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Previously, we identified a set of osmium, ruthenium, and iridium half-sandwich complexes of 1-<jats:italic>N<\/jats:italic>-(\u03b2-<jats:sc>d<\/jats:sc>-glucopyranosyl)-4-hetaryl-1,2,3-triazole-type N,N-chelators with potent and selective activity against a large set of diverse neoplasia cell models and multiresistant Gram-positive bacteria (methicillin-resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) and vancomycin-resistant <jats:italic>Enterococcus<\/jats:italic> (VRE)). Our aim in this study was to assess how the configuration of the C1 carbon in the glucose moiety affects the biological activity of the complexes. Thus, 1-<jats:italic>N<\/jats:italic>-(\u03b1-<jats:sc>d<\/jats:sc>-glucopyranosyl)-4-hetaryl-1,2,3-triazoles were synthesized and used as N,N-bidentate ligands to result in half-sandwich type complexes analogous to the earlier reported ones. Overall, the newly prepared complexes with the \u03b1-anomeric carbohydrate moiety had similar biological properties to the complexes with the \u03b2-anomeric carbohydrate unit in terms of their biological activity on cancer cells or primary human cells. 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