{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:28:24Z","timestamp":1791728904412,"version":"4.3.4"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p>\n                    The influence of metal ions, the state of metal salt, and ligands on the sterilization ability of (Metalorganic frameworks) MOFs to effectively achieve sterilization has been investigated in this study. Initially, the MOFs were synthesized by elements of Zn, Ag, and Cd for the same periodic and main group of Cu. This illustrated that the atomic structure of Cu was more beneficial for coordinating with ligands. To further induce the maximum amount of Cu\n                    <jats:sup>2+<\/jats:sup>\n                    ions in the Cu-MOFs to achieve the highest sterilization, various Cu-MOFs synthesized by the different valences of Cu, various states of copper salts, and organic ligands were performed, respectively. The results demonstrated that Cu-MOFs synthesized by 3, 5-dimethyl-1, 2, 4-triazole and tetrakis (acetonitrile) copper(I) tetrafluoroborate presented the largest inhibition-zone diameter of 40.17\u00a0mm towards\n                    <jats:italic>Staphylococcus Aureus<\/jats:italic>\n                    (\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ) under dark conditions. The proposed mechanism of Cu (\u2161) in MOFs could significantly cause multiple toxic effects, such as the generation of reactive oxygen species, and lipid peroxidation in\n                    <jats:italic>S. aureus<\/jats:italic>\n                    cells, when the bacteria was anchored by the Cu-MOFs\n                    <jats:italic>via<\/jats:italic>\n                    electrostatic interaction. Finally, the broad antimicrobial properties of Cu-MOFs against\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (\n                    <jats:italic>E. coli<\/jats:italic>\n                    ),\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    (\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    ), and\n                    <jats:italic>S. aureus<\/jats:italic>\n                    were demonstrated. In conclusion, the Cu-3, 5-dimethyl-1, 2, 4-triazole MOFs appeared to be potential antibacterial catalysts in the antimicrobial field.\n                  <\/jats:p>","DOI":"10.3389\/fchem.2023.1124303","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:39Z","timestamp":1676419239000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["The synthesis and highly effective antibacterial properties of Cu-3, 5-dimethy l-1, 2, 4-triazole metal organic frameworks"],"prefix":"10.3389","volume":"11","author":[{"given":"Xiaolin","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengna","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiquan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujian","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchun","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuning","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hexing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"69272","DOI":"10.1007\/s11356-021-15295-2","article-title":"Remarkable adsorption of hydroquinone as an anion contaminant by using the magnetic supported bimetallic (NiCu-MOF@MAC) nanocomposites in aqueous solutions","volume":"28","author":"AkbarBandari","year":"2021","journal-title":"Environ. Sci. Pollut. R."},{"key":"B2","doi-asserted-by":"publisher","first-page":"128547","DOI":"10.1016\/j.molstruc.2020.128547","article-title":"Six new palladium(II) mixed ligand complexes of 2-3-4-monosubstituted derivative of pyridine ring with caffeine moiety: Synthesis, spectroscopic, morphological structures, thermal, antimicrobial and anticancer properties","volume":"1218","author":"Al-Saif","year":"2020","journal-title":"J. Mol. Struct."},{"key":"B3","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.mssp.2006.01.035","article-title":"Analysis of electrically active N\u2013O complexes in nitrogen-doped CZ silicon crystals by FTIR spectroscopy","volume":"9","author":"Alt","year":"2006","journal-title":"Mat. Sci. SEMICON. Proc."