{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:03:42Z","timestamp":1793333022407,"version":"4.5.0"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p>\n                    This study aimed to explore the effects of exosomes derived from human gingival mesenchymal stem cells (GMSC-Exo) on the inflammatory response of periodontal ligament stem cells (PDLSCs) in an inflammatory microenvironment in order to restore the regenerative potential of PDLSCs, which promotes periodontal tissue regeneration in patients with periodontitis. Periodontitis is a chronic infectious disease characterized by periodontal tissue inflammation and alveolar bone destruction. PDLSCs are regarded as promising seed cells for restoring periodontal tissue defects because of their ability to regenerate cementum\/PDL-like tissue and alveolar bone. However, PDLSCs in the inflammatory environment show significantly attenuated regenerative potential. GMSC-Exo have been reported to have anti-inflammatory and immunosuppressive properties. In this study, we investigated the effects of GMSC-Exo on the inflammatory response of PDLSCs induced by lipopolysaccharides (LPS). LPS was used to simulate the inflammatory microenvironment of periodontitis\n                    <jats:italic>in vitro<\/jats:italic>\n                    . GMSC-Exo were extracted from the culture supernatant of GMSCs by ultracentrifugation. We found that GMSC-Exo attenuated the inflammatory response of PDLSCs induced by LPS. Furthermore, compared to treatment with LPS, treatment with GMSC-Exo attenuated the expression of NF-\u03baB signaling and Wnt5a in LPS-induced PDLSCs. In conclusion, we confirmed that GMSC-Exo could suppress the inflammatory response of PDLSCs by regulating the expression of NF-\u03baB signaling and Wnt5a, which paves the way for the establishment of a therapeutic approach for periodontitis.\n                  <\/jats:p>","DOI":"10.3389\/fchem.2022.863364","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T01:32:55Z","timestamp":1649208775000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":55,"title":["Exosomes Derived From Human Gingival Mesenchymal Stem Cells Attenuate the Inflammatory Response in Periodontal Ligament Stem Cells"],"prefix":"10.3389","volume":"10","author":[{"given":"Jiayao","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhe","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanchen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.3390\/cells8091060","article-title":"An Autocrine Wnt5a Loop Promotes NF-\u039ab Pathway Activation and Cytokine\/Chemokine Secretion in Melanoma","volume":"8","author":"Barbero","year":"2019","journal-title":"Cells"},{"key":"B2","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1111\/adj.12015","article-title":"Oral Health and Systemic Health - the Great Disconnect","volume":"57","author":"Bartold","year":"2012","journal-title":"Aust. Dent J."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.3390\/cells9051222","article-title":"Cytokines Differently Define the Immunomodulation of Mesenchymal Stem Cells from the Periodontal Ligament","volume":"9","author":"Behm","year":"2020","journal-title":"Cells"},{"key":"B4","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1034\/j.1600-051x.2001.028009840.x","article-title":"Cytokine Gene Expression in Chronic Periodontitis","volume":"28","author":"Bickel","year":"2001","journal-title":"J. Clin. Periodontol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1089\/scd.2019.0021","article-title":"Extracellular Vesicles Suppress Basal and Lipopolysaccharide-Induced NF\u03baB Activity in Human Periodontal Ligament Stem Cells","volume":"28","author":"\u010cebatari\u016bnien\u0117","year":"2019","journal-title":"Stem Cell Develop."