{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:32:35Z","timestamp":1782941555486,"version":"3.54.5"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> The present research aimed to fractionate <jats:italic>Xanthium strumarium<\/jats:italic> L. (XSL) foliage phenolics into a set of solvents and evaluate their antioxidant potential and <jats:italic>in-vivo<\/jats:italic> anti-diabetic activity against Alloxan monohydrate-induced diabetic mice.<\/jats:p><jats:p><jats:bold>Methodology:<\/jats:bold> For this purpose, XSL foliage was fractionated into petroleum ether, ethyl acetate, ethanol, and water <jats:italic>via<\/jats:italic> orbital type shaking and tested for the presence of phenolics, and their antioxidant and antidiabetic potential.<\/jats:p><jats:p><jats:bold>Results and discussion:<\/jats:bold> The results revealed that the ethyl acetate fraction of XSL foliage contained the highest amount of total phenolics 95.25\u00a0mg GAE\/g of extract, followed by ethanol (65.14\u00a0mg GAE\/g), petroleum ether (25.12\u00a0mg GAE\/g), water (12.20\u00a0mg GAE\/g), and XSL powder (69.13\u00a0mg GAE\/g). At the end of treatment time (day 18 of oral administration of 400\u00a0mg\/kg body weight of mice), the ethyl acetate fraction significantly (<jats:italic>p<\/jats:italic> \u2264 0.05) lowered blood glucose level (353 \u00b1 10.6 to 220 \u00b1 25.5\u00a0mg\/dL) which might due to the elevated level of phenolic compounds in this fraction.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Overall, it can be speculated that ethyl acetate and ethanol may work efficiently for the enrichment of XSL phenolic without compromising their antidiabetic potential.<\/jats:p>","DOI":"10.3389\/fchem.2023.1279729","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T10:35:26Z","timestamp":1700822126000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Fractionation of Xanthium strumarium L. foliage phenolics, in-vitro antioxidant activities, and in-vivo anti-diabetic potential"],"prefix":"10.3389","volume":"11","author":[{"given":"Asma","family":"Shaheen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumia","family":"Akram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Sharif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayoub","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Adnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Mushtaq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"B1","first-page":"397","article-title":"Biochemical evaluation and hypoglycemic activity of ethanolic extract of Xanthium strumarium L. on normoglycemic and alloxan-induced diabetic mice","volume":"2","author":"Ahmad","year":"2016","journal-title":"Indian J. 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