{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:01:46Z","timestamp":1785391306481,"version":"3.55.0"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Corchorus olitorius<\/jats:italic>\n                      L., known in Arab countries as molokhia, is a leafy plant rich in many carotenoids, minerals, and vitamins; its seeds are also reported to offer cardioprotective effects. Although the cardioprotective effects of molokhia are ascribed to the presence of cardiac glycoside compounds, the exact action mechanisms remain uninvestigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this study, we examined the potential of molokhia seeds to protect against cardiopathy by isolating the major constituents of\n                      <jats:italic>C. olitorius<\/jats:italic>\n                      seeds, analyzing its gene expression\n                      <jats:italic>in vivo,<\/jats:italic>\n                      and conducting computational studies to demonstrate the cardioprotective activities of these constituents.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Crude extracts of\n                      <jats:italic>C. olitorius<\/jats:italic>\n                      seeds were found to reduce the expression of\n                      <jats:italic>IL-1\u03b2<\/jats:italic>\n                      ,\n                      <jats:italic>IL-6<\/jats:italic>\n                      ,\n                      <jats:italic>TNF-\u03b1<\/jats:italic>\n                      ,\n                      <jats:italic>NF-\u03baB<\/jats:italic>\n                      ,\n                      <jats:italic>ICAM-1<\/jats:italic>\n                      , and\n                      <jats:italic>MMP-9<\/jats:italic>\n                      that had increased upon the administration of doxorubicin (DOX). Electrocardiographic studies showed reduced heart rate along with prolongation of the PR interval, QRS complex, and ST segment upon\n                      <jats:italic>Corchorus<\/jats:italic>\n                      administration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings of this study demonstrate that the cardioprotective effects of molokhia seeds against DOX-induced cardiotoxicity are probably mediated via anti-inflammatory actions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fchem.2026.1810825","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:40:43Z","timestamp":1785390043000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated in vivo and in silico validation of Corchorus olitorius seed-mediated cardioprotection against doxorubicin-induced cardiotoxicity via network pharmacology, molecular docking, and molecular dynamics"],"prefix":"10.3389","volume":"14","author":[{"given":"Fatma Mohamed","family":"Abd El-Mordy","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy (Girls), Al-Azhar University","place":["Cairo, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif A.","family":"Maher","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, New Valley University","place":["El-kharga, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar Y.","family":"Tammam","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, New Valley University","place":["El-kharga, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud A.","family":"Elrehany","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Minia University","place":["Minia, Egypt"]},{"name":"Department of Biochemistry, Faculty of Pharmacy, Deraya University, Universities Zone","place":["New Minia City, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Hisham","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University","place":["New Minia, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remon R.","family":"Rofaeil","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Deraya University, Universities Zone","place":["New Minia City, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa E.","family":"Rateb","sequence":"additional","affiliation":[{"name":"Natural and Medical Sciences Research Center, University of Nizwa","place":["Nizwa, Oman"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham F.","family":"Oraby","sequence":"additional","affiliation":[{"name":"Biotechnology\/Molecular Biology and Biomedical Sciences Programs, Faculty of Basic and Applied Science, Egypt-Japan University of Science and Technology (EJUST), New Borg El-Arab City","place":["Alexandria, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud A. 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