{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:18:42Z","timestamp":1793125122654,"version":"4.5.0"},"reference-count":203,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p>\n                    The continuing rapid expansion of\n                    <jats:sup>99m<\/jats:sup>\n                    Tc diagnostic agents always calls for scaling up\n                    <jats:sup>99m<\/jats:sup>\n                    Tc production to cover increasing clinical demand. Nevertheless,\n                    <jats:sup>99m<\/jats:sup>\n                    Tc availability depends mainly on the fission-produced\n                    <jats:sup>99<\/jats:sup>\n                    Mo supply. This supply is seriously influenced during renewed emergency periods, such as the past\n                    <jats:sup>99<\/jats:sup>\n                    Mo production crisis or the current COVID-19 pandemic. Consequently, these interruptions have promoted the need for\n                    <jats:sup>99m<\/jats:sup>\n                    Tc production through alternative strategies capable of providing clinical-grade\n                    <jats:sup>99m<\/jats:sup>\n                    Tc with high purity. In the light of this context, this review illustrates diverse production routes that either have commercially been used or new strategies that offer potential solutions to promote a rapid production growth of\n                    <jats:sup>99m<\/jats:sup>\n                    Tc. These techniques have been selected, highlighted, and evaluated to imply their impact on developing\n                    <jats:sup>99m<\/jats:sup>\n                    Tc production. Furthermore, their advantages and limitations, current situation, and long-term perspective were also discussed. It appears that, on the one hand, careful attention needs to be devoted to enhancing the\n                    <jats:sup>99<\/jats:sup>\n                    Mo economy. It can be achieved by utilizing\n                    <jats:sup>98<\/jats:sup>\n                    Mo neutron activation in commercial nuclear power reactors and using accelerator-based\n                    <jats:sup>99<\/jats:sup>\n                    Mo production, especially the photonuclear transmutation strategy. On the other hand, more research efforts should be devoted to widening the utility of\n                    <jats:sup>99<\/jats:sup>\n                    Mo\/\n                    <jats:sup>99m<\/jats:sup>\n                    Tc generators, which incorporate nanomaterial-based sorbents and promote their development, validation, and full automization in the near future. These strategies are expected to play a vital role in providing sufficient clinical-grade\n                    <jats:sup>99m<\/jats:sup>\n                    Tc, resulting in a reasonable cost per patient dose.\n                  <\/jats:p>","DOI":"10.3389\/fchem.2022.926258","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T11:11:11Z","timestamp":1658488271000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":54,"title":["New strategies for a sustainable 99mTc supply to meet increasing medical demands: Promising solutions for current problems"],"prefix":"10.3389","volume":"10","author":[{"given":"Mohamed F.","family":"Nawar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"T\u00fcrler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1080\/10506890903178913","article-title":"MYRRHA, a multipurposehybrid research reactor for high-end applications","volume":"20","author":"Abderrahim","year":"2010","journal-title":"Nucl. 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