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We predicted its potential anticancer targets based on network pharmacology and then verified the inhibitory effect of the active compound <jats:bold>S11<\/jats:bold> on the pathway PI3K\/AKT by enzyme inhibition and molecular docking assay. In addition, compound S11 exhibited a potent anti-inflammatory effect on macrophages, effectively reducing the levels of inflammatory mediators TNF-\u03b1, IL-10 and HO-1. Compound <jats:bold>S11<\/jats:bold> can be used as a new chemical entity for the discovery of new anti-cancer drugs or anti-inflammatory drugs.<\/jats:p>","DOI":"10.3389\/fchem.2024.1529211","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T08:37:10Z","timestamp":1737448630000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Design and synthesis of phenylthiophosphoryl dichloride derivatives and evaluation of their antitumour and anti-inflammatory activities"],"prefix":"10.3389","volume":"12","author":[{"given":"Chunyun","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haichun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"6076","DOI":"10.1007\/s12035-017-0798-6","article-title":"Natural dietary supplementation of anthocyanins via PI3K\/Akt\/Nrf2\/HO-1 pathways mitigate oxidative stress, neurodegeneration, and memory impairment in a mouse model of alzheimer's disease","volume":"55","author":"Ali","year":"2018","journal-title":"Mol. 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