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We determined the major ingredients and additives in twelve unused cannabis vape oil cartridge samples obtained before (<jats:italic>n<\/jats:italic> = 2) and during the EVALI outbreak (<jats:italic>n<\/jats:italic> = 10) in California from September 2018 to December 2019. We tested for major constituents in vape oil liquid, vape oil vapor, and vape oil aerosol phases. A nontargeted Gas Chromatography Mass Spectrometry direct injection screening method was developed for vape oils, a headspace heating module used for vape oil vapors and a solid-phase microextraction (SPME) vaping rig for aerosols generated by vaping. We have identified more than 100 terpenes and natural extracts, 19 cannabinoids, and other potential toxic additives such as Vitamin E Acetate, Polyethylene Glycols, and Medium Chain Triglycerides. We determined more terpenes and minor cannabinoids can be produced <jats:italic>via<\/jats:italic> vaporizing and aerosolizing the vape oil. Delta9-THC and potential toxic additives were found at lower levels in the vapor and aerosol than in the vape liquid.<\/jats:p>","DOI":"10.3389\/fchem.2021.694905","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T05:53:12Z","timestamp":1626846792000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":51,"title":["Major Constituents of Cannabis Vape Oil Liquid, Vapor and Aerosol in California Vape Oil Cartridge Samples"],"prefix":"10.3389","volume":"9","author":[{"given":"Weihong","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Vrdoljak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ven-Chi","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahman","family":"Moezzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"key":"B4","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1164\/rccm.202003-0654le","article-title":"Potential of Ethenone (Ketene) to Contribute to E-Cigarette, or Vaping, Product Use-Associated Lung Injury","volume":"202","author":"Attfield","year":"2020","journal-title":"Am. 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