{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:33:35Z","timestamp":1784259215157,"version":"3.55.0"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","award":["K123975 K142141 FK125067 TKP2020-IKA-04 TKP2021-EGA-19 TKP2021-EGA-20 POST-COVID2021-33"],"award-info":[{"award-number":["K123975 K142141 FK125067 TKP2020-IKA-04 TKP2021-EGA-19 TKP2021-EGA-20 POST-COVID2021-33"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p>The toxicity of and resistance to platinum complexes as cisplatin, oxaliplatin or carboplatin calls for the replacement of these therapeutic agents in clinical settings. We have previously identified a set of half sandwich-type osmium, ruthenium and iridium complexes with bidentate glycosyl heterocyclic ligands exerting specific cytostatic activity on cancer cells but not on non-transformed primary cells. The apolar nature of the complexes, conferred by large, apolar benzoyl protective groups on the hydroxyl groups of the carbohydrate moiety, was the main molecular feature to induce cytostasis. We exchanged the benzoyl protective groups to straight chain alkanoyl groups with varying length (3 to 7 carbon units) that increased the IC<jats:sub>50<\/jats:sub>value as compared to the benzoyl-protected complexes and rendered the complexes toxic. These results suggest a need for aromatic groups in the molecule. The pyridine moiety of the bidentate ligand was exchanged for a quinoline group to enlarge the apolar surface of the molecule. This modification decreased the IC<jats:sub>50<\/jats:sub>value of the complexes. The complexes containing [(\u03b7<jats:sup>6<\/jats:sup>-<jats:italic>p<\/jats:italic>-cymene)Ru(II)], [(\u03b7<jats:sup>6<\/jats:sup>-<jats:italic>p<\/jats:italic>-cymene)Os(II)] or [(\u03b7<jats:sup>5<\/jats:sup>-Cp*)Ir(III)] were biologically active unlike the complex containing [(\u03b7<jats:sup>5<\/jats:sup>-Cp*)Rh(III)]. The complexes with cytostatic activity were active on ovarian cancer (A2780, ID8), pancreatic adenocarcinoma (Capan2), sarcoma (Saos) and lymphoma cell lines (L428), but not on primary dermal fibroblasts and their activity was dependent on reactive oxygen species production. Importantly, these complexes were cytostatic on cisplatin-resistant A2780 ovarian cancer cells with similar IC<jats:sub>50<\/jats:sub>values as on cisplatin-sensitive A2780 cells. In addition, the quinoline-containing Ru and Os complexes and the short chain alkanoyl-modified complexes (C3 and C4) proved to be bacteriostatic in multiresistant Gram-positive<jats:italic>Enterococcus<\/jats:italic>and<jats:italic>Staphylococcus aureus<\/jats:italic>isolates. Hereby, we identified a set of complexes with submicromolar to low micromolar inhibitory constants against a wide range of cancer cells, including platinum resistant cells and against multiresistant Gram-positive bacteria.<\/jats:p>","DOI":"10.3389\/fchem.2023.1086267","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T11:15:42Z","timestamp":1675077342000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Half sandwich-type osmium, ruthenium, iridium and rhodium complexes with bidentate glycosyl heterocyclic ligands induce cytostasis in platinum-resistant ovarian cancer cells and bacteriostasis in Gram-positive multiresistant bacteria"],"prefix":"10.3389","volume":"11","author":[{"given":"Istv\u00e1n","family":"Kacsir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienn","family":"Sipos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00edmea","family":"Kiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelin","family":"Major","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolett","family":"Bajusz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emese","family":"T\u00f3th","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Bugly\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Soms\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Kardos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9va","family":"Bokor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/360438","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxid. Med. Cell Longev."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1016\/s0891-5849(01)00756-0","article-title":"Partial protection by poly(ADP-ribose) polymerase inhibitors from nitroxyl-induced cytotoxity in thymocytes","volume":"31","author":"Bai","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2647","DOI":"10.3390\/cancers12092647","article-title":"Inhibition of DNA repair pathways and induction of ROS are potential mechanisms of action of the small molecule inhibitor BOLD-100 in breast cancer","volume":"12","author":"Bakewell","year":"2020","journal-title":"Cancers (Basel)"},{"key":"B4","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1046\/j.1523-1747.2003.12329.x","article-title":"Role of intracellular calcium mobilization and cell-density-dependent signaling in oxidative-stress-induced cytotoxicity in HaCaT keratinocytes","volume":"121","author":"Bakondi","year":"2003","journal-title":"J. Invest. Dermatol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"868234","DOI":"10.3389\/fchem.2022.868234","article-title":"Targeting multiresistant Gram-positive bacteria by ruthenium, osmium, iridium and rhodium half-sandwich type complexes with bidentate monosaccharide ligands","volume":"10","author":"Bal\u00e1zs","year":"2022","journal-title":"Front. Chem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"9046","DOI":"10.1002\/chem.200801032","article-title":"In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands","volume":"14","author":"Berger","year":"2008","journal-title":"Chemistry\u2014A Eur. J."