{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T01:34:34Z","timestamp":1792892074774,"version":"4.5.0"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p>In order to make better use of the two local dominant plant resources of <jats:italic>Ginkgo biloba<\/jats:italic> and <jats:italic>Zingiber officinale<\/jats:italic> from Yongzhou in Hunan province, the <jats:italic>in vitro<\/jats:italic> neuroprotective and antioxidant activities of extracts from the <jats:italic>G. biloba<\/jats:italic> leaf and <jats:italic>Z. officinale<\/jats:italic> rhizome, and the correlation between these two kinds of activities, were analyzed. The <jats:italic>in vivo<\/jats:italic> effects of these two plant extracts on aged mice blood physiology and central neuron cell activity were then determined after continuous gavage with the best polarity part at different concentrations (2, 4, 8\u00a0mg\/ml). The results showed that the cell survival rate and superoxide dismutase (SOD) activity of the induced injury central neurons increased, although the malondialdehyde (MDA) content decreased gradually with the extract concentrations increasing in a certain range. Different polarity parts performed differently, even though they had the same concentration, with <jats:italic>G. biloba<\/jats:italic> always performing better than the <jats:italic>Z. officinale<\/jats:italic> rhizome at the same concentration and polarity. The order of <jats:italic>G. biloba<\/jats:italic> extract from superior to inferior was ethanol, ethyl acetate, n-butanol, chloroform, water, and petroleum ether (except that the petroleum ether part performed slightly better than the water part at 0.4 and 0.5\u00a0mg\/ml), while the order of <jats:italic>Z. officinale<\/jats:italic> rhizome extract from superior to inferior was ethanol, chloroform, n-butanol, ethyl acetate, water, and petroleum ether. These two plant extracts demonstrated good <jats:italic>in vitro<\/jats:italic> effect against oxygen free radicals; the scavenging rate of superoxide free radicals had a significant positive correlation with the cell survival rate. The <jats:italic>in vivo<\/jats:italic> central nerve cell activity and SOD, glutathione peroxidase (GSH-PX) activity in aged mice blood serum increased while the MDA content decreased with treatment with these two extracts (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). There were no significant changes in the number of leukocytes, lymphocytes, red blood cells, hemoglobin content, blood urine nitrogen, uric acid, creatinine, and the enzyme activity of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) (<jats:italic>p<\/jats:italic> &amp;gt; 0.05). <jats:italic>G. biloba<\/jats:italic> had a better <jats:italic>in vivo<\/jats:italic> effect than <jats:italic>Z. officinale<\/jats:italic> rhizome even though their concentration and polarity part were same. These results could provide some references for better development of these two plant extracts from Yongzhou in the field of neuroprotection.<\/jats:p>","DOI":"10.3389\/fchem.2022.984495","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T09:19:32Z","timestamp":1662542372000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Neuroprotective and antioxidant activities of different polarity parts of the extracts of the Ginkgo biloba leaf and Zingiber officinale rhizome from Yongzhou"],"prefix":"10.3389","volume":"10","author":[{"given":"Zuoying","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongling","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3969\/j.issn.1006-6179.2019.06.009","article-title":"Effects of astragalus polysaccharides on growth performance, blood physiological and biochemical indexes and incidence of diarrhea in breeding rhesus monkeys[J]","volume":"36","author":"Chen","year":"2019","journal-title":"Laboratory Animal Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.sjbs.2020.10.027","article-title":"Ginger extract attenuates labetalol induced apoptosis, DNA damage, histological and ultrastructural changes in the heart of rat fetuses","volume":"28","author":"El-Borm","year":"2021","journal-title":"Saudi J. 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