{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T08:48:02Z","timestamp":1786783682418,"version":"build-2736575974"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p>The combination of photothermal therapy (PTT) and chemotherapy can remarkably improve the permeability of the cell membrane and reduce the concentration of chemotherapy agents that not only kill the tumor cells effectively but also have adverse effects on normal tissues. It is of great meaning to construct nanomaterials that could be simultaneously applied for tumor eradication with PTT and chemotherapy. In this work, we developed a novel gold nanorod coated with mesoporous organosilica nanoparticles (oMSN-GNR), which presented as an optimal photothermal contrast agent. Moreover, after doxorubicin loading (oMSN-GNR\u2013DOX), the organosilica shell exhibited biodegradable properties under high glutathione in the tumor microenvironment, resulting in massively releasing doxorubicin to kill tumor cells. More importantly, the hyperthermia effect of GNR cores under near-infrared light provided promising opportunities for localized photothermal ablation <jats:italic>in vivo<\/jats:italic>. Therefore, the combination of precise chemotherapy and highly effective PTT successfully inhibited tumor growth in liver tumor-bearing mice. This versatile synergistic therapy with local heating and chemotherapeutics precise release opens up the potential clinical application of PTT and chemotherapy therapeutics for malignant tumor eradication.<\/jats:p>","DOI":"10.3389\/fchem.2022.842682","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T09:14:09Z","timestamp":1645780449000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Glutathione-Sensitive Mesoporous Organosilica-Coated Gold Nanorods as Drug Delivery System for Photothermal Therapy-Enhanced Precise Chemotherapy"],"prefix":"10.3389","volume":"10","author":[{"given":"Hui","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingwei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beibei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianhai","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianzhao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1021\/mp5000482","article-title":"Redox Potential Ultrasensitive Nanoparticle for the Targeted Delivery of Camptothecin to HER2-Positive Cancer Cells","volume":"11","author":"Bahadur","year":"2014","journal-title":"Mol. Pharmaceutics"},{"key":"B2","doi-asserted-by":"publisher","first-page":"8884","DOI":"10.1039\/c5nr00473j","article-title":"Combined Chemo- and Photo-thermal Therapy Delivered by Multifunctional Theranostic Gold Nanorod-Loaded Microcapsules","volume":"7","author":"Chen","year":"2015","journal-title":"Nanoscale"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.jconrel.2011.01.030","article-title":"Glutathione-responsive Nano-Vehicles as a Promising Platform for Targeted Intracellular Drug and Gene Delivery","volume":"152","author":"Cheng","year":"2011","journal-title":"J. Controlled Release"},{"key":"B4","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.lungcan.2014.08.012","article-title":"Chemotherapy for Locally Advanced and Metastatic Pulmonary Carcinoid Tumors","volume":"86","author":"Chong","year":"2014","journal-title":"Lung Cancer"},{"key":"B5","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/nrc3672","article-title":"Thermal Ablation of Tumours: Biological Mechanisms and Advances in Therapy","volume":"14","author":"Chu","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"B6","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1038\/nrclinonc.2012.99","article-title":"Reducing the Toxicity of Cancer Therapy: Recognizing Needs, Taking Action","volume":"9","author":"Cleeland","year":"2012","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.canlet.2008.04.026","article-title":"Gold Nanorod Assisted Near-Infrared Plasmonic Photothermal Therapy (PPTT) of Squamous Cell Carcinoma in Mice","volume":"269","author":"Dickerson","year":"2008","journal-title":"Cancer Lett."},{"key":"B8","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.canlet.2005.07.035","article-title":"Selective Laser Photo-thermal Therapy of Epithelial Carcinoma Using Anti-EGFR Antibody Conjugated Gold Nanoparticles","volume":"239","author":"Elsayed","year":"2006","journal-title":"Cancer Lett."},{"key":"B9","doi-asserted-by":"publisher","first-page":"221","DOI":"10.7497\/j.issn.2095-3941.2012.04.002","article-title":"Functionalized Gold Nanorods for Tumor Imaging and Targeted Therapy","volume":"9","author":"Gui","year":"2012","journal-title":"Cancer Biol. Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1146\/annurev.physchem.57.032905.104533","article-title":"Coherent Excitation of Vibrational Modes in Metallic Nanoparticles","volume":"57","author":"Hartland","year":"2006","journal-title":"Annu. Rev. Phys. Chem."