{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:04:51Z","timestamp":1789542291970,"version":"build-2803163510"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002349","name":"Academy of Scientific Research and Technology","doi-asserted-by":"publisher","award":["43990SF RSP 2023R78"],"award-info":[{"award-number":["43990SF RSP 2023R78"]}],"id":[{"id":"10.13039\/501100002349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p>This study presents a novel method for synthesizing 1,4-disubstituted 1,2,3-triazole derivatives through a one-pot, multi-component addition reaction using flower-like Cu<jats:sub>2<\/jats:sub>O microbeads as a catalyst. The flower-like Cu<jats:sub>2<\/jats:sub>O microbeads were synthesized using an aqueous extract of <jats:italic>Artimisia Campestris L.<\/jats:italic> This extract demonstrated the capability to reduce and stabilize Cu<jats:sub>2<\/jats:sub>O particles during their initial formation, resulting in the formation of a porous flower-like morphology. These Cu<jats:sub>2<\/jats:sub>O microbeads exhibit distinctive features, including a cubic close-packed (ccp) crystal structure with an average crystallite size of 22.8\u00a0nm, bandgap energy of 2.7\u00a0eV and a particle size of 6\u00a0\u00b5m. Their catalytic activity in synthesizing 1,4-disubstituted 1,2,3-triazole derivatives was investigated through systematic exploration of key parameters such as catalyst quantity (1, 5, 10, 15, 20, and 30\u00a0mg\/mL), solvent type (dimethylformamide\/H<jats:sub>2<\/jats:sub>O, ethanol\/H<jats:sub>2<\/jats:sub>O, dichloromethane\/H<jats:sub>2<\/jats:sub>O, chloroform, acetone, and dimethyl sulfoxide), and catalyst reusability (four cycles). The Cu<jats:sub>2<\/jats:sub>O microbeads significantly increased the product yield from 20% to 85.3%. The green synthesis and outstanding catalytic attributes make these flower-like Cu<jats:sub>2<\/jats:sub>O microbeads promising, efficient, and recyclable catalysts for sustainable and effective chemical transformations.<\/jats:p>","DOI":"10.3389\/fchem.2023.1342988","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T04:25:56Z","timestamp":1705379156000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Plant mediated synthesis of flower-like Cu2O microbeads from Artimisia campestris L. extract for the catalyzed synthesis of 1,4-disubstituted 1,2,3-triazole derivatives"],"prefix":"10.3389","volume":"11","author":[{"given":"Halla","family":"Abdelbaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar","family":"Djemoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lahcene","family":"Souli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Souadia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Ridha","family":"Ouahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brahim","family":"Djemoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mokhtar Boualem","family":"Lahrech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Messaoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilham","family":"Ben Amor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Benarfa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Alsalme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhael","family":"Bechelany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Barhoum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3390\/catal12010068","article-title":"Supported metal catalysts for the synthesis of N-heterocycles","volume":"12","author":"Aronica","year":"2022","journal-title":"Catalysts"},{"key":"B2","doi-asserted-by":"publisher","first-page":"214","DOI":"10.22034\/IJND.2022.687833","article-title":"Green synthesis, characterization and antimicrobial activity of nanosized Cuprous Oxide fabricated using aqueous extracts of Allium cepa and Raphanus sativus","volume":"13","author":"Bale","year":"2022","journal-title":"Int. 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