{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:18:24Z","timestamp":1793312304587,"version":"4.5.0"},"reference-count":86,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"Typha domingensis<\/jats:italic>, a medicinal plant with significant traditional importance for curing various human diseases, has potentially bioactive compounds but was less explored previously. Therefore, this study aims to investigate the therapeutic potential of T. domingensis<\/jats:italic> by evaluating the phytochemical profile through high-performance liquid chromatography (HPLC) techniques and its biological activities (in vitro<\/jats:italic> and in vivo<\/jats:italic>) from the methanolic extract derived from the entire plant (TDME). The secondary metabolite profile of TDME regulated by reverse phase ultra-high-performance liquid chromatography\u2013mass spectrometry (RP-UHPLC\u2013MS) revealed some bioactive compounds by -ve and +ve modes of ionization. The HPLC quantification study showed the precise quantity of polyphenols (p<\/jats:italic>-coumaric acid, 207.47; gallic acid, 96.25; and kaempferol, 95.78\u00a0\u03bcg\/g extract). The enzyme inhibition assays revealed the IC50<\/jats:sub> of TDME as 44.75 \u00b1 0.51, 52.71 \u00b1 0.01, and 67.19 \u00b1 0.68\u00a0\u00b5gmL-1<\/jats:sup>, which were significant compared to their respective standards (indomethacin, 18.03 \u00b1 0.12; quercetin, 4.11 \u00b1 0.01; and thiourea, 8.97 \u00b1 0.11) for lipoxygenase, \u03b1-glucosidase, and urease, respectively. Safety was assessed by in vitro<\/jats:italic> hemolysis (4.25% \u00b1 0.16% compared to triton \u00d7 100, 93.51% \u00b1 0.36%), which was further confirmed (up to 10\u00a0g\/kg) by an in vivo<\/jats:italic> model of rats. TDME demonstrated significant (p<\/jats:italic> &lt; 0.05) potential in analgesic activity by hot plate and tail immersion tests and anti-inflammatory activity by the carrageenan-induced hind paw edema model. Pain latency decreased significantly, and the anti-inflammatory effect increased in a dose-dependent way. Additionally, in silico<\/jats:italic> molecular docking revealed that 1,3,4,5-tetracaffeoylquinic acid and formononetin 7-O-glucoside-6\u2033-O-malonate possibly contribute to enzyme inhibitory activities due to their higher binding affinities compared to standard inhibitors. An in silico<\/jats:italic> absorption, distribution, metabolism, excretion, and toxicological study also predicted the pharmacokinetics and safety of the chosen compounds identified from TDME. To sum up, it was shown that TDME contains bioactive chemicals and has strong biological activities. The current investigations on T. domingensis<\/jats:italic> could be extended to explore its potential applications in nutraceutical industries and encourage the isolation of novel molecules with anti-inflammatory and analgesic effects.<\/jats:p>","DOI":"10.3389\/fchem.2023.1273191","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T16:22:09Z","timestamp":1699546929000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Phytochemical characterization of Typha domingensis and the assessment of therapeutic potential using in vitro and in vivo biological activities and in silico studies"],"prefix":"10.3389","volume":"11","author":[{"given":"Rizwana","family":"Dilshad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kashif-ur-Rehman","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif Ansari","family":"Shaik Mohammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa E.","family":"Sherif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huma","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maqsood","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal Ahmad","family":"Ghalloo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Yasmin","family":"Begum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1053744","DOI":"10.3389\/fphar.2022.1053744","article-title":"Metals-triggered compound cdpdp exhibits anti-arthritic behavior by downregulating the inflammatory cytokines, and modulating the oxidative storm in mice models with extensive admet, docking and simulation