},{"key":"B4","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3390\/antibiotics9030119","article-title":"Insights into acinetobacter baumannii: A review of microbiological, virulence, and resistance traits in a threatening nosocomial pathogen","volume":"9","author":"Ayoub Moubareck","year":"2020","journal-title":"ANTIBIOTICS"},{"key":"B5","doi-asserted-by":"publisher","first-page":"122339","DOI":"10.1016\/j.ijpharm.2022.122339","article-title":"Synergistic wound healing by novel Ag@ZIF-8 nanostructures","volume":"629","author":"Barjasteh","year":"2022","journal-title":"Int. J. Pharm."},{"key":"B6","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1021\/jp411033h","article-title":"Molecular structures and absorption spectra assignment of corrole NH tautomers","volume":"118","author":"Beenken","year":"2014","journal-title":"J. Phys. Chem. A"},{"key":"B7","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jinorgbio.2016.09.014","article-title":"Coordination ability and biological activity of a naringenin thiosemicarbazone","volume":"165","author":"Brodowska","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"B8","doi-asserted-by":"publisher","first-page":"10574","DOI":"10.1039\/C7TA02282D","article-title":"Copper on carbon materials: Stabilization by nitrogen doping","volume":"5","author":"Bulushev","year":"2017","journal-title":"J. Mat. Chem. A"},{"key":"B9","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.carbon.2018.07.032","article-title":"Channelling and induced defects at ion-bombarded aligned multiwall carbon nanotubes","volume":"139","author":"D'Acunto","year":"2018","journal-title":"Carbon"},{"key":"B10","doi-asserted-by":"publisher","first-page":"7378","DOI":"10.1039\/D0CY01500H","article-title":"Photoelectrocatalytic bacterial inactivation of Acinetobacter baumannii on Cu2O\/TiO2@Cu mesh photoanodes","volume":"10","author":"Ding","year":"2020","journal-title":"Catal. Sci. Technol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1021\/es8025424","article-title":"Oxidation of antibacterial compounds by ozone and hydroxyl radical: Elimination of biological activity during aqueous ozonation processes","volume":"43","author":"Dodd","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.biomaterials.2017.08.024","article-title":"Metal-carbenicillin framework-based nanoantibiotics with enhanced penetration and highly efficient inhibition of MRSA","volume":"144","author":"Duan","year":"2017","journal-title":"BIOMATERIALS"},{"key":"B13","doi-asserted-by":"publisher","first-page":"108668","DOI":"10.1016\/j.jece.2022.108668","article-title":"Fabrication and characterization of polymer nanocomposites membrane (Cu-MOF@CA\/PES) for water treatment","volume":"10","author":"Gowriboy","year":"2022","journal-title":"J. Environ. Chem. Eng."},{"key":"B14","doi-asserted-by":"publisher","first-page":"126336","DOI":"10.1016\/j.jhazmat.2021.126336","article-title":"Biosorption of heavy metal ions by green alga Neochloris oleoabundans: Effects of metal ion properties and cell wall structure","volume":"418","author":"Gu","year":"2021","journal-title":"J. HAZARD. Mat."},{"key":"B15","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.tibtech.2012.06.004","article-title":"Antibacterial properties of nanoparticles","volume":"30","author":"Hajipour","year":"2012","journal-title":"TRENDS. Biotechnol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1039\/C5EE03440J","article-title":"Vertically oriented cobalt selenide\/NiFe layered-double-hydroxide nanosheets supported on exfoliated graphene foil: An efficient 3D electrode for overall water splitting","volume":"9","author":"Hou","year":"2016","journal-title":"Energy Environ. Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.micromeso.2016.01.003","article-title":"Applicability of using CO2 adsorption isotherms to determine BET surface areas of microporous materials","volume":"224","author":"Kim","year":"2016","journal-title":"MICROPOR. MESOPOR. Mat."},{"key":"B18","doi-asserted-by":"publisher","first-page":"138618","DOI":"10.1016\/j.cej.2022.138618","article-title":"The key role of carboxylate ligands in Ru@Ni-MOFs\/NF in promoting water dissociation kinetics for effective hydrogen evolution in alkaline media","volume":"451","author":"Li","year":"2023","journal-title":"Chem. Eng. J."