{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:29:38Z","timestamp":1791563378279,"version":"4.3.4"},"reference-count":91,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Alcoholic fatty liver disease (AFLD) is a common consequence of chronic alcohol consumption, characterized by lipid accumulation and oxidative stress in the liver. Cytochrome P450 (CYP450) enzymes play essential roles in metabolizing alcohol and other compounds. However, the specific long-term effects of alcohol on these enzymes remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study the examines influence of prolonged ethanol exposure on CYP450 activity and expression in AFLD using a rat model. Key enzymes such as CYP2E1, CYP2D6, and CYP3A1 were assessed in relation to lipid accumulation and oxidative stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant alterations were identified in the expression and activity of CYP2E1, CYP2D6, and CYP3A1, which were associated with increased lipid accumulation and oxidative stress in the liver. Additionally, the expression of P-glycoprotein (P-gp) was elevated, suggesting that chronic alcohol intake may impact drug transport and excretion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These findings provide new insights into the molecular mechanisms of AFLD and highlight the potential of CYP450 modulation as a therapeutic target. By elucidating how long-term ethanol exposure disrupts hepatic CYP450 enzyme profiles, this research lays the groundwork for developing personalized therapeutic strategies to improve outcomes for patients with AFLD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fchem.2025.1509785","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T05:30:14Z","timestamp":1747114214000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Chronic alcohol intake disrupts cytochrome P450 enzyme activity in alcoholic fatty liver disease: insights into metabolic alterations and therapeutic targets"],"prefix":"10.3389","volume":"13","author":[{"given":"Qian","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"145","DOI":"10.54548\/njps.v38i2.4","article-title":"Protocatechuic acid modulates hepatic oxidative stress and inflammation linked to DMN exposure in rat","volume":"38","author":"Asejeje","year":"2023","journal-title":"NJPS"},{"key":"B2","doi-asserted-by":"publisher","first-page":"328","DOI":"10.2174\/1389200222666210114122729","article-title":"HMG-CoA reductase inhibitors (statins) and their drug interactions involving CYP enzymes, P-glycoprotein and OATP transporters-an overview","volume":"22","author":"Balasubramanian","year":"2021","journal-title":"CDM"},{"key":"B3","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1002\/cpt.2973","article-title":"Evaluation of cytochrome P450\u2010mediated cannabinoid\u2010drug interactions in healthy adult participants","volume":"114","author":"Bansal","year":"2023","journal-title":"Clin Pharma Ther."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.2215\/cjn.0000000000000196","article-title":"Pharmacokinetic properties of dapagliflozin in hemodialysis and peritoneal dialysis patients","volume":"18","author":"Barreto","year":"2023","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"102081","DOI":"10.1016\/j.redox.2021.102081","article-title":"H2O2-mediated autophagy during ethanol metabolism","volume":"46","author":"Chen","year":"2021","journal-title":"Redox Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1007\/s10753-023-01851-0","article-title":"Integrated machine learning and bioinformatic analyses constructed a network between mitochondrial dysfunction and immune microenvironment of periodontitis","volume":"46","author":"Chen","year":"2023","journal-title":"Inflammation"},{"key":"B7","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1002\/cpt.1768","article-title":"A scoping review of the evidence behind cytochrome P450 2D6 isoenzyme inhibitor classifications","volume":"108","author":"Cicali","year":"2020","journal-title":"Clin Pharma Ther."},{"key":"B8","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/bf00296940","article-title":"Alcohol-inducible cytochrome P-450 (P-450ALC)","volume":"60","author":"Coon","year":"1987","journal-title":"Arch. Toxicol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1275710","DOI":"10.3389\/fcvm.2023.1275710","article-title":"Development and validation of a nomogram to predict the five-year risk of revascularization for non-culprit lesion progression in STEMI patients after primary PCI","volume":"10","author":"Dai","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"13866","DOI":"10.1038\/s41598-023-40798-y","article-title":"The morphology, morphometry and functionality of fresh and cryopreserved wisent (Bison bonasus) epididymal spermatozoa","volume":"13","author":"Eberhardt","year":"2023","journal-title":"Sci. Rep."