studies","volume":"13","author":"Abbas","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"100276","DOI":"10.1016\/j.jctube.2021.100276","article-title":"In-silico design and admet predictions of some new imidazo [1, 2-A] pyridine-3-carboxamides (ipas) as anti-tubercular agents","volume":"25","author":"Abdullahi","year":"2021","journal-title":"J. Of Clin. Tuberc. And Other Mycobact. Dis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"E0193451","DOI":"10.1371\/journal.pone.0193451","article-title":"Ursolic acid rich ocimum sanctum L leaf extract loaded nanostructured lipid carriers ameliorate adjuvant induced arthritis in rats by inhibition of cox-1, cox-2, tnf-\u0391 and il-1: pharmacological and docking studies","volume":"13","author":"Ahmad","year":"2018","journal-title":"Plos One"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/3818945","article-title":"In vitro antimicrobial bioassays, dpph radical scavenging activity, and ftir spectroscopy analysis of Heliotropium bacciferum","volume":"2016","author":"Ahmad","year":"2016","journal-title":"Biomed Res. Int."},{"key":"B5","doi-asserted-by":"publisher","first-page":"104345","DOI":"10.1016\/j.arabjc.2022.104345","article-title":"Phytochemical, antioxidant, enzyme inhibitory, thrombolytic, antibacterial, antiviral and in silico studies of Acacia jacquemontii leaves","volume":"15","author":"Ahmed","year":"","journal-title":"Arabian J. Of Chem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"4113","DOI":"10.3390\/molecules27134113","article-title":"Comprehensive phytochemical profiling, biological activities, and molecular docking studies of pleurospermum candollei: an insight into potential for natural products development","volume":"27","author":"Ahmed","year":"","journal-title":"Molecules"},{"key":"B7","doi-asserted-by":"publisher","first-page":"117316","DOI":"10.1016\/j.envpol.2021.117316","article-title":"Foliar architecture and physio-biochemical plasticity determines survival of Typha domingensis pers. Ecotypes in nickel and salt affected soil","volume":"286","author":"Akhter","year":"2021","journal-title":"Environ. Pollut."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/j.jep.2010.11.036","article-title":"The potential role of female flowers inflorescence of Typha domingensis pers. In wound management","volume":"133","author":"Akkol","year":"2011","journal-title":"J. Of Ethnopharmacol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"104455","DOI":"10.1016\/j.arabjc.2022.104455","article-title":"Phytochemical, antimicrobial, antidiabetic, thrombolytic, anticancer activities, and in silico studies of Ficus palmata forssk","volume":"16","author":"Al-Qahtani","year":"2023","journal-title":"Arabian J. Of Chem."},{"key":"B10","doi-asserted-by":"publisher","first-page":"126","DOI":"10.33794\/qjas.2021.132392.1017","article-title":"Analytical study of phytochemicals and antioxidant activity of pollen (Typha domingensis pers.) extracted from the papyrus plant and its use in cake enrichment","volume":"11","author":"Aljazy","year":"2021","journal-title":"Al-Qadisiyah J. Agric. Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"115240","DOI":"10.1016\/j.biopha.2023.115240","article-title":"Cardioprotective effect of 2-methoxy phenol derivatives against oxidative stress-induced vascular complications: an integrated in vitro, in silico, and in vivo investigation","volume":"165","author":"Aqeel","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"B12","doi-asserted-by":"publisher","first-page":"114942","DOI":"10.1016\/j.jep.2021.114942","article-title":"Chemical profiling of Justicia vahlii roth.