},{"key":"B7","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1002\/cmdc.202000456","article-title":"Glycoconjugated metal complexes as cancer diagnostic and therapeutic agents","volume":"16","author":"Bononi","year":"2020","journal-title":"Chemmedchem"},{"key":"B8","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/j.2517-6161.1964.tb00553.x","article-title":"An analysis of transformations","volume":"26","author":"Box","year":"1964","journal-title":"J. R. Stat. Soc. B"},{"key":"B9","first-page":"97","article-title":"Cisplatin-based chemotherapy of human cancers","volume":"11","author":"Brown","year":"2019","journal-title":"J. Cancer Sci. Ther."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e000154","DOI":"10.1136\/esmoopen-2016-000154","article-title":"Safety and activity of IT-139, a ruthenium-based compound, in patients with advanced solid tumours: a first-in-human, open-label, dose-escalation phase I study with expansion cohort","volume":"1","author":"Burris","year":"2016","journal-title":"ESMO Open"},{"key":"B11","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s10534-018-0160-0","article-title":"Determination of in vitro absorption in Caco-2 monolayers of anticancer Ru(II)-based complexes acting as dual human topoisomerase and PARP inhibitors","volume":"32","author":"De Camargo","year":"2019","journal-title":"Biometals"},{"key":"B12","volume-title":"MIC determination of non-fastidious and fastidious organisms","year":"2021"},{"key":"B13","doi-asserted-by":"publisher","first-page":"6412","DOI":"10.2174\/0929867326666190124124350","article-title":"Synthesis, biological activity and medicinal applications of ruthenium complexes containing carbohydrate ligands","volume":"26","author":"Fernandes","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1038\/bjc.2015.359","article-title":"Molecular targets for anticancer redox chemotherapy and cisplatin-induced ototoxicity: the role of curcumin on pSTAT3 and nrf-2 signalling","volume":"113","author":"Fetoni","year":"2015","journal-title":"Br. J. Cancer"},{"key":"B15","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.jorganchem.2013.09.004","article-title":"Synthesis, characterization and cytotoxicity of cyclopentadienyl ruthenium(II) complexes containing carbohydrate-derived ligands","volume":"760","author":"Florindo","year":"2014","journal-title":"J. Organomet. Chem."},{"key":"B16","doi-asserted-by":"publisher","first-page":"4339","DOI":"10.1021\/acs.jmedchem.5b00403","article-title":"Cyclopentadienyl-Ruthenium(II) and iron(II) organometallic compounds with carbohydrate derivative ligands as good colorectal anticancer agents","volume":"58","author":"Florindo","year":"2015","journal-title":"J. Med. Chem."},{"key":"B17","doi-asserted-by":"publisher","first-page":"11926","DOI":"10.1039\/c6dt01571a","article-title":"New [(\u03b75-C5H5)Ru(N\u2013N)(PPh3)] [PF6] compounds: colon anticancer activity and GLUT-mediated cellular uptake of carbohydrate-appended complexes","volume":"45","author":"Florindo","year":"2016","journal-title":"Dalton Trans."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3165","DOI":"10.1002\/cmdc.202100157","article-title":"Platinum cyclooctadiene complexes with activity against gram-positive bacteria","volume":"16","author":"Frei","year":"2021","journal-title":"ChemMedChem"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.2174\/1871520619666190318152726","article-title":"Antitumour and toxicity evaluation of a Ru(II)-Cyclopentadienyl complex in a prostate cancer model by imaging tools","volume":"19","author":"Gano","year":"2019","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s00407-012-0098-5","article-title":"The Hill equation and the origin of quantitative pharmacology","volume":"66","author":"Gesztelyi","year":"2012","journal-title":"Archive Hist. Exact Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.jorganchem.2018.04.021","article-title":"Half-sandwich complexes of platinum group metals (Ir, Rh, Ru and Os) and some recent biological and catalytic applications","volume":"866","author":"Gichumbi","year":"2018","journal-title":"J. Organomet. Chem."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1039\/c1ra00998b","article-title":"Synthesis and X-ray diffraction structures of novel half-sandwich Os(II)-and Ru(II)-hydroxamate complexes","volume":"2","author":"God\u00f3","year":"2012","journal-title":"RSC Adv."