},{"key":"B11","doi-asserted-by":"publisher","first-page":"970292","DOI":"10.3389\/fphys.2022.970292","article-title":"The AMPK pathway in fatty liver disease","volume":"13","author":"Fang","year":"2022","journal-title":"Front. Physiol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"7531","DOI":"10.3390\/molecules27217531","article-title":"Propolis efficacy: the quest for eco-friendly solvents","volume":"27","author":"Freitas","year":"2022","journal-title":"Molecules"},{"key":"B13","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.jhep.2022.09.020","article-title":"Mitochondrial alterations in fatty liver diseases","volume":"78","author":"Fromenty","year":"2023","journal-title":"J. Hepatology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/j.cmet.2022.05.008","article-title":"MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH","volume":"34","author":"Gao","year":"2022","journal-title":"Cell Metab."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e78022","DOI":"10.7554\/elife.78022","article-title":"FSH-blocking therapeutic for osteoporosis","volume":"11","author":"Gera","year":"2022","journal-title":"eLife"},{"key":"B16","doi-asserted-by":"publisher","first-page":"106291","DOI":"10.1016\/j.jsbmb.2023.106291","article-title":"18-Oxocortisol: a journey","volume":"230","author":"Gomez-Sanchez","year":"2023","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"103342","DOI":"10.1016\/j.critrevonc.2021.103342","article-title":"Potential cytochrome P450-mediated pharmacokinetic interactions between herbs, food, and dietary supplements and cancer treatments","volume":"166","author":"Gougis","year":"2021","journal-title":"Crit. Rev. Oncology\/Hematology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"15489","DOI":"10.3390\/ijms232415489","article-title":"Non-alcoholic fatty liver disease (NAFLD) pathogenesis and natural products for prevention and treatment","volume":"23","author":"Guo","year":"2022","journal-title":"IJMS"},{"key":"B19","doi-asserted-by":"publisher","first-page":"8221","DOI":"10.3390\/ijms22158221","article-title":"CYP2E1 in alcoholic and non-alcoholic liver injury. Roles of ROS, reactive intermediates and lipid overload","volume":"22","author":"Harjum\u00e4ki","year":"2021","journal-title":"IJMS"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1111\/cts.13661","article-title":"Protocol of the IntenSify\u2010Trial: an open\u2010label phase I trial of the CYP3A inhibitor cobicistat and the cytostatics gemcitabine and nab\u2010paclitaxel in patients with advanced stage or metastatic pancreatic ductal adenocarcinoma to evaluate the combination\u2019s pharmacokinetics, safety, and efficacy","volume":"16","author":"Hohmann","year":"2023","journal-title":"Clin. Transl. Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"450","DOI":"10.3724\/sp.j.1123.2022.07018","article-title":"Influence of ethanol content on the detection of volatile components in Huangjiu","volume":"41","author":"Hu","year":"2023","journal-title":"CJCSP"},{"key":"B22","doi-asserted-by":"publisher","first-page":"120964","DOI":"10.1016\/j.lfs.2022.120964","article-title":"Purpurin ameliorates alcohol-induced hepatotoxicity by reducing ROS generation and promoting Nrf2 expression","volume":"309","author":"Hussain","year":"2022","journal-title":"Life Sci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1093\/eurheartj\/ehab221","article-title":"Colchicine and the heart","volume":"42","author":"Imazio","year":"2021","journal-title":"Eur. Heart J."},{"key":"B24","doi-asserted-by":"publisher","first-page":"109701","DOI":"10.1016\/j.abb.2023.109701","article-title":"CYP2E1 triggered GRP78\/ATF6\/CHOP signaling axis inhibit apoptosis and promotes progression of hepatocellular carcinoma","volume":"745","author":"Ishteyaque","year":"2023","journal-title":"Archives Biochem. Biophysics"},{"key":"B25","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/bcpt.13780","article-title":"Drug metabolism and drug transport of the 100 most prescribed oral drugs","volume":"131","author":"Iversen","year":"2022","journal-title":"Basic Clin. Pharma Tox"},{"key":"B26","doi-asserted-by":"publisher","first-page":"59","DOI":"10.2131\/jts.43.59","article-title":"Relative contribution of rat CYP isoforms responsible for stereoselective metabolism of carvedilol","volume":"43","author":"Iwaki","year":"2018","journal-title":"J. Toxicol. Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"963598","DOI":"10.3389\/fnut.2022.963598","article-title":"Poria cocos polysaccharide prevents alcohol-induced hepatic injury and inflammation by repressing oxidative stress and gut leakiness","volume":"9","author":"Jiang","year":"2022","journal-title":"Front. Nutr."