{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:05:26Z","timestamp":1784419526977,"version":"3.55.0"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p>Quercetin (QR) is a natural flavonol compound widely distributed in the plant kingdom with extensive pharmacological effects. To find the potential clinical indications of QR, 156 differentially expressed genes (DEGs) regulated by QR were obtained from the Gene Expression Omnibus database, and new potential pharmacological effects and clinical indications of QR were repurposed by integrating compounds with similar gene perturbation signatures and associated-disease signatures to QR based on the Connectivity Map and Coexpedia platforms. The results suggested QR has mainly potential therapeutic effects on multiple sclerosis (MS), osteoarthritis, type 2 diabetes mellitus, and acute leukemia. Then, MS was selected for subsequent animal experiments as a representative potential indication, and it found that QR significantly delays the onset time of classical MS model animal mice and ameliorates the inflammatory infiltration and demyelination in the central nervous system. Combined with network pharmacology technology, the therapeutic mechanism of QR on MS was further demonstrated to be related to the inhibition of the expression of inflammatory cytokines (TNF-\u03b1, IL-6, IL-1\u03b2, IFN-\u03b3, IL-17A, and IL-2) related to TNF-\u03b1\/TNFR1 signaling pathway. In conclusion, this study expanded the clinical indications of QR and preliminarily confirmed the therapeutic effect and potential mechanism of QR on MS.<\/jats:p>","DOI":"10.3389\/fchem.2023.1250043","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T05:48:05Z","timestamp":1694152085000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Drug repurposing based on the similarity gene expression signatures to explore for potential indications of quercetin: a case study of multiple sclerosis"],"prefix":"10.3389","volume":"11","author":[{"given":"Yulong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuqing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfa","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,9,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"110594","DOI":"10.1016\/j.biopha.2020.110594","article-title":"Diacerein: recent insight into pharmacological activities and molecular pathways","volume":"131","author":"Almezgagi","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"B2","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1177\/1078155220975825","article-title":"A drug repositioning success: the repositioned therapeutic applications and mechanisms of action of thalidomide","volume":"27","author":"Amare","year":"2021","journal-title":"J. Oncol. Pharm. Pract."},{"key":"B3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1159\/000064410","article-title":"Function of the hypothalamo-pituitary-adrenal axis and humoral immune mechanisms during experimental allergic encephalomyelitis in SJL\/J mice","volume":"10","author":"Andreini","year":"2002","journal-title":"Neuroimmunomodulation"},{"key":"B4","doi-asserted-by":"publisher","first-page":"172784","DOI":"10.1016\/j.ejphar.2019.172784","article-title":"Old wine in new bottles: drug repurposing in oncology","volume":"866","author":"Antoszczak","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"842641","DOI":"10.3389\/fcvm.2022.842641","article-title":"In silico drug screening approach using l1000-based connectivity map and its application to COVID-19","volume":"9","author":"Asano","year":"2022","journal-title":"Front. Cardiovasc Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1017\/S0007114510000711","article-title":"Quercetin supplementation and its effect on human monocyte gene expression profiles in vivo","volume":"104","author":"Boomgaarden","year":"2010","journal-title":"Br. J. Nutr."},{"key":"B7","doi-asserted-by":"publisher","first-page":"11879","DOI":"10.1073\/pnas.211178398","article-title":"Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-\u03b1","volume":"98","author":"Carter","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.3390\/v14112365","article-title":"Quercetin inhibits Hsp70 blocking of bovine viral diarrhea Virus infection and replication in the early stage of Virus infection","volume":"14","author":"Chen","year":"2022","journal-title":"Viruses"},{"key":"B9","doi-asserted-by":"publisher","first-page":"640778","DOI":"10.3389\/fimmu.2021.640778","article-title":"Illumination of molecular pathways in multiple sclerosis lesions and the immune mechanism of matrine treatment in EAE, a mouse model of MS","volume":"12","author":"Dou","year":"2021","journal-title":"Front. Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"112058","DOI":"10.1016\/j.fct.2021.112058","article-title":"Computational pharmacology and bioinformatics to explore the potential mechanism of Schisandra against atherosclerosis","volume":"150","author":"Duan","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"303","DOI":"10.2174\/1566524019666190405094125","article-title":"Revealing the synergistic mechanism of multiple components in compound fengshiding capsule for rheumatoid arthritis therapeutics by network pharmacology","volume":"19","author":"Duan","year":"2019","journal-title":"Curr. Mol. Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and Python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model"},{"key":"B13","doi-asserted-by":"publisher","first-page":"CD005117","DOI":"10.1002\/14651858.CD005117.pub3","article-title":"Diacerein for osteoarthritis","volume":"2","author":"Fidelix","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.3389\/fimmu.2019.01200","article-title":"Glucocorticoid therapy of multiple sclerosis patients induces anti-inflammatory polarization and increased chemotaxis of monocytes","volume":"10","author":"Fischer","year":"2019","journal-title":"Front. Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1080\/14737175.2020.1776610","article-title":"Cannabis and multiple sclerosis","volume":"20","author":"Fragoso","year":"2020","journal-title":"Expert Rev. Neurother."},{"key":"B16","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.cytogfr.2018.07.001","article-title":"Autophagy and proinflammatory cytokines: interactions and clinical implications","volume":"43","author":"Ge","year":"2018","journal-title":"Cytokine Growth Factor Rev."},{"key":"B17","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1084\/jem.20160517","article-title":"CNS-targeted autoimmunity leads to increased influenza mortality in mice","volume":"214","author":"Glenn","year":"2017","journal-title":"J. Exp. Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2451","DOI":"10.2337\/dc14-0398","article-title":"Effect of exenatide, sitagliptin, or glimepiride on beta-cell secretory capacity in early type 2 diabetes","volume":"37","author":"Gudipaty","year":"2014","journal-title":"Diabetes Care"},{"key":"B19","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1111\/dom.14875","article-title":"A 96-week, double-blind, randomized controlled trial comparing bexagliflozin to glimepiride as an adjunct to metformin for the treatment of type 2 diabetes in adults","volume":"25","author":"Halvorsen","year":"2023","journal-title":"Diabetes Obes. Metab."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1126\/science.1116304","article-title":"Small-molecule inhibition of TNF-\u03b1","volume":"310","author":"He","year":"2005","journal-title":"Science"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1084\/jem.20040819","article-title":"Flavonoids influence monocytic GTPase activity and are protective in experimental allergic encephalitis","volume":"200","author":"Hendriks","year":"2004","journal-title":"J. Exp. Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"577269","DOI":"10.1016\/j.jneuroim.2020.577269","article-title":"Involvement of NF\u0199B and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS","volume":"345","author":"Hilliard","year":"2020","journal-title":"J. Neuroimmunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"e83922","DOI":"10.1371\/journal.pone.0083922","article-title":"Combining machine learning systems and multiple docking simulation packages to improve docking prediction reliability for network pharmacology","volume":"8","author":"Hsin","year":"2013","journal-title":"PLoS One"},{"key":"B24","doi-asserted-by":"publisher","first-page":"474267","DOI":"10.3389\/fphar.2021.474267","article-title":"The advantages of connectivity map applied in traditional Chinese medicine","volume":"12","author":"Jiang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1080\/07315724.2016.1140093","article-title":"The effect of quercetin on inflammatory factors and clinical symptoms in women with rheumatoid arthritis: a double-blind, randomized controlled trial","volume":"36","author":"Javadi","year":"2017","journal-title":"J. Am. Coll. Nutr."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e552","DOI":"10.1016\/S2352-3026(21)00192-7","article-title":"Venetoclax plus intensive chemotherapy with cladribine, idarubicin, and cytarabine in patients with newly diagnosed acute myeloid leukaemia or high-risk myelodysplastic syndrome: a cohort from a single-centre, single-arm, phase 2 trial","volume":"8","author":"Kadia","year":"2021","journal-title":"Lancet Haematol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"482","DOI":"10.3390\/cells9020482","article-title":"T helper cells: the modulators of inflammation in multiple sclerosis","volume":"9","author":"Kunkl","year":"2020","journal-title":"Cells"},{"key":"B28","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.intimp.2019.01.017","article-title":"Quercetin reduces Streptococcus suis virulence by inhibiting suilysin activity and inflammation","volume":"69","author":"Li","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"e9357","DOI":"10.7717\/peerj.9357","article-title":"Host transcriptome-guided drug repurposing for COVID-19 treatment: a meta-analysis based approach","volume":"8","author":"Loganathan","year":"2020","journal-title":"PeerJ"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e22660","DOI":"10.1096\/fj.202201683R","article-title":"Molecular interaction networks and drug development: novel approach to drug target identification and drug repositioning","volume":"37","author":"Loscalzo","year":"2023","journal-title":"FASEB J."