(Acanthaceae) using uplc-qtof-ms and gc-ms analysis and evaluation of acute oral toxicity, antineuropathic and antioxidant activities","volume":"287","author":"Basit","year":"2022","journal-title":"J. Of Ethnopharmacol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"103058","DOI":"10.1016\/j.fbio.2023.103058","article-title":"Protective effect of chemically characterized extract of viola stocksii boiss. Against breast cancer and vincristine induced neuropathic pain by alleviation of oxidative stress and inflammatory markers","volume":"56","author":"Basit","year":"2023","journal-title":"Food Biosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"165","DOI":"10.2307\/1352181","article-title":"Cattail invasion and persistence in A coastal salt marsh: the role of salinity reduction","volume":"10","author":"Beare","year":"1987","journal-title":"Estuaries"},{"key":"B15","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/0005-2760(72)90059-8","article-title":"In vitro and in vivo inhibition of hepatic cholesterol synthesis by 3-hydroxy-3-methylglutaric acid","volume":"260","author":"Beg","year":"1972","journal-title":"Biochimica Biophysica Acta (Bba)-Lipids And Lipid Metabolism"},{"key":"B16","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/0043-1648(72)90314-6","article-title":"Lubrication of polythene by oleamide and stearamide","volume":"19","author":"Briscoe","year":"1972","journal-title":"Wear"},{"key":"B17","doi-asserted-by":"publisher","first-page":"67","DOI":"10.4314\/tjpr.v13i1.10","article-title":"Antioxidant, Iron-chelating and Anti-glucosidase Activities of Solanum tuberosum<\/i> and Brassica juncea<\/i> residue smoke water compounds with proteins involved in coronavirus infection","volume":"34","author":"Dave","year":"2020","journal-title":"Phytotherapy Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"104133","DOI":"10.1016\/j.arabjc.2022.104133","article-title":"Phytochemical profiling, in vitro biological activities, and in-silico molecular docking studies of Typha domingensis","volume":"15","author":"Dilshad","year":"2022","journal-title":"Arabian J. Of Chem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/j.bmc.2019.02.021","article-title":"Design and total synthesis of (-)-Codonopsinine,(-)-Codonopsine and codonopsinine analogues by O-(2-Oxopyrrolidin-5-Yl) trichloroacetimidate as amidoalkylating agent with improved antimicrobial activity via solid lipid nanoparticle formulations","volume":"27","author":"El-Nezhawy","year":"2019","journal-title":"Bioorg. Med. Chem."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/1518511","article-title":"Chemical composition and the anticancer, antimicrobial, and antioxidant properties of Acacia honey from the hail region: the in vitro and in silico investigation","volume":"2022","author":"Hamadou","year":"2022","journal-title":"Evidence-Based Complementary And Altern. Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.phytol.2015.05.010","article-title":"Gas chromatography mass spectrometry based profiling of Alkyl coumarates and ferulates in two species of Cattail (Typha domingensis P., and Typha latifolia L.)","volume":"13","author":"He","year":"2015","journal-title":"Phytochem. Lett."},{"key":"B29","doi-asserted-by":"publisher","first-page":"598","DOI":"10.3390\/md17110598","article-title":"Identification of fromiamycalin and halaminol A from Australian marine sponge extracts with anthelmintic activity against Haemonchus contortus","volume":"17","author":"Herath","year":"2019","journal-title":"Mar. Drugs"},{"key":"B30","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1515\/znc-1987-0314","article-title":"Further characterization of chickpea isoflavone 7-O-Glucoside-6\"-O-malonate: malonylesterase: evidence for A highly specific, membrane-bound enzyme in roots of cicer arietinum L","volume":"42","author":"Hinderer","year":"1987","journal-title":"Z. F\u00fcr Naturforsch. C"},{"key":"B31","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/s41392-021-00553-z","article-title":"From purines to purinergic signalling: molecular functions and human diseases","volume":"6","author":"Huang","year":"2021","journal-title":"Signal Transduct. And Target. Ther."