},{"key":"B6","doi-asserted-by":"publisher","first-page":"788","DOI":"10.3390\/medicina57080788","article-title":"WNT-5a and SOST Levels in Gingival Crevicular Fluid Depend on the Inflammatory and Osteoclastogenic Activities of Periodontal Tissues","volume":"57","author":"Chatzopoulos","year":"2021","journal-title":"Medicina"},{"key":"B7","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1111\/jre.12720","article-title":"Progranulin Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells via Tumor Necrosis Factor Receptors to Inhibit TNF\u2010\u03b1 Sensitized NF\u2010kB and Activate ERK\/JNK Signaling","volume":"55","author":"Chen","year":"2020","journal-title":"J. Periodont Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1182\/blood.2019001366","article-title":"Cirmtuzumab Blocks Wnt5a\/ROR1 Stimulation of NF-\u039ab to Repress Autocrine STAT3 Activation in Chronic Lymphocytic Leukemia","volume":"134","author":"Chen","year":"2019","journal-title":"Blood"},{"key":"B9","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/prd.12007","article-title":"Periodontal Disease and Systemic Illness: Will the Evidence Ever Be Enough?","volume":"62","author":"Cullinan","year":"2013","journal-title":"Periodontol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"784","DOI":"10.3390\/cells8080784","article-title":"Mesenchymal Stem Cell Migration and Tissue Repair","volume":"8","author":"Fu","year":"2019","journal-title":"Cells"},{"key":"B11","doi-asserted-by":"publisher","first-page":"116","DOI":"10.4252\/wjsc.v10.i9.116","article-title":"Gingival-Derived Mesenchymal Stem Cells: An Endless Resource for Regenerative Dentistry","volume":"10","author":"Grawish","year":"2018","journal-title":"Wjsc"},{"key":"B12","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1902\/jop.1994.65.3.260","article-title":"Assessment of Risk for Periodontal Disease. I. Risk Indicators for Attachment Loss","volume":"65","author":"Grossi","year":"1994","journal-title":"J. Periodontol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.3390\/cells9051157","article-title":"Mesenchymal Stem\/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration","volume":"9","author":"Ha","year":"2020","journal-title":"Cells"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1002\/jcp.26086","article-title":"Wnt5a Suppresses Osteoblastic Differentiation of Human Periodontal Ligament Stem Cell\u2010like Cells via Ror2\/JNK Signaling","volume":"233","author":"Hasegawa","year":"2018","journal-title":"J. Cel Physiol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.joen.2013.09.011","article-title":"Lipopolysaccharide Enhances Wnt5a Expression through Toll-like Receptor 4, Myeloid Differentiating Factor 88, Phosphatidylinositol 3-OH Kinase\/AKT and Nuclear Factor Kappa B Pathways in Human Dental Pulp Stem Cells","volume":"40","author":"He","year":"2014","journal-title":"J. Endodontics"},{"key":"B16","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.archoralbio.2018.11.007","article-title":"Gingival Mesenchymal Stem Cells Attenuate Pro-inflammatory Macrophages Stimulated with Oxidized Low-Density Lipoprotein and Modulate Lipid Metabolism","volume":"98","author":"Hong","year":"2019","journal-title":"Arch. Oral Biol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1080\/08820139.2020.1712416","article-title":"Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Novel Cell-free Therapy","volume":"49","author":"Jafarinia","year":"2020","journal-title":"Immunological Invest."},{"key":"B18","doi-asserted-by":"publisher","first-page":"5138","DOI":"10.1111\/jcmm.16506","article-title":"Functional Differences of Toll\u2010like Receptor 4 in Osteogenesis, Adipogenesis and Chondrogenesis in Human Bone Marrow\u2010derived Mesenchymal Stem Cells","volume":"25","author":"Khodabandehloo","year":"2021","journal-title":"J. Cel Mol Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"eaai8524","DOI":"10.1126\/scitranslmed.aai8524","article-title":"The Fas\/Fap-1\/Cav-1 Complex Regulates IL-1RA Secretion in Mesenchymal Stem Cells to Accelerate Wound Healing","volume":"10","author":"Kou","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/prd.12146","article-title":"Molecular Basis for Immunohistochemical and Inflammatory Changes during Progression of Gingivitis to Periodontitis","volume":"76","author":"Kurgan","year":"2018","journal-title":"Periodontol. 2000"},{"key":"B21","doi-asserted-by":"publisher","first-page":"eaba6884","DOI":"10.1126\/sciadv.aba6884","article-title":"Shattering Barriers toward Clinically Meaningful MSC Therapies","volume":"6","author":"Levy","year":"2020","journal-title":"Sci. Adv."