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This involved a meticulously orchestrated reaction, exploiting the in situ generated pyrazole alongside aromatic aldehydes, ammonium acetate, and (thio) barbituric acid. The present work manifests outstanding advantages, offering a novel and great method for the optimal synthesis of two valuable heterocyclic series especially five new derivatives. The resulting novel biocompatible composite was comprehensively characterized through a range of analytical techniques, including FT-IR, NH<jats:sub>3<\/jats:sub> and CO<jats:sub>2<\/jats:sub>-TPD, XRD, TEM, FE-SEM, VSM, EDX, elemental CHNS analysis, ICP-MS, and NMR spectroscopy. Notably, the study represents a critical step in the preparation of advanced materials from accessible and cost-effective precursors.<\/jats:p>","DOI":"10.3389\/fchem.2024.1395008","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T11:20:48Z","timestamp":1715772048000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Melamine phosphate-modified magnetic chitosan: a novel biocompatible catalyst for the synthesis of biological tetrahydrodipyrazolopyridine and pyrazolopyranopyrimidine derivatives"],"prefix":"10.3389","volume":"12","author":[{"given":"Maryam","family":"Mousavi-Ebadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Safaei-Ghomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.jiec.2021.04.003","article-title":"Hierarchical composite catalysts of MCM-41 on zeolite Beta for conversion of heavy reformate to xylenes","volume":"98","author":"Ali","year":"2021","journal-title":"J. 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