{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:17:33Z","timestamp":1783401453275,"version":"3.54.6"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p>Two Cu(II) compounds based on tetrazole-carboxylate ligands, [Cu(phtza)<jats:sub>2<\/jats:sub>(H<jats:sub>2<\/jats:sub>O)<jats:sub>2<\/jats:sub>]\u22193H<jats:sub>2<\/jats:sub>O (<jats:bold>1<\/jats:bold>) and [Cu(atzipa)<jats:sub>2<\/jats:sub>]\u22192H<jats:sub>2<\/jats:sub>O (<jats:bold>2<\/jats:bold>) (phtza = 2,2'-(5,5'-(1,3-phenylene)bis(2<jats:italic>H<\/jats:italic>-tetrazole-5,2-diyl))diacetate, atzipa = 3-(5-amino-1<jats:italic>H<\/jats:italic>-tetrazol-1-yl)isopropanoic anion), were designed and synthesized by hydrothermal reactions. The X-ray diffraction results show that the two compounds show two-dimensional (2D) layer structures. Nanoprecipitation with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)<jats:sub>-2000<\/jats:sub>] (DSPE-PEG<jats:sub>-2000<\/jats:sub>) contributes to the formation of the nanoparticles (NPs) with excellent water dispersity. <jats:italic>In vitro<\/jats:italic> study indicates that the two NPs exert considerable cytotoxicity toward human hepatocellular carcinoma cells (HepG2 and Huh7) with low half-maximal inhibitory concentration (IC<jats:sub>50<\/jats:sub>). However, the cytotoxicity of such NPs is negligible in normal cells (HL-7702). The cytotoxicity of these NPs was also investigated by the flow cytometry and Calcein-AM\/PI (live\/dead) co-stained experiments. The results promise the great potential of these NPs for chemodynamic therapy against cancer cells.<\/jats:p>","DOI":"10.3389\/fchem.2022.915247","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T05:51:15Z","timestamp":1661752275000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Two copper(II) compounds derived from tetrazole carboxylates for chemodynamic therapy against hepatocellular carcinoma cells"],"prefix":"10.3389","volume":"10","author":[{"given":"Xinya","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuandan","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Litao","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengfeng","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3390\/medicina56010015","article-title":"Tumor microenvironment","volume":"56","author":"Arneth","year":"2020","journal-title":"Medicina"},{"key":"B2","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.ccr.2010.10.038","article-title":"Triazoles and tetrazoles: Prime ligands to generate remarkable coordination materials","volume":"255","author":"Aromi","year":"2011","journal-title":"Coord. Chem. Rev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"120598","DOI":"10.1016\/j.ica.2021.120598","article-title":"Synthesis and anticancer property of two Sm(III) compounds based on tetrazole ligands","volume":"528","author":"Dai","year":"2021","journal-title":"Inorganica Chim. Acta"},{"key":"B4","doi-asserted-by":"publisher","first-page":"4951","DOI":"10.1038\/s41467-020-18745-6","article-title":"Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death","volume":"11","author":"Deng","year":"2020","journal-title":"Nat. Commun."},{"key":"B5","doi-asserted-by":"publisher","first-page":"12533","DOI":"10.1039\/c5cc04468e","article-title":"Direct white-light and a dual-channel barcode module from Pr(iii)-MOF crystals","volume":"51","author":"Du","year":"2015","journal-title":"Chem. Commun."},{"key":"B6","doi-asserted-by":"publisher","first-page":"16902","DOI":"10.1021\/ja508938f","article-title":"Intracellular CO release from composite of ferritin and ruthenium carbonyl complexes","volume":"136","author":"Fujita","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2103627","DOI":"10.1002\/adma.202103627","article-title":"Singlet oxygen \u201cafterglow\u201d therapy with NIR-II fluorescent molecules","volume":"33","author":"H Zou","year":"2021","journal-title":"Adv. Mat."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1038\/s41551-020-0599-5","article-title":"Burst release of encapsulated annexin A5 in tumours boosts cytotoxic T-cell responses by blocking the phagocytosis of apoptotic cells","volume":"4","author":"Li","year":"2020","journal-title":"Nat. Biomed. Eng."