},{"key":"B23","doi-asserted-by":"publisher","first-page":"e5896","DOI":"10.1002\/aoc.5896","article-title":"Ruthenium tetrazene complexes bearing glucose moieties on their periphery: Synthesis, characterization, and in vitro cytotoxicity","volume":"34","author":"Hamala","year":"2020","journal-title":"Appl. Organomet. Chem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3389\/fchem.2013.00027","article-title":"Influence of the \u03c0-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes","volume":"1","author":"Hanif","year":"2013","journal-title":"Front. Chem."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1016\/j.drudis.2014.06.016","article-title":"Development of anticancer agents: wizardry with osmium","volume":"19","author":"Hanif","year":"2014","journal-title":"Drug Discov. Today"},{"key":"B26","doi-asserted-by":"publisher","first-page":"2574","DOI":"10.2174\/092986708785908978","article-title":"Carbohydrate-metal complexes and their potential as anticancer agents","volume":"15","author":"Hartinger","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2688","DOI":"10.2174\/156802611798040769","article-title":"Polynuclear ruthenium, osmium and gold complexes. The quest for innovative anticancer chemotherapeutics","volume":"11","author":"Hartinger","year":"2011","journal-title":"Curr. Top. Med. Chem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"6408","DOI":"10.1039\/c6an01596d","article-title":"Accurate quantification of apoptosis progression and toxicity using a dielectrophoretic approach","volume":"141","author":"Henslee","year":"2016","journal-title":"Analyst"},{"key":"B29","doi-asserted-by":"publisher","first-page":"4976","DOI":"10.3390\/ijms23094976","article-title":"Highly cytotoxic osmium(II) compounds and their ruthenium(II) analogues targeting ovarian carcinoma cell lines and evading cisplatin resistance mechanisms","volume":"23","author":"Hildebrandt","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B30","volume-title":"Trithiolato-bridged dinuclear arene ruthenium(ll)- glycoconjugates: Synthesis and antiparasitic activity","author":"Holzer","year":"2022"},{"key":"B31","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1099\/jmm.0.001172","article-title":"Repurposing bioactive compounds for treating multidrug-resistant pathogens","volume":"69","author":"Hummell","year":"2020","journal-title":"J. Med. Microbiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"105901","DOI":"10.1016\/j.bioorg.2022.105901","article-title":"New glycoconjugation strategies for ruthenium(II) arene complexes via phosphane ligands and assessment of their antiproliferative activity","volume":"126","author":"Iacopini","year":"2022","journal-title":"Bioorg. Chem."},{"key":"B33","doi-asserted-by":"publisher","first-page":"10454","DOI":"10.3390\/ijms221910454","article-title":"Ruthenium half-sandwich type complexes with bidentate monosaccharide ligands show antineoplastic activity in ovarian cancer cell models through reactive oxygen species production","volume":"22","author":"Kacsir","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"813","DOI":"10.3390\/ijms23020813","article-title":"Reactive oxygen species production is responsible for antineoplastic activity of osmium, ruthenium, iridium and rhodium half-sandwich type complexes with bidentate glycosyl hetero-cyclic ligands in various cancer cell models","volume":"23","author":"Kacsir","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1021\/acs.chemrev.8b00271","article-title":"Toward multi-targeted platinum and ruthenium drugs-A new paradigm in cancer drug treatment regimens?","volume":"119","author":"Kenny","year":"2019","journal-title":"Chem. Rev."},{"key":"B36","doi-asserted-by":"publisher","first-page":"9934","DOI":"10.1039\/c8dt01858h","article-title":"Anticancer activity of complexes of the third row transition metals, rhenium, osmium, and iridium","volume":"47","author":"Konkankit","year":"2018","journal-title":"Dalton Trans."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.3390\/cancers11091255","article-title":"Lithocholic acid, a metabolite of the microbiome, increases oxidative stress in breast cancer","volume":"11","author":"Kov\u00e1cs","year":"2019","journal-title":"Cancers (Basel)"},{"key":"B38","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.euros.2022.04.015","article-title":"A phase 1b clinical study of intravesical photodynamic therapy in patients with Bacillus calmette-gu\u00e9rin-unresponsive non-muscle-invasive bladder cancer","volume":"41","author":"Kulkarni","year":"2022","journal-title":"Eur. Urol. Open Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s10637-014-0179-1","article-title":"Phase I\/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy","volume":"33","author":"Leijen","year":"2015","journal-title":"Investig. New Drugs"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1016\/j.ccr.2013.01.034","article-title":"Bioactive iridium and rhodium complexes as therapeutic agents","volume":"257","author":"Leung","year":"2013","journal-title":"Coord. Chem. Rev."