{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T07:06:21Z","timestamp":1774940781071,"version":"3.50.1"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Chem."],"abstract":"<jats:p>\n                    Morinda officinalis, a traditional Chinese medicine, is an authentic medicinal herb from Deqing, Guangdong, and is also one of China\u2019s famous \u201cFour Great Southern Medicinals\u201d. It is widely used as a dietary supplement in the southern regions and is known for its effects on kidney yang, as well as strengthening bones and muscles. The main active components of\n                    <jats:italic>Morinda officinalis<\/jats:italic>\n                    include sugars, anthraquinones, and iridoids. Among these, sugars-including monosaccharides, polysaccharides, and oligosaccharides-are considered the primary bioactive constituents. In recent years, pharmacological studies have indicated that the oligosaccharide components of\n                    <jats:italic>Morinda officinalis<\/jats:italic>\n                    possess significant pharmacological activities, such as antidepressant, anti-Alzheimer\u2019s, and anti-osteoporosis effects, highlighting their potential for further development and utilization. Therefore, this paper reviews the separation processes and pharmacological activities of oligosaccharide components in\n                    <jats:italic>Morinda officinalis<\/jats:italic>\n                    , and summarizes the research and application hotspots of\n                    <jats:italic>Morinda officinalis<\/jats:italic>\n                    oligosaccharides, aiming to provide a theoretical basis for further research.\n                  <\/jats:p>","DOI":"10.3389\/fchem.2026.1813259","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:34:03Z","timestamp":1774935243000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Research progress on the oligosaccharide components and pharmacological activities of Morinda officinalis"],"prefix":"10.3389","volume":"14","author":[{"given":"Yan","family":"Lei","sequence":"first","affiliation":[{"name":"College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University","place":["Shenyang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, State Key Laboratory of Bioactive Molecules and Druggability Assessment, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxian","family":"Dan","sequence":"additional","affiliation":[{"name":"Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, State Key Laboratory of Bioactive Molecules and Druggability Assessment, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongxian","family":"Xie","sequence":"additional","affiliation":[{"name":"Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, State Key Laboratory of Bioactive Molecules and Druggability Assessment, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, State Key Laboratory of Bioactive Molecules and Druggability Assessment, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinluan","family":"Wang","sequence":"additional","affiliation":[{"name":"Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences (CAS)","place":["Shenzhen, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second 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