},{"key":"B11","doi-asserted-by":"publisher","first-page":"3832","DOI":"10.1002\/adma.200800921","article-title":"Enhancing the Toxicity of Cancer Chemotherapeutics with Gold Nanorod Hyperthermia","volume":"20","author":"Hauck","year":"2008","journal-title":"Adv. Mater."},{"key":"B12","doi-asserted-by":"publisher","first-page":"13549","DOI":"10.1073\/pnas.2232479100","article-title":"Nanoshell-mediated Near-Infrared thermal Therapy of Tumors under Magnetic Resonance Guidance","volume":"100","author":"Hirsch","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.colsurfb.2019.05.025","article-title":"Multifunctional PEG-B-Polypeptide-Decorated Gold Nanorod for Targeted Combined Chemo-Photothermal Therapy of Breast Cancer","volume":"181","author":"Hou","year":"2019","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1021\/ja057254a","article-title":"Cancer Cell Imaging and Photothermal Therapy in the Near-Infrared Region by Using Gold Nanorods","volume":"128","author":"Huang","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"B15","doi-asserted-by":"publisher","first-page":"4880","DOI":"10.1002\/adma.200802789","article-title":"Gold Nanorods: From Synthesis and Properties to Biological and Biomedical Applications","volume":"21","author":"Huang","year":"2009","journal-title":"Adv. Mater."},{"key":"B16","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1093\/annonc\/mdl417","article-title":"Chemotherapy for Advanced, Recurrent or Metastatic Endometrial Cancer: a Systematic Review of Cochrane Collaboration","volume":"18","author":"Humber","year":"2007","journal-title":"Ann. Oncol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.2217\/nnm.14.147","article-title":"Gold Nanoparticle-Mediated Photothermal Therapy: Current Status and Future Perspective","volume":"9","author":"Hwang","year":"2014","journal-title":"Nanomedicine"},{"key":"B18","doi-asserted-by":"publisher","first-page":"7918","DOI":"10.1002\/anie.20060247110.1002\/ange.200602471","article-title":"Designed Fabrication of Multifunctional Magnetic Gold Nanoshells and Their Application to Magnetic Resonance Imaging and Photothermal Therapy","volume":"118","author":"Kim","year":"2006","journal-title":"Angew. Chem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"6570","DOI":"10.1039\/b815918a","article-title":"Disulfide-cross-linked PEG-Poly(amino Acid)s Copolymer Micelles for Glutathione-Mediated Intracellular Drug Delivery","volume":"48","author":"Koo","year":"2008","journal-title":"Chem. Commun."},{"key":"B20","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1080\/01442350050034180","article-title":"Shape and Size Dependence of Radiative, Non-radiative and Photothermal Properties of Gold Nanocrystals","volume":"19","author":"Link","year":"2000","journal-title":"Int. Rev. Phys. Chem."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1902634","DOI":"10.1002\/adfm.201902634","article-title":"Mesoporous Silica Nanoparticles for Drug Delivery","volume":"30","author":"Manzano","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"B22","doi-asserted-by":"publisher","first-page":"3388","DOI":"10.1021\/nn400223a","article-title":"pH-Responsive Assembly of Gold Nanoparticles and \"Spatiotemporally Concerted\" Drug Release for Synergistic Cancer Therapy","volume":"7","author":"Nam","year":"2013","journal-title":"ACS Nano"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1038\/s41467-018-03473-9","article-title":"Chemo-photothermal Therapy Combination Elicits Anti-tumor Immunity against Advanced Metastatic Cancer","volume":"9","author":"Nam","year":"2018","journal-title":"Nat. Commun."},{"key":"B24","doi-asserted-by":"publisher","first-page":"15952","DOI":"10.1021\/acsami.7b03017","article-title":"Nuclear-Targeting Gold Nanorods for Extremely Low NIR Activated Photothermal Therapy","volume":"9","author":"Pan","year":"2017","journal-title":"ACS Appl. Mater. Inter."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2919","DOI":"10.1021\/nn900215k","article-title":"Multifunctional Nanoparticles for Combined Doxorubicin and Photothermal Treatments","volume":"3","author":"Park","year":"2009","journal-title":"ACS Nano"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1016\/j.ccr.2005.01.030","article-title":"Gold Nanorods: Synthesis, Characterization and Applications","volume":"249","author":"Perezjuste","year":"2005","journal-title":"Coord. Chem. Rev."},{"key":"B27","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1021\/nl034223+","article-title":"Biomolecular Recognition Based on Single Gold Nanoparticle Light Scattering","volume":"3","author":"Raschke","year":"2003","journal-title":"Nano Lett."