{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:03:39Z","timestamp":1790107419183,"version":"4.0.1"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020912","name":"King Faisal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004686","name":"Deanship of Scientific Research, King Faisal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p>Reduction of 4,4\u2032-diselanediyldianiline (<jats:bold>1<\/jats:bold>) followed by the reaction with bromo-4-(bromomethyl)benzene afforded the corresponding 4-((4-bromobenzyl)selanyl)aniline (<jats:bold>2<\/jats:bold>) in 85% yield. <jats:italic>N<\/jats:italic>-Maleanilic acid <jats:bold>3<\/jats:bold> was obtained in 94% yield via the reaction of selenoamine <jats:bold>2<\/jats:bold> with toxilic anhydride. Subsequent dehydration of <jats:italic>N<\/jats:italic>-maleanilic acid <jats:bold>3<\/jats:bold> using acetic anhydride furnished the unexpected isomaleimide 5-((4-((4-bromophenyl)selanyl)phenyl)imino)furan-2(5H)-one (<jats:bold>4<\/jats:bold>) instead of the maleimide <jats:bold>5<\/jats:bold>. The molecular structure of compound <jats:bold>4<\/jats:bold> was confirmed by mass spectrometry, <jats:sup>1<\/jats:sup>H- and <jats:sup>13<\/jats:sup>C-NMR spectroscopy, and X-ray diffraction analysis. Their cytotoxicity was assessed against two oligodendrocytes, and their respective redox properties were evaluated using 2\u2032,7\u2032-dichlorodihydrofluorescein diacetate (H2-DCFDA) assay. Furthermore, their antiapoptotic potential was also evaluated by flow cytometry. The compound crystallizes in triclinic P-1 space group with unit cell parameters a = 5.7880 (4)\u00a0\u00c5, b = 9.8913 (6)\u00a0\u00c5, c = 14.5951 (9)\u00a0\u00c5, V = 1731.0 (3)\u00a0\u00c5<jats:sup>3<\/jats:sup> and Z = 2. The crystal packing is stabilized by intermolecular hydrogen bonding, \u03c0\u00b7\u00b7\u00b7\u03c0, C-Br\u00b7\u00b7\u00b7\u03c0 stacking interactions, and other non-covalent interactions. The mapping of different Hirshfeld surfaces and 2D-fingerprint were used to investigate intermolecular interactions. The interaction energies that stabilize the crystal packing were calculated and graphically represented as framework energy diagrams. We present a computational investigation of compound 4\u2019s molecular structure at the Density Functional Theory level using the B3LYP method and the 6-31G ++ basis set in this paper. The optimized structure matches the experimental outcome. The global reactivity descriptors and molecular electrostatic potential (M.E.P.) map emphasize the molecule\u2019s reactive locations, allowing reactivity prediction. The charge transfer properties of molecules can be estimated by examining Frontier molecular orbitals.<\/jats:p>","DOI":"10.3389\/fchem.2022.961787","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T04:29:56Z","timestamp":1659673796000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Unexpected kinetically controlled organoselenium-based isomaleimide: X-ray structure, hirshfeld surface analysis, 3D energy framework approach, and density functional theory calculation"],"prefix":"10.3389","volume":"10","author":[{"given":"Saad","family":"Shaaban","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hela","family":"Ferjani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany M.","family":"Abd El-Lateef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai M.","family":"Khalaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Gouda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Alaasar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek A.","family":"Yousef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"12952","DOI":"10.3390\/ijms222312952","article-title":"The effect of organoselenium compounds on histone deacetylase inhibition and their potential for cancer therapy","volume":"22","author":"Adimulam","year":"2021","journal-title":"Int. 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