},{"key":"B32","doi-asserted-by":"publisher","first-page":"997","DOI":"10.3390\/molecules21080997","article-title":"Potential application of P-coumaric acid on differentiation of C2c12 skeletal muscle and 3t3-L1 preadipocytes\u2014an in vitro and in silico approach","volume":"21","author":"Ilavenil","year":"2016","journal-title":"Molecules"},{"key":"B33","doi-asserted-by":"publisher","first-page":"112966","DOI":"10.1016\/j.jep.2020.112966","article-title":"Pharmacological evaluation of analgesic, anti-inflammatory and antipyretic activities of ethanolic extract of Indigofera argentea Burm. f","volume":"259","author":"Javed","year":"2020","journal-title":"Burm. F. J. Of Ethnopharmacol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"225","DOI":"10.22038\/ijbms.2019.32806.7897","article-title":"Pharmacological effects of gallic acid in health and diseases: a mechanistic review","volume":"22","author":"Kahkeshani","year":"2019","journal-title":"Iran. J. Of Basic Med. Sci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.3390\/plants11202722","article-title":"Recent updates on phytoconstituent alpha-glucosidase inhibitors: an approach towards the treatment of type two diabetes","volume":"11","author":"Kashtoh","year":"2022","journal-title":"Plants"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/6519712","article-title":"Phytochemical, cytotoxic, and antimicrobial evaluation of tribulus terrestris L., Typha domingensis pers., and ricinus communis L.: scientific evidences for folkloric uses","volume":"2022","author":"Khalid","year":"2022","journal-title":"Evidence-Based Complementary And Altern. Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.jsps.2023.04.028","article-title":"A detailed biochemical characterization, toxicological assessment and molecular docking studies of launaea fragilis: an important medicinal xero-halophyte","volume":"31","author":"Khan","year":"2023","journal-title":"Saudi Pharm. J."},{"key":"B38","doi-asserted-by":"publisher","first-page":"633","DOI":"10.3390\/bioengineering9110633","article-title":"Integrated bioinformatics-based subtractive genomics approach to decipher the therapeutic drug target and its possible intervention against brucellosis","volume":"9","author":"Khan","year":"","journal-title":"Bioengineering"},{"key":"B39","doi-asserted-by":"publisher","first-page":"46358","DOI":"10.1021\/acsomega.2c04977","article-title":"Anti-diabetic activity of brucine in streptozotocin-induced rats: in silico, in vitro, and in vivo studies","volume":"7","author":"Khan","year":"","journal-title":"Acs Omega"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-03344-6_27","article-title":"Phenolic acids and their health-promoting activity","volume":"2","author":"Khatri","year":"2019","journal-title":"Plant And Hum. Health"},{"key":"B41","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1271\/bbb.61.439","article-title":"Production of nigerose, nigerosyl glucose, and nigerosyl maltose by acremonium sp. S4g13","volume":"61","author":"Konishi","year":"1997","journal-title":"Biosci. Biotechnol. And Biochem."},{"key":"B42","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1517\/13543776.2011.574615","article-title":"Urease inhibitors as potential drugs for gastric and urinary tract infections: a patent review","volume":"21","author":"Kosikowska","year":"2011","journal-title":"Expert Opin. Ther. Pat."},{"key":"B43","doi-asserted-by":"publisher","first-page":"517","DOI":"10.5958\/0974-360x.2015.00086.4","article-title":"Gc-ms\/ms study of parthenium hysterophorus L (N. Am) stem, antimicrobial activity","volume":"8","author":"Krishnaveni","year":"2015","journal-title":"Res. J. Of Pharm. And Technol."},{"key":"B44","first-page":"59","article-title":"Acute toxicity study of extracts of Eichhornia crassipes (mart.) solms","volume":"5","author":"Lalitha","year":"2012","journal-title":"Asian J. Pharm. Clin. Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.addr.2012.09.019","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"64","author":"Lipinski","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B46","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1080\/14756366.2016.1235041","article-title":"Multicomponent pattern and biological activities of seven asphodeline taxa: potential sources of natural-functional ingredients for bioactive formulations","volume":"32","author":"Locatelli","year":"2017","journal-title":"J. Of Enzyme Inhibition And Med. Chem."