},{"key":"B41","doi-asserted-by":"publisher","first-page":"102129","DOI":"10.1016\/j.redox.2021.102129","article-title":"A bioactive ligand-conjugated iridium(III) metal-based complex as a Keap1-Nrf2 protein-protein interaction inhibitor against acetaminophen-induced acute liver injury","volume":"48","author":"Li","year":"2021","journal-title":"Redox Biol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"14498","DOI":"10.1039\/d1dt02909f","article-title":"Metal complexes against breast cancer stem cells","volume":"50","author":"Li","year":"2021","journal-title":"Dalton Trans."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1021\/ar400266c","article-title":"Organoiridium complexes: anticancer agents and catalysts","volume":"47","author":"Liu","year":"2014","journal-title":"Accounts Chem. Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"9904","DOI":"10.1039\/c9cc04098f","article-title":"Functionalization and cancer-targeting design of ruthenium complexes for precise cancer therapy","volume":"55","author":"Liu","year":"2019","journal-title":"Chem. Commun."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1038\/s41598-017-01624-4","article-title":"DNA methylation and transcriptome changes associated with cisplatin resistance in ovarian cancer","volume":"7","author":"Lund","year":"2017","journal-title":"Sci. Rep."},{"key":"B46","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3390\/inorganics9040026","article-title":"Anticancer half-sandwich rhodium(III) complexes","volume":"9","author":"M\u00e1likov\u00e1","year":"2021","journal-title":"Inorganics"},{"key":"B47","doi-asserted-by":"publisher","first-page":"39748","DOI":"10.1039\/d1ra06559a","article-title":"Pd(ii) and Pt(ii) complexes of tridentate ligands with selective toxicity against Cryptococcus neoformans and Candida albicans","volume":"11","author":"Mansour","year":"2021","journal-title":"RSC Adv."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e0187789","DOI":"10.1371\/journal.pone.0187789","article-title":"PARP10 (ARTD10) modulates mitochondrial function","volume":"13","author":"M\u00e1rton","year":"2018","journal-title":"PLoS One"},{"key":"B49","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1080\/09674845.2012.11669916","article-title":"Antibacterial effects on acinetobacter species of commonly employed antineoplastic agents used in the treatment of haematological malignancies: an in vitro laboratory evaluation","volume":"69","author":"Mccarron","year":"2012","journal-title":"Br. J. Biomed. Sci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.semcancer.2020.08.013","article-title":"New approaches for targeting platinum-resistant ovarian cancer","volume":"77","author":"Mcmullen","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1039\/c7cs00332c","article-title":"Structure\u2013activity relationships for ruthenium and osmium anticancer agents \u2013 towards clinical development","volume":"47","author":"Meier-Menches","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"B52","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/3527607692.ch2","article-title":"Ruthenium arene anticancer complexes","volume-title":"Bioorganometallics","author":"MelChart","year":"2005"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1016\/j.biopha.2018.08.051","article-title":"Acute toxic effects of ruthenium (II)\/amino acid\/diphosphine complexes on Swiss mice and zebrafish embryos","volume":"107","author":"Mello-Andrade","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"B54","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1139\/cjpp-2020-0349","article-title":"Redox and apoptotic potential of novel ruthenium complexes in rat blood and heart","volume":"99","author":"Mihajlovic","year":"2020","journal-title":"Can. J. Physiology Pharmacol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1080\/17425255.2020.1806235","article-title":"Strategies to reduce the risk of platinum containing antineoplastic drug-induced ototoxicity","volume":"16","author":"Mukherjea","year":"2020","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"112483","DOI":"10.1016\/j.ejmech.2020.112483","article-title":"Synthesis, structure and anti-cancer activity of osmium complexes bearing pi-bound arene substituents and phosphane Co-ligands: A review","volume":"201","author":"Nabiyeva","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"B57","doi-asserted-by":"publisher","first-page":"12016","DOI":"10.1039\/c9cc03822a","article-title":"Anticancer organorhodium and -iridium complexes with low toxicity in vivo but high potency in vitro: DNA damage, reactive oxygen species formation, and haemolytic activity","volume":"55","author":"Parveen","year":"2019","journal-title":"Chem. Commun."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1016\/j.jinorgbio.2011.09.021","article-title":"Platinum(II) and palladium(II) complexes with (N, N') and (C, N, N')- ligands derived from pyrazole as anticancer and antimalarial agents: synthesis, characterization and in vitro activities","volume":"105","author":"Quirante","year":"2011","journal-title":"J. Inorg. Biochem."