},{"key":"B22","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/scrt456","article-title":"Lipopolysaccharide Differentially Affects the Osteogenic Differentiation of Periodontal Ligament Stem Cells and Bone Marrow Mesenchymal Stem Cells through Toll-like Receptor 4 Mediated Nuclear Factor \u03baB Pathway","volume":"5","author":"Li","year":"2014","journal-title":"Stem Cel Res Ther"},{"key":"B23","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s13287-016-0361-9","article-title":"Therapeutic Effects of Human Gingiva-Derived Mesenchymal Stromal Cells on Murine Contact Hypersensitivity via Prostaglandin E2-EP3 Signaling","volume":"7","author":"Li","year":"2016","journal-title":"Stem Cel Res Ther"},{"key":"B24","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s00011-021-01478-7","article-title":"Mechanism of Bone Marrow Mesenchymal Stem Cells Secreting miR-26a Exosomes Affecting High Glucose-Induced Skin Fibroblasts Function by Regulating TLR4\/NF-\u039ab Signaling","volume":"70","author":"Li","year":"2021","journal-title":"Inflamm. Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1007\/s40618-020-01405-3","article-title":"Bone Marrow Mesenchymal Stem Cells-Induced Exosomal microRNA-486-3p Protects against Diabetic Retinopathy through TLR4\/NF-\u039ab axis Repression","volume":"44","author":"Li","year":"2021","journal-title":"J. Endocrinol. Invest."},{"key":"B26","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1016\/j.joca.2018.04.002","article-title":"Wnt5a Suppresses Inflammation-Driven Intervertebral Disc Degeneration via a TNF-\u0391\/nf-\u039ab-Wnt5a Negative-Feedback Loop","volume":"26","author":"Li","year":"2018","journal-title":"Osteoarthritis and Cartilage"},{"key":"B27","doi-asserted-by":"publisher","first-page":"105801","DOI":"10.1016\/j.intimp.2019.105801","article-title":"Exendin-4 Regulates Wnt and NF-\u039ab Signaling in Lipopolysaccharide-Induced Human Periodontal Ligament Stem Cells to Promote Osteogenic Differentiation","volume":"75","author":"Liu H","year":"2019","journal-title":"Int. Immunopharmacology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1186\/s13287-019-1409-4","article-title":"Macrophage Polarization in Periodontal Ligament Stem Cells Enhanced Periodontal Regeneration","volume":"10","author":"Liu","year":"","journal-title":"Stem Cel Res Ther"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.7150\/ijms.35369","article-title":"Exosomes Released by Bone Marrow Mesenchymal Stem Cells Attenuate Lung Injury Induced by Intestinal Ischemia Reperfusion via the TLR4\/NF-\u039ab Pathway","volume":"16","author":"Liu","year":"2019","journal-title":"Int. J. Med. Sci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s10555-020-09878-7","article-title":"The Emerging Role of Wnt5a in the Promotion of a Pro-inflammatory and Immunosuppressive Tumor Microenvironment","volume":"39","author":"Lopez-Bergami","year":"2020","journal-title":"Cancer Metastasis Rev."},{"key":"B31","doi-asserted-by":"publisher","first-page":"e2296","DOI":"10.1038\/cddis.2016.204","article-title":"Double-edged-sword Effect of IL-1\u03b2 on the Osteogenesis of Periodontal Ligament Stem Cells via Crosstalk between the NF-\u039ab, MAPK and BMP\/Smad Signaling Pathways","volume":"7","author":"Mao","year":"2016","journal-title":"Cell Death Dis"},{"key":"B32","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1186\/s13287-018-1004-0","article-title":"Exosomes Derived from MiR-92a-3p-Overexpressing Human Mesenchymal Stem Cells Enhance Chondrogenesis and Suppress Cartilage Degradation via Targeting WNT5A","volume":"9","author":"Mao","year":"2018","journal-title":"Stem Cel Res Ther"},{"key":"B33","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/prd.12104","article-title":"Molecular Aspects of the Pathogenesis of Periodontitis","volume":"69","author":"Meyle","year":"20152000","journal-title":"Periodontol. 2000"},{"key":"B34","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.actbio.2020.12.046","article-title":"Exosomes from TNF-\u03b1-Treated Human Gingiva-Derived MSCs Enhance M2 Macrophage Polarization and Inhibit Periodontal Bone Loss","volume":"122","author":"Nakao","year":"2021","journal-title":"Acta Biomater."