{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:42:37Z","timestamp":1781786557773,"version":"3.54.5"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p>Structures containing galactose and GalNAc residues are specifically recognized by asialoglycoprotein receptors, allowing them to selectively internalize by hepatocytes for drug-targeting delivery. However, methods for direct synthesis of GalNAc glycosides are still challenging due to the poor participating group of 2-acetamido. Here, we develop a facile strategy to synthesize various GalNAc glycosides by employing a series of rare earth metal triflates, and the results demonstrate that both <jats:italic>\u03b1<\/jats:italic>-glycosides and <jats:italic>\u03b2<\/jats:italic>-glycosides of GalNAc can be obtained by conducting with Hf(OTf)<jats:sub>4<\/jats:sub> and Sc(OTf)<jats:sub>3<\/jats:sub>, respectively. These applicable results indicate that any interested GalNAc-containing substrates could be prepared by this simple strategy.<\/jats:p>","DOI":"10.3389\/fchem.2022.1029911","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T09:17:54Z","timestamp":1666775874000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Selective synthesis of \u03b1- and \u03b2-glycosides of N-acetyl galactosamine using rare earth metal triflates"],"prefix":"10.3389","volume":"10","author":[{"given":"Jiajia","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihao","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"18760","DOI":"10.1002\/ange.202103768","article-title":"Enzyme-cleavable linkers for protein chemical synthesis through solid-phase ligations","volume":"60","author":"Abboud","year":"2021","journal-title":"Angew. 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