{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:46:48Z","timestamp":1771645608093,"version":"3.50.1"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007530","name":"National Taiwan University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Severe protein clumping in the lens can block light and lead to vision issues in cataract patients. Recent studies have linked \u03b2-crystallins, which are key proteins in the lens, to the development of cataracts. Specifically, the S175G\/H181Q mutation in the \u03b2B2-crystallin gene plays a major role in cataract formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To understand how this mutation can be activated, we utilized computational methods to predict activators from Phaseolus vulgaris. The Schr\u00f6dinger platform was employed to screen bioactive compounds and simulate molecular interactions in order to analyze binding and structural changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results indicated that these phytochemicals are stable near S175G\/H181Q.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These findings suggest novel approaches that could potentially be developed into effective anticataract medications through further refinement and additional testing, ultimately resulting in the creation of more potent agents for cataract treatment.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fchem.2024.1421534","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T06:53:28Z","timestamp":1737096808000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["In silico identification of the anticataract target of \u03b2B2-crystallin from Phaseolus vulgaris: a new insight into cataract treatment"],"prefix":"10.3389","volume":"12","author":[{"given":"Sunday Amos","family":"Onikanni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adewale Oluwaseun","family":"Fadaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran Nhat Phong","family":"Dao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valens","family":"Munyembaraga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Nyau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole Remaliah Samantha","family":"Sibuyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morenike Grace","family":"Ajayi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Thi Ai","family":"Nhung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Ejiofor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basiru Olaitan","family":"Ajiboye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minh Hoang","family":"Le","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hen-Hong","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3697","DOI":"10.1080\/07391102.2020.1850363","article-title":"In silico inhibition of SGTP4 as a therapeutic target for the treatment of schistosomiasis","volume":"40","author":"Adekiya","year":"2022","journal-title":"J. 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