},{"key":"B47","doi-asserted-by":"publisher","first-page":"3057","DOI":"10.1016\/j.phytochem.2004.08.048","article-title":"Bioactive apocarotenoids annuionones F and G: structural revision of annuionones A, B and E","volume":"65","author":"Mac\u0131as","year":"2004","journal-title":"Phytochemistry"},{"key":"B48","doi-asserted-by":"publisher","first-page":"146","DOI":"10.2174\/157340911795677602","article-title":"Molecular docking: a powerful approach for structure-based drug discovery","volume":"7","author":"Meng","year":"2011","journal-title":"Curr. Computer-Aided Drug Des."},{"key":"B49","doi-asserted-by":"publisher","first-page":"109073","DOI":"10.1016\/j.dyepig.2020.109073","article-title":"Synthesis, characterization and antimicrobial activity of some new azo dyes derived from 4-hydroxy-6-methyl-2h-pyran-2-one and its dihydro derivative","volume":"188","author":"Mohamed-Smati","year":"2021","journal-title":"Dyes And Pigments"},{"key":"B50","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/bf02861252","article-title":"Cattails (Typha spp.)\u2014weed problem or potential crop?","volume":"29","author":"Morton","year":"1975","journal-title":"Econ. Bot."},{"key":"B51","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3390\/brainsci11020259","article-title":"Phytochemical analysis, in vitro anticholinesterase, antioxidant activity and in vivo nootropic effect of Ferula ammoniacum (dorema ammoniacum) D. Don. In scopolamine-induced memory impairment in mice","volume":"11","author":"Nazir","year":"2021","journal-title":"Brain Sci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.3390\/metabo12111147","article-title":"Spirulina platensis suppressed inos and proinflammatory cytokines in lipopolysaccharide-induced Bv2 microglia","volume":"12","author":"Ngu","year":"2022","journal-title":"Metabolites"},{"key":"B53","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.foodchem.2017.05.043","article-title":"Utilization of quercetin and quercetin glycosides from onion (allium cepa L.) solid waste as an antioxidant, urease and xanthine oxidase inhibitors","volume":"235","author":"Nile","year":"2017","journal-title":"Food Chem."},{"key":"B54","doi-asserted-by":"publisher","first-page":"6685","DOI":"10.3390\/molecules27196685","article-title":"Metabolic profiling by gc-ms, in vitro biological potential, and in silico molecular docking studies of verbena officinalis","volume":"27","author":"Nisar","year":"2022","journal-title":"Molecules"},{"key":"B55","doi-asserted-by":"publisher","first-page":"182","DOI":"10.7324\/JAPS.2017.70626","article-title":"Antioxidant activities and chemical composition of various crude extracts of lepidagathis keralensis","volume":"7","author":"Palakkal","year":"2017","journal-title":"J. Of Appl. Pharm. Sci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.21746\/aps.2018.7.3.2","article-title":"Taxonomical and pharmacological status of Typha: a review","volume":"7","author":"Pandey","year":"2018","journal-title":"Ann. Of Plant Sci."},{"key":"B57","first-page":"30","article-title":"Preliminary phytochemical analysis of Typha domingensis rhizome aqueous extracts","volume":"37","author":"Rao","year":"2016","journal-title":"Int. J. Pharm. Sci. Rev. Res."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1136459","DOI":"10.3389\/fphar.2023.1136459","article-title":"Antiarthritic potential of the butanol fraction of Sesuvium sesuvioides: an in vitro, in vivo, and in silico evaluation","volume":"14","author":"Sajid-Ur-Rehman","year":"2023","journal-title":"Front. Pharmacol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1007\/s10787-021-00824-9","article-title":"Phytochemical profiling, in vitro and in vivo anti-inflammatory, analgesic and antipyretic potential of Sesuvium sesuvioides (fenzl) verdc.(aizoaceae)","volume":"29","author":"Sajid-Ur-Rehman","year":"2021","journal-title":"Inflammopharmacology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.fct.2018.11.016","article-title":"Biological, chemical and toxicological perspectives on aerial and roots of filago germanica (L.) huds: functional approaches for novel phyto-pharmaceuticals","volume":"123","author":"Saleem","year":"2019","journal-title":"Food And Chem. Toxicol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/0028-3908(76)90037-x","article-title":"Antinociceptive activity of narcotic agonist and partial agonist analgesics and other agents in