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.2147\/dmso.s449494","article-title":"A review: cytochrome P450 in alcoholic and non-alcoholic fatty liver disease","volume":"17","author":"Jiang","year":"2024","journal-title":"DMSO"},{"key":"B29","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.freeradbiomed.2022.08.037","article-title":"Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate experimental non-alcoholic steatohepatitis via Nrf2\/NQO-1 pathway","volume":"192","author":"Kang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.alcohol.2020.08.001","article-title":"Alcohol suppresses cardiovascular diurnal variations in male normotensive rats: role of reduced PER2 expression and CYP2E1 hyperactivity in the heart","volume":"89","author":"Katary","year":"2020","journal-title":"Alcohol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1002\/ame2.12436","article-title":"Uncovering the impact of alcohol on internal organs and reproductive health: exploring TLR4\/NF\u2010kB and CYP2E1\/ROS\/Nrf2 pathways","volume":"7","author":"Kong","year":"2024","journal-title":"Anim Models Exp Med"},{"key":"B32","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13046-020-01782-w","article-title":"Alcoholic fatty liver disease inhibited the co-expression of Fmo5 and PPAR\u03b1 to activate the NF-\u03baB signaling pathway, thereby reducing liver injury via inducing gut microbiota disturbance","volume":"40","author":"Kong","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1016\/j.jcis.2023.09.162","article-title":"Characterization of nanodisc-forming peptides for membrane protein studies","volume":"653","author":"Krishnarjuna","year":"2024","journal-title":"J. Colloid Interface Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"104952","DOI":"10.1016\/j.ebiom.2023.104952","article-title":"Lactobacillus acidophilus suppresses non-alcoholic fatty liver disease-associated hepatocellular carcinoma through producing valeric acid","volume":"100","author":"Lau","year":"2024","journal-title":"eBioMedicine"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1239704","DOI":"10.1117\/12.2651704","article-title":"Infrared spectroscopy for neurochemical monitoring of alcohol and its metabolites","author":"Lee","year":"2023","journal-title":"Front. Biol. Detect. Nanosensors Syst."},{"key":"B36","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.chom.2023.11.006","article-title":"Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism","volume":"32","author":"Li","year":"2024","journal-title":"Cell Host and Microbe"},{"key":"B37","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1080\/00498254.2023.2211135","article-title":"Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study","volume":"53","author":"Li","year":"","journal-title":"Xenobiotica"},{"key":"B38","doi-asserted-by":"publisher","first-page":"3322","DOI":"10.3390\/molecules23123322","article-title":"Cardioprotective effects of puerarin-V on isoproterenol-induced myocardial infarction mice is associated with regulation of PPAR-\u03a5\/NF-\u03baB pathway","volume":"23","author":"Li","year":"2018","journal-title":"Molecules"},{"key":"B39","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s12986-023-00762-z","article-title":"METTL3 exacerbates insulin resistance in hepatocytes by regulating m6A modification of cytochrome P450 2B6","volume":"20","author":"Li","year":"","journal-title":"Nutr. Metab. (Lond)"},{"key":"B40","doi-asserted-by":"publisher","first-page":"6518","DOI":"10.21037\/apm-21-1224","article-title":"The association between cytochrome P450 polymorphisms and anti-tuberculosis drug-induced liver injury: a systematic review and meta-analysis","volume":"10","author":"Liu","year":"2021","journal-title":"Ann. Palliat. Med."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2766","DOI":"10.1080\/15548627.2020.1839286","article-title":"Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3","volume":"17","author":"Liu","year":"2020","journal-title":"Autophagy"},{"key":"B42","doi-asserted-by":"publisher","first-page":"433","DOI":"10.3724\/sp.j.1123.2021.09010","article-title":"Fast screening and confirmation of 73 common prohibited compounds in cosmetics by ultra performance liquid chromatography-quadrupole-time-of-flight high resolution mass spectrometry","volume":"40","author":"Li","year":"2022","journal-title":"CJCSP"},{"key":"B43","doi-asserted-by":"publisher","first-page":"97","DOI":"10.5055\/ajdm.2018.0291","article-title":"Humerus intraosseous administration of epinephrine in normovolemic and hypovolemic porcine model","volume":"13","author":"Long","year":"2018","journal-title":"Am. J. Disaster Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1111\/liv.15600","article-title":"Inhibition of ACSS2 attenuates alcoholic liver steatosis via epigenetically regulating de novo lipogenesis","volume":"43","author":"Lu","year":"2023","journal-title":"Liver Int."