{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:33:21Z","timestamp":1792427601385,"version":"4.5.0"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010847","name":"Health and Family Planning Commission of Jiangxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p>\n                    Rutaecarpine (RUT) is a natural pentacyclic indolopyridoquinazolinone alkaloid first isolated from one of the most famous traditional Chinese herbs,\n                    <jats:italic>Evodia rutaecarpa<\/jats:italic>\n                    , which is used for treating a variety of ailments, including headaches, gastrointestinal disorders,\n                    <jats:italic>postpartum<\/jats:italic>\n                    hemorrhage, amenorrhea, difficult menstruation, and other diseases. Accumulating pharmacological studies showed that RUT possesses a wide range of pharmacological effects through different mechanisms. However, its poor physicochemical properties and moderate biological activities have hampered its clinical application. In this regard, the modification of RUT aimed at seeking its derivatives with better physicochemical properties and more potency has been extensively studied. These derivatives exhibit diverse pharmacological activities, including anti-inflammatory, anti-atherogenic, anti-Alzheimer\u2019s disease, antitumor, and antifungal activities via a variety of mechanisms, such as inhibiting cyclooxygenase-2 (COX-2), acetylcholine (AChE), phosphodiesterase 4B (PDE4B), phosphodiesterase 5 (PDE5), or topoisomerases (Topos). From this perspective, this paper provides a comprehensive description of RUT derivatives by focusing on their diverse biological activities. This review aims to give an insight into the biological activities of RUT derivatives and encourage further exploration of RUT.\n                  <\/jats:p>","DOI":"10.3389\/fchem.2023.1199799","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T13:26:29Z","timestamp":1698845189000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Promising derivatives of rutaecarpine with diverse pharmacological activities"],"prefix":"10.3389","volume":"11","author":[{"given":"Deping","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1161\/CIRCULATIONAHA.114.013730","article-title":"Anti-inflammatory and antiatherogenic effects of the NLRP3 inflammasome inhibitor arglabin in ApoE2.Ki mice fed a high-fat diet","volume":"131","author":"Abderrazak","year":"2015","journal-title":"Circulation"},{"key":"B2","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.ejphar.2014.10.026","article-title":"Tadalafil enhances working memory, and reduces hippocampal oxidative stress in both young and aged mice","volume":"745","author":"Al-Amin","year":"2014","journal-title":"Eur. 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