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The Hosomi-Sakurai allylation is the allylation of ketones and aldehyde with nucleophilic allylsilanes catalyzed with Lewis acid mainly used to extend the C-C bond in a molecule and also create a new site for manipulation due to the facile transformation of the <jats:italic>pi<\/jats:italic> (\u03c0) bond at the end of its chain. This review highlights only portions of natural product synthetic works that feature the Hosomi-Sakurai allylation reaction or its modification as a key transformation in the synthetic route.<\/jats:p>","DOI":"10.3389\/fchem.2025.1527387","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T11:00:47Z","timestamp":1743159647000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Application of Hosomi-Sakurai allylation reaction in total synthesis of biologically active natural products"],"prefix":"10.3389","volume":"13","author":[{"given":"Justice","family":"Akwensi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T.","family":"Kumah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorcas","family":"Osei-Safo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Amewu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.4028\/www.scientific.net\/AMR.146-147.1597","article-title":"Microstructural morphology and formation mechanism of rapidly solidified Al-21Si multi-alloys","author":"Aiqin","year":"2011","journal-title":"Adv. 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