the tail-immersion test in mice and rats","volume":"15","author":"Sewell","year":"1976","journal-title":"Neuropharmacology"},{"key":"B62","doi-asserted-by":"publisher","first-page":"584","DOI":"10.3390\/app13010584","article-title":"Phytochemical profiling of the ethanolic extract of zaleya pentandra L. Jaffery and its biological activities by in-vitro assays and in-silico molecular docking","volume":"13","author":"Shahid","year":"2023","journal-title":"Appl. Sci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"E0266094","DOI":"10.1371\/journal.pone.0266094","article-title":"Profiling of phytochemicals from aerial parts of Terminalia neotaliala using lc-esi-ms2 and determination of antioxidant and enzyme inhibition activities","volume":"17","author":"Shahzad","year":"2022","journal-title":"Plos One"},{"key":"B64","doi-asserted-by":"publisher","first-page":"731","DOI":"10.2174\/1871520621666211013115500","article-title":"Computational exploration of anti-cancer potential of guaiane dimers from xylopia vielana by targeting B-raf kinase using chemo-informatics, molecular docking, and Md simulation studies","volume":"22","author":"Shams Ul Hassan","year":"2022","journal-title":"Anti-Cancer Agents Med. Chem. Former. Curr. Med. Chemistry-Anti-Cancer Agents)"},{"key":"B65","doi-asserted-by":"publisher","first-page":"17","DOI":"10.4103\/0973-1229.58817","article-title":"Modern medicine: towards prevention, cure, well-being and longevity","volume":"8","author":"Singh","year":"2010","journal-title":"Mens. Sana Monogr."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/3176391","article-title":"Antilipoxygenase and anti-inflammatory activities of streblus asper leaf extract on xylene-induced ear edema in mice","volume":"2020","author":"Singsai","year":"2020","journal-title":"Adv. Pharmacol. And Pharm. Sci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"51","DOI":"10.2174\/1573407213666170210143503","article-title":"Anticancer activity of aminoacid linked novel 4-methylumbelliferone derivatives","volume":"15","author":"Sinha","year":"2019","journal-title":"Curr. Bioact. Compd."},{"key":"B68","doi-asserted-by":"publisher","first-page":"210","DOI":"10.4314\/ajtcam.v10i5.2","article-title":"The role and place of medicinal plants in the strategies for disease prevention","volume":"10","author":"Sofowora","year":"2013","journal-title":"Afr. J. Of Traditional, Complementary And Altern. Med."},{"key":"B69","doi-asserted-by":"publisher","first-page":"115070","DOI":"10.1016\/j.psychres.2023.115070","article-title":"Potential plasma biomarker panels identification for the diagnosis of first-episode schizophrenia and monitoring antipsychotic monotherapy with the use of Metabolomics analyses","volume":"321","author":"Song","year":"2023","journal-title":"Psychiatry Res."},{"key":"B70","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1517\/13543784.9.9.2121","article-title":"Potential use of lipoxygenase inhibitors for cancer chemoprevention","volume":"9","author":"Steele","year":"2000","journal-title":"Expert Opin. Investigational Drugs"},{"key":"B71","doi-asserted-by":"publisher","first-page":"104784","DOI":"10.1016\/j.arabjc.2023.104784","article-title":"Chemical profiling and evaluation of toxicological, antioxidant, anti-inflammatory, anti-nociceptive and tyrosinase inhibitory potential of portulacaria afra using in-vitro, in-vivo and in-silico studies","volume":"16","author":"Tabassum","year":"2023","journal-title":"Arabian J. Of Chem."},{"key":"B72","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.3390\/molecules27082377","article-title":"Phytochemical profiling, antioxidant, anti-inflammatory, thrombolytic, hemolytic activity in vitro and in silico potential of portulacaria afra","volume":"27","author":"Tabassum","year":"2022","journal-title":"Molecules"},{"key":"B73","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1248\/cpb.56.936","article-title":"Prediction of cyclooxygenase inhibitory activity of curcuma rhizome from chromatograms by multivariate analysis","volume":"56","author":"Tanaka","year":"2008","journal-title":"Chem. And Pharm. Bull."