},{"key":"B9","doi-asserted-by":"publisher","first-page":"9885","DOI":"10.1002\/anie.201806551","article-title":"Phthalocyanine-assembled nanodots as photosensitizers for highly efficient Type\u2005I photoreactions in photodynamic therapy","volume":"57","author":"Li","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"B10","doi-asserted-by":"publisher","first-page":"9937","DOI":"10.1021\/jacs.9b03457","article-title":"Synthesis of copper peroxide nanodots for H2O2 self-supplying chemodynamic therapy","volume":"141","author":"Lin","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"B11","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1107\/s0108767307043930","article-title":"A short history of SHELX","author":"Sheldrick","year":"2008","journal-title":"Acta Crystallogr. A"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1039\/c9qm00158a","article-title":"Heavy atom-free semiconducting polymer with high singlet oxygen quantum yield for prostate cancer synergistic phototherapy","volume":"3","author":"Shen","year":"2019","journal-title":"Mat. Chem. Front."},{"key":"B13","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s11243-015-0003-6","article-title":"Three new manganese(II) coordination complexes based on tetrazole carboxylate ligands","volume":"41","author":"Shen","year":"2016","journal-title":"Transit. Metall. Chem."},{"key":"B14","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21442","article-title":"Cancer statistics, 2018","volume":"68","author":"Siegel","year":"2018","journal-title":"Ca. Cancer J. Clin."},{"key":"B15","doi-asserted-by":"publisher","first-page":"8158","DOI":"10.1021\/jacs.8b13902","article-title":"Self-assembled responsive bilayered vesicles with adjustable oxidative stress for enhanced cancer imaging and therapy","volume":"141","author":"Song","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"B16","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1007\/s11243-016-0099-3","article-title":"Substituent-dependent formation of Co(II) complexes based on phenyl-tetrazole acetic acid: From bis- to tristetrazole acetic acid","volume":"41","author":"Sun","year":"2016","journal-title":"Transit. Metall. Chem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1002\/adma.201603702","article-title":"Drug therapy: An amphiphilic ruthenium polymetallodrug for combined photodynamic therapy and photochemotherapy in vivo (adv. Mater. 6\/2017)","volume":"29","author":"Sun","year":"2017","journal-title":"Adv. Mat."},{"key":"B18","doi-asserted-by":"publisher","first-page":"10832","DOI":"10.1002\/chem.201701224","volume":"23","author":"Sun","year":"2017","journal-title":"Chem. Eur. J."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2610","DOI":"10.1021\/acsnano.7b08628","article-title":"Organic semiconducting photoacoustic nanodroplets for laser-activatable ultrasound imaging and combinational cancer therapy","volume":"12","author":"Tang","year":"2018","journal-title":"ACS Nano"},{"key":"B20","doi-asserted-by":"publisher","first-page":"4742","DOI":"10.1039\/c4sc01255k","article-title":"In vivo anti-tumor activity of the organometallic ruthenium(ii)-arene complex [Ru(\u03b76-p-cymene)Cl2(pta)] (RAPTA-C) in human ovarian and colorectal carcinomas","volume":"5","author":"Weiss","year":"2014","journal-title":"Chem. Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"9804","DOI":"10.1002\/anie.201202992","article-title":"Low-Energy selective capture of carbon dioxide by a pre-designed elastic single-molecule trap","volume":"51","author":"Wriedt","year":"2012","journal-title":"Angew. Chem. Int. Ed."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1039\/c8qm00304a","article-title":"(2-(4-Bromophenyl)ethene-1, 1, 2-triyl)tribenzene with aggregation induced emission for ablation of HeLa cells","volume":"2","author":"Yang","year":"2018","journal-title":"Mat. Chem. Front."},{"key":"B23","doi-asserted-by":"publisher","first-page":"111127","DOI":"10.1016\/j.jinorgbio.2020.111127","article-title":"Two photoactive Ru (II) compounds based on tetrazole ligands for photodynamic therapy","volume":"210","author":"Yang","year":"2020","journal-title":"J. Inorg. Biochem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ica.2014.04.013","article-title":"Syntheses, structures and properties of five coordinating metallic complexes with the new carboxylate-bis(tetrazolyl)amine ligand","volume":"419","author":"Yang","year":"2014","journal-title":"Inorganica Chim. Acta"},{"key":"B25","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.jinorgbio.2019.01.015","article-title":"Photochemical property of two Ru(II) compounds based on 5-(2-pyrazinyl)tetrazole for cancer phototherapy by changing auxiliary ligand","volume":"193","author":"Yang","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"14687","DOI":"10.1021\/jacs.9b06086","article-title":"Precision cancer theranostic platform by in situ polymerization in perylene diimide-hybridized hollow mesoporous organosilica nanoparticles","volume":"141","author":"Yang","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"B27","doi-asserted-by":"publisher","first-page":"526","DOI":"10.7150\/thno.30779","article-title":"Stimuli-responsive nanotheranostics for real-time monitoring drug release by photoacoustic imaging","volume":"9","author":"Yang","year":"2019","journal-title":"Theranostics"},{"key":"B28","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.inoche.2017.08.018","article-title":"One Cu(II) compound derived from 5-(2-pyridyl)tetrazole-2-isopropanoic acid against Hela cells","volume":"84","author":"Zhai","year":"2017","journal-title":"Inorg. Chem. Commun."