{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:11:29Z","timestamp":1793106689931,"version":"4.5.0"},"reference-count":111,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Salvia miltiorrhiza<\/jats:italic> Bunge is the dried root and rhizome of <jats:italic>Salvia miltiorrhiza<\/jats:italic> Bunge, a labiatae plant. <jats:italic>Salvia miltiorrhiza<\/jats:italic> polysaccharide (SMP) is the main active component of <jats:italic>Salvia miltiorrhiza<\/jats:italic> Bunge. The extraction methods of SMP mainly include water extraction, ultrasonic extraction, enzyme extraction, microwave-assisted extraction and acid-base extraction. It is mainly composed of glucose, arabinose, rhamnose, galactose and other monosaccharides. SMP has a variety of biological activities, including immune regulation, anti-tum, anti-oxidation, myocardial protection, liver protection and so on.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p><jats:italic>Salvia miltiorrhiza<\/jats:italic> polysaccharide is widely used in nutraceuticals and pharmaceuticals, and has high research value. Natural polysaccharides are non-toxic, soluble in water, and have a wide range of biological activities, so they have broad research prospects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The data was collected using different online resources including PubMed, Google Scholar, and Web of Science using keywords given below.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the past decades, various reports have shown that the pharmacological activities of <jats:italic>Salvia miltiorrhiza<\/jats:italic> polysaccharides have good effects, and the side effects are small.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This paper summarizes the extraction and purification methods, molecular weight, monosaccharide composition, glycosidic linkage, pharmacological activity, toxicity, product development, clinical research and other contents of <jats:italic>Salvia miltiorrhiza<\/jats:italic> polysaccharides in recent years, providing a theoretical basis for further study of <jats:italic>Salvia miltiorrhiza<\/jats:italic> polysaccharides.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fchem.2025.1492533","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T07:10:01Z","timestamp":1741936201000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Advances in the structural characterization and pharmacological activity of Salvia miltiorrhiza polysaccharides"],"prefix":"10.3389","volume":"13","author":[{"given":"Ke","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Ning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Ping","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Bin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1021\/acs.jmedchem.0c01530","article-title":"Peptide-drug conjugates with different linkers for cancer therapy","volume":"64","author":"Alas","year":"2021","journal-title":"J. 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