},{"key":"B35","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41368-019-0064-z","article-title":"The Cytokine Network Involved in the Host Immune Response to Periodontitis","volume":"11","author":"Pan","year":"2019","journal-title":"Int. J. Oral Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1007\/s10753-015-0173-6","article-title":"Exosomes from Human Dental Pulp Stem Cells Suppress Carrageenan-Induced Acute Inflammation in Mice","volume":"38","author":"Pivorait\u0117","year":"2015","journal-title":"Inflammation"},{"key":"B37","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s10735-021-09975-z","article-title":"Wnt5a Up-Regulates Periostin through CaMKII Pathway to Influence Periodontal Tissue Destruction in Early Periodontitis","volume":"52","author":"Qian","year":"2021","journal-title":"J. Mol. Histol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/2546367","article-title":"Exosomes from Human Gingiva-Derived Mesenchymal Stem Cells Combined with Biodegradable Chitin Conduits Promote Rat Sciatic Nerve Regeneration","volume":"2019","author":"Rao","year":"2019","journal-title":"Stem Cell Int"},{"key":"B39","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0140-6736(04)16627-0","article-title":"Investigation of Multipotent Postnatal Stem Cells from Human Periodontal Ligament","volume":"364","author":"Seo","year":"2004","journal-title":"The Lancet"},{"key":"B40","doi-asserted-by":"publisher","first-page":"904","DOI":"10.3389\/fphys.2017.00904","article-title":"GMSC-derived Exosomes Combined with a Chitosan\/Silk Hydrogel Sponge Accelerates Wound Healing in a Diabetic Rat Skin Defect Model","volume":"8","author":"Shi","year":"2017","journal-title":"Front. Physiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1164\/rccm.201908-1513OC","article-title":"Hyperoxia Injury in the Developing Lung Is Mediated by Mesenchymal Expression of Wnt5A","volume":"201","author":"Sucre","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.4049\/jimmunol.1900532","article-title":"IL-10 Dampens an IL-17-Mediated Periodontitis-Associated Inflammatory Network","volume":"204","author":"Sun","year":"2020","journal-title":"J.I."},{"key":"B43","doi-asserted-by":"publisher","first-page":"108261","DOI":"10.1016\/j.intimp.2021.108261","article-title":"IgD Promotes Pannus Formation by Activating Wnt5A-Fzd5-CTHRC1-NF-\u039ab Signaling Pathway in FLS of CIA Rats and the Regulation of IgD-Fc-Ig Fusion Protein","volume":"101","author":"Tai","year":"2021","journal-title":"Int. Immunopharmacology"},{"key":"B44","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/nri.2017.142","article-title":"NF-\u03baB, Inflammation, Immunity and Cancer: Coming of Age","volume":"18","author":"Taniguchi","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1089\/scd.2019.0031","article-title":"Periodontal Ligament Stem Cells: Regenerative Potency in Periodontium","volume":"28","author":"Tomokiyo","year":"2019","journal-title":"Stem Cell Develop."},{"key":"B46","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1089\/scd.2019.0025","article-title":"Periodontal Ligament Stem Cells: Current Knowledge and Future Perspectives","volume":"28","author":"Trubiani","year":"2019","journal-title":"Stem Cell Develop."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/7625134","article-title":"EZH2 Regulates Lipopolysaccharide-Induced Periodontal Ligament Stem Cell Proliferation and Osteogenesis through TLR4\/MyD88\/NF-\u039ab Pathway","volume":"2021","author":"Wang","year":"2021","journal-title":"Stem Cell Int."},{"key":"B48","doi-asserted-by":"publisher","first-page":"106030","DOI":"10.1016\/j.intimp.2019.106030","article-title":"Role of Gingival Mesenchymal Stem Cell Exosomes in Macrophage Polarization under Inflammatory Conditions","volume":"81","author":"Wang","year":"2020","journal-title":"Int. Immunopharmacology"},{"key":"B49","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3892\/mmr.2020.11806","article-title":"Role of Wnt5a in Periodontal Tissue Development, Maintenance, and Periodontitis: Implications for Periodontal Regeneration (Review)","volume":"23","author":"Wei","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"B50","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1097\/TA.0000000000002698","article-title":"Early Single-Dose Exosome Treatment Improves Neurologic Outcomes in a 7-Day Swine Model of Traumatic Brain Injury and Hemorrhagic Shock","volume":"89","author":"Williams","year":"2020","journal-title":"J. Trauma Acute Care Surg."