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Supramolecular nanomedicines made from <jats:italic>in-situ<\/jats:italic> self-assembling peptides have emerged as a promising strategy in designing and fabricating nanomedicines. <jats:italic>In-situ<\/jats:italic> self-assambly (SA) allows the combination of nanomedicines approach with prodrug approach, which exhibited both advantages of these strategies while addressed the problems of both and thus receiving more and more research attention. In this review, we summarized recently designed supramolecular nanomedicines of <jats:italic>in-situ<\/jats:italic> SA peptides in the manner of applications and design principles, and the interaction between the materials and biological environments was also discussed.<\/jats:p>","DOI":"10.3389\/fchem.2022.815551","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T05:59:56Z","timestamp":1643954396000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Supramolecular Nanomedicines of In-Situ Self-Assembling Peptides"],"prefix":"10.3389","volume":"10","author":[{"given":"Ying","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"735","DOI":"10.3390\/biom9110735","article-title":"Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements","volume":"9","author":"Aggarwal","year":"2019","journal-title":"Biomolecules"},{"key":"B2","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1021\/acsnano.9b08209","article-title":"A Near-Infrared Peptide Probe with Tumor-Specific Excretion-Retarded Effect for Image-Guided Surgery of Renal Cell Carcinoma","volume":"14","author":"An","year":"2020","journal-title":"ACS Nano"},{"key":"B3","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/nbt.3330","article-title":"Principles of Nanoparticle Design for Overcoming Biological Barriers to Drug Delivery","volume":"33","author":"Blanco","year":"2015","journal-title":"Nat. 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