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1400405","DOI":"10.1002\/admi.201400405","article-title":"Spatioselective fabrication of highly effective antibacterial layer by surface-anchored discrete metal-organic frameworks","volume":"2","author":"Li","year":"2015","journal-title":"Adv. Mat. INTERFACES"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1111\/raq.12639","article-title":"Interactions and associated resistance development mechanisms between microplastics, antibiotics and heavy metals in the aquaculture environment","volume":"14","author":"Li","year":"2022","journal-title":"Rev. AQUACULT."},{"key":"B21","first-page":"79","volume-title":"A concise handbook of spectral interpretation","author":"Lijun Wu","year":"2013"},{"key":"B22","doi-asserted-by":"publisher","first-page":"128909","DOI":"10.1016\/j.molstruc.2020.128909","article-title":"A novel imidazole-based tri-nitrogen metal cations probe with better-selectivity in ionic radius and acting as a Zn2+ fluorescence turn-on sensor2+ fluorescence turn-on sensor","volume":"1222","author":"Liu","year":"2020","journal-title":"J. Mol. Struct."},{"key":"B23","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.tifs.2021.01.012","article-title":"Antibacterial mechanisms and applications of metal-organic frameworks and their derived nanomaterials","volume":"109","author":"Liu","year":"2021","journal-title":"TRENDS FOOD. Sci. Tech."},{"key":"B24","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1002\/chem.201801983","article-title":"Recent progress in two-dimensional antimicrobial nanomaterials","volume":"25","author":"Miao","year":"2019","journal-title":"CHEM-EUR. J."},{"key":"B25","doi-asserted-by":"publisher","first-page":"9658","DOI":"10.1016\/j.ceramint.2017.04.137","article-title":"Preparation of novel Cu\/TiO2 mischcrystal composites and antibacterial activities for Escherichia coli under visible light","volume":"43","author":"Miao","year":"2017","journal-title":"Ceram. Int."},{"key":"B26","doi-asserted-by":"publisher","first-page":"7787","DOI":"10.1039\/C5CS00041F","article-title":"Inorganic nanoparticles engineered to attack bacteria","volume":"44","author":"Miller","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"B27","doi-asserted-by":"publisher","first-page":"107960","DOI":"10.1016\/j.compscitech.2019.107960","article-title":"Highly-efficient microwave absorptivity in reduced graphene oxide modified with PTA@ imidazolium based dicationic ionic liquid and fluorine atom","volume":"188","author":"Mohamadi","year":"2020","journal-title":"Compos. Sci. Technol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.molstruc.2008.02.016","article-title":"N\u2013H.O hydrogen bonding. FT-IR, NIR and 1H NMR study of N-methylpropionamide-Dialkyl ether systems","volume":"889","author":"Nikoli\u0107","year":"2008","journal-title":"J. Mol. Struct."},{"key":"B29","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1186\/s11671-017-2317-0","article-title":"Biosafety and antibacterial ability of graphene and graphene oxide in vitro and in vivo","volume":"12","author":"Pang","year":"2017","journal-title":"NANOSCALE Res. Lett."},{"key":"B30","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.carres.2009.12.010","article-title":"Metal-carboxylate interactions in metal-alginate complexes studied with FTIR spectroscopy","volume":"345","author":"Papageorgiou","year":"2010","journal-title":"CARBOHYD. Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.porgcoat.2012.10.019","article-title":"Characterization of tertiary amine and epoxy functional all-acrylic coating system","volume":"76","author":"Par\u0131ldar","year":"2013","journal-title":"Prog. Org. Coat."},{"key":"B32","doi-asserted-by":"publisher","first-page":"214121","DOI":"10.1016\/j.ccr.2021.214121","article-title":"Antimicrobial MOFs","volume":"446","author":"Pettinari","year":"2021","journal-title":"Coord. Chem. Rev."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1800011","DOI":"10.1002\/adfm.201800011","article-title":"pH-responsive, light-triggered on-demand antibiotic release from functional metal-organic framework for bacterial infection combination therapy","volume":"28","author":"Song","year":"2018","journal-title":"Adv. Funct. Mat."