},{"key":"B74","first-page":"218","article-title":"Isolation and identification of 5-acetylamino-6-formylamino-3-methyluracil as A major metabolite of caffeine in man","volume":"11","author":"Tang","year":"1983","journal-title":"Drug Metabolism And Dispos."},{"key":"B75","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1042\/bj20031695","article-title":"N-cyclohexanecarbonylpentadecylamine: a selective inhibitor of the acid amidase hydrolysing N-acylethanolamines, as A tool to distinguish acid amidase from fatty acid amide hydrolase","volume":"379","author":"Tsuboi","year":"2004","journal-title":"Biochem. J."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/ecam\/nep111","article-title":"Cytotoxic effects of Bangladeshi medicinal plant extracts","volume":"2011","author":"Uddin","year":"2011","journal-title":"Evidence-Based Complementary And Altern. Med."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1016\/j.fitote.2011.08.005","article-title":"Down regulation of gene related sex hormone synthesis pathway in mouse testes by miroestrol and deoxymiroestrol","volume":"82","author":"Udomsuk","year":"2011","journal-title":"Fitoterapia"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/7801543","article-title":"Medicinal plants of the family lamiaceae in pain therapy: a review","volume":"2018","author":"Uritu","year":"2018","journal-title":"Pain Res. And Manag."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1096\/fj.04-1990fje","article-title":"Theobromine inhibits sensory nerve activation and cough","volume":"19","author":"Usmani","year":"2005","journal-title":"Faseb J."},{"key":"B80","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/s0378-8741(96)01476-6","article-title":"Antiinflammatory activity of extracts from aloe vera gel","volume":"55","author":"V\u00e1zquez","year":"1996","journal-title":"J. Of Ethnopharmacol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1002\/ptr.5528","article-title":"Antidiabetic effects of simple phenolic acids: a comprehensive review","volume":"30","author":"Vinayagam","year":"2016","journal-title":"Phytotherapy Res."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1934578X1400900","DOI":"10.1177\/1934578x1400900719","article-title":"Phenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant pleurospermum amabile","volume":"9","author":"Wangchuk","year":"2014","journal-title":"Nat. Product. Commun."},{"key":"B83","doi-asserted-by":"publisher","first-page":"3085","DOI":"10.1016\/j.foodchem.2013.05.145","article-title":"Synthesis and characterisation of galactosyl glycerol by \u0392-galactosidase catalysed reverse hydrolysis of galactose and glycerol","volume":"141","author":"Wei","year":"2013","journal-title":"Food Chem."},{"key":"B84","doi-asserted-by":"publisher","first-page":"E10366","DOI":"10.1016\/j.heliyon.2022.e10366","article-title":"Bridelia ferruginea benth.; an ethnomedicinal, phytochemical, pharmacological and toxicological review","volume":"8","author":"Yeboah","year":"2022","journal-title":"Heliyon"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1080\/14786419.2018.1539979","article-title":"Identification of anti-nociceptive constituents from the pollen of Typha angustifolia L. Using effect-directed fractionation","volume":"34","author":"Zeng","year":"2020","journal-title":"Nat. Prod. Res."},{"key":"B86","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.foodchem.2018.10.074","article-title":"Determination of phenolic acid profiles by hplc-ms in vegetables commonly consumed in China","volume":"276","author":"Zhang","year":"2019","journal-title":"Food Chem."}],"container-title":["Frontiers in Chemistry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fchem.2023.1273191\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T16:22:17Z","timestamp":1699546937000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fchem.2023.1273191\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,8]]},"references-count":86,"alternative-id":["10.3389\/fchem.2023.1273191"],"URL":"https:\/\/doi.org\/10.3389\/fchem.2023.1273191","relation":{},"ISSN":["2296-2646"],"issn-type":[{"value":"2296-2646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,8]]},"article-number":"1273191"}}