},{"key":"B45","doi-asserted-by":"publisher","first-page":"G483","DOI":"10.1152\/ajpgi.00281.2023","article-title":"Interaction between fatty acid oxidation and ethanol metabolism in liver","volume":"326","author":"Lu","year":"2024","journal-title":"Am. J. Physiology-Gastrointestinal Liver Physiology"},{"key":"B46","doi-asserted-by":"publisher","first-page":"9514","DOI":"10.3390\/ijms24119514","article-title":"Cloning and functional characterization of cold-inducible MYB-like 17 transcription factor in rapeseed (Brassica napus L.)","volume":"24","author":"Luo","year":"2023","journal-title":"IJMS"},{"key":"B47","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.apsb.2020.11.006","article-title":"S-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling","volume":"11","author":"Luo","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"B48","doi-asserted-by":"publisher","first-page":"9712","DOI":"10.26355\/eurrev_202009_23063","article-title":"MiR-181-5p protects mice from sepsis via repressing HMGB1 in an experimental model","volume":"24","author":"Ma","year":"2020","journal-title":"Eur. Rev."},{"key":"B49","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/s41419-022-04903-9","article-title":"Ferutinin induces osteoblast differentiation of DPSCs via induction of KLF2 and autophagy\/mitophagy","volume":"13","author":"Maity","year":"2022","journal-title":"Cell Death Dis."},{"key":"B50","doi-asserted-by":"publisher","first-page":"2984","DOI":"10.1038\/s41598-022-07022-9","article-title":"CYP2B6 allelic variants and non-genetic factors influence CYP2B6 enzyme function","volume":"12","author":"Mang\u00f3","year":"2022","journal-title":"Sci. Rep."},{"key":"B51","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3390\/cells11020288","article-title":"Role of mitochondrial cytochrome P450 2E1 in healthy and diseased liver","volume":"11","author":"Massart","year":"2022","journal-title":"Cells"},{"key":"B52","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.3390\/molecules24102006","article-title":"Multiclass classifier for P-glycoprotein substrates, inhibitors, and non-active compounds","volume":"24","author":"Mora Lagares","year":"2019","journal-title":"Molecules"},{"key":"B53","doi-asserted-by":"publisher","first-page":"e0277614","DOI":"10.1371\/journal.pone.0277614","article-title":"Atractylodes lancea for cholangiocarcinoma: modulatory effects on CYP1A2 and CYP3A1 and pharmacokinetics in rats and biodistribution in mice","volume":"17","author":"Muhamad","year":"2022","journal-title":"PLoS ONE"},{"key":"B54","doi-asserted-by":"publisher","first-page":"153577","DOI":"10.1016\/j.tox.2023.153577","article-title":"Effects of perfluorooctanoic acid (PFOA) on gene expression profiles via nuclear receptors in HepaRG cells: comparative study with in vitro transactivation assays","volume":"494","author":"Murase","year":"2023","journal-title":"Toxicology"},{"key":"B55","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1055\/a-2111-6649","article-title":"Altered gene expression of cytochrome P450 and ABC transporter in human hepatocellular carcinoma HepG2 cells exposed to bardoxolone methyl","volume":"73","author":"Nagai","year":"2023","journal-title":"Drug Res. (Stuttg)"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1124\/dmd.121.000442","article-title":"Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis-drug interactions","volume":"49","author":"Nasrin","year":"2021","journal-title":"Drug Metab. Dispos."},{"key":"B57","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1080\/00952990.2022.2128361","article-title":"Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation","volume":"49","author":"Niedzwiedz-Massey","year":"2022","journal-title":"Am. J. Drug Alcohol Abuse"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1016\/j.jceh.2022.05.004","article-title":"Pathogenesis of alcohol-associated liver disease","volume":"12","author":"Osna","year":"2022","journal-title":"J. Clin. Exp. Hepatology"},{"key":"B59","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1053\/j.gastro.2004.10.045","article-title":"Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells","volume":"128","author":"Otani","year":"2005","journal-title":"Gastroenterology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"105739","DOI":"10.1016\/j.tiv.2023.105739","article-title":"Inhibitory effects of the main metabolites