},{"key":"B31","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1002\/ana.25197","article-title":"Inflammatory intrathecal profiles and cortical damage in multiple sclerosis","volume":"83","author":"Magliozzi","year":"2018","journal-title":"Ann. Neurol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1007\/s00277-022-04764-4","article-title":"Benefit of high-dose idarubicin as induction therapy in acute myeloid leukemia: a prospective phase 2 study","volume":"101","author":"Mao","year":"2022","journal-title":"Ann. Hematol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/0014-4886(95)90044-6","article-title":"Inhibition of tumor necrosis factor is protective against neurologic dysfunction after active immunization of Lewis rats with myelin basic protein","volume":"131","author":"Martin","year":"1995","journal-title":"Exp. Neurol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"654489","DOI":"10.3389\/fphar.2021.654489","article-title":"Microglia specific drug targeting using natural products for the regulation of redox imbalance in neurodegeneration","volume":"12","author":"Maurya","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1002\/pros.23536","article-title":"Quercetin protects against chronic prostatitis in rat model through NF-\u03baB and MAPK signaling pathways","volume":"78","author":"Meng","year":"2018","journal-title":"Prostate"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1016\/j.celrep.2015.02.051","article-title":"Activation of necroptosis in multiple sclerosis","volume":"10","author":"Ofengeim","year":"2015","journal-title":"Cell Rep."},{"key":"B37","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1097\/WCO.0000000000000622","article-title":"Multiple sclerosis: clinical aspects","volume":"31","author":"Oh","year":"2018","journal-title":"Curr. Opin. Neurol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/bph.13139","article-title":"Microglial M1\/M2 polarization and metabolic states","volume":"173","author":"Orihuela","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1016\/j.drudis.2019.06.014","article-title":"Drug repurposing: a promising tool to accelerate the drug discovery process","volume":"24","author":"Parvathaneni","year":"2019","journal-title":"Drug Discov. Today"},{"key":"B40","doi-asserted-by":"publisher","first-page":"e200051","DOI":"10.1212\/NXI.0000000000200051","article-title":"Recurrent optic neuritis and perineuritis followed by an unexpected discovery: from the national multiple sclerosis society case conference proceedings","volume":"10","author":"Pimentel Maldonado","year":"2023","journal-title":"Neurol. Neuroimmunol. Neuroinflamm"},{"key":"B41","doi-asserted-by":"publisher","first-page":"e20191247","DOI":"10.1084\/jem.20191247","article-title":"Effects of interleukin-2 in immunostimulation and immunosuppression","volume":"217","author":"Pol","year":"2020","journal-title":"J. Exp. Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/nrd.2018.168","article-title":"Drug repurposing: progress, challenges and recommendations","volume":"18","author":"Pushpakom","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"B43","doi-asserted-by":"publisher","first-page":"625991","DOI":"10.3389\/fphar.2021.625991","article-title":"Computational drug repositioning and experimental validation of ivermectin in treatment of gastric cancer","volume":"12","author":"Rabben","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"3834","DOI":"10.1039\/d1nr06001e","article-title":"Hydrogel-mediated topical delivery of steroids can effectively alleviate psoriasis via attenuating the autoimmune responses","volume":"14","author":"Rana","year":"2022","journal-title":"Nanoscale"},{"key":"B45","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1056\/NEJMra1401483","article-title":"Multiple sclerosis","volume":"378","author":"Reich","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/s41401-021-00752-y","article-title":"Benzimidazoles induce concurrent apoptosis and pyroptosis of human glioblastoma cells via arresting cell cycle","volume":"43","author":"Ren","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"B47","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s12974-015-0293-9","article-title":"Astrocyte response to IFN-gamma limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitis","volume":"12","author":"Savarin","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"B48","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1017\/S0007114515005310","article-title":"Quercetin lowers plasma uric acid in pre-hyperuricaemic males: a randomised, double-blinded, placebo-controlled, cross-over trial","volume":"115","author":"Shi","year":"2016","journal-title":"Br. J. Nutr."