},{"key":"B34","doi-asserted-by":"publisher","first-page":"5471","DOI":"10.1021\/nn101558x","article-title":"Electronic-structure-dependent bacterial cytotoxicity of single-walled carbon nanotubes","volume":"4","author":"Vecitis","year":"2010","journal-title":"ACS Nano"},{"key":"B35","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.carbon.2018.03.053","article-title":"Argon atoms insertion in diamond: New insights in the identification of carbon C 1s peak in X-ray photoelectron spectroscopy analysis","volume":"134","author":"Veyan","year":"2018","journal-title":"Carbon"},{"key":"B36","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.bioactmat.2022.01.036","article-title":"Triple-synergistic MOF-nanozyme for efficient antibacterial treatment","volume":"17","author":"Wang","year":"2022","journal-title":"Bioact. Mat."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2070138","DOI":"10.1002\/adma.202070138","article-title":"Antibiotic\u2010free strategies: Antibiotic\u2010free antibacterial strategies enabled by nanomaterials: Progress and perspectives (adv. Mater. 18\/2020)","volume":"32","author":"Wang","year":"2020","journal-title":"Adv. Mat."},{"key":"B38","doi-asserted-by":"publisher","first-page":"17979","DOI":"10.1021\/jacs.7b09281","article-title":"Photocontrol of antibacterial activity: Shifting from UV to red light activation","volume":"139","author":"Wegener","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"B39","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.foodcont.2018.11.011","article-title":"Porous metal-organic framework (MOF) Carrier for incorporation of volatile antimicrobial essential oil","volume":"98","author":"Wu","year":"2019","journal-title":"FOOD control."},{"key":"B40","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.msec.2017.07.027","article-title":"Preparation of spherical metal\u2013organic frameworks encapsulating ag nanoparticles and study on its antibacterial activity","volume":"80","author":"Ximing","year":"2017","journal-title":"Mat. Sci. Eng. C"},{"key":"B41","doi-asserted-by":"publisher","first-page":"5258","DOI":"10.1039\/C4DT04030A","article-title":"The concept of mixed organic ligands in metal-organic frameworks: Design, tuning and functions","volume":"44","author":"Yin","year":"2015","journal-title":"DALTON T"},{"key":"B42","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1186\/s11671-017-2290-7","article-title":"One-pot synthesis of hierarchical flower-like Pd-Cu alloy support on graphene towards ethanol oxidation","volume":"12","author":"Zhang","year":"2017","journal-title":"NANOSCALE Res. Lett."},{"key":"B43","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.ijbiomac.2022.01.074","article-title":"Ag@MOF-loaded p-coumaric acid modified chitosan\/chitosan nanoparticle and polyvinyl alcohol\/starch bilayer films for food packing applications","volume":"202","author":"Zhang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"3793","DOI":"10.1039\/D2TB00195K","article-title":"Mineralization of calcium phosphate on two-dimensional polymer films with controllable density of carboxyl groups","volume":"10","author":"Zhang","year":"2022","journal-title":"J. Mat. Chem. B"},{"key":"B45","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1002\/adhm.201100043","article-title":"Highly potent bactericidal activity of porous metal-organic frameworks","volume":"1","author":"Zhuang","year":"2012","journal-title":"Adv. Healthc. Mat."}],"container-title":["Frontiers in Chemistry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fchem.2023.1124303\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:42Z","timestamp":1676419242000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fchem.2023.1124303\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,15]]},"references-count":45,"alternative-id":["10.3389\/fchem.2023.1124303"],"URL":"https:\/\/doi.org\/10.3389\/fchem.2023.1124303","relation":{},"ISSN":["2296-2646"],"issn-type":[{"value":"2296-2646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,15]]},"article-number":"1124303"}}