},{"key":"B51","doi-asserted-by":"publisher","first-page":"5956","DOI":"10.7150\/thno.33872","article-title":"Mesenchymal Stem Cell-Derived Exosomes as a Nanotherapeutic Agent for Amelioration of Inflammation-Induced Astrocyte Alterations in Mice","volume":"9","author":"Xian","year":"2019","journal-title":"Theranostics"},{"key":"B52","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/scrt525","article-title":"Wnt5a Regulates Dental Follicle Stem\/Progenitor Cells of the Periodontium","volume":"5","author":"Xiang","year":"2014","journal-title":"Stem Cel Res Ther"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.21037\/atm-20-6420","article-title":"Ginkgolide B Attenuates Collagen-Induced Rheumatoid Arthritis and Regulates Fibroblast-like Synoviocytes-Mediated Apoptosis and Inflammation","volume":"8","author":"Xie","year":"2020","journal-title":"Ann. Transl Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.3892\/ijo.2014.2342","article-title":"Oncogenic Effects of WNT5A in Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma","volume":"44","author":"Yap","year":"2014","journal-title":"Int. J. Oncol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/s00059-019-4837-0","article-title":"Alprostadil Attenuates LPS-Induced Cardiomyocyte Injury by Inhibiting the Wnt5a\/JNK\/NF-\u03baB Pathway","volume":"45","author":"Yu","year":"2020","journal-title":"Herz"},{"key":"B56","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/jre.12702","article-title":"Wnt5a Is Involved in LOX\u20101 and TLR4 Induced Host Inflammatory Response in Peri\u2010implantitis","volume":"55","author":"Zhang","year":"2020","journal-title":"J. Periodont Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"7787","DOI":"10.4049\/jimmunol.0902318","article-title":"Mesenchymal Stem Cells Derived from Human Gingiva Are Capable of Immunomodulatory Functions and Ameliorate Inflammation-Related Tissue Destruction in Experimental Colitis","volume":"183","author":"Zhang","year":"2009","journal-title":"J. Immunol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3892\/ijmm.2021.4872","article-title":"Quercetin Reverses TNF-\u03b1 I-nduced O-steogenic D-amage to H-uman P-eriodontal L-igament S-tem C-ells by S-uppressing the NF-\u03baB\/NLRP3 I-nflammasome P-athway","volume":"47","author":"Zhang","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1167\/iovs.18-25617","article-title":"Exosomes Derived from Mesenchymal Stem Cells Modulate MiR-126 to Ameliorate Hyperglycemia-Induced Retinal Inflammation via Targeting HMGB1","volume":"60","author":"Zhang","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1177\/0022034518804531","article-title":"SIS-ECM Laden with GMSC-Derived Exosomes Promote Taste Bud Regeneration","volume":"98","author":"Zhang","year":"2019","journal-title":"J. Dent Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"107455","DOI":"10.1016\/j.intimp.2021.107455","article-title":"Effect of Gingival Mesenchymal Stem Cell-Derived Exosomes on Inflammatory Macrophages in a High-Lipid Microenvironment","volume":"94","author":"Zhang","year":"2021","journal-title":"Int. Immunopharmacology"},{"key":"B62","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1210\/jc.2014-2419","article-title":"Up-Regulated Expression of WNT5a Increases Inflammation and Oxidative Stress via PI3K\/AKT\/NF-\u03baB Signaling in the Granulosa Cells of PCOS Patients","volume":"100","author":"Zhao","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/1327405","article-title":"Oral Mesenchymal Stem\/Progenitor Cells: The Immunomodulatory Masters","volume":"2020","author":"Zhou","year":"2020","journal-title":"Stem Cell Int."}],"container-title":["Frontiers in Chemistry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fchem.2022.863364\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T01:32:57Z","timestamp":1649208777000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fchem.2022.863364\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,6]]},"references-count":63,"alternative-id":["10.3389\/fchem.2022.863364"],"URL":"https:\/\/doi.org\/10.3389\/fchem.2022.863364","relation":{},"ISSN":["2296-2646"],"issn-type":[{"value":"2296-2646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,6]]},"article-number":"863364"}}