},{"key":"B59","doi-asserted-by":"publisher","first-page":"2915","DOI":"10.3390\/cancers12102915","article-title":"Indoxylsulfate, a metabolite of the microbiome, has cytostatic effects in breast cancer via activation of AHR and PXR receptors and induction of oxidative stress","volume":"12","author":"S\u00e1ri","year":"","journal-title":"Cancers (Basel)"},{"key":"B60","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.3390\/cancers12092411","article-title":"Indolepropionic acid, a metabolite of the microbiome, has cytostatic properties in breast cancer by activating AHR and PXR receptors and inducing oxidative stress","volume":"12","author":"S\u00e1ri","year":"","journal-title":"Cancers (Basel)"},{"key":"B61","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s10020-021-00295-2","article-title":"The role of the microbiome in ovarian cancer: mechanistic insights into oncobiosis and to bacterial metabolite signaling","volume":"27","author":"Sipos","year":"2021","journal-title":"Mol. Med."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1093\/jnci\/82.13.1107","article-title":"New colorimetric cytotoxicity assay for anticancer-drug screening","volume":"82","author":"Skehan","year":"1990","journal-title":"J. Natl. Cancer Inst."},{"key":"B63","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1089\/ars.2020.8024","article-title":"Nuclear factor erythroid 2-related factor 2 in regulating cancer metabolism","volume":"33","author":"Smolkov\u00e1","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"B64","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.ccr.2019.06.001","article-title":"Non-platinum complexes containing releasable biologically active ligands","volume":"395","author":"\u0160tarha","year":"2019","journal-title":"Coord. Chem. Rev."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1016\/j.jinorgbio.2011.07.018","article-title":"DNA as molecular target of analogous palladium and platinum anti-trypanosoma cruzi compounds: a comparative study","volume":"105","author":"Vieites","year":"2011","journal-title":"J. Inorg. Biochem."},{"key":"B66","doi-asserted-by":"publisher","first-page":"3753","DOI":"10.4049\/jimmunol.161.7.3753","article-title":"Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death","volume":"161","author":"Vir\u00e1g","year":"1998","journal-title":"J. Immunol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1039\/c8qi00476e","article-title":"Mitochondria-targeted half-sandwich rutheniumII diimine complexes: anticancer and antimetastasis via ROS-mediated signalling","volume":"5","author":"Xu","year":"2018","journal-title":"Inorg. Chem. Front."},{"key":"B68","doi-asserted-by":"publisher","first-page":"13397","DOI":"10.1021\/acs.jmedchem.0c00950","article-title":"Platinum-based combination therapy: Molecular rationale, current clinical uses, and future perspectives","volume":"63","author":"Yu","year":"2020","journal-title":"J. Med. Chem."},{"key":"B69","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.3762\/bjoc.14.284","article-title":"Repurposing the anticancer drug cisplatin with the aim of developing novel Pseudomonas aeruginosa infection control agents","volume":"14","author":"Yuan","year":"2018","journal-title":"Beilstein J. Org. Chem."},{"key":"B70","doi-asserted-by":"publisher","first-page":"213285","DOI":"10.1016\/j.ccr.2020.213285","article-title":"Platinum(II) and ruthenium(II) complexes in medicine: Antimycobacterial and anti-HIV activities","volume":"414","author":"Yufanyi","year":"2020","journal-title":"Coord. Chem. Rev."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1002\/cmdc.202000391","article-title":"Combining PARP inhibition with platinum, ruthenium or gold complexes for cancer therapy","volume":"15","author":"Yusoh","year":"2020","journal-title":"ChemMedChem"},{"key":"B72","doi-asserted-by":"publisher","first-page":"5771","DOI":"10.1039\/c7cs00195a","article-title":"The development of anticancer ruthenium(II) complexes: from single molecule compounds to nanomaterials","volume":"46","author":"Zeng","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"B73","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.freeradbiomed.2016.11.032","article-title":"4-hydroxynonenal-mediated signaling and aging","volume":"111","author":"Zhang","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1074\/jbc.m110.171124","article-title":"Cisplatin inhibits protein splicing, suggesting inteins as therapeutic targets in mycobacteria","volume":"286","author":"Zhang","year":"2011","journal-title":"J. Biol. Chem."}],"container-title":["Frontiers in Chemistry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fchem.2023.1086267\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T21:12:31Z","timestamp":1701810751000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fchem.2023.1086267\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,30]]},"references-count":74,"alternative-id":["10.3389\/fchem.2023.1086267"],"URL":"https:\/\/doi.org\/10.3389\/fchem.2023.1086267","relation":{},"ISSN":["2296-2646"],"issn-type":[{"value":"2296-2646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,30]]},"article-number":"1086267"}}