{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:53:41Z","timestamp":1753890821139,"version":"3.41.2"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Tripterygium species have been traditionally used in Chinese medicine for treating various conditions. The aim of the study was to construct a drug-modified renal infarction targeting liposome (rTor-LIP) containing <jats:italic>Tripterygium<\/jats:italic> in order to improve the therapeutic effect on renal injury.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> rTor-LIP was prepared using the extruder method containing <jats:italic>Tripterygium<\/jats:italic> solution. The preparation was characterized by transmission electron microscopy, Marvin laser particle size analyzer, and Western blotting. <jats:italic>In vitro<\/jats:italic> experiments were conducted to verify the biocompatibility of rTor-LIP, and <jats:italic>in vivo<\/jats:italic> experiments were conducted to verify the therapeutic effect of rTor- LIP on renal injury.<\/jats:p><jats:p><jats:bold>Results and discussion:<\/jats:bold> The surface of rTor-LIP was regular and oval. In vitro results showed that after co-incubation with rTor-LIP, endothelial cells did not show significant apoptosis, and there were no significant abnormalities in the mitochondrial metabolism. The <jats:italic>in vivo<\/jats:italic> results showed that the morphology of endothelial cells in the rTor-LIP group was uniform and the cytoplasmic striations were clear, but the local striations had disappeared. Thus, rTor-LIP nano-targeted liposomes can effectively target hypoxic kidney tissue, providing a new idea for the treatment of renal infarction.<\/jats:p>","DOI":"10.3389\/fchem.2024.1427670","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T05:00:22Z","timestamp":1719810022000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Tripterygium drug-loaded liposome alleviates renal function by promoting vascularization and inhibiting fibrosis"],"prefix":"10.3389","volume":"12","author":[{"given":"Ziwei","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifeng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1093\/jmcb\/mjab066","article-title":"cGAS\u2012STING signaling and function in metabolism and kidney diseases","volume":"13","author":"Bai","year":"2021","journal-title":"J. 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