of Apatinib on CYP450 isozymes in human and rat liver microsomes","volume":"95","author":"Pang","year":"2024","journal-title":"Toxicol. Vitro"},{"key":"B61","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.3390\/cancers15092627","article-title":"Performance and safety of eus ablation techniques for pancreatic cystic lesions: a systematic review and meta-analysis","volume":"15","author":"Papaefthymiou","year":"2023","journal-title":"Cancers"},{"key":"B62","doi-asserted-by":"publisher","first-page":"409","DOI":"10.3390\/cells11030409","article-title":"S-adenosylmethionine: from the discovery of its inhibition of tumorigenesis to its use as a therapeutic agent","volume":"11","author":"Pascale","year":"2022","journal-title":"Cells"},{"key":"B63","doi-asserted-by":"publisher","first-page":"114408","DOI":"10.1016\/j.jep.2021.114408","article-title":"Evaluation of potential herb-drug interactions based on the effect of Suxiao Jiuxin Pill on CYP450 enzymes and transporters","volume":"280","author":"Qiang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.3390\/nu16081174","article-title":"The role of oxidative stress in alcoholic fatty liver disease: a systematic review and meta-analysis of preclinical studies","volume":"16","author":"Rabelo","year":"2024","journal-title":"Nutrients"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1016\/j.jhep.2023.06.003","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"79","author":"Rinella","year":"2023","journal-title":"J. Hepatology"},{"key":"B66","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41572-018-0014-7","article-title":"Alcoholic liver disease","volume":"4","author":"Seitz","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"B67","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1164\/rccm.202207-1393oc","article-title":"Antimicrobial exposures in critically ill patients receiving extracorporeal membrane oxygenation","volume":"207","author":"Shekar","year":"2023","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.3390\/molecules26061791","article-title":"A novel dual drug approach that combines ivermectin and dihydromyricetin (DHM) to reduce alcohol drinking and preference in mice","volume":"26","author":"Silva","year":"2021","journal-title":"Molecules"},{"key":"B69","doi-asserted-by":"publisher","first-page":"114","DOI":"10.4103\/indianjpsychiatry.indianjpsychiatry_893_21","article-title":"Caveats of mental healthcare act-2017: recommendation for amendments","volume":"65","author":"Singh","year":"2023","journal-title":"Indian J. Psychiatry"},{"key":"B70","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.hroo.2022.10.016","article-title":"Special issue on electrophysiology and arrhythmia management around the globe: challenges and opportunities explored","volume":"3","author":"Srivatsa","year":"2022","journal-title":"Heart rhythm."},{"key":"B71","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.ejim.2023.07.029","article-title":"Cannabidiol\u2019s impact on drug-metabolization","volume":"118","author":"St\u00f6llberger","year":"2023","journal-title":"Eur. J. Intern. Med."},{"key":"B72","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3177\/jnsv.66.191","article-title":"Coleus forskohlii extract attenuated the beneficial effect of diet-treatment on NASH in mouse model","volume":"66","author":"Suzuki","year":"2020","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/s41588-022-01078-z","article-title":"A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation","volume":"54","author":"Vujkovic","year":"2022","journal-title":"Nat. Genet."},{"key":"B74","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1124\/dmd.119.086769","article-title":"Activation of pregnane X receptor\u2013cytochrome P450s Axis: a possible reason for the enhanced accelerated blood clearance phenomenon of PEGylated liposomes in vivo","volume":"47","author":"Wang","year":"2019","journal-title":"Drug Metab. Dispos."},{"key":"B75","doi-asserted-by":"publisher","first-page":"111910","DOI":"10.1016\/j.ecoenv.2021.111910","article-title":"Novel insights into cytochrome P450 enzyme and solute carrier families in cadmium-induced liver injury of pigs","volume":"211","author":"Wang","year":"","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"B76","doi-asserted-by":"publisher","first-page":"108151","DOI":"10.1016\/j.intimp.2021.108151","article-title":"Silencing miR-181b-5p upregulates PIAS1 to repress oxidative stress and inflammatory response in rats with alcoholic fatty liver disease through inhibiting PRMT1","volume":"101","author":"Wang","year":"","journal-title":"Int. Immunopharmacol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1002\/cpt.3055","article-title":"Comparative intra\u2010subject analysis of gene expression and protein abundance of major and minor drug metabolizing enzymes in healthy human jejunum and liver","volume":"115","author":"Wenzel","year":"2023","journal-title":"Clin Pharma Ther."