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Chem."],"abstract":"<jats:p>This study developed a cost-efficient hydration\/asymmetric transfer hydrogenation (ATH) process for the one-pot synthesis of valuable chiral alcohols from alkynes. During this process, the initial homogeneous cobaloxime-catalyzed hydration of alkynes was followed by heterogeneous Ru\/diamine-catalyzed ATH transformation of the <jats:italic>in-situ<\/jats:italic> generated ketones, which provided varieties of chiral alcohols in good yields with up to 99% <jats:italic>ee<\/jats:italic> values. The immobilized Ru\/diamine catalyst could be recycled at least three times before its deactivation in the sequential reaction system. This work shows a general method for developing one-pot asymmetric sequential catalysis towards sustainable organic synthesis.<\/jats:p>","DOI":"10.3389\/fchem.2021.732542","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T06:16:18Z","timestamp":1632291378000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrated Cobaloxime and Mesoporous Silica-Supported Ruthenium\/Diamine Co-Catalysis for One-Pot Hydration\/Reduction Enantioselective Sequential Reaction of Alkynes"],"prefix":"10.3389","volume":"9","author":[{"given":"Zeyang","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaihong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haocheng","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanli","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoming","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxia","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,9,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3079","DOI":"10.1021\/cr0201068","article-title":"Transition-Metal-Catalyzed Addition of Heteroatom\u2212Hydrogen Bonds to Alkynes","volume":"104","author":"Alonso","year":"2004","journal-title":"Chem. 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