{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T08:27:24Z","timestamp":1774513644322,"version":"3.50.1"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p>\n                    A palladium-catalyzed asymmetric three-component synthesis of\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -arylglycine derivatives starting from glyoxylic acid, sulfonamides and arylboronic acids is reported. This novel, operationally simple method offers access to the\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -arylglycine scaffold in good yields and enantioselectivities. The utilization of \u03b1 tailored catalyst system enables the enantioselective synthesis of the desired\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -arylglycines despite a fast racemic background reaction. The obtained products can be directly employed as building blocks in peptide synthesis.\n                  <\/jats:p>","DOI":"10.3389\/fchem.2023.1165618","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T01:49:58Z","timestamp":1678672198000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Palladium-catalyzed asymmetric three-component reaction between glyoxylic acid, sulfonamides and arylboronic acids for the synthesis of \u03b1-arylglycine derivatives"],"prefix":"10.3389","volume":"11","author":[{"given":"Bastian","family":"Jakob","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas M.","family":"Diehl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Horst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Kelm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Manolikakes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4116","DOI":"10.1021\/acs.orglett.6b02045","article-title":"Palladium-catalyzed enantioselective three-component synthesis of \u03b1-arylglycines","volume":"18","author":"Beisel","year":"","journal-title":"Org. 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