthesis","author":"Lubell","year":"2005"},{"key":"B32","first-page":"146","article-title":"Randomised, double-blind, placebo-controlled trial of IL1-trap, rilonacept, in systemic sclerosis. A phase I\/II biomarker trial","volume":"36","author":"Mantero","year":"2018","journal-title":"Clin. Exp. Rheumatol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.4049\/jimmunol.1601600","article-title":"Antenatal suppression of IL-1 protects against inflammation-induced fetal injury and improves neonatal and developmental outcomes in mice","volume":"198","author":"Nadeau-Vall\u00e9e","year":"2017","journal-title":"J. Immunol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3402","DOI":"10.4049\/jimmunol.1500758","article-title":"Novel noncompetitive IL-1 receptor-biased ligand prevents infection- and inflammation-induced preterm birth","volume":"195","author":"Nadeau-Vall\u00e9e","year":"2015","journal-title":"J. Immunol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1074\/jbc.M116.759837","article-title":"An L- to d-amino acid conversion in an endosomolytic analog of the cell-penetrating peptide TAT influences proteolytic stability, endocytic uptake, and endosomal escape","volume":"292","author":"Najjar","year":"2017","journal-title":"J. Biol. Chem."},{"key":"B36","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1517\/14728210802568764","article-title":"Emerging tocolytics: challenges in designing and testing drugs to delay preterm delivery and prolong pregnancy","volume":"13","author":"Olson","year":"2008","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1097\/00003246-199707000-00010","article-title":"Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. the interleukin-1 receptor antagonist sepsis investigator group","volume":"25","author":"Opal","year":"1997","journal-title":"Crit. Care Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.2174\/092986706777442066","article-title":"The application of Freidinger lactams and their analogs in the design of conformationally constrained peptidomimetics","volume":"13","author":"Perdih","year":"2006","journal-title":"Curr. Med. Chem."},{"key":"B39","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1530\/REP-15-0258","article-title":"Specific inhibition of C-Jun N-terminal kinase delays preterm labour and reduces mortality","volume":"150","author":"Pirianov","year":"2015","journal-title":"Reproduction"},{"key":"B40","first-page":"141","article-title":"Mid-trimester amniotic fluid interleukins (IL-1\u03b2, IL-10 and IL-18) as possible predictors of preterm delivery","volume":"25","author":"Puchner","year":"2011","journal-title":"In Vivo"},{"key":"B41","doi-asserted-by":"publisher","first-page":"6977","DOI":"10.4049\/jimmunol.180.10.6977","article-title":"Development of a novel noncompetitive antagonist of IL-1 receptor","volume":"180","author":"Quiniou","year":"2008","journal-title":"J. Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"R1009","DOI":"10.1152\/ajpregu.90766.2008","article-title":"VRQ397 (CRAVKY): a novel noncompetitive V2 receptor antagonist","volume":"297","author":"Rihakova","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1161\/ATVBAHA.113.301331","article-title":"Microglia and interleukin-1\u03b2 in ischemic retinopathy elicit microvascular degeneration through neuronal semaphorin-3A","volume":"33","author":"Rivera","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"557","DOI":"10.7326\/M16-2391","article-title":"Cytokine inhibition in patients with chronic fatigue syndrome: a randomized trial","volume":"166","author":"Roerink","year":"2017","journal-title":"Ann. Intern. Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/0002-9378(89)90172-5","article-title":"Infection and labor. III. Interleukin-1: a signal for the onset of parturition","volume":"160","author":"Romero","year":"1989","journal-title":"Am. J. Obstetr. Gynecol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1002\/bip.21288","article-title":"Insertion of multiple alpha-amino gamma-lactam (Agl) residues into a peptide sequence by solid-phase synthesis on synphase lanterns","volume":"94","author":"Ronga","year":"2010","journal-title":"Biopolymers"},{"key":"B47","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1615\/CritRevEukaryotGeneExpr.2016016525","article-title":"Cyclic peptides for protein-protein interaction targets: applications to human disease","volume":"26","author":"Rubin","year":"2016","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1039\/b915220b","article-title":"A novel dipeptidomimetic containing a cyclic threonine","volume":"46","author":"Sicherl","year":"2010","journal-title":"Chem. Commun."},{"key":"B49","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/7081_2017_204","article-title":"Aminolactam, N-aminoimidazolone, and N-aminoimdazolidinone peptide mimics","volume-title":"Peptidomimetics I","author":"St-Cyr","year":"2017"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1021\/ol1000582","article-title":"Alpha-amino-beta-hydroxy-gamma-lactam for constraining peptide Ser and Thr residue conformation","volume":"12","author":"St-Cyr","year":"2010","journal-title":"Org. Lett."},{"key":"B51","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/S0014-5793(01)02314-6","article-title":"A small peptide derived from Flt-1 (VEGFR-1) functions as an angiogenic inhibitor","volume":"494","author":"Tan","year":"2001","journal-title":"FEBS Lett."},{"key":"B52","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/j.1399-3011.1989.tb00207.x","article-title":"Crystal-state structural analysis of two \u03b3-lactam-restricted analogs of Pro-Leu-Gly-NH2","volume":"33","author":"Valle","year":"2009","journal-title":"Int. J. Pept. Protein Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"cm1","DOI":"10.1126\/scisignal.3105cm1","article-title":"Interleukin-1 (IL-1) pathway","volume":"3","author":"Weber","year":"2010","journal-title":"Sci. Signal."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1167\/iovs.15-17411","article-title":"Vascular normalization by ROCK inhibitor: therapeutic potential of Ripasudil (K-115) eye drop in retinal angiogenesis and hypoxia","volume":"57","author":"Yamaguchi","year":"2016","journal-title":"Invest. Ophthamol. Vis. Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.jsgi.2005.06.006","article-title":"Effect of stimulation and antagonism of interleukin-1 signaling on preterm delivery in mice","volume":"12","author":"Yoshimura","year":"2005","journal-title":"J. Soc. Gynecol. Investig."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1021\/jm00402a031","article-title":"Dopamine receptor modulation by conformationally constrained analogs of Pro-Leu-Gly-NH2","volume":"31","author":"Yu","year":"1988","journal-title":"J. Med. Chem."},{"key":"B57","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1006\/bbrc.1996.1028","article-title":"A superactive peptidomimetic analog of a farnesylated dodecapeptide yeast pheromone","volume":"224","author":"Zhang","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Frontiers in Chemistry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fchem.2019.00023\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T04:25:13Z","timestamp":1550031913000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fchem.2019.00023\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,13]]},"references-count":57,"alternative-id":["10.3389\/fchem.2019.00023"],"URL":"https:\/\/doi.org\/10.3389\/fchem.2019.00023","relation":{},"ISSN":["2296-2646"],"issn-type":[{"value":"2296-2646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,13]]},"article-number":"23"}}