},{"key":"B78","doi-asserted-by":"publisher","first-page":"508","DOI":"10.2174\/1389200223666220630124403","article-title":"Pharmacokinetics and metabolism of traditional Chinese medicine in the treatmentof COVID-19","volume":"23","author":"Xu","year":"2022","journal-title":"CDM"},{"key":"B79","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1186\/s12967-023-04166-8","article-title":"Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease","volume":"21","author":"Yan","year":"","journal-title":"J. Transl. Med."},{"key":"B80","doi-asserted-by":"publisher","first-page":"106621","DOI":"10.1016\/j.phrs.2022.106621","article-title":"Diosgenin alleviates nonalcoholic steatohepatitis through affecting liver-gut circulation","volume":"187","author":"Yan","year":"","journal-title":"Pharmacol. Res."},{"key":"B81","doi-asserted-by":"publisher","first-page":"e140687","DOI":"10.1172\/jci.insight.140687","article-title":"The role of SHP\/REV-ERB\u03b1\/CYP4A axis in the pathogenesis of alcohol-associated liver disease","volume":"6","author":"Yang","year":"2021","journal-title":"JCI Insight"},{"key":"B82","doi-asserted-by":"publisher","first-page":"8100","DOI":"10.1002\/cam4.4320","article-title":"Downregulation of CYP2E1 is associated with poor prognosis and tumor progression of gliomas","volume":"10","author":"Ye","year":"2021","journal-title":"Cancer Med."},{"key":"B83","first-page":"245","article-title":"Overview: how is alcohol metabolized by the body?","volume":"29","author":"Zakhari","year":"2006","journal-title":"Alcohol Res. Health"},{"key":"B84","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.cbi.2019.05.038","article-title":"CYP3A suppression during diet-induced nonalcoholic fatty liver disease is independent of PXR regulation","volume":"308","author":"Zeng","year":"2019","journal-title":"Chemico-Biological Interact."},{"key":"B85","doi-asserted-by":"publisher","first-page":"103728","DOI":"10.1016\/j.drudis.2023.103728","article-title":"Comparison and summary of in silico prediction tools for CYP450-mediated drug metabolism","volume":"28","author":"Zhai","year":"2023","journal-title":"Drug Discov. Today"},{"key":"B86","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2147\/dddt.s385981","article-title":"Review on the diverse biological effects of glabridin","volume":"17","author":"Zhang","year":"","journal-title":"DDDT"},{"key":"B87","doi-asserted-by":"publisher","first-page":"102012","DOI":"10.1016\/j.clinre.2022.102012","article-title":"Identification of differentially expressed miRNAs and key genes involved in the progression of alcoholic fatty liver disease using rat models","volume":"46","author":"Zhang","year":"2022","journal-title":"Clin. Res. Hepatology Gastroenterology"},{"key":"B88","doi-asserted-by":"publisher","first-page":"100694","DOI":"10.1016\/j.jhepr.2023.100694","article-title":"Association of per- and polyfluoroalkyl substance exposure with fatty liver disease risk in US adults","volume":"5","author":"Zhang","year":"","journal-title":"JHEP Rep."},{"key":"B89","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.ajem.2020.11.003","article-title":"Effects of morphine on P2Y12 platelet inhibitors in patients with acute myocardial infarction: a meta-analysis","volume":"41","author":"Zhang","year":"2021","journal-title":"Am. J. Emerg. Med."},{"key":"B90","doi-asserted-by":"publisher","first-page":"12808","DOI":"10.3390\/ijms222312808","article-title":"Cytochrome P450 enzymes and drug metabolism in humans","volume":"22","author":"Zhao","year":"2021","journal-title":"IJMS"},{"key":"B91","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1210\/clinem\/dgad421","article-title":"The value of targeting CXCR4 with 68Ga-pentixafor PET\/CT for subtyping primary aldosteronism","volume":"109","author":"Zheng","year":"2023","journal-title":"J. Clin. Endocrinol. and Metabolism"}],"container-title":["Frontiers in Chemistry"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fchem.2025.1509785\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T05:30:17Z","timestamp":1747114217000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fchem.2025.1509785\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,13]]},"references-count":91,"alternative-id":["10.3389\/fchem.2025.1509785"],"URL":"https:\/\/doi.org\/10.3389\/fchem.2025.1509785","relation":{},"ISSN":["2296-2646"],"issn-type":[{"value":"2296-2646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,13]]},"article-number":"1509785"}}