{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:48:29Z","timestamp":1753890509268,"version":"3.41.2"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p>Herein, we report an efficient method for the synthesis of (Z)-\u03b2-halovinyl ketones through a one-pot Sonogashira coupling and hydrohalogenation reaction promoted by palladium-copper catalyst and Br\u00f8nsted acid. The ynone intermediates are generated <jats:italic>in situ<\/jats:italic> from readily available acid chlorides and terminal alkynes at room temperature, which are directly converted to (Z)-\u03b2-halovinyl ketones by treating with triflic acid. This method avoids the use of an external halogen source and features broad substrate scope, high yield, and good to excellent stereoselectivity.<\/jats:p>","DOI":"10.3389\/fchem.2020.621545","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T13:20:15Z","timestamp":1619097615000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["One-Pot Synthesis of (Z)-\u03b2-Halovinyl Ketones via the Cascade of Sonogashira Coupling and Hydrohalogenation"],"prefix":"10.3389","volume":"8","author":[{"given":"Fa-Jie","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenguo","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daesung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanzhi","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1021\/ar980063a","article-title":"Anionic Pd(0) and Pd(II) intermediates in palladium-catalyzed heck and cross-coupling reactions","volume":"33","author":"Amatore","year":"2000","journal-title":"Acc. 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