},{"key":"B29","doi-asserted-by":"publisher","first-page":"120380","DOI":"10.1016\/j.ica.2021.120380","article-title":"Synthesis and anticancer property of three new Cu(II) coordination polymers constructed by the bifunctional substituted-polynitrogen heterocyclic ligands","volume":"522","author":"Zhang","year":"2021","journal-title":"Inorganica Chim. Acta"},{"key":"B30","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.ccr.2015.08.006","article-title":"High-energy metal\u2013organic frameworks (HE-MOFs): Synthesis, structure and energetic performance","volume":"307","author":"Zhang","year":"2016","journal-title":"Coord. Chem. Rev."},{"key":"B31","doi-asserted-by":"publisher","first-page":"20208","DOI":"10.1002\/anie.202009442","article-title":"Dual-emissive platinum(II) metallacage with a sensitive oxygen response for imaging of hypoxia and imaging-guided chemotherapy","volume":"59","author":"Zhu","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"B32","doi-asserted-by":"publisher","first-page":"27887","DOI":"10.1039\/c5ra03296b","article-title":"Synthesis, crystal structure and catalytic property of a new samarium compound derived from 5-(pyrazin-2-yl)tetrazole-2-acetic acid","volume":"5","author":"Zou","year":"2015","journal-title":"RSC Adv."},{"key":"B33","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.ica.2014.08.058","article-title":"Three new alkaline Earth coordination compounds based on 5-(2-pyrimidyl)tetrazole-2-acetic acid","volume":"423","author":"Zou","year":"2014","journal-title":"Inorganica Chim. Acta"},{"key":"B34","doi-asserted-by":"publisher","first-page":"3229","DOI":"10.1515\/nanoph-2021-0209","article-title":"Phototherapy meets immunotherapy: A win\u2013win strategy to fight against cancer","volume":"10","author":"Zou","year":"2021","journal-title":"Nanophotonics"},{"key":"B35","doi-asserted-by":"publisher","first-page":"3444","DOI":"10.1080\/00958972.2014.965163","article-title":"pH-dependent synthesis of a cadmium coordination compound from a compound based on Hpytz ligand [Hpytz = 5-(4-pyridyl)tetrazole]","volume":"67","author":"Zou","year":"2014","journal-title":"J. Coord. Chem."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1002\/zaac.201400106","article-title":"Three new coordination compounds with neodymium based on tetrazole containing carboxylic acid ligands","volume":"640","author":"Zou","year":"2014","journal-title":"Z. Anorg. Allg. Chem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.ica.2014.06.029","article-title":"Four new zinc coordination compounds derived from various tetrazole-containing carboxylic acids and 4, 4\u2032-bipyridine","volume":"421","author":"Zou","year":"2014","journal-title":"Inorganica Chim. Acta"},{"key":"B38","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ica.2014.07.034","article-title":"Construction of six new coordination complexes with 5-(3-pyridyl) tetrazole-2-acetato","volume":"423","author":"Zou","year":"2014","journal-title":"Inorganica Chim. Acta"},{"key":"B39","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1071\/ch14442","article-title":"Group position-dependent structurally diverse coordination compounds based on isomeric ligands","volume":"68","author":"Zou","year":"2015","journal-title":"Aust. J. Chem."},{"key":"B40","doi-asserted-by":"publisher","first-page":"8833","DOI":"10.1002\/anie.201914384","article-title":"A phototheranostic strategy to continuously deliver singlet oxygen in the dark and hypoxic tumor microenvironment","volume":"59","author":"Zou","year":"2020","journal-title":"Angew. Chem. Int. Ed."}],"container-title":["Frontiers in Chemistry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fchem.2022.915247\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T05:51:18Z","timestamp":1661752278000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fchem.2022.915247\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,29]]},"references-count":40,"alternative-id":["10.3389\/fchem.2022.915247"],"URL":"https:\/\/doi.org\/10.3389\/fchem.2022.915247","relation":{},"ISSN":["2296-2646"],"issn-type":[{"value":"2296-2646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,29]]},"article-number":"915247"}}