{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T05:53:12Z","timestamp":1775713992984,"version":"3.50.1"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p>\n                    The yeast\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    is one of the most prevalent fungal pathogens. It induces superficial and systemic infections in immunocompromised patients. The high pathogenicity of\n                    <jats:italic>Candida<\/jats:italic>\n                    species may be related to their adherence to the host tissues. Cell surface glycans are important receptors for\n                    <jats:italic>C. albicans<\/jats:italic>\n                    and warrant the development of anti-adherence ligands that can mimic them and disrupt\n                    <jats:italic>C. albicans<\/jats:italic>\n                    \u2013epithelial cell interactions. A divalent galactoside glycomimetic containing 1,2,3-triazole units was found to be one of the most potent inhibitors of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    adhesion to exfoliated buccal epithelial cells. Based on this lead molecule, herein we report on the synthesis and evaluation of a new series of mono- and divalent glycosides, featuring isophthalamide and benzene scaffolds with\n                    <jats:italic>C<\/jats:italic>\n                    -glycosyl isoxazoline and isoxazole, as well as\n                    <jats:italic>N<\/jats:italic>\n                    -glycosyl 1,2,3-triazole units. The new compounds were obtained by 1,3-dipolar cycloaddition reactions between the above scaffolds functionalized with one or two alkenyl or alkynyl moieties and glycosyl nitrile oxides and glycosyl azides, respectively. The tested deprotected compounds were non-toxic to the\n                    <jats:italic>C. albicans<\/jats:italic>\n                    cells and exhibited significant inhibition of\n                    <jats:italic>C. albicans<\/jats:italic>\n                    adhesion, showing good and moderate inhibition in exclusion and competitive assays, respectively. This study demonstrated the utility of isoxazole\/isoxazoline heterocycles to replace 1,2,3-triazoles in aromatic-core glycoconjugates to furnish anti-adhesion molecules equipotent with the lead and also showed that the simple benzene core can serve well in potential anti-adhesives against\n                    <jats:italic>C. albicans<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.3389\/fchem.2026.1794047","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T05:21:04Z","timestamp":1775712064000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of mono- and di-(C-glycopyranosyl-isoxazol(in)yl) derivatives on aromatic scaffolds and their evaluation as anti-adherence agents of Candida albicans"],"prefix":"10.3389","volume":"14","author":[{"given":"T\u00edmea","family":"Kasz\u00e1s","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry, University of Debrecen","place":["Debrecen, Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bence","family":"Szak\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, University of Debrecen","place":["Debrecen, Hungary"]},{"name":"Doctoral School of Chemistry, University of Debrecen","place":["Debrecen, Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tekla","family":"Bl\u00e1ga","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, University of Debrecen","place":["Debrecen, Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle","family":"Doherty","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Maynooth University","place":["Maynooth, Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Keenan-Dillon","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Maynooth University","place":["Maynooth, Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shauna","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Biology, Maynooth University","place":["Maynooth, Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Kavanagh","sequence":"additional","affiliation":[{"name":"Department of Biology, Maynooth University","place":["Maynooth, Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trinidad","family":"Velasco-Torrijos","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Maynooth University","place":["Maynooth, Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Soms\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, University of Debrecen","place":["Debrecen, Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marietta","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, University of Debrecen","place":["Debrecen, Hungary"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1074\/jbc.M509297200","article-title":"Glycosyl-phosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions","volume":"281","author":"Albrecht","year":"2006","journal-title":"J. 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