{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:12:45Z","timestamp":1792033965492,"version":"4.4.0"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p>\n                    Diabetes mellitus is a multi-systematic chronic metabolic disorder and life-threatening disease resulting from impaired glucose homeostasis. The inhibition of glucosidase, particularly\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -glucosidase, could serve as an effective methodology in treating diabetes. Attributed to the catalytic function of glucosidase, the present research focuses on the synthesis of sulfonamide-based acyl pyrazoles\n                    <jats:bold>(5a-k)<\/jats:bold>\n                    followed by their\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in silico<\/jats:italic>\n                    screening against\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -glucosidase. The envisaged structures of prepared compounds were confirmed through NMR and FTIR spectroscopy and mass spectrometry. All compounds were found to be more potent against\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -glucosidase than the standard drug, acarbose (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 35.1 \u00b1 0.14\u00a0\n                    <jats:italic>\u00b5<\/jats:italic>\n                    M), with IC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging from 1.13 to 28.27\u00a0\n                    <jats:italic>\u00b5<\/jats:italic>\n                    M. However, compound\n                    <jats:bold>5a<\/jats:bold>\n                    displayed the highest anti-diabetic activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 1.13 \u00b1 0.06\u00a0\n                    <jats:italic>\u00b5<\/jats:italic>\n                    M). Furthermore,\n                    <jats:italic>in silico<\/jats:italic>\n                    studies revealed the intermolecular interactions of most potent compounds (\n                    <jats:bold>5a<\/jats:bold>\n                    and\n                    <jats:bold>5b<\/jats:bold>\n                    ), with active site residues reflecting the importance of pyrazole and sulfonamide moieties. This interaction pattern clearly manifests various structure\u2013activity relationships, while the docking results correspond to the IC\n                    <jats:sub>50<\/jats:sub>\n                    values of tested compounds. Hence, recent investigation reveals the medicinal significance of sulfonamide-clubbed pyrazole derivatives as prospective therapeutic candidates for treating type 2 diabetes mellitus (T2DM).\n                  <\/jats:p>","DOI":"10.3389\/fchem.2024.1380523","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:42:25Z","timestamp":1713314545000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Acyl pyrazole sulfonamides as new antidiabetic agents: synthesis, glucosidase inhibition studies, and molecular docking analysis"],"prefix":"10.3389","volume":"12","author":[{"given":"Atteeque","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumera","family":"Zaib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mashooq Ahmad","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aamer","family":"Saeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Zain","family":"Altaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima Tuz","family":"Zahra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghulam","family":"Shabir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehal","family":"Rana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imtiaz","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.bioorg.2018.03.011","article-title":"Design, synthesis, analgesic, anti-inflammatory activity of novel pyrazolones possessing aminosulfonyl pharmacophore as inhibitors of COX-2\/5-LOX enzymes: histopathological and docking studies","volume":"78","author":"Abdelgawad","year":"2018","journal-title":"Bioorg Chem."},{"key":"B2","article-title":"Synthesis and in vitro antitumor activity of some new fused pyrazole ring system containing sulfonamide, sulfonylurea and thiourea pharmacophores as anti-cancer agents","author":"Abdul-Gafoor","year":"2016","journal-title":"Dr. Diss. 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