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1042622","DOI":"10.3389\/fimmu.2022.1042622","article-title":"The dichotomous outcomes of TNF\u03b1 signaling in CD4+ T cells","volume":"13","author":"Skartsis","year":"2022","journal-title":"Front. Immunol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1016\/j.cell.2017.10.049","article-title":"A next generation connectivity map: l1000 platform and the first 1,000,000 profiles","volume":"171","author":"Subramanian","year":"2017","journal-title":"Cell"},{"key":"B51","doi-asserted-by":"publisher","first-page":"e0276538","DOI":"10.1371\/journal.pone.0276538","article-title":"Carotenoids as potential inhibitors of TNF\u03b1 in COVID-19 treatment","volume":"17","author":"Taghipour","year":"2022","journal-title":"PLoS One"},{"key":"B52","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"B53","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s00401-015-1402-7","article-title":"The role of IL-17 in CNS diseases","volume":"129","author":"Waisman","year":"2015","journal-title":"Acta Neuropathol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"5340","DOI":"10.2174\/0929867325666181101115801","article-title":"A review of drug repositioning based chemical-induced cell line expression data","volume":"27","author":"Wang","year":"","journal-title":"Curr. Med. Chem."},{"key":"B55","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.4049\/jimmunol.1100333","article-title":"Antiasthmatic drugs targeting the cysteinyl leukotriene receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis","volume":"187","author":"Wang","year":"2011","journal-title":"J. Immunol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"13703","DOI":"10.1111\/jcmm.15928","article-title":"Methylprednisolone alleviates multiple sclerosis by expanding myeloid-derived suppressor cells via glucocorticoid receptor beta and S100A8\/9 up-regulation","volume":"24","author":"Wang","year":"","journal-title":"J. Cell Mol. Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"13628","DOI":"10.1038\/s41598-018-31957-7","article-title":"Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis","volume":"8","author":"Williams","year":"2018","journal-title":"Sci. Rep."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.2174\/1568026617666161116143440","article-title":"Bioinformatics and drug discovery","volume":"17","author":"Xia","year":"2017","journal-title":"Curr. Top. Med. Chem."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.7150\/ijbs.24612","article-title":"Review of drug repositioning approaches and resources","volume":"14","author":"Xue","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/8825387","article-title":"Quercetin: its main pharmacological activity and potential application in clinical medicine","volume":"2020","author":"Yang","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2021\/6678662","article-title":"The therapeutic effects and mechanisms of quercetin on metabolic diseases: pharmacological data and clinical evidence","volume":"2021","author":"Yi","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"B62","doi-asserted-by":"publisher","first-page":"3493","DOI":"10.1016\/j.apsb.2021.03.032","article-title":"Ginsenoside Rg1 ameliorates blood-brain barrier disruption and traumatic brain injury via attenuating macrophages derived exosomes miR-21 release","volume":"11","author":"Zhai","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"B63","doi-asserted-by":"publisher","first-page":"5399","DOI":"10.1172\/JCI121901","article-title":"TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation","volume":"128","author":"Zhang","year":"2018","journal-title":"J. Clin. Invest."},{"key":"B64","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.neulet.2017.04.005","article-title":"Matrine promotes NT3 expression in CNS cells in experimental autoimmune encephalomyelitis","volume":"649","author":"Zhang","year":"2017","journal-title":"Neurosci. Lett."},{"key":"B65","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jep.2018.02.014","article-title":"Bu Shen Yi Sui capsule promotes remyelination correlating with Sema3A\/NRP-1, LIF\/LIFR and Nkx6.2 in mice with experimental autoimmune encephalomyelitis","volume":"217","author":"Zhao","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"153736","DOI":"10.1016\/j.phymed.2021.153736","article-title":"A review on pharmacological activities and synergistic effect of quercetin with small molecule agents","volume":"92","author":"Zou","year":"2021","journal-title":"Phytomedicine"}],"container-title":["Frontiers in Chemistry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fchem.2023.1250043\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T05:48:08Z","timestamp":1694152088000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fchem.2023.1250043\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,8]]},"references-count":66,"alternative-id":["10.3389\/fchem.2023.1250043"],"URL":"https:\/\/doi.org\/10.3389\/fchem.2023.1250043","relation":{},"ISSN":["2296-2646"],"issn-type":[{"value":"2296-2646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,8]]},"article-number":"1250043"}}