},{"key":"B28","doi-asserted-by":"publisher","first-page":"131","DOI":"10.2174\/1389201053642376","article-title":"Targeting Therapeutic and Imaging Agents to Folate Receptor Positive Tumors","volume":"6","author":"Reddy","year":"2005","journal-title":"Curr. Pharm. Biotechnol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1021\/nl404316v","article-title":"Biphase Stratification Approach to Three-Dimensional Dendritic Biodegradable Mesoporous Silica Nanospheres","volume":"14","author":"Shen","year":"2014","journal-title":"Nano Lett."},{"key":"B30","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1126\/scitranslmed.3003377","article-title":"Data-driven Prediction of Drug Effects and Interactions","volume":"4","author":"Tatonetti","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"B31","doi-asserted-by":"publisher","first-page":"10623","DOI":"10.1021\/ja1022267","article-title":"Noninvasive Remote-Controlled Release of Drug Molecules In Vitro Using Magnetic Actuation of Mechanized Nanoparticles","volume":"132","author":"Thomas","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"B32","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3390\/molecules23010047","article-title":"Mesoporous Silica Nanoparticles for Drug Delivery: Current Insights","volume":"23","author":"Vallet-Reg\u00ed","year":"2018","journal-title":"Molecules"},{"key":"B33","doi-asserted-by":"publisher","first-page":"24368","DOI":"10.1021\/acsami.6b05907","article-title":"Biologically Inspired Polydopamine Capped Gold Nanorods for Drug Delivery and Light-Mediated Cancer Therapy","volume":"8","author":"Wang","year":"2016","journal-title":"ACS Appl. Mater. Inter."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1109\/TBME.2015.2403276","article-title":"Photoacoustic-Based-Close-Loop Temperature Control for Nanoparticle Hyperthermia","volume":"62","author":"Xiaohua","year":"2015","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3030","DOI":"10.1021\/cm401115b","article-title":"Spatially Confined Fabrication of Core-Shell Gold Nanocages@Mesoporous Silica for Near-Infrared Controlled Photothermal Drug Release","volume":"25","author":"Yang","year":"2013","journal-title":"Chem. Mater."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2890","DOI":"10.1002\/adma.201104797","article-title":"Near-Infrared Light-Triggered, Targeted Drug Delivery to Cancer Cells by Aptamer Gated Nanovehicles","volume":"24","author":"Yang","year":"2012","journal-title":"Adv. Mater."},{"key":"B37","doi-asserted-by":"publisher","first-page":"4361","DOI":"10.2147\/IJN.S165359","article-title":"Reduction-sensitive CD44 Receptor-Targeted Hyaluronic Acid Derivative Micelles for Doxorubicin Delivery","volume":"13","author":"Yang","year":"2018","journal-title":"Int. J. Nanomedicine."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1039\/D0MA00782J","article-title":"Mesoporous Silica-Coated Gold Nanorods Loaded with Tetrazolyl Phthalocyanine as NIR Light-Activated Nano-Switches for Synergistic Photothermal and Photodynamic Inactivation of Antibiotic-Resistant Escherichia coli","volume":"2","author":"Ye","year":"2021","journal-title":"Mater. Adv."},{"key":"B39","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.msec.2018.06.044","article-title":"Synthesis and Biological Evaluation of Redox\/NIR Dual Stimulus-Responsive Polymeric Nanoparticles for Targeted Delivery of Cisplatin","volume":"92","author":"You","year":"2018","journal-title":"Mater. Sci. Eng. C"},{"key":"B40","doi-asserted-by":"publisher","first-page":"5302","DOI":"10.1039\/d1bm00106j","article-title":"Phycocyanin-functionalized Black Phosphorus Quantum Dots Enhance PDT\/PTT Therapy by Inducing ROS and Irreparable DNA Damage","volume":"9","author":"Zhang","year":"2021","journal-title":"Biomater. Sci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"7317","DOI":"10.1021\/ja412735p","article-title":"Near Infrared Laser-Induced Targeted Cancer Therapy Using Thermoresponsive Polymer Encapsulated Gold Nanorods","volume":"136","author":"Zhang","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1002\/adma.201104714","article-title":"Mesoporous Silica-Coated Gold Nanorods as a Light-Mediated Multifunctional Theranostic Platform for Cancer Treatment","volume":"24","author":"Zhang","year":"2012","journal-title":"Adv. Mater."}],"container-title":["Frontiers in Chemistry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fchem.2022.842682\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T09:14:14Z","timestamp":1645780454000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fchem.2022.842682\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,25]]},"references-count":42,"alternative-id":["10.3389\/fchem.2022.842682"],"URL":"https:\/\/doi.org\/10.3389\/fchem.2022.842682","relation":{},"ISSN":["2296-2646"],"issn-type":[{"value":"2296-2646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,25]]},"article-number":"842682"}}